NYD-SP28 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nexin-dynein regulatory complex 2

Species:

Leishmania major

UniProt:

Q4Q8R5_LEIMA

TriTrypDb:

LmjF.28.0050 , LMJLV39_280005500 , LMJSD75_280005400

Length:

488

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005858	axonemal dynein complex	4	12
GO:0005875	microtubule associated complex	2	12
GO:0005929	cilium	4	4
GO:0005930	axoneme	2	2
GO:0030286	dynein complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0042995	cell projection	2	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0110165	cellular anatomical entity	1	4
GO:0120025	plasma membrane bounded cell projection	3	4
GO:1902494	catalytic complex	2	12
GO:0031514	motile cilium	5	2

Expansion

Sequence features

Q4Q8R5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8R5

Function

Biological processes
Term	Name	Level	Count
GO:0001539	cilium or flagellum-dependent cell motility	3	2
GO:0003352	regulation of cilium movement	6	2
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0032886	regulation of microtubule-based process	4	2
GO:0043933	protein-containing complex organization	4	12
GO:0048870	cell motility	2	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0060285	cilium-dependent cell motility	4	2
GO:0060632	regulation of microtubule-based movement	5	2
GO:0065003	protein-containing complex assembly	5	12
GO:0065007	biological regulation	1	2
GO:0070286	axonemal dynein complex assembly	6	12
GO:0071840	cellular component organization or biogenesis	2	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	239	241	PF00675	0.474
CLV_NRD_NRD_1	358	360	PF00675	0.605
CLV_NRD_NRD_1	62	64	PF00675	0.224
CLV_NRD_NRD_1	70	72	PF00675	0.220
CLV_NRD_NRD_1	8	10	PF00675	0.179
CLV_PCSK_KEX2_1	318	320	PF00082	0.494
CLV_PCSK_KEX2_1	357	359	PF00082	0.474
CLV_PCSK_KEX2_1	62	64	PF00082	0.233
CLV_PCSK_KEX2_1	8	10	PF00082	0.203
CLV_PCSK_PC1ET2_1	318	320	PF00082	0.494
CLV_PCSK_PC1ET2_1	357	359	PF00082	0.474
CLV_PCSK_SKI1_1	11	15	PF00082	0.215
CLV_PCSK_SKI1_1	149	153	PF00082	0.408
CLV_PCSK_SKI1_1	258	262	PF00082	0.408
CLV_PCSK_SKI1_1	274	278	PF00082	0.414
CLV_PCSK_SKI1_1	282	286	PF00082	0.419
CLV_PCSK_SKI1_1	398	402	PF00082	0.351
CLV_PCSK_SKI1_1	410	414	PF00082	0.350
CLV_PCSK_SKI1_1	91	95	PF00082	0.205
CLV_Separin_Metazoa	59	63	PF03568	0.399
DEG_APCC_DBOX_1	148	156	PF00400	0.505
DEG_Nend_UBRbox_1	1	4	PF02207	0.432
DOC_CYCLIN_RxL_1	318	328	PF00134	0.357
DOC_CYCLIN_RxL_1	407	416	PF00134	0.415
DOC_CYCLIN_RxL_1	8	18	PF00134	0.452
DOC_MAPK_gen_1	318	329	PF00069	0.382
DOC_MAPK_gen_1	8	15	PF00069	0.379
DOC_SPAK_OSR1_1	391	395	PF12202	0.449
DOC_USP7_MATH_1	3	7	PF00917	0.452
DOC_USP7_MATH_1	361	365	PF00917	0.503
DOC_USP7_MATH_1	458	462	PF00917	0.585
DOC_USP7_MATH_1	93	97	PF00917	0.420
DOC_USP7_UBL2_3	283	287	PF12436	0.391
LIG_14-3-3_CanoR_1	11	16	PF00244	0.358
LIG_14-3-3_CanoR_1	439	445	PF00244	0.604
LIG_14-3-3_CanoR_1	62	66	PF00244	0.472
LIG_14-3-3_CterR_2	483	488	PF00244	0.560
LIG_Actin_WH2_2	135	151	PF00022	0.489
LIG_Actin_WH2_2	178	195	PF00022	0.503
LIG_BIR_III_2	377	381	PF00653	0.504
LIG_deltaCOP1_diTrp_1	384	393	PF00928	0.392
LIG_deltaCOP1_diTrp_1	39	45	PF00928	0.405
LIG_FHA_1	110	116	PF00498	0.493
LIG_FHA_1	230	236	PF00498	0.514
LIG_FHA_1	441	447	PF00498	0.480
LIG_FHA_1	75	81	PF00498	0.420
LIG_FHA_2	174	180	PF00498	0.521
LIG_FHA_2	333	339	PF00498	0.411
LIG_FHA_2	76	82	PF00498	0.534
LIG_LIR_Gen_1	384	394	PF02991	0.483
