FIST_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8R4_LEIMA

TriTrypDb:

LmjF.28.0060 , LMJLV39_280005600 , LMJSD75_280005500

Length:

485

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q8R4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8R4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	18	20	PF00675	0.573
CLV_NRD_NRD_1	2	4	PF00675	0.540
CLV_NRD_NRD_1	209	211	PF00675	0.357
CLV_NRD_NRD_1	400	402	PF00675	0.617
CLV_NRD_NRD_1	45	47	PF00675	0.572
CLV_NRD_NRD_1	52	54	PF00675	0.614
CLV_NRD_NRD_1	6	8	PF00675	0.547
CLV_PCSK_KEX2_1	18	20	PF00082	0.573
CLV_PCSK_KEX2_1	2	4	PF00082	0.540
CLV_PCSK_KEX2_1	382	384	PF00082	0.537
CLV_PCSK_KEX2_1	400	402	PF00082	0.645
CLV_PCSK_KEX2_1	45	47	PF00082	0.594
CLV_PCSK_KEX2_1	6	8	PF00082	0.547
CLV_PCSK_PC1ET2_1	382	384	PF00082	0.537
CLV_PCSK_PC7_1	2	8	PF00082	0.675
CLV_PCSK_SKI1_1	259	263	PF00082	0.538
CLV_PCSK_SKI1_1	297	301	PF00082	0.414
CLV_PCSK_SKI1_1	318	322	PF00082	0.398
CLV_PCSK_SKI1_1	33	37	PF00082	0.625
CLV_PCSK_SKI1_1	54	58	PF00082	0.637
CLV_PCSK_SKI1_1	7	11	PF00082	0.568
DEG_APCC_DBOX_1	5	13	PF00400	0.603
DEG_Nend_UBRbox_1	1	4	PF02207	0.552
DEG_ODPH_VHL_1	384	395	PF01847	0.578
DEG_SCF_TRCP1_1	339	344	PF00400	0.385
DEG_SPOP_SBC_1	404	408	PF00917	0.627
DEG_SPOP_SBC_1	473	477	PF00917	0.414
DOC_CDC14_PxL_1	148	156	PF14671	0.494
DOC_CKS1_1	26	31	PF01111	0.579
DOC_CYCLIN_RxL_1	30	40	PF00134	0.527
DOC_MAPK_DCC_7	423	431	PF00069	0.663
DOC_MAPK_gen_1	259	268	PF00069	0.440
DOC_MAPK_gen_1	315	323	PF00069	0.421
DOC_MAPK_gen_1	382	389	PF00069	0.588
DOC_MAPK_gen_1	6	14	PF00069	0.669
DOC_MAPK_MEF2A_6	175	182	PF00069	0.443
DOC_MAPK_MEF2A_6	315	323	PF00069	0.401
DOC_MAPK_MEF2A_6	324	332	PF00069	0.414
DOC_MAPK_MEF2A_6	423	431	PF00069	0.551
DOC_PP1_RVXF_1	51	58	PF00149	0.530
DOC_PP2B_LxvP_1	218	221	PF13499	0.586
DOC_PP4_FxxP_1	345	348	PF00568	0.381
DOC_PP4_FxxP_1	456	459	PF00568	0.465
DOC_PP4_MxPP_1	346	349	PF00568	0.348
DOC_USP7_MATH_1	13	17	PF00917	0.693
DOC_USP7_MATH_1	221	225	PF00917	0.700
DOC_USP7_MATH_1	473	477	PF00917	0.414
DOC_USP7_MATH_1	59	63	PF00917	0.591
DOC_WW_Pin1_4	115	120	PF00397	0.536
DOC_WW_Pin1_4	25	30	PF00397	0.496
DOC_WW_Pin1_4	455	460	PF00397	0.570
LIG_14-3-3_CanoR_1	297	306	PF00244	0.422
LIG_14-3-3_CanoR_1	474	479	PF00244	0.409
LIG_14-3-3_CanoR_1	6	14	PF00244	0.677
LIG_BIR_III_2	162	166	PF00653	0.481
LIG_BRCT_BRCA1_1	157	161	PF00533	0.543
LIG_BRCT_BRCA1_1	237	241	PF00533	0.508
LIG_BRCT_BRCA1_1	316	320	PF00533	0.438
LIG_Clathr_ClatBox_1	377	381	PF01394	0.530
LIG_EVH1_1	82	86	PF00568	0.552
LIG_FHA_1	298	304	PF00498	0.355
LIG_FHA_1	72	78	PF00498	0.517
LIG_FHA_2	462	468	PF00498	0.460
LIG_LIR_Apic_2	305	310	PF02991	0.496
LIG_LIR_Apic_2	342	348	PF02991	0.424
LIG_LIR_Gen_1	158	165	PF02991	0.497
LIG_LIR_Gen_1	475	485	PF02991	0.431
LIG_LIR_Gen_1	94	104	PF02991	0.537
LIG_LIR_Nem_3	158	164	PF02991	0.513
LIG_LIR_Nem_3	317	323	PF02991	0.399
LIG_LYPXL_S_1	218	222	PF13949	0.506
LIG_LYPXL_yS_3	219	222	PF13949	0.518
LIG_MLH1_MIPbox_1	237	241	PF16413	0.526
LIG_SH2_CRK	90	94	PF00017	0.612
LIG_SH2_GRB2like	90	93	PF00017	0.585
LIG_SH2_NCK_1	307	311	PF00017	0.558
LIG_SH2_PTP2	143	146	PF00017	0.508
LIG_SH2_STAP1	193	197	PF00017	0.439
LIG_SH2_STAP1	97	101	PF00017	0.506
