ATP pyrophosphate-lyase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

oxygen-sensing adenylate cyclase

Species:

Leishmania major

UniProt:

Q4Q8R1_LEIMA

TriTrypDb:

LmjF.28.0090 , LMJLV39_280006000 , LMJSD75_280005900

Length:

616

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4Q8R1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8R1

Function

Biological processes
Term	Name	Level	Count
GO:0000302	response to reactive oxygen species	4	2
GO:0001666	response to hypoxia	3	2
GO:0003032	detection of oxygen	4	2
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006163	purine nucleotide metabolic process	5	7
GO:0006164	purine nucleotide biosynthetic process	6	7
GO:0006171	cAMP biosynthetic process	8	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006753	nucleoside phosphate metabolic process	4	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0006810	transport	3	2
GO:0006950	response to stress	2	2
GO:0006979	response to oxidative stress	3	2
GO:0007165	signal transduction	2	7
GO:0008152	metabolic process	1	7
GO:0009058	biosynthetic process	2	7
GO:0009117	nucleotide metabolic process	5	7
GO:0009150	purine ribonucleotide metabolic process	6	7
GO:0009152	purine ribonucleotide biosynthetic process	7	7
GO:0009165	nucleotide biosynthetic process	6	7
GO:0009187	cyclic nucleotide metabolic process	6	7
GO:0009190	cyclic nucleotide biosynthetic process	7	7
GO:0009259	ribonucleotide metabolic process	5	7
GO:0009260	ribonucleotide biosynthetic process	6	7
GO:0009593	detection of chemical stimulus	3	2
GO:0009628	response to abiotic stimulus	2	2
GO:0009987	cellular process	1	7
GO:0015669	gas transport	4	2
GO:0015671	oxygen transport	5	2
GO:0018130	heterocycle biosynthetic process	4	7
GO:0019438	aromatic compound biosynthetic process	4	7
GO:0019637	organophosphate metabolic process	3	7
GO:0019693	ribose phosphate metabolic process	4	7
GO:0031279	regulation of cyclase activity	4	2
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0034654	nucleobase-containing compound biosynthetic process	4	7
GO:0035556	intracellular signal transduction	3	7
GO:0036293	response to decreased oxygen levels	4	2
GO:0042221	response to chemical	2	2
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044249	cellular biosynthetic process	3	7
GO:0044271	cellular nitrogen compound biosynthetic process	4	7
GO:0044281	small molecule metabolic process	2	7
GO:0045761	regulation of adenylate cyclase activity	5	2
GO:0046058	cAMP metabolic process	7	7
GO:0046390	ribose phosphate biosynthetic process	5	7
GO:0046483	heterocycle metabolic process	3	7
GO:0050789	regulation of biological process	2	7
GO:0050790	regulation of catalytic activity	3	2
GO:0050794	regulation of cellular process	3	7
