TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8R6_LEIMA

TriTrypDb:

LmjF.28.0040 , LMJLV39_280005400 , LMJSD75_280005300

Length:

916

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q8R6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8R6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	809	813	PF00656	0.424
CLV_NRD_NRD_1	208	210	PF00675	0.644
CLV_NRD_NRD_1	277	279	PF00675	0.574
CLV_NRD_NRD_1	331	333	PF00675	0.370
CLV_NRD_NRD_1	368	370	PF00675	0.431
CLV_NRD_NRD_1	385	387	PF00675	0.297
CLV_NRD_NRD_1	467	469	PF00675	0.473
CLV_NRD_NRD_1	502	504	PF00675	0.396
CLV_NRD_NRD_1	621	623	PF00675	0.354
CLV_NRD_NRD_1	774	776	PF00675	0.503
CLV_NRD_NRD_1	911	913	PF00675	0.535
CLV_PCSK_KEX2_1	269	271	PF00082	0.570
CLV_PCSK_KEX2_1	277	279	PF00082	0.590
CLV_PCSK_KEX2_1	368	370	PF00082	0.426
CLV_PCSK_KEX2_1	502	504	PF00082	0.379
CLV_PCSK_KEX2_1	52	54	PF00082	0.576
CLV_PCSK_KEX2_1	774	776	PF00082	0.514
CLV_PCSK_KEX2_1	911	913	PF00082	0.522
CLV_PCSK_PC1ET2_1	269	271	PF00082	0.591
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.564
CLV_PCSK_PC1ET2_1	911	913	PF00082	0.522
CLV_PCSK_PC7_1	364	370	PF00082	0.567
CLV_PCSK_PC7_1	498	504	PF00082	0.434
CLV_PCSK_SKI1_1	128	132	PF00082	0.513
CLV_PCSK_SKI1_1	17	21	PF00082	0.446
CLV_PCSK_SKI1_1	173	177	PF00082	0.557
CLV_PCSK_SKI1_1	209	213	PF00082	0.573
CLV_PCSK_SKI1_1	277	281	PF00082	0.606
CLV_PCSK_SKI1_1	316	320	PF00082	0.491
CLV_PCSK_SKI1_1	369	373	PF00082	0.373
CLV_PCSK_SKI1_1	416	420	PF00082	0.472
CLV_PCSK_SKI1_1	436	440	PF00082	0.382
CLV_PCSK_SKI1_1	477	481	PF00082	0.420
CLV_PCSK_SKI1_1	503	507	PF00082	0.426
CLV_PCSK_SKI1_1	587	591	PF00082	0.543
CLV_PCSK_SKI1_1	622	626	PF00082	0.341
CLV_PCSK_SKI1_1	715	719	PF00082	0.433
CLV_PCSK_SKI1_1	774	778	PF00082	0.494
CLV_PCSK_SKI1_1	819	823	PF00082	0.320
CLV_Separin_Metazoa	600	604	PF03568	0.492
DEG_APCC_DBOX_1	368	376	PF00400	0.490
DEG_APCC_DBOX_1	415	423	PF00400	0.349
DEG_APCC_DBOX_1	502	510	PF00400	0.413
DEG_APCC_DBOX_1	621	629	PF00400	0.342
DEG_APCC_DBOX_1	669	677	PF00400	0.420
DOC_CKS1_1	73	78	PF01111	0.664
DOC_CYCLIN_RxL_1	14	22	PF00134	0.439
DOC_CYCLIN_RxL_1	313	323	PF00134	0.379
DOC_CYCLIN_RxL_1	498	510	PF00134	0.505
DOC_CYCLIN_RxL_1	712	722	PF00134	0.481
DOC_MAPK_gen_1	115	123	PF00069	0.659
DOC_MAPK_gen_1	209	219	PF00069	0.536
DOC_MAPK_gen_1	386	392	PF00069	0.470
DOC_MAPK_gen_1	410	419	PF00069	0.467
DOC_MAPK_gen_1	91	98	PF00069	0.586
DOC_MAPK_MEF2A_6	115	123	PF00069	0.636
DOC_MAPK_MEF2A_6	209	217	PF00069	0.537
DOC_MAPK_MEF2A_6	727	735	PF00069	0.382
DOC_MAPK_MEF2A_6	91	98	PF00069	0.539
DOC_PP1_RVXF_1	15	21	PF00149	0.449
DOC_PP1_RVXF_1	299	305	PF00149	0.551
