Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8Q2_LEIMA

TriTrypDb:

LmjF.28.0180 , LMJLV39_280006900 , LMJSD75_280006800

Length:

212

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	7
GO:0016020	membrane	2	5

Expansion

Sequence features

Q4Q8Q2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8Q2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	40	42	PF00675	0.517
CLV_PCSK_KEX2_1	40	42	PF00082	0.520
CLV_PCSK_KEX2_1	46	48	PF00082	0.654
CLV_PCSK_PC1ET2_1	46	48	PF00082	0.654
CLV_PCSK_SKI1_1	13	17	PF00082	0.455
CLV_PCSK_SKI1_1	155	159	PF00082	0.461
CLV_PCSK_SKI1_1	96	100	PF00082	0.414
DEG_APCC_DBOX_1	154	162	PF00400	0.461
DEG_MDM2_SWIB_1	8	15	PF02201	0.318
DEG_SCF_FBW7_1	172	178	PF00400	0.407
DOC_CKS1_1	172	177	PF01111	0.484
DOC_CYCLIN_yClb5_NLxxxL_5	96	102	PF00134	0.322
DOC_PP2B_LxvP_1	195	198	PF13499	0.451
DOC_USP7_MATH_1	50	54	PF00917	0.617
DOC_WW_Pin1_4	110	115	PF00397	0.290
DOC_WW_Pin1_4	171	176	PF00397	0.492
DOC_WW_Pin1_4	46	51	PF00397	0.655
DOC_WW_Pin1_4	96	101	PF00397	0.463
LIG_14-3-3_CanoR_1	128	134	PF00244	0.487
LIG_14-3-3_CanoR_1	186	191	PF00244	0.505
LIG_Actin_WH2_2	172	188	PF00022	0.361
LIG_BIR_II_1	1	5	PF00653	0.633
LIG_BRCT_BRCA1_1	192	196	PF00533	0.365
LIG_EVH1_2	4	8	PF00568	0.328
LIG_FHA_1	111	117	PF00498	0.291
LIG_FHA_1	93	99	PF00498	0.464
LIG_FHA_2	20	26	PF00498	0.475
LIG_LIR_Apic_2	178	184	PF02991	0.445
LIG_LIR_Gen_1	119	127	PF02991	0.502
LIG_LIR_Gen_1	25	33	PF02991	0.401
LIG_LIR_Nem_3	169	173	PF02991	0.374
LIG_LIR_Nem_3	25	30	PF02991	0.384
LIG_LIR_Nem_3	70	75	PF02991	0.456
LIG_LYPXL_yS_3	164	167	PF13949	0.538
LIG_PCNA_PIPBox_1	68	77	PF02747	0.330
LIG_PCNA_yPIPBox_3	63	75	PF02747	0.346
LIG_Pex14_1	12	16	PF04695	0.457
LIG_Pex14_2	26	30	PF04695	0.349
LIG_Pex14_2	75	79	PF04695	0.482
LIG_Pex14_2	8	12	PF04695	0.512
LIG_SH2_CRK	173	177	PF00017	0.466
LIG_SH2_CRK	181	185	PF00017	0.531
LIG_SH2_GRB2like	120	123	PF00017	0.376
LIG_SH2_STAP1	10	14	PF00017	0.447
LIG_SH2_STAP1	83	87	PF00017	0.501
LIG_SH2_STAT5	120	123	PF00017	0.488
LIG_SH2_STAT5	156	159	PF00017	0.529
LIG_SH2_STAT5	173	176	PF00017	0.378
LIG_SH3_3	169	175	PF00018	0.379
LIG_SUMO_SIM_par_1	113	119	PF11976	0.461
LIG_SUMO_SIM_par_1	164	169	PF11976	0.490
LIG_TYR_ITIM	15	20	PF00017	0.532
LIG_UBA3_1	57	63	PF00899	0.580
MOD_CDK_SPK_2	46	51	PF00069	0.591
MOD_CK1_1	132	138	PF00069	0.554
MOD_CK1_1	19	25	PF00069	0.433
MOD_GlcNHglycan	42	45	PF01048	0.639
MOD_GlcNHglycan	52	55	PF01048	0.496
MOD_GSK3_1	171	178	PF00069	0.407
MOD_GSK3_1	185	192	PF00069	0.558
MOD_GSK3_1	46	53	PF00069	0.589
MOD_GSK3_1	92	99	PF00069	0.460
MOD_N-GLC_1	96	101	PF02516	0.359
MOD_NEK2_1	16	21	PF00069	0.470
MOD_NEK2_1	166	171	PF00069	0.382
MOD_NEK2_1	185	190	PF00069	0.449
MOD_NEK2_2	67	72	PF00069	0.450
MOD_PKA_1	40	46	PF00069	0.604
MOD_PKA_2	185	191	PF00069	0.587
MOD_PKA_2	40	46	PF00069	0.604
MOD_PKA_2	50	56	PF00069	0.559
MOD_Plk_2-3	149	155	PF00069	0.491
MOD_Plk_4	132	138	PF00069	0.554
MOD_Plk_4	16	22	PF00069	0.388
MOD_Plk_4	186	192	PF00069	0.521
MOD_Plk_4	67	73	PF00069	0.509
MOD_ProDKin_1	110	116	PF00069	0.286
MOD_ProDKin_1	171	177	PF00069	0.490
MOD_ProDKin_1	46	52	PF00069	0.644
MOD_ProDKin_1	96	102	PF00069	0.464
TRG_DiLeu_BaLyEn_6	111	116	PF01217	0.462
TRG_DiLeu_BaLyEn_6	162	167	PF01217	0.503
TRG_ENDOCYTIC_2	164	167	PF00928	0.458
TRG_ENDOCYTIC_2	17	20	PF00928	0.526
TRG_ENDOCYTIC_2	173	176	PF00928	0.376
TRG_ENDOCYTIC_2	83	86	PF00928	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5Y0	Leptomonas seymouri	74%	100%
A0A1X0NVB8	Trypanosomatidae	40%	98%
A0A3S7X140	Leishmania donovani	93%	100%
A0A422N4D7	Trypanosoma rangeli	44%	100%
A4HG59	Leishmania braziliensis	76%	100%
A4I391	Leishmania infantum	93%	100%
D0A7R7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AZH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5AS20	Trypanosoma cruzi	47%	100%