GO:0050896	response to stimulus	1	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051339	regulation of lyase activity	4	2
GO:0051606	detection of stimulus	2	2
GO:0052652	cyclic purine nucleotide metabolic process	6	7
GO:0055086	nucleobase-containing small molecule metabolic process	3	7
GO:0065007	biological regulation	1	7
GO:0065009	regulation of molecular function	2	2
GO:0070482	response to oxygen levels	3	2
GO:0070483	detection of hypoxia	4	2
GO:0071704	organic substance metabolic process	2	7
GO:0072521	purine-containing compound metabolic process	4	7
GO:0072522	purine-containing compound biosynthetic process	5	7
GO:0090407	organophosphate biosynthetic process	4	7
GO:1901135	carbohydrate derivative metabolic process	3	7
GO:1901137	carbohydrate derivative biosynthetic process	4	7
GO:1901293	nucleoside phosphate biosynthetic process	5	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:1901362	organic cyclic compound biosynthetic process	4	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:1901566	organonitrogen compound biosynthetic process	4	7
GO:1901576	organic substance biosynthetic process	3	7
GO:1901700	response to oxygen-containing compound	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0004016	adenylate cyclase activity	3	2
GO:0005344	oxygen carrier activity	2	2
GO:0005488	binding	1	7
GO:0009975	cyclase activity	2	2
GO:0016829	lyase activity	2	5
GO:0016849	phosphorus-oxygen lyase activity	3	2
GO:0019825	oxygen binding	3	7
GO:0019826	oxygen sensor activity	2	2
GO:0020037	heme binding	4	7
GO:0036094	small molecule binding	2	7
GO:0046906	tetrapyrrole binding	3	7
GO:0070025	carbon monoxide binding	2	2
GO:0097159	organic cyclic compound binding	2	7
GO:0140104	molecular carrier activity	1	2
GO:0140299	small molecule sensor activity	1	2
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	428	432	PF00656	0.423
CLV_C14_Caspase3-7	6	10	PF00656	0.707
CLV_NRD_NRD_1	198	200	PF00675	0.441
CLV_NRD_NRD_1	415	417	PF00675	0.491
CLV_NRD_NRD_1	505	507	PF00675	0.423
CLV_NRD_NRD_1	7	9	PF00675	0.715
CLV_PCSK_KEX2_1	415	417	PF00082	0.491
CLV_PCSK_KEX2_1	505	507	PF00082	0.423
CLV_PCSK_KEX2_1	7	9	PF00082	0.664
CLV_PCSK_KEX2_1	80	82	PF00082	0.631
CLV_PCSK_PC1ET2_1	80	82	PF00082	0.631
CLV_PCSK_SKI1_1	131	135	PF00082	0.491
CLV_PCSK_SKI1_1	175	179	PF00082	0.350
CLV_PCSK_SKI1_1	203	207	PF00082	0.408
CLV_PCSK_SKI1_1	228	232	PF00082	0.559
CLV_PCSK_SKI1_1	297	301	PF00082	0.472
CLV_PCSK_SKI1_1	333	337	PF00082	0.467
CLV_PCSK_SKI1_1	438	442	PF00082	0.423
CLV_PCSK_SKI1_1	605	609	PF00082	0.522
CLV_Separin_Metazoa	453	457	PF03568	0.370
DEG_Nend_UBRbox_2	1	3	PF02207	0.626
DOC_CKS1_1	559	564	PF01111	0.682
DOC_MAPK_gen_1	113	121	PF00069	0.491
DOC_MAPK_gen_1	199	210	PF00069	0.373
DOC_MAPK_gen_1	398	407	PF00069	0.458