DOC_PP1_RVXF_1	654	661	PF00149	0.461
DOC_PP2B_LxvP_1	121	124	PF13499	0.704
DOC_PP4_MxPP_1	1	4	PF00568	0.655
DOC_USP7_MATH_1	153	157	PF00917	0.597
DOC_USP7_MATH_1	320	324	PF00917	0.499
DOC_USP7_MATH_1	339	343	PF00917	0.302
DOC_USP7_MATH_1	438	442	PF00917	0.497
DOC_USP7_MATH_1	473	477	PF00917	0.451
DOC_USP7_MATH_1	559	563	PF00917	0.451
DOC_USP7_MATH_1	690	694	PF00917	0.695
DOC_USP7_MATH_1	741	745	PF00917	0.489
DOC_USP7_UBL2_3	406	410	PF12436	0.504
DOC_USP7_UBL2_3	907	911	PF12436	0.392
DOC_WW_Pin1_4	142	147	PF00397	0.630
DOC_WW_Pin1_4	203	208	PF00397	0.657
DOC_WW_Pin1_4	72	77	PF00397	0.655
LIG_14-3-3_CanoR_1	104	111	PF00244	0.694
LIG_14-3-3_CanoR_1	277	282	PF00244	0.576
LIG_14-3-3_CanoR_1	297	301	PF00244	0.420
LIG_14-3-3_CanoR_1	340	346	PF00244	0.413
LIG_14-3-3_CanoR_1	477	485	PF00244	0.474
LIG_14-3-3_CanoR_1	502	506	PF00244	0.476
LIG_14-3-3_CanoR_1	507	515	PF00244	0.498
LIG_14-3-3_CanoR_1	542	552	PF00244	0.507
LIG_14-3-3_CanoR_1	603	611	PF00244	0.349
LIG_14-3-3_CanoR_1	677	683	PF00244	0.463
LIG_Actin_WH2_2	651	669	PF00022	0.475
LIG_APCC_ABBA_1	867	872	PF00400	0.400
LIG_CtBP_PxDLS_1	124	128	PF00389	0.613
LIG_deltaCOP1_diTrp_1	862	870	PF00928	0.455
LIG_FHA_1	192	198	PF00498	0.710
LIG_FHA_1	297	303	PF00498	0.622
LIG_FHA_1	394	400	PF00498	0.406
LIG_FHA_1	530	536	PF00498	0.486
LIG_FHA_1	596	602	PF00498	0.424
LIG_FHA_1	700	706	PF00498	0.526
LIG_FHA_1	803	809	PF00498	0.398
LIG_FHA_1	813	819	PF00498	0.276
LIG_FHA_1	837	843	PF00498	0.369
LIG_FHA_1	864	870	PF00498	0.352
LIG_FHA_1	885	891	PF00498	0.422
LIG_FHA_1	897	903	PF00498	0.326
LIG_FHA_2	103	109	PF00498	0.600
LIG_FHA_2	131	137	PF00498	0.594
LIG_FHA_2	227	233	PF00498	0.549
LIG_FHA_2	307	313	PF00498	0.494
LIG_FHA_2	761	767	PF00498	0.360
LIG_FHA_2	804	810	PF00498	0.392
LIG_IRF3_LxIS_1	851	856	PF10401	0.437
LIG_LIR_Gen_1	517	525	PF02991	0.343
LIG_LIR_Gen_1	680	691	PF02991	0.518
LIG_LIR_Gen_1	766	776	PF02991	0.385
LIG_LIR_Nem_3	400	405	PF02991	0.425
LIG_LIR_Nem_3	517	523	PF02991	0.342
LIG_LIR_Nem_3	567	572	PF02991	0.467
LIG_PCNA_yPIPBox_3	570	582	PF02747	0.358
LIG_Pex14_2	398	402	PF04695	0.467
LIG_SH2_STAP1	39	43	PF00017	0.466
LIG_SH2_STAP1	520	524	PF00017	0.338
LIG_SH2_STAT3	39	42	PF00017	0.465
LIG_SH2_STAT5	816	819	PF00017	0.448
LIG_SH3_2	80	85	PF14604	0.713
LIG_SH3_2	99	104	PF14604	0.614
LIG_SH3_3	119	125	PF00018	0.527
LIG_SH3_3	137	143	PF00018	0.586
LIG_SH3_3	152	158	PF00018	0.596
LIG_SH3_3	2	8	PF00018	0.706
LIG_SH3_3	71	77	PF00018	0.711
LIG_SH3_3	755	761	PF00018	0.458
LIG_SH3_3	841	847	PF00018	0.453
LIG_SH3_3	96	102	PF00018	0.606
LIG_Sin3_3	489	496	PF02671	0.335
LIG_SUMO_SIM_anti_2	453	458	PF11976	0.461
