UDENN FLCN/SMCR8-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8R3_LEIMA

TriTrypDb:

LmjF.28.0070 , LMJLV39_280005700 , LMJSD75_280005600

Length:

516

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8R3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8R3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	119	121	PF00675	0.463
CLV_NRD_NRD_1	270	272	PF00675	0.388
CLV_NRD_NRD_1	339	341	PF00675	0.532
CLV_NRD_NRD_1	447	449	PF00675	0.437
CLV_NRD_NRD_1	5	7	PF00675	0.608
CLV_PCSK_FUR_1	380	384	PF00082	0.377
CLV_PCSK_FUR_1	445	449	PF00082	0.392
CLV_PCSK_KEX2_1	119	121	PF00082	0.505
CLV_PCSK_KEX2_1	258	260	PF00082	0.461
CLV_PCSK_KEX2_1	382	384	PF00082	0.451
CLV_PCSK_KEX2_1	447	449	PF00082	0.437
CLV_PCSK_KEX2_1	5	7	PF00082	0.608
CLV_PCSK_PC1ET2_1	258	260	PF00082	0.461
CLV_PCSK_PC1ET2_1	382	384	PF00082	0.451
CLV_PCSK_SKI1_1	119	123	PF00082	0.508
CLV_PCSK_SKI1_1	188	192	PF00082	0.425
CLV_PCSK_SKI1_1	249	253	PF00082	0.437
CLV_PCSK_SKI1_1	259	263	PF00082	0.334
CLV_PCSK_SKI1_1	329	333	PF00082	0.507
CLV_PCSK_SKI1_1	336	340	PF00082	0.514
DEG_APCC_DBOX_1	258	266	PF00400	0.413
DEG_APCC_DBOX_1	418	426	PF00400	0.312
DEG_APCC_KENBOX_2	321	325	PF00400	0.533
DEG_SPOP_SBC_1	302	306	PF00917	0.489
DOC_CYCLIN_RxL_1	116	125	PF00134	0.391
DOC_CYCLIN_yCln2_LP_2	145	151	PF00134	0.281
DOC_MAPK_DCC_7	171	181	PF00069	0.380
DOC_MAPK_gen_1	230	238	PF00069	0.522
DOC_MAPK_gen_1	258	264	PF00069	0.460
DOC_MAPK_gen_1	428	435	PF00069	0.296
DOC_MAPK_gen_1	443	451	PF00069	0.407
DOC_MAPK_MEF2A_6	23	30	PF00069	0.538
DOC_PP2B_LxvP_1	348	351	PF13499	0.447
DOC_PP4_MxPP_1	251	254	PF00568	0.307
DOC_SPAK_OSR1_1	430	434	PF12202	0.292
DOC_USP7_MATH_1	217	221	PF00917	0.602
DOC_USP7_MATH_1	302	306	PF00917	0.556
DOC_USP7_MATH_1	459	463	PF00917	0.426
DOC_USP7_MATH_1	93	97	PF00917	0.620
DOC_WW_Pin1_4	14	19	PF00397	0.472
DOC_WW_Pin1_4	303	308	PF00397	0.572
DOC_WW_Pin1_4	475	480	PF00397	0.508
LIG_14-3-3_CanoR_1	112	118	PF00244	0.406
LIG_14-3-3_CanoR_1	139	148	PF00244	0.333
LIG_14-3-3_CanoR_1	340	345	PF00244	0.454
LIG_14-3-3_CanoR_1	383	391	PF00244	0.580
LIG_14-3-3_CanoR_1	419	423	PF00244	0.408
LIG_14-3-3_CanoR_1	489	493	PF00244	0.432
LIG_14-3-3_CanoR_1	49	53	PF00244	0.467
LIG_14-3-3_CanoR_1	5	15	PF00244	0.588
LIG_Actin_WH2_2	324	342	PF00022	0.515
LIG_BRCT_BRCA1_1	41	45	PF00533	0.635
LIG_Clathr_ClatBox_1	121	125	PF01394	0.360
