Putative DNA-direcetd RNA polymerase II,subunit 9

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA-direcetd RNA polymerase II, subunit 9, putative

Species:

Leishmania major

UniProt:

Q4Q8Q8_LEIMA

TriTrypDb:

LmjF.28.0120 , LMJLV39_280006300 , LMJSD75_280006200

Length:

140

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000428	DNA-directed RNA polymerase complex	4	3
GO:0005665	RNA polymerase II, core complex	4	2
GO:0030880	RNA polymerase complex	3	3
GO:0032991	protein-containing complex	1	3
GO:0055029	nuclear DNA-directed RNA polymerase complex	3	2
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	3
GO:0140513	nuclear protein-containing complex	2	2
GO:0140535	intracellular protein-containing complex	2	3
GO:1902494	catalytic complex	2	3
GO:1990234	transferase complex	3	3

Expansion

Sequence features

Q4Q8Q8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8Q8

Function

Biological processes
Term	Name	Level	Count
GO:0001192	maintenance of transcriptional fidelity during transcription elongation	6	2
GO:0001193	maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II	7	2
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006259	DNA metabolic process	4	2
GO:0006281	DNA repair	5	2
GO:0006283	transcription-coupled nucleotide-excision repair	7	2
GO:0006289	nucleotide-excision repair	6	2
GO:0006352	DNA-templated transcription initiation	6	2
GO:0006367	transcription initiation at RNA polymerase II promoter	7	2
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0006950	response to stress	2	2
GO:0006974	DNA damage response	4	2
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009059	macromolecule biosynthetic process	4	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0018130	heterocycle biosynthetic process	4	11
GO:0019438	aromatic compound biosynthetic process	4	11
GO:0032774	RNA biosynthetic process	5	11
GO:0033554	cellular response to stress	3	2
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034654	nucleobase-containing compound biosynthetic process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0046483	heterocycle metabolic process	3	11
GO:0050896	response to stimulus	1	2
GO:0051716	cellular response to stimulus	2	2
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:1901362	organic cyclic compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11
GO:0006351	DNA-templated transcription	7	9
GO:0097659	nucleic acid-templated transcription	6	9
GO:0006379	mRNA cleavage	7	1
GO:0016071	mRNA metabolic process	6	1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0090501	RNA phosphodiester bond hydrolysis	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	6	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016779	nucleotidyltransferase activity	4	1
GO:0034062	5'-3' RNA polymerase activity	5	1
GO:0097747	RNA polymerase activity	4	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_Nend_UBRbox_2	1	3	PF02207	0.706
DOC_MAPK_MEF2A_6	57	66	PF00069	0.457
DOC_PP4_FxxP_1	105	108	PF00568	0.421
DOC_USP7_MATH_1	95	99	PF00917	0.332
DOC_USP7_UBL2_3	92	96	PF12436	0.567
LIG_BIR_III_4	69	73	PF00653	0.618
LIG_Pex14_1	42	46	PF04695	0.385
LIG_SH2_STAP1	38	42	PF00017	0.485
LIG_SH2_STAT5	119	122	PF00017	0.343
LIG_SH2_STAT5	46	49	PF00017	0.401
LIG_SH3_3	87	93	PF00018	0.601
LIG_SH3_4	92	99	PF00018	0.563
MOD_N-GLC_1	12	17	PF02516	0.587
MOD_N-GLC_1	36	41	PF02516	0.555
MOD_N-GLC_2	45	47	PF02516	0.415
MOD_NEK2_1	20	25	PF00069	0.461
MOD_PIKK_1	4	10	PF00454	0.636
MOD_Plk_1	114	120	PF00069	0.467
MOD_Plk_1	36	42	PF00069	0.497
MOD_Plk_1	4	10	PF00069	0.669
MOD_Plk_4	114	120	PF00069	0.421
MOD_SUMO_rev_2	51	59	PF00179	0.424

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P727	Leptomonas seymouri	85%	100%
A0A0S4IUR8	Bodo saltans	54%	100%
A0A1X0NWR1	Trypanosomatidae	61%	100%
A0A3R7LHZ7	Trypanosoma rangeli	61%	100%
A0A3S7X159	Leishmania donovani	97%	100%
A4HG54	Leishmania braziliensis	93%	100%
A4I385	Leishmania infantum	97%	100%
D0A7R2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9AZH3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
P27999	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
P36954	Homo sapiens	30%	100%
P36958	Drosophila melanogaster	32%	100%
P60898	Mus musculus	30%	100%
P60899	Sus scrofa	30%	100%
Q32P73	Bos taurus	30%	100%
Q6FS48	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	31%	100%
Q6NLH0	Arabidopsis thaliana	29%	100%
Q755B3	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	29%	100%
Q8L5V0	Arabidopsis thaliana	31%	100%
Q965S0	Caenorhabditis elegans	29%	84%