LIG_SUMO_SIM_anti_2	744	750	PF11976	0.365
LIG_SUMO_SIM_par_1	449	455	PF11976	0.540
LIG_TRAF2_1	163	166	PF00917	0.679
LIG_TRAF2_1	597	600	PF00917	0.526
LIG_UBA3_1	869	875	PF00899	0.286
LIG_WRC_WIRS_1	328	333	PF05994	0.372
MOD_CDC14_SPxK_1	206	209	PF00782	0.541
MOD_CDK_SPxK_1	203	209	PF00069	0.546
MOD_CDK_SPxK_1	72	78	PF00069	0.580
MOD_CDK_SPxxK_3	203	210	PF00069	0.544
MOD_CK1_1	10	16	PF00069	0.493
MOD_CK1_1	126	132	PF00069	0.599
MOD_CK1_1	138	144	PF00069	0.592
MOD_CK1_1	323	329	PF00069	0.382
MOD_CK1_1	355	361	PF00069	0.574
MOD_CK1_1	393	399	PF00069	0.433
MOD_CK1_1	684	690	PF00069	0.583
MOD_CK1_1	693	699	PF00069	0.564
MOD_CK1_1	710	716	PF00069	0.354
MOD_CK1_1	744	750	PF00069	0.387
MOD_CK1_1	788	794	PF00069	0.409
MOD_CK1_1	856	862	PF00069	0.391
MOD_CK1_1	876	882	PF00069	0.350
MOD_CK1_1	884	890	PF00069	0.439
MOD_CK2_1	102	108	PF00069	0.670
MOD_CK2_1	130	136	PF00069	0.593
MOD_CK2_1	32	38	PF00069	0.624
MOD_CK2_1	444	450	PF00069	0.489
MOD_CK2_1	475	481	PF00069	0.433
MOD_CK2_1	640	646	PF00069	0.399
MOD_CK2_1	803	809	PF00069	0.469
MOD_GlcNHglycan	140	143	PF01048	0.656
MOD_GlcNHglycan	155	158	PF01048	0.599
MOD_GlcNHglycan	21	24	PF01048	0.407
MOD_GlcNHglycan	237	240	PF01048	0.659
MOD_GlcNHglycan	322	325	PF01048	0.484
MOD_GlcNHglycan	341	344	PF01048	0.285
MOD_GlcNHglycan	357	360	PF01048	0.392
MOD_GlcNHglycan	392	395	PF01048	0.411
MOD_GlcNHglycan	446	449	PF01048	0.532
MOD_GlcNHglycan	481	484	PF01048	0.564
MOD_GlcNHglycan	494	497	PF01048	0.533
MOD_GlcNHglycan	708	712	PF01048	0.484
MOD_GlcNHglycan	742	746	PF01048	0.385
MOD_GlcNHglycan	80	83	PF01048	0.746
MOD_GlcNHglycan	858	861	PF01048	0.389
MOD_GlcNHglycan	878	881	PF01048	0.237
MOD_GlcNHglycan	9	12	PF01048	0.550
MOD_GSK3_1	126	133	PF00069	0.625
MOD_GSK3_1	138	145	PF00069	0.540
MOD_GSK3_1	296	303	PF00069	0.529
MOD_GSK3_1	323	330	PF00069	0.342
MOD_GSK3_1	348	355	PF00069	0.490
MOD_GSK3_1	393	400	PF00069	0.421
MOD_GSK3_1	440	447	PF00069	0.563
MOD_GSK3_1	473	480	PF00069	0.384
MOD_GSK3_1	497	504	PF00069	0.491
MOD_GSK3_1	778	785	PF00069	0.372
MOD_GSK3_1	849	856	PF00069	0.383
MOD_LATS_1	585	591	PF00433	0.375
MOD_N-GLC_1	529	534	PF02516	0.381
MOD_N-GLC_1	778	783	PF02516	0.323
MOD_N-GLC_1	812	817	PF02516	0.367
MOD_NEK2_1	19	24	PF00069	0.458
MOD_NEK2_1	296	301	PF00069	0.579
MOD_NEK2_1	32	37	PF00069	0.538
MOD_NEK2_1	390	395	PF00069	0.381
MOD_NEK2_1	457	462	PF00069	0.432
MOD_NEK2_1	479	484	PF00069	0.509
MOD_NEK2_1	640	645	PF00069	0.388
MOD_NEK2_1	802	807	PF00069	0.477
MOD_NEK2_1	853	858	PF00069	0.381
MOD_NEK2_1	873	878	PF00069	0.293
MOD_NEK2_2	327	332	PF00069	0.347
MOD_NEK2_2	863	868	PF00069	0.404
MOD_PIKK_1	457	463	PF00454	0.540
MOD_PIKK_1	884	890	PF00454	0.369