LIG_CSL_BTD_1	15	18	PF09270	0.553
LIG_eIF4E_1	140	146	PF01652	0.459
LIG_FHA_1	155	161	PF00498	0.358
LIG_FHA_1	298	304	PF00498	0.418
LIG_FHA_1	312	318	PF00498	0.463
LIG_FHA_1	35	41	PF00498	0.571
LIG_FHA_1	386	392	PF00498	0.419
LIG_FHA_1	69	75	PF00498	0.627
LIG_FHA_1	95	101	PF00498	0.582
LIG_FHA_2	403	409	PF00498	0.533
LIG_FHA_2	462	468	PF00498	0.550
LIG_FHA_2	81	87	PF00498	0.386
LIG_LIR_Apic_2	61	66	PF02991	0.606
LIG_LIR_Gen_1	141	149	PF02991	0.453
LIG_LIR_Gen_1	159	166	PF02991	0.371
LIG_LIR_Gen_1	187	197	PF02991	0.565
LIG_LIR_Gen_1	222	231	PF02991	0.469
LIG_LIR_Gen_1	289	299	PF02991	0.539
LIG_LIR_Gen_1	421	431	PF02991	0.466
LIG_LIR_Nem_3	107	113	PF02991	0.468
LIG_LIR_Nem_3	141	145	PF02991	0.363
LIG_LIR_Nem_3	159	165	PF02991	0.374
LIG_LIR_Nem_3	173	178	PF02991	0.387
LIG_LIR_Nem_3	187	193	PF02991	0.484
LIG_LIR_Nem_3	222	227	PF02991	0.498
LIG_LIR_Nem_3	289	294	PF02991	0.541
LIG_LIR_Nem_3	296	301	PF02991	0.556
LIG_LIR_Nem_3	42	48	PF02991	0.661
LIG_LIR_Nem_3	421	427	PF02991	0.440
LIG_LIR_Nem_3	467	472	PF02991	0.578
LIG_PDZ_Class_3	511	516	PF00595	0.652
LIG_SH2_CRK	194	198	PF00017	0.441
LIG_SH2_CRK	291	295	PF00017	0.519
LIG_SH2_CRK	63	67	PF00017	0.478
LIG_SH2_STAP1	374	378	PF00017	0.420
LIG_SH2_STAP1	46	50	PF00017	0.555
LIG_SH2_STAP1	469	473	PF00017	0.535
LIG_SH2_STAT5	180	183	PF00017	0.358
LIG_SH2_STAT5	280	283	PF00017	0.539
LIG_SH2_STAT5	352	355	PF00017	0.407
LIG_SH2_STAT5	472	475	PF00017	0.593
LIG_SH3_3	392	398	PF00018	0.516
LIG_SH3_3	50	56	PF00018	0.531
LIG_SUMO_SIM_anti_2	240	247	PF11976	0.463
LIG_SUMO_SIM_par_1	34	42	PF11976	0.604
LIG_UBA3_1	244	249	PF00899	0.443
MOD_CDC14_SPxK_1	306	309	PF00782	0.510
MOD_CDK_SPxK_1	303	309	PF00069	0.500
MOD_CK1_1	115	121	PF00069	0.494
MOD_CK1_1	170	176	PF00069	0.560
MOD_CK1_1	225	231	PF00069	0.573
MOD_CK1_1	34	40	PF00069	0.439
MOD_CK1_1	343	349	PF00069	0.394
MOD_CK1_1	385	391	PF00069	0.453
MOD_CK1_1	475	481	PF00069	0.523
MOD_CK1_1	7	13	PF00069	0.518
MOD_CK2_1	14	20	PF00069	0.452
MOD_CK2_1	312	318	PF00069	0.586
MOD_CK2_1	354	360	PF00069	0.569
MOD_CK2_1	402	408	PF00069	0.556
MOD_CK2_1	461	467	PF00069	0.489
MOD_CK2_1	80	86	PF00069	0.493
MOD_GlcNHglycan	125	129	PF01048	0.467
MOD_GlcNHglycan	172	175	PF01048	0.477
MOD_GlcNHglycan	219	222	PF01048	0.568
MOD_GlcNHglycan	314	317	PF01048	0.616
MOD_GlcNHglycan	391	394	PF01048	0.514
MOD_GlcNHglycan	6	9	PF01048	0.563
MOD_GSK3_1	111	118	PF00069	0.507
