MFS domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

major facilitator superfamily, putative

Species:

Leishmania major

UniProt:

Q4Q8Q5_LEIMA

TriTrypDb:

LmjF.28.0150 , LMJLV39_280006600 , LMJSD75_280006500

Length:

528

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4Q8Q5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8Q5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	11
GO:0022857	transmembrane transporter activity	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	238	242	PF00656	0.540
CLV_C14_Caspase3-7	511	515	PF00656	0.624
CLV_NRD_NRD_1	106	108	PF00675	0.267
CLV_NRD_NRD_1	228	230	PF00675	0.305
CLV_NRD_NRD_1	455	457	PF00675	0.358
CLV_NRD_NRD_1	68	70	PF00675	0.495
CLV_PCSK_KEX2_1	106	108	PF00082	0.267
CLV_PCSK_KEX2_1	228	230	PF00082	0.305
CLV_PCSK_KEX2_1	455	457	PF00082	0.332
CLV_PCSK_KEX2_1	467	469	PF00082	0.308
CLV_PCSK_PC1ET2_1	467	469	PF00082	0.364
CLV_PCSK_PC7_1	224	230	PF00082	0.305
CLV_PCSK_SKI1_1	139	143	PF00082	0.277
CLV_PCSK_SKI1_1	159	163	PF00082	0.108
CLV_PCSK_SKI1_1	282	286	PF00082	0.463
DEG_COP1_1	481	489	PF00400	0.677
DOC_CYCLIN_RxL_1	295	306	PF00134	0.325
DOC_CYCLIN_yCln2_LP_2	187	193	PF00134	0.348
DOC_CYCLIN_yCln2_LP_2	254	260	PF00134	0.499
DOC_MAPK_gen_1	106	112	PF00069	0.467
DOC_MAPK_gen_1	159	169	PF00069	0.434
DOC_MAPK_gen_1	228	234	PF00069	0.505
DOC_MAPK_MEF2A_6	162	171	PF00069	0.438
DOC_MAPK_RevD_3	440	456	PF00069	0.404
DOC_PP1_RVXF_1	137	143	PF00149	0.306
DOC_PP2B_LxvP_1	187	190	PF13499	0.433
DOC_PP2B_LxvP_1	254	257	PF13499	0.499
DOC_USP7_MATH_1	201	205	PF00917	0.433
DOC_USP7_MATH_1	317	321	PF00917	0.443
DOC_USP7_MATH_1	374	378	PF00917	0.531
DOC_USP7_MATH_1	386	390	PF00917	0.306
DOC_USP7_UBL2_3	66	70	PF12436	0.299
DOC_WW_Pin1_4	308	313	PF00397	0.284
LIG_14-3-3_CanoR_1	179	185	PF00244	0.276
LIG_14-3-3_CanoR_1	229	235	PF00244	0.540
LIG_14-3-3_CanoR_1	298	303	PF00244	0.411
LIG_14-3-3_CanoR_1	323	327	PF00244	0.440
LIG_14-3-3_CanoR_1	57	62	PF00244	0.262
LIG_14-3-3_CanoR_1	69	79	PF00244	0.144
LIG_Actin_WH2_2	90	108	PF00022	0.376
LIG_BIR_III_2	514	518	PF00653	0.708
LIG_BRCT_BRCA1_1	119	123	PF00533	0.297
LIG_BRCT_BRCA1_1	182	186	PF00533	0.290
LIG_EH1_1	435	443	PF00400	0.358
LIG_FHA_1	129	135	PF00498	0.292
LIG_FHA_1	304	310	PF00498	0.374
LIG_FHA_1	323	329	PF00498	0.323
LIG_FHA_1	359	365	PF00498	0.387
LIG_FHA_1	414	420	PF00498	0.501
LIG_FHA_1	430	436	PF00498	0.263
LIG_FHA_1	455	461	PF00498	0.592
LIG_FHA_1	502	508	PF00498	0.747
LIG_FHA_1	511	517	PF00498	0.744
LIG_FHA_2	233	239	PF00498	0.525
