Putative phopshatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dual specificity phopshatase, putative

Species:

Leishmania major

UniProt:

Q4Q8Q3_LEIMA

TriTrypDb:

LmjF.28.0170 , LMJLV39_280006800 , LMJSD75_280006700

Length:

424

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005929	cilium	4	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12

Expansion

Sequence features

Q4Q8Q3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8Q3

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009966	regulation of signal transduction	4	2
GO:0009968	negative regulation of signal transduction	5	2
GO:0009987	cellular process	1	12
GO:0010646	regulation of cell communication	4	2
GO:0010648	negative regulation of cell communication	5	2
GO:0016311	dephosphorylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0023051	regulation of signaling	3	2
GO:0023057	negative regulation of signaling	4	2
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043408	regulation of MAPK cascade	6	2
GO:0043409	negative regulation of MAPK cascade	7	2
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0048519	negative regulation of biological process	3	2
GO:0048523	negative regulation of cellular process	4	2
GO:0048583	regulation of response to stimulus	3	2
GO:0048585	negative regulation of response to stimulus	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0065007	biological regulation	1	2
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1902531	regulation of intracellular signal transduction	5	2
GO:1902532	negative regulation of intracellular signal transduction	6	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004721	phosphoprotein phosphatase activity	3	12
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	4	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0016791	phosphatase activity	5	12
GO:0042578	phosphoric ester hydrolase activity	4	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	116	120	PF00656	0.483
CLV_NRD_NRD_1	104	106	PF00675	0.477
CLV_NRD_NRD_1	188	190	PF00675	0.490
CLV_NRD_NRD_1	57	59	PF00675	0.656
CLV_PCSK_KEX2_1	188	190	PF00082	0.477
CLV_PCSK_KEX2_1	241	243	PF00082	0.356
CLV_PCSK_PC1ET2_1	241	243	PF00082	0.523
CLV_PCSK_PC7_1	237	243	PF00082	0.580
CLV_PCSK_SKI1_1	242	246	PF00082	0.390
CLV_PCSK_SKI1_1	356	360	PF00082	0.367
CLV_PCSK_SKI1_1	368	372	PF00082	0.309
CLV_PCSK_SKI1_1	381	385	PF00082	0.328
CLV_Separin_Metazoa	414	418	PF03568	0.526
DOC_CYCLIN_yClb5_NLxxxL_5	134	143	PF00134	0.513
DOC_CYCLIN_yCln2_LP_2	223	229	PF00134	0.460
DOC_MAPK_gen_1	241	247	PF00069	0.435
DOC_MAPK_gen_1	352	360	PF00069	0.365
DOC_MAPK_gen_1	55	65	PF00069	0.622
DOC_PP2B_LxvP_1	325	328	PF13499	0.340
DOC_USP7_MATH_1	333	337	PF00917	0.475
DOC_USP7_MATH_1	6	10	PF00917	0.665
DOC_USP7_MATH_1	94	98	PF00917	0.460
DOC_USP7_UBL2_3	102	106	PF12436	0.319
DOC_USP7_UBL2_3	55	59	PF12436	0.725
LIG_14-3-3_CanoR_1	105	110	PF00244	0.274
LIG_14-3-3_CanoR_1	237	245	PF00244	0.492
LIG_14-3-3_CanoR_1	291	297	PF00244	0.379
LIG_14-3-3_CanoR_1	43	49	PF00244	0.650
LIG_14-3-3_CanoR_1	58	65	PF00244	0.527
LIG_14-3-3_CanoR_1	80	84	PF00244	0.538
LIG_14-3-3_CanoR_1	91	99	PF00244	0.521
LIG_Actin_WH2_2	278	293	PF00022	0.328
LIG_Actin_WH2_2	367	383	PF00022	0.475
LIG_Actin_WH2_2	92	107	PF00022	0.467
LIG_AP2alpha_1	341	345	PF02296	0.475
LIG_AP2alpha_2	181	183	PF02296	0.501
LIG_APCC_ABBA_1	296	301	PF00400	0.410
LIG_APCC_ABBA_1	338	343	PF00400	0.437
LIG_BIR_II_1	1	5	PF00653	0.685
LIG_BRCT_BRCA1_1	164	168	PF00533	0.508
LIG_BRCT_BRCA1_1	27	31	PF00533	0.747
LIG_BRCT_BRCA1_1	44	48	PF00533	0.461
LIG_FHA_1	135	141	PF00498	0.456
LIG_FHA_1	238	244	PF00498	0.551
LIG_FHA_1	293	299	PF00498	0.336
LIG_FHA_1	369	375	PF00498	0.367
LIG_FHA_1	48	54	PF00498	0.685
LIG_FHA_2	382	388	PF00498	0.364
LIG_FHA_2	66	72	PF00498	0.604