MOD_GSK3_1	222	229	PF00069	0.576
MOD_GSK3_1	297	304	PF00069	0.527
MOD_GSK3_1	339	346	PF00069	0.339
MOD_GSK3_1	385	392	PF00069	0.505
MOD_GSK3_1	402	409	PF00069	0.470
MOD_GSK3_1	6	13	PF00069	0.606
MOD_NEK2_1	111	116	PF00069	0.417
MOD_NEK2_1	138	143	PF00069	0.363
MOD_NEK2_1	339	344	PF00069	0.539
MOD_NEK2_1	4	9	PF00069	0.524
MOD_NEK2_1	452	457	PF00069	0.462
MOD_NEK2_1	48	53	PF00069	0.602
MOD_NEK2_1	80	85	PF00069	0.406
MOD_NEK2_2	280	285	PF00069	0.437
MOD_PK_1	322	328	PF00069	0.415
MOD_PKA_1	340	346	PF00069	0.505
MOD_PKA_1	382	388	PF00069	0.395
MOD_PKA_2	111	117	PF00069	0.437
MOD_PKA_2	138	144	PF00069	0.353
MOD_PKA_2	170	176	PF00069	0.471
MOD_PKA_2	339	345	PF00069	0.510
MOD_PKA_2	382	388	PF00069	0.395
MOD_PKA_2	4	10	PF00069	0.601
MOD_PKA_2	418	424	PF00069	0.374
MOD_PKA_2	48	54	PF00069	0.492
MOD_PKA_2	488	494	PF00069	0.430
MOD_Plk_1	124	130	PF00069	0.418
MOD_Plk_1	286	292	PF00069	0.528
MOD_Plk_1	322	328	PF00069	0.548
MOD_Plk_1	385	391	PF00069	0.442
MOD_Plk_1	504	510	PF00069	0.650
MOD_Plk_1	93	99	PF00069	0.421
MOD_Plk_2-3	482	488	PF00069	0.559
MOD_Plk_4	106	112	PF00069	0.504
MOD_Plk_4	130	136	PF00069	0.443
MOD_Plk_4	156	162	PF00069	0.406
MOD_Plk_4	219	225	PF00069	0.526
MOD_Plk_4	247	253	PF00069	0.438
MOD_Plk_4	322	328	PF00069	0.475
MOD_Plk_4	366	372	PF00069	0.427
MOD_Plk_4	385	391	PF00069	0.303
MOD_Plk_4	452	458	PF00069	0.500
MOD_Plk_4	48	54	PF00069	0.498
MOD_Plk_4	504	510	PF00069	0.576
MOD_ProDKin_1	14	20	PF00069	0.472
MOD_ProDKin_1	303	309	PF00069	0.580
MOD_ProDKin_1	475	481	PF00069	0.511
MOD_SUMO_for_1	284	287	PF00179	0.452
TRG_DiLeu_BaEn_1	386	391	PF01217	0.472
TRG_DiLeu_BaEn_1	69	74	PF01217	0.629
TRG_DiLeu_BaLyEn_6	174	179	PF01217	0.386
TRG_ENDOCYTIC_2	180	183	PF00928	0.358
TRG_ENDOCYTIC_2	194	197	PF00928	0.527
TRG_ENDOCYTIC_2	291	294	PF00928	0.538
TRG_ENDOCYTIC_2	374	377	PF00928	0.443
TRG_ER_diArg_1	119	121	PF00400	0.456
TRG_ER_diArg_1	4	6	PF00400	0.607
TRG_ER_diArg_1	445	448	PF00400	0.426
TRG_NES_CRM1_1	196	208	PF08389	0.297
TRG_Pf-PMV_PEXEL_1	36	41	PF00026	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ13	Leptomonas seymouri	56%	99%
A0A3R7L246	Trypanosoma rangeli	24%	100%
A0A3S7X131	Leishmania donovani	87%	98%
A4HG50	Leishmania braziliensis	72%	99%
A4I380	Leishmania infantum	87%	98%
E9AZG8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%
V5BGK7	Trypanosoma cruzi	24%	100%