LIG_FHA_2	241	247	PF00498	0.525
LIG_FHA_2	509	515	PF00498	0.624
LIG_FXI_DFP_1	46	50	PF00024	0.348
LIG_GBD_Chelix_1	206	214	PF00786	0.433
LIG_GBD_Chelix_1	437	445	PF00786	0.433
LIG_LIR_Apic_2	370	376	PF02991	0.376
LIG_LIR_Apic_2	82	87	PF02991	0.290
LIG_LIR_Gen_1	130	141	PF02991	0.347
LIG_LIR_Gen_1	15	25	PF02991	0.649
LIG_LIR_Gen_1	174	184	PF02991	0.285
LIG_LIR_Gen_1	325	335	PF02991	0.301
LIG_LIR_Nem_3	100	105	PF02991	0.450
LIG_LIR_Nem_3	130	136	PF02991	0.317
LIG_LIR_Nem_3	15	21	PF02991	0.598
LIG_LIR_Nem_3	174	180	PF02991	0.290
LIG_LIR_Nem_3	182	187	PF02991	0.290
LIG_LIR_Nem_3	27	33	PF02991	0.405
LIG_LIR_Nem_3	272	278	PF02991	0.317
LIG_LIR_Nem_3	325	330	PF02991	0.301
LIG_LIR_Nem_3	333	338	PF02991	0.275
LIG_LIR_Nem_3	365	371	PF02991	0.295
LIG_LIR_Nem_3	40	44	PF02991	0.267
LIG_LIR_Nem_3	481	485	PF02991	0.647
LIG_MYND_3	423	427	PF01753	0.376
LIG_MYND_3	486	490	PF01753	0.716
LIG_NRBOX	93	99	PF00104	0.449
LIG_OCRL_FandH_1	334	346	PF00620	0.325
LIG_PCNA_PIPBox_1	353	362	PF02747	0.411
LIG_Pex14_2	156	160	PF04695	0.499
LIG_Pex14_2	184	188	PF04695	0.290
LIG_REV1ctd_RIR_1	282	292	PF16727	0.250
LIG_SH2_CRK	271	275	PF00017	0.290
LIG_SH2_CRK	360	364	PF00017	0.290
LIG_SH2_CRK	47	51	PF00017	0.318
LIG_SH2_NCK_1	271	275	PF00017	0.291
LIG_SH2_SRC	79	82	PF00017	0.411
LIG_SH2_STAP1	271	275	PF00017	0.290
LIG_SH2_STAP1	360	364	PF00017	0.290
LIG_SH2_STAP1	72	76	PF00017	0.250
LIG_SH2_STAP1	81	85	PF00017	0.306
LIG_SH2_STAT5	102	105	PF00017	0.450
LIG_SH2_STAT5	231	234	PF00017	0.438
LIG_SH2_STAT5	271	274	PF00017	0.325
LIG_SH2_STAT5	291	294	PF00017	0.282
LIG_SH2_STAT5	31	34	PF00017	0.361
LIG_SH2_STAT5	360	363	PF00017	0.433
LIG_SH2_STAT5	408	411	PF00017	0.268
LIG_SH2_STAT5	45	48	PF00017	0.225
LIG_SH2_STAT5	525	528	PF00017	0.580
LIG_SH2_STAT5	72	75	PF00017	0.271
LIG_SH2_STAT5	79	82	PF00017	0.342
LIG_SH3_3	306	312	PF00018	0.411
LIG_SH3_3	366	372	PF00018	0.290
LIG_SH3_3	500	506	PF00018	0.761
LIG_SUMO_SIM_anti_2	113	118	PF11976	0.376
LIG_SUMO_SIM_anti_2	447	454	PF11976	0.318
LIG_SUMO_SIM_anti_2	89	95	PF11976	0.380
LIG_TRAF2_1	242	245	PF00917	0.509
LIG_TYR_ITIM	258	263	PF00017	0.433
LIG_WRC_WIRS_1	359	364	PF05994	0.325
LIG_WRC_WIRS_1	38	43	PF05994	0.290
MOD_CK1_1	16	22	PF00069	0.663
MOD_CK1_1	240	246	PF00069	0.540
MOD_CK1_1	462	468	PF00069	0.594
MOD_CK1_1	52	58	PF00069	0.300
MOD_CK2_1	230	236	PF00069	0.525
MOD_CK2_1	239	245	PF00069	0.511
MOD_GlcNHglycan	15	18	PF01048	0.323
MOD_GlcNHglycan	153	156	PF01048	0.250
MOD_GlcNHglycan	203	206	PF01048	0.433