DOC_MAPK_gen_1	482	490	PF00069	0.427
DOC_MAPK_gen_1	49	57	PF00069	0.604
DOC_MAPK_HePTP_8	395	407	PF00069	0.423
DOC_MAPK_HePTP_8	442	454	PF00069	0.423
DOC_MAPK_MEF2A_6	113	121	PF00069	0.491
DOC_MAPK_MEF2A_6	146	153	PF00069	0.423
DOC_MAPK_MEF2A_6	203	210	PF00069	0.435
DOC_MAPK_MEF2A_6	398	407	PF00069	0.423
DOC_MAPK_MEF2A_6	438	446	PF00069	0.423
DOC_MAPK_MEF2A_6	482	490	PF00069	0.427
DOC_MAPK_NFAT4_5	203	211	PF00069	0.547
DOC_PP1_RVXF_1	116	122	PF00149	0.396
DOC_PP2B_LxvP_1	373	376	PF13499	0.591
DOC_PP4_FxxP_1	324	327	PF00568	0.370
DOC_USP7_MATH_1	343	347	PF00917	0.467
DOC_USP7_MATH_1	376	380	PF00917	0.547
DOC_USP7_MATH_1	406	410	PF00917	0.491
DOC_USP7_UBL2_3	76	80	PF12436	0.608
DOC_WW_Pin1_4	558	563	PF00397	0.615
LIG_14-3-3_CanoR_1	278	284	PF00244	0.438
LIG_14-3-3_CanoR_1	310	318	PF00244	0.399
LIG_14-3-3_CanoR_1	605	614	PF00244	0.574
LIG_APCC_ABBA_1	179	184	PF00400	0.291
LIG_APCC_ABBA_1	262	267	PF00400	0.510
LIG_BRCT_BRCA1_1	378	382	PF00533	0.536
LIG_BRCT_BRCA1_1	9	13	PF00533	0.759
LIG_CaM_IQ_9	230	246	PF13499	0.485
LIG_deltaCOP1_diTrp_1	195	202	PF00928	0.374
LIG_eIF4E_1	204	210	PF01652	0.537
LIG_FHA_1	379	385	PF00498	0.353
LIG_FHA_1	435	441	PF00498	0.423
LIG_FHA_1	481	487	PF00498	0.423
LIG_FHA_1	67	73	PF00498	0.562
LIG_FHA_1	87	93	PF00498	0.252
LIG_FHA_2	385	391	PF00498	0.423
LIG_FHA_2	4	10	PF00498	0.709
LIG_FHA_2	426	432	PF00498	0.370
LIG_LIR_Gen_1	169	179	PF02991	0.386
LIG_LIR_Gen_1	188	197	PF02991	0.249
LIG_LIR_Gen_1	269	279	PF02991	0.542
LIG_LIR_Gen_1	345	356	PF02991	0.451
LIG_LIR_Gen_1	497	507	PF02991	0.423
LIG_LIR_Gen_1	534	543	PF02991	0.427
LIG_LIR_Gen_1	572	582	PF02991	0.485
LIG_LIR_Gen_1	608	616	PF02991	0.646
LIG_LIR_LC3C_4	63	67	PF02991	0.577
LIG_LIR_Nem_3	188	194	PF02991	0.408
LIG_LIR_Nem_3	195	201	PF02991	0.475
LIG_LIR_Nem_3	236	240	PF02991	0.486
LIG_LIR_Nem_3	269	274	PF02991	0.557
LIG_LIR_Nem_3	345	351	PF02991	0.454
LIG_LIR_Nem_3	379	385	PF02991	0.434
LIG_LIR_Nem_3	420	424	PF02991	0.420
LIG_LIR_Nem_3	497	503	PF02991	0.423
LIG_LIR_Nem_3	534	539	PF02991	0.427
LIG_LIR_Nem_3	572	577	PF02991	0.483
LIG_LIR_Nem_3	584	588	PF02991	0.528
LIG_LIR_Nem_3	608	614	PF02991	0.625
LIG_LIR_Nem_3	87	93	PF02991	0.451
LIG_Pex14_1	350	354	PF04695	0.411
LIG_Pex14_2	178	182	PF04695	0.370
LIG_Pex14_2	324	328	PF04695	0.370
LIG_Pex14_2	336	340	PF04695	0.370
LIG_Pex14_2	348	352	PF04695	0.355
LIG_Pex14_2	382	386	PF04695	0.370
LIG_Pex14_2	607	611	PF04695	0.590
LIG_SH2_CRK	144	148	PF00017	0.491
LIG_SH2_CRK	500	504	PF00017	0.423
LIG_SH2_PTP2	287	290	PF00017	0.441
LIG_SH2_SRC	287	290	PF00017	0.441
LIG_SH2_STAP1	107	111	PF00017	0.381
LIG_SH2_STAP1	225	229	PF00017	0.532
LIG_SH2_STAP1	258	262	PF00017	0.427
LIG_SH2_STAT5	204	207	PF00017	0.491
LIG_SH2_STAT5	287	290	PF00017	0.489
LIG_SH2_STAT5	538	541	PF00017	0.460