LIG_LIR_Gen_1	39	46	PF02991	0.405
LIG_LIR_Nem_3	204	210	PF02991	0.440
LIG_LIR_Nem_3	384	389	PF02991	0.427
LIG_LIR_Nem_3	39	45	PF02991	0.405
LIG_PCNA_PIPBox_1	421	430	PF02747	0.382
LIG_PCNA_yPIPBox_3	410	424	PF02747	0.375
LIG_SH2_CRK	452	456	PF00017	0.607
LIG_SH2_NCK_1	132	136	PF00017	0.514
LIG_SH2_NCK_1	452	456	PF00017	0.660
LIG_SH2_NCK_1	469	473	PF00017	0.630
LIG_SH2_STAT5	221	224	PF00017	0.554
LIG_SH2_STAT5	427	430	PF00017	0.381
LIG_SUMO_SIM_anti_2	57	62	PF11976	0.416
LIG_SUMO_SIM_par_1	441	447	PF11976	0.466
LIG_TRAF2_1	25	28	PF00917	0.443
LIG_TRAF2_1	308	311	PF00917	0.514
LIG_UBA3_1	323	331	PF00899	0.370
MOD_CK1_1	247	253	PF00069	0.360
MOD_CK1_1	461	467	PF00069	0.565
MOD_CK2_1	173	179	PF00069	0.570
MOD_CK2_1	332	338	PF00069	0.448
MOD_CK2_1	75	81	PF00069	0.442
MOD_GlcNHglycan	211	214	PF01048	0.467
MOD_GlcNHglycan	34	37	PF01048	0.311
MOD_GlcNHglycan	348	351	PF01048	0.517
MOD_GlcNHglycan	363	367	PF01048	0.569
MOD_GSK3_1	11	18	PF00069	0.489
MOD_GSK3_1	244	251	PF00069	0.429
MOD_GSK3_1	28	35	PF00069	0.412
MOD_GSK3_1	440	447	PF00069	0.532
MOD_GSK3_1	61	68	PF00069	0.472
MOD_N-GLC_1	306	311	PF02516	0.491
MOD_N-GLC_1	345	350	PF02516	0.516
MOD_N-GLC_1	458	463	PF02516	0.595
MOD_NEK2_1	15	20	PF00069	0.496
MOD_NEK2_1	245	250	PF00069	0.367
MOD_NEK2_1	313	318	PF00069	0.419
MOD_NEK2_1	438	443	PF00069	0.471
MOD_NEK2_1	444	449	PF00069	0.455
MOD_NEK2_1	75	80	PF00069	0.420
MOD_PIKK_1	404	410	PF00454	0.364
MOD_PIKK_1	444	450	PF00454	0.483
MOD_PKA_2	438	444	PF00069	0.577
MOD_PKA_2	61	67	PF00069	0.472
MOD_PKB_1	9	17	PF00069	0.482
MOD_Plk_1	274	280	PF00069	0.387
MOD_Plk_1	429	435	PF00069	0.423
MOD_Plk_1	461	467	PF00069	0.624
MOD_Plk_1	65	71	PF00069	0.472
MOD_Plk_1	81	87	PF00069	0.443
MOD_Plk_2-3	429	435	PF00069	0.467
MOD_Plk_2-3	81	87	PF00069	0.452
MOD_Plk_4	100	106	PF00069	0.507
MOD_Plk_4	11	17	PF00069	0.358
MOD_Plk_4	440	446	PF00069	0.484
MOD_Plk_4	461	467	PF00069	0.522
MOD_Plk_4	75	81	PF00069	0.420
MOD_SUMO_rev_2	133	142	PF00179	0.428
MOD_SUMO_rev_2	158	166	PF00179	0.428
TRG_DiLeu_BaEn_2	472	478	PF01217	0.556
TRG_DiLeu_BaEn_4	415	421	PF01217	0.359
TRG_DiLeu_BaLyEn_6	146	151	PF01217	0.479
TRG_DiLeu_BaLyEn_6	319	324	PF01217	0.492
TRG_ENDOCYTIC_2	207	210	PF00928	0.444
TRG_ENDOCYTIC_2	452	455	PF00928	0.604
TRG_ENDOCYTIC_2	469	472	PF00928	0.575
TRG_ER_diArg_1	358	360	PF00400	0.605
TRG_ER_diArg_1	61	63	PF00400	0.416
TRG_ER_diArg_1	8	11	PF00400	0.404
TRG_NES_CRM1_1	422	435	PF08389	0.523
TRG_Pf-PMV_PEXEL_1	149	153	PF00026	0.468
TRG_Pf-PMV_PEXEL_1	164	168	PF00026	0.372
TRG_Pf-PMV_PEXEL_1	297	301	PF00026	0.421
TRG_Pf-PMV_PEXEL_1	410	414	PF00026	0.446
TRG_Pf-PMV_PEXEL_1	418	422	PF00026	0.435
TRG_Pf-PMV_PEXEL_1	44	48	PF00026	0.266
TRG_Pf-PMV_PEXEL_1	52	57	PF00026	0.281

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5X5	Leptomonas seymouri	75%	95%
A0A0S4J2B0	Bodo saltans	48%	94%
A0A1X0NVC5	Trypanosomatidae	54%	96%
A0A3Q8IHV5	Leishmania donovani	95%	100%
A0A3R7MHP0	Trypanosoma rangeli	53%	96%
A4HG48	Leishmania braziliensis	83%	95%
A4I378	Leishmania infantum	95%	100%
A8JB22	Chlamydomonas reinhardtii	28%	85%
D0A7Q6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	96%
E9AZG6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	95%
Q2TA16	Bos taurus	28%	98%
Q4R7G7	Macaca fascicularis	30%	100%
Q5XIJ8	Rattus norvegicus	28%	97%
Q6DHI2	Danio rerio	26%	99%
Q8IXS2	Homo sapiens	30%	100%
Q8VHI7	Mus musculus	29%	99%
V5AS08	Trypanosoma cruzi	53%	95%