LIG_LIR_Gen_1	126	135	PF02991	0.504
LIG_LIR_Gen_1	165	174	PF02991	0.566
LIG_LIR_Gen_1	212	223	PF02991	0.519
LIG_LIR_Gen_1	228	235	PF02991	0.426
LIG_LIR_Gen_1	265	276	PF02991	0.428
LIG_LIR_Gen_1	283	290	PF02991	0.249
LIG_LIR_Gen_1	297	307	PF02991	0.413
LIG_LIR_Gen_1	8	15	PF02991	0.657
LIG_LIR_Nem_3	126	130	PF02991	0.496
LIG_LIR_Nem_3	165	171	PF02991	0.571
LIG_LIR_Nem_3	228	232	PF02991	0.523
LIG_LIR_Nem_3	265	271	PF02991	0.431
LIG_LIR_Nem_3	283	287	PF02991	0.227
LIG_LIR_Nem_3	297	302	PF02991	0.269
LIG_LIR_Nem_3	342	348	PF02991	0.351
LIG_LIR_Nem_3	8	13	PF02991	0.624
LIG_LYPXL_L_2	276	285	PF13949	0.420
LIG_Pex14_2	341	345	PF04695	0.348
LIG_PTB_Apo_2	121	128	PF02174	0.510
LIG_SH2_CRK	229	233	PF00017	0.573
LIG_SH2_STAP1	412	416	PF00017	0.363
LIG_SH2_STAT5	149	152	PF00017	0.511
LIG_SH2_STAT5	284	287	PF00017	0.371
LIG_SH2_STAT5	306	309	PF00017	0.447
LIG_SH2_STAT5	376	379	PF00017	0.319
LIG_SH3_3	112	118	PF00018	0.536
LIG_SH3_3	179	185	PF00018	0.493
LIG_SH3_3	314	320	PF00018	0.395
LIG_Sin3_3	388	395	PF02671	0.449
LIG_SUMO_SIM_anti_2	386	393	PF11976	0.449
LIG_SUMO_SIM_par_1	113	119	PF11976	0.466
LIG_SUMO_SIM_par_1	200	206	PF11976	0.510
LIG_TRAF2_1	210	213	PF00917	0.469
LIG_TRAF2_1	411	414	PF00917	0.359
LIG_TYR_ITIM	227	232	PF00017	0.549
LIG_TYR_ITIM	282	287	PF00017	0.493
LIG_UBA3_1	377	381	PF00899	0.449
MOD_CK1_1	162	168	PF00069	0.510
MOD_CK1_1	23	29	PF00069	0.675
MOD_CK1_1	289	295	PF00069	0.317
MOD_CK1_1	32	38	PF00069	0.640
MOD_CK1_1	47	53	PF00069	0.563
MOD_CK1_1	61	67	PF00069	0.589
MOD_CK1_1	79	85	PF00069	0.384
MOD_CK2_1	105	111	PF00069	0.527
MOD_CK2_1	200	206	PF00069	0.510
MOD_CK2_1	207	213	PF00069	0.397
MOD_CK2_1	63	69	PF00069	0.568
MOD_GlcNHglycan	127	130	PF01048	0.512
MOD_GlcNHglycan	35	38	PF01048	0.614
MOD_GlcNHglycan	60	63	PF01048	0.647
MOD_GlcNHglycan	87	90	PF01048	0.396
MOD_GlcNHglycan	92	95	PF01048	0.426
MOD_GSK3_1	134	141	PF00069	0.408
MOD_GSK3_1	25	32	PF00069	0.708
MOD_GSK3_1	364	371	PF00069	0.326
MOD_GSK3_1	415	422	PF00069	0.619
MOD_GSK3_1	61	68	PF00069	0.527
MOD_GSK3_1	90	97	PF00069	0.454
MOD_N-GLC_1	123	128	PF02516	0.557
MOD_N-GLC_1	159	164	PF02516	0.439
MOD_N-GLC_1	85	90	PF02516	0.384
MOD_NEK2_1	123	128	PF00069	0.540
MOD_NEK2_1	139	144	PF00069	0.285
MOD_NEK2_1	286	291	PF00069	0.441
MOD_NEK2_1	31	36	PF00069	0.719
MOD_NEK2_1	366	371	PF00069	0.343
MOD_NEK2_1	415	420	PF00069	0.505
MOD_NEK2_1	90	95	PF00069	0.466
MOD_PIKK_1	256	262	PF00454	0.303
MOD_PKA_1	105	111	PF00069	0.528
MOD_PKA_1	58	64	PF00069	0.617
MOD_PKA_2	236	242	PF00069	0.546
MOD_PKA_2	42	48	PF00069	0.645
MOD_PKA_2	79	85	PF00069	0.554
MOD_PKA_2	90	96	PF00069	0.405
MOD_Plk_1	159	165	PF00069	0.436
MOD_Plk_1	333	339	PF00069	0.475
MOD_Plk_1	76	82	PF00069	0.448
MOD_Plk_1	85	91	PF00069	0.356
MOD_Plk_2-3	15	21	PF00069	0.732
MOD_Plk_2-3	225	231	PF00069	0.525
MOD_Plk_4	143	149	PF00069	0.384
MOD_Plk_4	200	206	PF00069	0.510
MOD_Plk_4	294	300	PF00069	0.404
MOD_Plk_4	333	339	PF00069	0.398
MOD_SUMO_rev_2	108	115	PF00179	0.462
MOD_SUMO_rev_2	9	18	PF00179	0.726
TRG_ENDOCYTIC_2	229	232	PF00928	0.523
TRG_ENDOCYTIC_2	284	287	PF00928	0.415
TRG_ENDOCYTIC_2	299	302	PF00928	0.220
TRG_ENDOCYTIC_2	412	415	PF00928	0.449
TRG_ER_diArg_1	187	189	PF00400	0.518
TRG_ER_diArg_1	250	253	PF00400	0.478
TRG_ER_diArg_1	416	419	PF00400	0.528
TRG_Pf-PMV_PEXEL_1	346	350	PF00026	0.458

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE85	Leptomonas seymouri	63%	100%
A0A0S4IVI6	Bodo saltans	32%	100%
A0A1X0NVC7	Trypanosomatidae	47%	100%
A0A3Q8IEF5	Leishmania donovani	96%	100%
A0A3R7KS85	Trypanosoma rangeli	45%	100%
A4HG58	Leishmania braziliensis	82%	100%
A4I390	Leishmania infantum	96%	100%
D0A7R6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AZH8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5B7J4	Trypanosoma cruzi	48%	100%