MOD_GlcNHglycan	306	309	PF01048	0.319
MOD_GlcNHglycan	364	367	PF01048	0.290
MOD_GlcNHglycan	376	379	PF01048	0.238
MOD_GlcNHglycan	438	441	PF01048	0.325
MOD_GlcNHglycan	461	464	PF01048	0.345
MOD_GlcNHglycan	54	57	PF01048	0.539
MOD_GSK3_1	12	19	PF00069	0.668
MOD_GSK3_1	145	152	PF00069	0.311
MOD_GSK3_1	171	178	PF00069	0.292
MOD_GSK3_1	304	311	PF00069	0.371
MOD_GSK3_1	358	365	PF00069	0.280
MOD_GSK3_1	409	416	PF00069	0.357
MOD_GSK3_1	501	508	PF00069	0.746
MOD_GSK3_1	515	522	PF00069	0.720
MOD_LATS_1	68	74	PF00433	0.299
MOD_N-GLC_1	413	418	PF02516	0.589
MOD_NEK2_1	117	122	PF00069	0.318
MOD_NEK2_1	149	154	PF00069	0.353
MOD_NEK2_1	171	176	PF00069	0.298
MOD_NEK2_1	269	274	PF00069	0.310
MOD_NEK2_1	330	335	PF00069	0.322
MOD_NEK2_1	342	347	PF00069	0.245
MOD_NEK2_1	362	367	PF00069	0.344
MOD_NEK2_1	409	414	PF00069	0.383
MOD_NEK2_1	436	441	PF00069	0.288
MOD_NEK2_1	444	449	PF00069	0.262
MOD_NEK2_1	461	466	PF00069	0.514
MOD_NEK2_1	507	512	PF00069	0.697
MOD_NEK2_2	79	84	PF00069	0.411
MOD_PIKK_1	149	155	PF00454	0.376
MOD_PIKK_1	417	423	PF00454	0.484
MOD_PKA_2	322	328	PF00069	0.428
MOD_PKA_2	409	415	PF00069	0.284
MOD_PKA_2	454	460	PF00069	0.557
MOD_Plk_1	473	479	PF00069	0.654
MOD_Plk_4	117	123	PF00069	0.367
MOD_Plk_4	128	134	PF00069	0.418
MOD_Plk_4	298	304	PF00069	0.381
MOD_Plk_4	322	328	PF00069	0.443
MOD_Plk_4	342	348	PF00069	0.108
MOD_Plk_4	358	364	PF00069	0.202
MOD_Plk_4	40	46	PF00069	0.290
MOD_Plk_4	79	85	PF00069	0.290
MOD_Plk_4	86	92	PF00069	0.290
MOD_ProDKin_1	308	314	PF00069	0.284
TRG_DiLeu_BaEn_1	433	438	PF01217	0.381
TRG_DiLeu_BaEn_4	23	29	PF01217	0.574
TRG_ENDOCYTIC_2	102	105	PF00928	0.450
TRG_ENDOCYTIC_2	132	135	PF00928	0.241
TRG_ENDOCYTIC_2	231	234	PF00928	0.525
TRG_ENDOCYTIC_2	260	263	PF00928	0.341
TRG_ENDOCYTIC_2	271	274	PF00928	0.230
TRG_ENDOCYTIC_2	31	34	PF00928	0.396
TRG_ENDOCYTIC_2	360	363	PF00928	0.290
TRG_ENDOCYTIC_2	384	387	PF00928	0.438
TRG_ER_diArg_1	105	107	PF00400	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7C2	Leptomonas seymouri	67%	94%
A0A0S4IUS4	Bodo saltans	53%	100%
A0A1X0NVY8	Trypanosomatidae	54%	100%
A0A3R7NBY9	Trypanosoma rangeli	52%	100%
A0A3S7X168	Leishmania donovani	91%	100%
A4I388	Leishmania infantum	92%	100%
D0A7R4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9AZH6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q1JQC1	Bos taurus	33%	100%
Q32LQ6	Danio rerio	36%	100%
Q5R8G5	Pongo abelii	33%	100%
Q5ZIT9	Gallus gallus	31%	100%
Q9DC37	Mus musculus	33%	100%
Q9H3U5	Homo sapiens	34%	100%
V5BBZ8	Trypanosoma cruzi	54%	100%