Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q8Q1_LEIMA

TriTrypDb:

LmjF.28.0190 , LMJLV39_280007000 , LMJSD75_280006900

Length:

517

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8Q1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8Q1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	251	255	PF00656	0.527
CLV_NRD_NRD_1	114	116	PF00675	0.509
CLV_NRD_NRD_1	122	124	PF00675	0.578
CLV_NRD_NRD_1	171	173	PF00675	0.689
CLV_NRD_NRD_1	228	230	PF00675	0.604
CLV_NRD_NRD_1	243	245	PF00675	0.593
CLV_NRD_NRD_1	247	249	PF00675	0.586
CLV_NRD_NRD_1	317	319	PF00675	0.582
CLV_NRD_NRD_1	346	348	PF00675	0.563
CLV_NRD_NRD_1	420	422	PF00675	0.557
CLV_PCSK_KEX2_1	114	116	PF00082	0.509
CLV_PCSK_KEX2_1	171	173	PF00082	0.689
CLV_PCSK_KEX2_1	228	230	PF00082	0.593
CLV_PCSK_KEX2_1	243	245	PF00082	0.593
CLV_PCSK_KEX2_1	317	319	PF00082	0.550
CLV_PCSK_KEX2_1	322	324	PF00082	0.500
CLV_PCSK_KEX2_1	346	348	PF00082	0.563
CLV_PCSK_KEX2_1	357	359	PF00082	0.553
CLV_PCSK_KEX2_1	420	422	PF00082	0.552
CLV_PCSK_KEX2_1	82	84	PF00082	0.486
CLV_PCSK_PC1ET2_1	322	324	PF00082	0.521
CLV_PCSK_PC1ET2_1	357	359	PF00082	0.617
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.486
CLV_PCSK_PC7_1	313	319	PF00082	0.553
CLV_PCSK_PC7_1	78	84	PF00082	0.481
CLV_PCSK_SKI1_1	133	137	PF00082	0.465
CLV_PCSK_SKI1_1	229	233	PF00082	0.567
CLV_PCSK_SKI1_1	244	248	PF00082	0.587
CLV_PCSK_SKI1_1	285	289	PF00082	0.581
CLV_PCSK_SKI1_1	317	321	PF00082	0.578
CLV_PCSK_SKI1_1	346	350	PF00082	0.626
CLV_PCSK_SKI1_1	511	515	PF00082	0.627
CLV_PCSK_SKI1_1	65	69	PF00082	0.478
CLV_PCSK_SKI1_1	82	86	PF00082	0.364
DEG_APCC_DBOX_1	233	241	PF00400	0.566
DEG_Nend_Nbox_1	1	3	PF02207	0.580
DEG_SPOP_SBC_1	143	147	PF00917	0.549
DOC_CKS1_1	230	235	PF01111	0.571
DOC_CYCLIN_RxL_1	241	251	PF00134	0.524
DOC_CYCLIN_yCln2_LP_2	302	305	PF00134	0.726
DOC_CYCLIN_yCln2_LP_2	386	389	PF00134	0.563
DOC_MAPK_MEF2A_6	228	237	PF00069	0.577
DOC_MAPK_RevD_3	97	111	PF00069	0.392
DOC_PP2B_LxvP_1	176	179	PF13499	0.635
DOC_PP2B_LxvP_1	302	305	PF13499	0.726
DOC_PP2B_LxvP_1	386	389	PF13499	0.563
DOC_PP4_FxxP_1	432	435	PF00568	0.623
DOC_USP7_MATH_1	143	147	PF00917	0.516
DOC_USP7_MATH_1	204	208	PF00917	0.651
DOC_USP7_MATH_1	253	257	PF00917	0.784
DOC_USP7_MATH_1	446	450	PF00917	0.722
DOC_USP7_MATH_2	279	285	PF00917	0.595
DOC_WW_Pin1_4	229	234	PF00397	0.571
DOC_WW_Pin1_4	288	293	PF00397	0.565
DOC_WW_Pin1_4	296	301	PF00397	0.584
DOC_WW_Pin1_4	427	432	PF00397	0.599
DOC_WW_Pin1_4	442	447	PF00397	0.725
DOC_WW_Pin1_4	450	455	PF00397	0.611
DOC_WW_Pin1_4	465	470	PF00397	0.521
LIG_14-3-3_CanoR_1	114	118	PF00244	0.584
