Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8Q7_LEIMA

TriTrypDb:

LmjF.28.0130 , LMJLV39_280006400 , LMJSD75_280006300

Length:

182

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	16
GO:0110165	cellular anatomical entity	1	16

Expansion

Sequence features

Q4Q8Q7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8Q7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	173	175	PF00082	0.500
CLV_PCSK_PC1ET2_1	173	175	PF00082	0.500
CLV_PCSK_SKI1_1	111	115	PF00082	0.529
DOC_MAPK_gen_1	38	47	PF00069	0.423
DOC_MAPK_gen_1	76	86	PF00069	0.471
DOC_MAPK_MEF2A_6	79	88	PF00069	0.488
DOC_USP7_MATH_1	156	160	PF00917	0.676
LIG_14-3-3_CanoR_1	5	9	PF00244	0.594
LIG_Actin_WH2_2	26	43	PF00022	0.381
LIG_Actin_WH2_2	95	113	PF00022	0.436
LIG_EH1_1	15	23	PF00400	0.376
LIG_FHA_1	122	128	PF00498	0.402
LIG_FHA_1	162	168	PF00498	0.622
LIG_FHA_1	72	78	PF00498	0.591
LIG_LIR_Gen_1	132	142	PF02991	0.410
LIG_LIR_Gen_1	42	50	PF02991	0.324
LIG_LIR_Nem_3	132	137	PF02991	0.372
LIG_LIR_Nem_3	23	27	PF02991	0.356
LIG_LIR_Nem_3	42	47	PF02991	0.309
LIG_NRBOX	76	82	PF00104	0.603
LIG_PCNA_PIPBox_1	138	147	PF02747	0.624
LIG_PDZ_Class_3	177	182	PF00595	0.658
LIG_Pex14_2	131	135	PF04695	0.358
LIG_Pex14_2	144	148	PF04695	0.585
LIG_SH2_CRK	137	141	PF00017	0.563
LIG_SH2_CRK	15	19	PF00017	0.436
LIG_SH2_STAP1	65	69	PF00017	0.553
LIG_SH2_STAT3	175	178	PF00017	0.715
LIG_SH2_STAT5	27	30	PF00017	0.366
LIG_SH2_STAT5	44	47	PF00017	0.374
LIG_SUMO_SIM_par_1	17	23	PF11976	0.381
LIG_SUMO_SIM_par_1	94	99	PF11976	0.370
LIG_TYR_ITIM	13	18	PF00017	0.443
LIG_WRC_WIRS_1	103	108	PF05994	0.474
LIG_WRC_WIRS_1	21	26	PF05994	0.459
MOD_CK1_1	105	111	PF00069	0.378
MOD_NEK2_1	114	119	PF00069	0.340
MOD_NEK2_1	121	126	PF00069	0.318
MOD_NEK2_1	33	38	PF00069	0.376
MOD_NEK2_1	4	9	PF00069	0.571
MOD_NEK2_1	63	68	PF00069	0.447
MOD_NEK2_1	88	93	PF00069	0.372
MOD_PKA_2	4	10	PF00069	0.618
MOD_Plk_4	114	120	PF00069	0.301
MOD_Plk_4	130	136	PF00069	0.253
TRG_DiLeu_BaEn_2	98	104	PF01217	0.461
TRG_DiLeu_BaLyEn_6	76	81	PF01217	0.586
TRG_ENDOCYTIC_2	137	140	PF00928	0.461
TRG_ENDOCYTIC_2	15	18	PF00928	0.408
TRG_ENDOCYTIC_2	27	30	PF00928	0.361
TRG_ENDOCYTIC_2	44	47	PF00928	0.373
TRG_Pf-PMV_PEXEL_1	153	157	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	38	42	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILT5	Leptomonas seymouri	62%	100%
A0A0N1PC80	Leptomonas seymouri	25%	99%
A0A0S4IY98	Bodo saltans	38%	100%
A0A0S4J4Y6	Bodo saltans	27%	100%
A0A0S4JQJ3	Bodo saltans	26%	100%
A0A1X0NLH1	Trypanosomatidae	27%	78%
A0A1X0NX01	Trypanosomatidae	41%	99%
A0A1X0NXC4	Trypanosomatidae	31%	100%
A0A3Q8IQ96	Leishmania donovani	91%	100%
A0A3R7JVT6	Trypanosoma rangeli	41%	99%
A4HBK6	Leishmania braziliensis	25%	99%
A4HG55	Leishmania braziliensis	70%	100%
A4I386	Leishmania infantum	90%	100%
E9AZH4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5BC06	Trypanosoma cruzi	32%	99%