Aminotran_5 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8Q0_LEIMA

TriTrypDb:

LmjF.28.0200 , LMJLV39_280007200 , LMJSD75_280007100

Length:

604

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8Q0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8Q0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	138	142	PF00656	0.589
CLV_NRD_NRD_1	114	116	PF00675	0.541
CLV_NRD_NRD_1	578	580	PF00675	0.404
CLV_NRD_NRD_1	585	587	PF00675	0.431
CLV_NRD_NRD_1	94	96	PF00675	0.609
CLV_PCSK_KEX2_1	538	540	PF00082	0.301
CLV_PCSK_KEX2_1	585	587	PF00082	0.433
CLV_PCSK_KEX2_1	64	66	PF00082	0.316
CLV_PCSK_KEX2_1	96	98	PF00082	0.666
CLV_PCSK_PC1ET2_1	538	540	PF00082	0.301
CLV_PCSK_PC1ET2_1	64	66	PF00082	0.335
CLV_PCSK_PC1ET2_1	96	98	PF00082	0.666
CLV_PCSK_SKI1_1	234	238	PF00082	0.299
CLV_PCSK_SKI1_1	579	583	PF00082	0.329
CLV_PCSK_SKI1_1	64	68	PF00082	0.303
CLV_Separin_Metazoa	227	231	PF03568	0.314
DEG_APCC_DBOX_1	233	241	PF00400	0.292
DEG_Nend_UBRbox_1	1	4	PF02207	0.322
DEG_SPOP_SBC_1	347	351	PF00917	0.291
DOC_CKS1_1	553	558	PF01111	0.305
DOC_CYCLIN_yCln2_LP_2	456	462	PF00134	0.284
DOC_MAPK_gen_1	366	375	PF00069	0.361
DOC_MAPK_MEF2A_6	234	241	PF00069	0.286
DOC_MAPK_NFAT4_5	234	242	PF00069	0.310
DOC_PP2B_LxvP_1	456	459	PF13499	0.284
DOC_PP2B_LxvP_1	76	79	PF13499	0.634
DOC_PP4_FxxP_1	408	411	PF00568	0.280
DOC_PP4_MxPP_1	77	80	PF00568	0.422
DOC_USP7_MATH_1	108	112	PF00917	0.603
DOC_USP7_MATH_1	123	127	PF00917	0.677
DOC_USP7_MATH_1	131	135	PF00917	0.577
DOC_USP7_MATH_1	186	190	PF00917	0.530
DOC_USP7_MATH_1	26	30	PF00917	0.482
DOC_USP7_MATH_1	491	495	PF00917	0.353
DOC_USP7_MATH_1	502	506	PF00917	0.234
DOC_USP7_MATH_1	83	87	PF00917	0.522
DOC_WW_Pin1_4	118	123	PF00397	0.496
DOC_WW_Pin1_4	192	197	PF00397	0.344
DOC_WW_Pin1_4	407	412	PF00397	0.333
DOC_WW_Pin1_4	552	557	PF00397	0.280
DOC_WW_Pin1_4	573	578	PF00397	0.424
DOC_WW_Pin1_4	89	94	PF00397	0.679
LIG_14-3-3_CanoR_1	152	157	PF00244	0.568
LIG_14-3-3_CanoR_1	547	553	PF00244	0.256
LIG_Actin_WH2_2	533	549	PF00022	0.397
LIG_BRCT_BRCA1_1	188	192	PF00533	0.446
LIG_BRCT_BRCA1_1	412	416	PF00533	0.277
LIG_FHA_1	134	140	PF00498	0.642
LIG_FHA_1	263	269	PF00498	0.295
LIG_FHA_1	284	290	PF00498	0.310
LIG_FHA_1	326	332	PF00498	0.293
LIG_FHA_1	338	344	PF00498	0.279
LIG_FHA_1	348	354	PF00498	0.305
LIG_FHA_1	357	363	PF00498	0.461
LIG_FHA_1	595	601	PF00498	0.449
LIG_FHA_2	119	125	PF00498	0.644
LIG_FHA_2	138	144	PF00498	0.454
LIG_FHA_2	553	559	PF00498	0.301
LIG_LIR_Apic_2	50	56	PF02991	0.405
LIG_LIR_Gen_1	150	161	PF02991	0.496
LIG_LIR_Gen_1	285	295	PF02991	0.286
LIG_LIR_Gen_1	454	462	PF02991	0.273
LIG_LIR_Gen_1	558	567	PF02991	0.284