LIG_14-3-3_CanoR_1	171	177	PF00244	0.544
LIG_14-3-3_CanoR_1	38	42	PF00244	0.677
LIG_14-3-3_CanoR_1	420	427	PF00244	0.639
LIG_14-3-3_CanoR_1	492	496	PF00244	0.645
LIG_14-3-3_CanoR_1	83	92	PF00244	0.442
LIG_Actin_WH2_2	87	105	PF00022	0.423
LIG_BRCT_BRCA1_1	145	149	PF00533	0.517
LIG_BRCT_BRCA1_1	283	287	PF00533	0.634
LIG_BRCT_BRCA1_1	338	342	PF00533	0.522
LIG_BRCT_BRCA1_1	394	398	PF00533	0.631
LIG_BRCT_BRCA1_1	428	432	PF00533	0.631
LIG_BRCT_BRCA1_2	394	400	PF00533	0.630
LIG_DCNL_PONY_1	1	4	PF03556	0.579
LIG_EH1_1	24	32	PF00400	0.497
LIG_eIF4E_1	467	473	PF01652	0.536
LIG_EVH1_2	388	392	PF00568	0.595
LIG_FHA_1	230	236	PF00498	0.572
LIG_FHA_1	413	419	PF00498	0.640
LIG_FHA_1	420	426	PF00498	0.572
LIG_FHA_1	51	57	PF00498	0.616
LIG_FHA_1	85	91	PF00498	0.382
LIG_FHA_2	249	255	PF00498	0.559
LIG_FHA_2	376	382	PF00498	0.603
LIG_LIR_Apic_2	429	435	PF02991	0.625
LIG_LIR_Gen_1	497	507	PF02991	0.597
LIG_LIR_Nem_3	284	290	PF02991	0.702
LIG_MYND_1	300	304	PF01753	0.624
LIG_MYND_1	431	435	PF01753	0.596
LIG_Pex14_2	149	153	PF04695	0.524
LIG_PTB_Apo_2	30	37	PF02174	0.562
LIG_Rb_pABgroove_1	9	17	PF01858	0.515
LIG_SH2_CRK	15	19	PF00017	0.727
LIG_SH2_STAP1	457	461	PF00017	0.664
LIG_SH2_STAP1	95	99	PF00017	0.545
LIG_SH2_STAT3	41	44	PF00017	0.529
LIG_SH2_STAT5	385	388	PF00017	0.679
LIG_SH2_STAT5	467	470	PF00017	0.565
LIG_SH2_STAT5	55	58	PF00017	0.639
LIG_SH3_2	239	244	PF14604	0.581
LIG_SH3_3	198	204	PF00018	0.595
LIG_SH3_3	230	236	PF00018	0.592
LIG_SH3_3	294	300	PF00018	0.585
LIG_SH3_3	363	369	PF00018	0.553
LIG_SH3_3	470	476	PF00018	0.678
LIG_SUMO_SIM_par_1	503	510	PF11976	0.545
LIG_TRAF2_1	20	23	PF00917	0.582
LIG_TRAF2_1	506	509	PF00917	0.628
LIG_TRFH_1	385	389	PF08558	0.490
LIG_UBA3_1	106	111	PF00899	0.455
LIG_WW_1	454	457	PF00397	0.557
LIG_WW_3	240	244	PF00397	0.582
MOD_CDK_SPK_2	229	234	PF00069	0.559
MOD_CDK_SPK_2	465	470	PF00069	0.515
MOD_CK1_1	129	135	PF00069	0.508
MOD_CK1_1	181	187	PF00069	0.686
MOD_CK1_1	296	302	PF00069	0.632
MOD_CK1_1	331	337	PF00069	0.510
MOD_CK1_1	375	381	PF00069	0.604
MOD_CK1_1	391	397	PF00069	0.620
MOD_CK1_1	419	425	PF00069	0.587
MOD_CK1_1	494	500	PF00069	0.649
MOD_CK2_1	16	22	PF00069	0.597
MOD_CK2_1	503	509	PF00069	0.643
MOD_Cter_Amidation	169	172	PF01082	0.641
MOD_Cter_Amidation	226	229	PF01082	0.640
MOD_GlcNHglycan	146	149	PF01048	0.641
MOD_GlcNHglycan	167	170	PF01048	0.531
MOD_GlcNHglycan	183	186	PF01048	0.550
MOD_GlcNHglycan	259	262	PF01048	0.648
MOD_GlcNHglycan	266	269	PF01048	0.606
MOD_GlcNHglycan	351	354	PF01048	0.698
MOD_GlcNHglycan	407	410	PF01048	0.589
MOD_GSK3_1	113	120	PF00069	0.509