LIG_SH3_1	456	462	PF00018	0.370
LIG_SH3_3	456	462	PF00018	0.370
LIG_SUMO_SIM_anti_2	63	69	PF11976	0.557
LIG_SUMO_SIM_par_1	63	69	PF11976	0.510
LIG_TRAF2_1	193	196	PF00917	0.423
LIG_UBA3_1	229	238	PF00899	0.553
LIG_UBA3_1	290	298	PF00899	0.288
LIG_WRC_WIRS_1	582	587	PF05994	0.581
MOD_CDK_SPxxK_3	558	565	PF00069	0.616
MOD_CK1_1	397	403	PF00069	0.491
MOD_CK1_1	82	88	PF00069	0.553
MOD_CK2_1	266	272	PF00069	0.491
MOD_CK2_1	384	390	PF00069	0.423
MOD_CK2_1	538	544	PF00069	0.423
MOD_CK2_1	55	61	PF00069	0.543
MOD_GlcNHglycan	214	217	PF01048	0.451
MOD_GlcNHglycan	279	282	PF01048	0.415
MOD_GlcNHglycan	359	362	PF01048	0.419
MOD_GlcNHglycan	40	43	PF01048	0.636
MOD_GSK3_1	252	259	PF00069	0.498
MOD_GSK3_1	3	10	PF00069	0.674
MOD_GSK3_1	362	369	PF00069	0.557
MOD_GSK3_1	374	381	PF00069	0.415
MOD_GSK3_1	390	397	PF00069	0.423
MOD_GSK3_1	425	432	PF00069	0.423
MOD_GSK3_1	605	612	PF00069	0.542
MOD_GSK3_1	82	89	PF00069	0.499
MOD_N-GLC_1	314	319	PF02516	0.370
MOD_N-GLC_1	53	58	PF02516	0.613
MOD_N-GLC_2	245	247	PF02516	0.596
MOD_N-GLC_2	515	517	PF02516	0.423
MOD_NEK2_1	136	141	PF00069	0.370
MOD_NEK2_1	229	234	PF00069	0.340
MOD_NEK2_1	277	282	PF00069	0.471
MOD_NEK2_1	328	333	PF00069	0.491
MOD_NEK2_1	35	40	PF00069	0.582
MOD_NEK2_2	581	586	PF00069	0.497
MOD_PKA_1	7	13	PF00069	0.718
MOD_PKA_2	277	283	PF00069	0.423
MOD_PKA_2	309	315	PF00069	0.423
MOD_PKA_2	50	56	PF00069	0.643
MOD_PKA_2	532	538	PF00069	0.423
MOD_PKA_2	7	13	PF00069	0.718
MOD_Plk_1	314	320	PF00069	0.423
MOD_Plk_1	480	486	PF00069	0.482
MOD_Plk_1	53	59	PF00069	0.612
MOD_Plk_1	82	88	PF00069	0.553
MOD_Plk_2-3	425	431	PF00069	0.370
MOD_Plk_4	129	135	PF00069	0.423
MOD_Plk_4	252	258	PF00069	0.463
MOD_Plk_4	35	41	PF00069	0.650
MOD_Plk_4	366	372	PF00069	0.683
MOD_Plk_4	429	435	PF00069	0.423
MOD_Plk_4	593	599	PF00069	0.445
MOD_ProDKin_1	558	564	PF00069	0.613
MOD_SUMO_rev_2	397	403	PF00179	0.341
MOD_SUMO_rev_2	420	429	PF00179	0.423
TRG_DiLeu_BaEn_1	590	595	PF01217	0.541
TRG_DiLeu_BaEn_1	61	66	PF01217	0.503
TRG_DiLeu_BaLyEn_6	413	418	PF01217	0.491
TRG_ENDOCYTIC_2	107	110	PF00928	0.370
TRG_ENDOCYTIC_2	221	224	PF00928	0.440
TRG_ENDOCYTIC_2	287	290	PF00928	0.441
TRG_ENDOCYTIC_2	500	503	PF00928	0.423
TRG_ER_diArg_1	115	118	PF00400	0.426
TRG_ER_diArg_1	414	416	PF00400	0.491
TRG_ER_diArg_1	46	49	PF00400	0.532
TRG_ER_diArg_1	484	487	PF00400	0.423
TRG_ER_diArg_1	505	507	PF00400	0.423
TRG_NES_CRM1_1	227	242	PF08389	0.553
TRG_NES_CRM1_1	439	453	PF08389	0.423
TRG_Pf-PMV_PEXEL_1	298	302	PF00026	0.498
TRG_Pf-PMV_PEXEL_1	415	420	PF00026	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P721	Leptomonas seymouri	69%	89%
A0A1X0NVA7	Trypanosomatidae	45%	100%
A0A3S7X137	Leishmania donovani	93%	100%
A4I382	Leishmania infantum	93%	100%
E9AZH0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	91%