LIG_SH2_STAT5	143	146	PF00017	0.508
LIG_SH2_STAT5	478	481	PF00017	0.428
LIG_SH3_3	325	331	PF00018	0.482
LIG_SH3_3	332	338	PF00018	0.460
LIG_SH3_3	421	427	PF00018	0.621
LIG_SH3_3	80	86	PF00018	0.529
LIG_SH3_3	98	104	PF00018	0.511
LIG_TRFH_1	345	349	PF08558	0.509
LIG_TYR_ITIM	191	196	PF00017	0.486
LIG_UBA3_1	376	382	PF00899	0.455
MOD_CK1_1	202	208	PF00069	0.461
MOD_CK1_1	273	279	PF00069	0.420
MOD_CK2_1	305	311	PF00069	0.566
MOD_Cter_Amidation	208	211	PF01082	0.340
MOD_Cter_Amidation	4	7	PF01082	0.665
MOD_GlcNHglycan	15	18	PF01048	0.533
MOD_GlcNHglycan	197	200	PF01048	0.463
MOD_GlcNHglycan	201	204	PF01048	0.425
MOD_GlcNHglycan	230	234	PF01048	0.712
MOD_GlcNHglycan	249	252	PF01048	0.364
MOD_GlcNHglycan	275	278	PF01048	0.478
MOD_GlcNHglycan	339	342	PF01048	0.426
MOD_GlcNHglycan	371	375	PF01048	0.388
MOD_GlcNHglycan	432	435	PF01048	0.595
MOD_GlcNHglycan	61	64	PF01048	0.555
MOD_GSK3_1	153	160	PF00069	0.533
MOD_GSK3_1	195	202	PF00069	0.552
MOD_GSK3_1	264	271	PF00069	0.425
MOD_GSK3_1	273	280	PF00069	0.345
MOD_GSK3_1	337	344	PF00069	0.525
MOD_GSK3_1	372	379	PF00069	0.557
MOD_GSK3_1	55	62	PF00069	0.623
MOD_GSK3_1	8	15	PF00069	0.587
MOD_N-GLC_1	355	360	PF02516	0.357
MOD_N-GLC_1	91	96	PF02516	0.549
MOD_N-GLC_2	110	112	PF02516	0.472
MOD_N-GLC_2	87	89	PF02516	0.499
MOD_NEK2_1	12	17	PF00069	0.562
MOD_NEK2_1	184	189	PF00069	0.456
MOD_NEK2_1	204	209	PF00069	0.433
MOD_NEK2_1	235	240	PF00069	0.515
MOD_NEK2_1	372	377	PF00069	0.620
MOD_NEK2_1	411	416	PF00069	0.513
MOD_NEK2_2	287	292	PF00069	0.453
MOD_OFUCOSY	446	451	PF10250	0.620
MOD_PIKK_1	20	26	PF00454	0.591
MOD_PKA_2	247	253	PF00069	0.544
MOD_PKA_2	473	479	PF00069	0.410
MOD_PKA_2	5	11	PF00069	0.646
MOD_Plk_1	235	241	PF00069	0.573
MOD_Plk_1	341	347	PF00069	0.538
MOD_Plk_1	355	361	PF00069	0.579
MOD_Plk_1	466	472	PF00069	0.532
MOD_Plk_1	91	97	PF00069	0.519
MOD_Plk_2-3	157	163	PF00069	0.506
MOD_Plk_2-3	305	311	PF00069	0.530
MOD_Plk_4	221	227	PF00069	0.524
MOD_Plk_4	235	241	PF00069	0.550
MOD_Plk_4	264	270	PF00069	0.436
MOD_Plk_4	330	336	PF00069	0.439
MOD_Plk_4	341	347	PF00069	0.516
MOD_Plk_4	372	378	PF00069	0.503
MOD_Plk_4	438	444	PF00069	0.476
MOD_Plk_4	467	473	PF00069	0.445
MOD_ProDKin_1	115	121	PF00069	0.539
MOD_ProDKin_1	25	31	PF00069	0.492
MOD_ProDKin_1	455	461	PF00069	0.565
MOD_SUMO_for_1	422	425	PF00179	0.568
MOD_SUMO_rev_2	47	56	PF00179	0.593
TRG_ENDOCYTIC_2	143	146	PF00928	0.517
TRG_ENDOCYTIC_2	193	196	PF00928	0.475
TRG_ENDOCYTIC_2	219	222	PF00928	0.518
TRG_ENDOCYTIC_2	478	481	PF00928	0.428
TRG_ENDOCYTIC_2	90	93	PF00928	0.500
TRG_ENDOCYTIC_2	97	100	PF00928	0.473
TRG_ER_diArg_1	1	3	PF00400	0.538
TRG_ER_diArg_1	18	20	PF00400	0.435
TRG_ER_diArg_1	66	69	PF00400	0.503
TRG_NES_CRM1_1	367	381	PF08389	0.551
TRG_Pf-PMV_PEXEL_1	33	37	PF00026	0.683
TRG_Pf-PMV_PEXEL_1	46	51	PF00026	0.603

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCN6	Leptomonas seymouri	77%	99%
A0A0S4J200	Bodo saltans	42%	95%
A0A1X0NVX9	Trypanosomatidae	57%	98%
A0A3Q8IDL9	Leishmania donovani	94%	100%
A0A3R7NQD0	Trypanosoma rangeli	51%	96%
A4HG49	Leishmania braziliensis	85%	100%
A4I379	Leishmania infantum	94%	100%
D0A7Q8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	98%
E9AZG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%