MOD_GSK3_1	125	132	PF00069	0.506
MOD_GSK3_1	133	140	PF00069	0.602
MOD_GSK3_1	177	184	PF00069	0.690
MOD_GSK3_1	253	260	PF00069	0.637
MOD_GSK3_1	333	340	PF00069	0.530
MOD_GSK3_1	342	349	PF00069	0.552
MOD_GSK3_1	368	375	PF00069	0.578
MOD_GSK3_1	387	394	PF00069	0.634
MOD_GSK3_1	412	419	PF00069	0.608
MOD_GSK3_1	442	449	PF00069	0.706
MOD_GSK3_1	461	468	PF00069	0.562
MOD_GSK3_1	474	481	PF00069	0.624
MOD_GSK3_1	84	91	PF00069	0.434
MOD_N-GLC_1	281	286	PF02516	0.611
MOD_N-GLC_1	446	451	PF02516	0.535
MOD_NEK2_1	102	107	PF00069	0.439
MOD_NEK2_1	257	262	PF00069	0.646
MOD_NEK2_1	283	288	PF00069	0.621
MOD_NEK2_1	337	342	PF00069	0.544
MOD_NEK2_1	36	41	PF00069	0.543
MOD_NEK2_1	392	397	PF00069	0.647
MOD_NEK2_1	74	79	PF00069	0.455
MOD_NEK2_2	137	142	PF00069	0.454
MOD_NEK2_2	436	441	PF00069	0.683
MOD_PIKK_1	178	184	PF00454	0.713
MOD_PIKK_1	25	31	PF00454	0.509
MOD_PIKK_1	420	426	PF00454	0.582
MOD_PIKK_1	497	503	PF00454	0.512
MOD_PKA_1	248	254	PF00069	0.531
MOD_PKA_1	346	352	PF00069	0.629
MOD_PKA_1	420	426	PF00069	0.556
MOD_PKA_2	113	119	PF00069	0.571
MOD_PKA_2	346	352	PF00069	0.629
MOD_PKA_2	37	43	PF00069	0.678
MOD_PKA_2	419	425	PF00069	0.592
MOD_PKA_2	491	497	PF00069	0.622
MOD_PKA_2	74	80	PF00069	0.467
MOD_Plk_1	125	131	PF00069	0.602
MOD_Plk_1	446	452	PF00069	0.538
MOD_Plk_1	50	56	PF00069	0.605
MOD_Plk_4	102	108	PF00069	0.423
MOD_Plk_4	137	143	PF00069	0.460
MOD_Plk_4	253	259	PF00069	0.693
MOD_Plk_4	328	334	PF00069	0.543
MOD_Plk_4	337	343	PF00069	0.483
MOD_Plk_4	375	381	PF00069	0.656
MOD_Plk_4	478	484	PF00069	0.504
MOD_Plk_4	494	500	PF00069	0.549
MOD_ProDKin_1	229	235	PF00069	0.572
MOD_ProDKin_1	288	294	PF00069	0.565
MOD_ProDKin_1	296	302	PF00069	0.588
MOD_ProDKin_1	427	433	PF00069	0.601
MOD_ProDKin_1	442	448	PF00069	0.726
MOD_ProDKin_1	450	456	PF00069	0.609
MOD_ProDKin_1	465	471	PF00069	0.521
MOD_SUMO_for_1	109	112	PF00179	0.481
MOD_SUMO_for_1	56	59	PF00179	0.625
TRG_DiLeu_BaEn_1	321	326	PF01217	0.534
TRG_DiLeu_BaEn_4	51	57	PF01217	0.616
TRG_DiLeu_BaLyEn_6	62	67	PF01217	0.545
TRG_ENDOCYTIC_2	15	18	PF00928	0.728
TRG_ER_diArg_1	113	115	PF00400	0.504
TRG_ER_diArg_1	228	230	PF00400	0.610
TRG_ER_diArg_1	242	244	PF00400	0.627
TRG_ER_diArg_1	317	319	PF00400	0.582
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.622
TRG_Pf-PMV_PEXEL_1	323	328	PF00026	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P724	Leptomonas seymouri	50%	71%
A0A3S7X148	Leishmania donovani	89%	100%
A4HG60	Leishmania braziliensis	58%	100%
A4I392	Leishmania infantum	89%	100%
E9AZI0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%