MOD_PKA_1	277	283	PF00069	0.666
MOD_PKA_2	103	109	PF00069	0.535
MOD_PKA_2	114	120	PF00069	0.575
MOD_PKA_2	277	283	PF00069	0.544
MOD_PKA_2	296	302	PF00069	0.423
MOD_PKA_2	339	345	PF00069	0.509
MOD_PKA_2	457	463	PF00069	0.459
MOD_PKA_2	497	503	PF00069	0.532
MOD_PKA_2	676	682	PF00069	0.479
MOD_PKA_2	684	690	PF00069	0.557
MOD_Plk_1	135	141	PF00069	0.722
MOD_Plk_1	306	312	PF00069	0.554
MOD_Plk_1	452	458	PF00069	0.420
MOD_Plk_1	515	521	PF00069	0.386
MOD_Plk_1	778	784	PF00069	0.412
MOD_Plk_1	803	809	PF00069	0.472
MOD_Plk_1	812	818	PF00069	0.421
MOD_Plk_1	85	91	PF00069	0.650
MOD_Plk_2-3	804	810	PF00069	0.358
MOD_Plk_4	192	198	PF00069	0.578
MOD_Plk_4	452	458	PF00069	0.396
MOD_Plk_4	515	521	PF00069	0.416
MOD_Plk_4	701	707	PF00069	0.632
MOD_Plk_4	734	740	PF00069	0.440
MOD_Plk_4	744	750	PF00069	0.337
MOD_Plk_4	782	788	PF00069	0.357
MOD_Plk_4	791	797	PF00069	0.263
MOD_Plk_4	812	818	PF00069	0.329
MOD_Plk_4	881	887	PF00069	0.501
MOD_ProDKin_1	142	148	PF00069	0.628
MOD_ProDKin_1	203	209	PF00069	0.657
MOD_ProDKin_1	72	78	PF00069	0.659
MOD_SUMO_for_1	405	408	PF00179	0.298
MOD_SUMO_for_1	739	742	PF00179	0.385
MOD_SUMO_for_1	903	906	PF00179	0.433
MOD_SUMO_rev_2	165	175	PF00179	0.622
TRG_DiLeu_BaEn_4	274	280	PF01217	0.505
TRG_DiLeu_BaEn_4	408	414	PF01217	0.391
TRG_DiLeu_BaEn_4	432	438	PF01217	0.458
TRG_DiLeu_BaLyEn_6	91	96	PF01217	0.552
TRG_ENDOCYTIC_2	520	523	PF00928	0.341
TRG_ENDOCYTIC_2	768	771	PF00928	0.349
TRG_ER_diArg_1	277	279	PF00400	0.616
TRG_ER_diArg_1	367	369	PF00400	0.433
TRG_ER_diArg_1	501	503	PF00400	0.399
TRG_ER_diArg_1	774	776	PF00400	0.416
TRG_ER_diLys_1	911	916	PF00400	0.439
TRG_NES_CRM1_1	708	722	PF08389	0.488
TRG_NLS_MonoCore_2	910	915	PF00514	0.469
TRG_NLS_MonoExtC_3	208	213	PF00514	0.673
TRG_NLS_MonoExtC_3	910	915	PF00514	0.469
TRG_NLS_MonoExtN_4	207	213	PF00514	0.647
TRG_NLS_MonoExtN_4	911	916	PF00514	0.488
TRG_Pf-PMV_PEXEL_1	288	293	PF00026	0.533
TRG_Pf-PMV_PEXEL_1	313	317	PF00026	0.475
TRG_Pf-PMV_PEXEL_1	369	373	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	477	481	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	503	508	PF00026	0.451
TRG_Pf-PMV_PEXEL_1	542	547	PF00026	0.382

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF72	Leptomonas seymouri	61%	99%
A0A0S4J1J7	Bodo saltans	30%	86%
A0A1X0NWQ3	Trypanosomatidae	35%	97%
A0A3Q8ICX2	Leishmania donovani	91%	100%
A0A3R7LZ16	Trypanosoma rangeli	36%	96%
A4HG47	Leishmania braziliensis	74%	100%
A4I377	Leishmania infantum	91%	100%
D0A7Q3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	97%
E9AZG5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BBZ0	Trypanosoma cruzi	36%	97%