Putative RNA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA binding protein, putative

Species:

Leishmania major

UniProt:

Q4Q8Q4_LEIMA

TriTrypDb:

LmjF.28.0160 , LMJLV39_280006700 , LMJSD75_280006600

Length:

196

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8Q4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8Q4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0005488	binding	1	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9
GO:0003723	RNA binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	50	54	PF00656	0.694
CLV_NRD_NRD_1	11	13	PF00675	0.479
CLV_NRD_NRD_1	17	19	PF00675	0.554
CLV_NRD_NRD_1	190	192	PF00675	0.534
CLV_NRD_NRD_1	44	46	PF00675	0.570
CLV_NRD_NRD_1	6	8	PF00675	0.529
CLV_NRD_NRD_1	78	80	PF00675	0.497
CLV_PCSK_KEX2_1	10	12	PF00082	0.529
CLV_PCSK_KEX2_1	17	19	PF00082	0.471
CLV_PCSK_KEX2_1	189	191	PF00082	0.537
CLV_PCSK_KEX2_1	44	46	PF00082	0.570
CLV_PCSK_PC7_1	7	13	PF00082	0.560
CLV_PCSK_SKI1_1	85	89	PF00082	0.412
CLV_PCSK_SKI1_1	99	103	PF00082	0.438
DOC_CYCLIN_RxL_1	11	24	PF00134	0.512
DOC_MAPK_gen_1	79	89	PF00069	0.444
DOC_MAPK_MEF2A_6	142	150	PF00069	0.425
DOC_USP7_UBL2_3	138	142	PF12436	0.553
LIG_FHA_1	124	130	PF00498	0.567
LIG_FHA_1	84	90	PF00498	0.403
LIG_FHA_2	105	111	PF00498	0.500
LIG_FHA_2	4	10	PF00498	0.609
LIG_FHA_2	45	51	PF00498	0.744
LIG_RPA_C_Fungi	20	32	PF08784	0.368
LIG_SH2_GRB2like	118	121	PF00017	0.374
LIG_SH2_STAP1	118	122	PF00017	0.570
LIG_SH2_STAT3	118	121	PF00017	0.619
LIG_SH2_STAT5	147	150	PF00017	0.489
LIG_SH3_3	54	60	PF00018	0.678
LIG_SUMO_SIM_par_1	106	112	PF11976	0.507
MOD_CK1_1	94	100	PF00069	0.491
MOD_CK2_1	3	9	PF00069	0.574
MOD_GlcNHglycan	38	42	PF01048	0.463
MOD_GlcNHglycan	93	96	PF01048	0.467
MOD_GSK3_1	21	28	PF00069	0.576
MOD_NEK2_1	104	109	PF00069	0.447
MOD_NEK2_1	146	151	PF00069	0.428
MOD_NEK2_1	21	26	PF00069	0.601
MOD_PKA_1	44	50	PF00069	0.584
MOD_PKA_2	44	50	PF00069	0.709
MOD_PKB_1	10	18	PF00069	0.591
MOD_Plk_4	104	110	PF00069	0.438
MOD_Plk_4	71	77	PF00069	0.544
MOD_SUMO_rev_2	55	64	PF00179	0.675
MOD_SUMO_rev_2	78	84	PF00179	0.603
TRG_DiLeu_BaEn_4	130	136	PF01217	0.534
TRG_ENDOCYTIC_2	147	150	PF00928	0.489
TRG_ER_diArg_1	10	12	PF00400	0.525
TRG_ER_diArg_1	17	19	PF00400	0.506
TRG_ER_diArg_1	188	191	PF00400	0.531
TRG_Pf-PMV_PEXEL_1	17	22	PF00026	0.562

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IEM8	Leishmania donovani	92%	100%
A0A422N4H9	Trypanosoma rangeli	43%	70%
A4HG57	Leishmania braziliensis	76%	100%
A4I389	Leishmania infantum	91%	100%
D0A7R5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	67%
E9AZH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BGL1	Trypanosoma cruzi	45%	70%