LIG_LIR_Nem_3	150	156	PF02991	0.515
LIG_LIR_Nem_3	285	291	PF02991	0.286
LIG_LIR_Nem_3	29	34	PF02991	0.431
LIG_LIR_Nem_3	385	391	PF02991	0.389
LIG_LIR_Nem_3	413	419	PF02991	0.302
LIG_LIR_Nem_3	449	455	PF02991	0.290
LIG_LIR_Nem_3	558	562	PF02991	0.282
LIG_NRBOX	11	17	PF00104	0.476
LIG_PTB_Apo_2	260	267	PF02174	0.278
LIG_REV1ctd_RIR_1	414	424	PF16727	0.403
LIG_RPA_C_Fungi	580	592	PF08784	0.481
LIG_SH2_CRK	53	57	PF00017	0.381
LIG_SH2_CRK	553	557	PF00017	0.229
LIG_SH2_NCK_1	553	557	PF00017	0.294
LIG_SH2_PTP2	559	562	PF00017	0.364
LIG_SH2_SRC	220	223	PF00017	0.366
LIG_SH2_SRC	58	61	PF00017	0.288
LIG_SH2_STAP1	220	224	PF00017	0.298
LIG_SH2_STAP1	242	246	PF00017	0.278
LIG_SH2_STAT5	288	291	PF00017	0.299
LIG_SH2_STAT5	346	349	PF00017	0.238
LIG_SH2_STAT5	455	458	PF00017	0.282
LIG_SH2_STAT5	476	479	PF00017	0.371
LIG_SH2_STAT5	522	525	PF00017	0.332
LIG_SH2_STAT5	545	548	PF00017	0.272
LIG_SH2_STAT5	559	562	PF00017	0.252
LIG_SH2_STAT5	58	61	PF00017	0.338
LIG_SH3_3	155	161	PF00018	0.513
LIG_SH3_3	504	510	PF00018	0.295
LIG_SH3_3	571	577	PF00018	0.525
LIG_SUMO_SIM_par_1	237	243	PF11976	0.278
LIG_SUMO_SIM_par_1	505	511	PF11976	0.305
LIG_SUMO_SIM_par_1	564	571	PF11976	0.354
LIG_TYR_ITSM	284	291	PF00017	0.306
LIG_WRC_WIRS_1	153	158	PF05994	0.463
LIG_WRC_WIRS_1	34	39	PF05994	0.442
LIG_WW_1	55	58	PF00397	0.328
MOD_CDC14_SPxK_1	576	579	PF00782	0.454
MOD_CDC14_SPxK_1	92	95	PF00782	0.530
MOD_CDK_SPK_2	407	412	PF00069	0.327
MOD_CDK_SPxK_1	573	579	PF00069	0.447
MOD_CDK_SPxK_1	89	95	PF00069	0.539
MOD_CDK_SPxxK_3	573	580	PF00069	0.348
MOD_CDK_SPxxK_3	89	96	PF00069	0.538
MOD_CK1_1	126	132	PF00069	0.557
MOD_CK1_1	148	154	PF00069	0.720
MOD_CK1_1	36	42	PF00069	0.433
MOD_CK1_1	395	401	PF00069	0.329
MOD_CK1_1	410	416	PF00069	0.314
MOD_CK1_1	516	522	PF00069	0.383
MOD_CK2_1	107	113	PF00069	0.602
MOD_CK2_1	114	120	PF00069	0.670
MOD_CK2_1	26	32	PF00069	0.422
MOD_CK2_1	302	308	PF00069	0.328
MOD_CK2_1	502	508	PF00069	0.277
MOD_CK2_1	552	558	PF00069	0.277
MOD_CK2_1	65	71	PF00069	0.386
MOD_CK2_1	95	101	PF00069	0.552
MOD_Cter_Amidation	93	96	PF01082	0.485
MOD_DYRK1A_RPxSP_1	118	122	PF00069	0.502
MOD_GlcNHglycan	124	128	PF01048	0.756
MOD_GlcNHglycan	162	165	PF01048	0.557
MOD_GlcNHglycan	350	353	PF01048	0.313
MOD_GlcNHglycan	412	415	PF01048	0.442
MOD_GlcNHglycan	482	485	PF01048	0.308
MOD_GlcNHglycan	548	551	PF01048	0.255
MOD_GSK3_1	114	121	PF00069	0.601
MOD_GSK3_1	133	140	PF00069	0.671
MOD_GSK3_1	141	148	PF00069	0.660
MOD_GSK3_1	16	23	PF00069	0.538
MOD_GSK3_1	406	413	PF00069	0.265
MOD_GSK3_1	426	433	PF00069	0.235
MOD_GSK3_1	45	52	PF00069	0.337
MOD_GSK3_1	475	482	PF00069	0.476
MOD_LATS_1	583	589	PF00433	0.318
MOD_N-GLC_1	192	197	PF02516	0.343
MOD_N-GLC_1	262	267	PF02516	0.283
MOD_N-GLC_1	337	342	PF02516	0.366
MOD_N-GLC_1	84	89	PF02516	0.496
MOD_NEK2_1	114	119	PF00069	0.544
MOD_NEK2_1	206	211	PF00069	0.255
MOD_NEK2_1	480	485	PF00069	0.287
MOD_NEK2_1	513	518	PF00069	0.360
MOD_NEK2_1	546	551	PF00069	0.372
MOD_NEK2_2	26	31	PF00069	0.443
MOD_NEK2_2	33	38	PF00069	0.421
MOD_PIKK_1	392	398	PF00454	0.421
MOD_PIKK_1	586	592	PF00454	0.370
MOD_PK_1	2	8	PF00069	0.430
MOD_PK_1	426	432	PF00069	0.397
MOD_PKA_1	585	591	PF00069	0.328
MOD_PKA_1	95	101	PF00069	0.606
MOD_PKA_2	114	120	PF00069	0.546
MOD_PKA_2	151	157	PF00069	0.590
MOD_PKA_2	546	552	PF00069	0.256
MOD_PKA_2	585	591	PF00069	0.520
MOD_Plk_1	148	154	PF00069	0.501
MOD_Plk_1	20	26	PF00069	0.466
MOD_Plk_1	262	268	PF00069	0.258
MOD_Plk_1	322	328	PF00069	0.392
MOD_Plk_1	49	55	PF00069	0.524
MOD_Plk_1	84	90	PF00069	0.702
MOD_Plk_2-3	137	143	PF00069	0.566
MOD_Plk_4	206	212	PF00069	0.367
MOD_Plk_4	26	32	PF00069	0.532
MOD_Plk_4	395	401	PF00069	0.277
MOD_Plk_4	426	432	PF00069	0.357
MOD_Plk_4	451	457	PF00069	0.280
MOD_Plk_4	502	508	PF00069	0.277
MOD_Plk_4	513	519	PF00069	0.300
MOD_Plk_4	84	90	PF00069	0.597
MOD_ProDKin_1	118	124	PF00069	0.500
MOD_ProDKin_1	192	198	PF00069	0.339
MOD_ProDKin_1	407	413	PF00069	0.342
MOD_ProDKin_1	552	558	PF00069	0.277
MOD_ProDKin_1	573	579	PF00069	0.423
MOD_ProDKin_1	89	95	PF00069	0.678
MOD_SUMO_rev_2	385	391	PF00179	0.337
TRG_DiLeu_BaEn_2	226	232	PF01217	0.389
TRG_DiLeu_LyEn_5	235	240	PF01217	0.337
TRG_ENDOCYTIC_2	288	291	PF00928	0.299
TRG_ENDOCYTIC_2	292	295	PF00928	0.286
TRG_ENDOCYTIC_2	455	458	PF00928	0.258
TRG_ENDOCYTIC_2	545	548	PF00928	0.257
TRG_ENDOCYTIC_2	559	562	PF00928	0.286
TRG_ER_diArg_1	365	368	PF00400	0.354
TRG_ER_diArg_1	585	587	PF00400	0.374
TRG_NLS_MonoExtC_3	114	120	PF00514	0.546
TRG_NLS_MonoExtC_3	94	99	PF00514	0.610
TRG_NLS_MonoExtN_4	93	100	PF00514	0.600
TRG_Pf-PMV_PEXEL_1	217	221	PF00026	0.408
TRG_Pf-PMV_PEXEL_1	22	27	PF00026	0.382
TRG_Pf-PMV_PEXEL_1	249	254	PF00026	0.297
TRG_Pf-PMV_PEXEL_1	313	317	PF00026	0.362
TRG_Pf-PMV_PEXEL_1	585	590	PF00026	0.437

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7G6	Leptomonas seymouri	68%	92%
A0A1X0NVS7	Trypanosomatidae	68%	100%
A0A3R7RDE4	Trypanosoma rangeli	67%	100%
A0A3S7X145	Leishmania donovani	92%	98%
A4HG61	Leishmania braziliensis	77%	99%
A7UX13	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	24%	100%
E9AZI1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	98%
Q3E6S9	Arabidopsis thaliana	26%	100%
Q9LGZ2	Oryza sativa subsp. japonica	26%	100%
Q9M1R1	Arabidopsis thaliana	26%	100%
V5D807	Trypanosoma cruzi	65%	100%