EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q8P7_LEIMA

TriTrypDb:

LmjF.28.0230 , LMJLV39_280007500 , LMJSD75_280007400

Length:

327

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8P7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8P7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	249	251	PF00675	0.626
CLV_PCSK_KEX2_1	248	250	PF00082	0.631
CLV_PCSK_KEX2_1	300	302	PF00082	0.561
CLV_PCSK_PC1ET2_1	300	302	PF00082	0.561
DOC_CKS1_1	15	20	PF01111	0.660
DOC_USP7_MATH_1	173	177	PF00917	0.640
DOC_USP7_MATH_1	198	202	PF00917	0.669
DOC_USP7_MATH_1	46	50	PF00917	0.577
DOC_USP7_MATH_1	97	101	PF00917	0.638
DOC_WW_Pin1_4	100	105	PF00397	0.627
DOC_WW_Pin1_4	137	142	PF00397	0.651
DOC_WW_Pin1_4	14	19	PF00397	0.679
DOC_WW_Pin1_4	260	265	PF00397	0.501
DOC_WW_Pin1_4	28	33	PF00397	0.594
LIG_14-3-3_CanoR_1	153	159	PF00244	0.610
LIG_14-3-3_CanoR_1	174	182	PF00244	0.621
LIG_14-3-3_CanoR_1	214	219	PF00244	0.681
LIG_14-3-3_CanoR_1	69	79	PF00244	0.661
LIG_BIR_II_1	1	5	PF00653	0.664
LIG_BRCT_BRCA1_1	308	312	PF00533	0.588
LIG_Clathr_ClatBox_1	165	169	PF01394	0.522
LIG_FHA_1	101	107	PF00498	0.620
LIG_FHA_1	170	176	PF00498	0.571
LIG_FHA_1	215	221	PF00498	0.765
LIG_FHA_1	242	248	PF00498	0.757
LIG_FHA_1	29	35	PF00498	0.704
LIG_FHA_2	153	159	PF00498	0.651
LIG_FHA_2	289	295	PF00498	0.433
LIG_FHA_2	6	12	PF00498	0.671
LIG_FXI_DFP_1	320	324	PF00024	0.575
LIG_LIR_Gen_1	290	299	PF02991	0.437
LIG_LIR_Gen_1	76	84	PF02991	0.710
LIG_LIR_Nem_3	276	282	PF02991	0.539
LIG_LIR_Nem_3	290	295	PF02991	0.529
LIG_LIR_Nem_3	76	81	PF02991	0.708
LIG_PDZ_Class_2	322	327	PF00595	0.629
LIG_Pex14_2	319	323	PF04695	0.638
LIG_SH3_1	261	267	PF00018	0.483
LIG_SH3_3	105	111	PF00018	0.679
LIG_SH3_3	136	142	PF00018	0.701
LIG_SH3_3	261	267	PF00018	0.483
LIG_SH3_3	292	298	PF00018	0.493
LIG_SUMO_SIM_anti_2	269	276	PF11976	0.444
LIG_SUMO_SIM_par_1	164	170	PF11976	0.520
LIG_SUMO_SIM_par_1	223	231	PF11976	0.628
LIG_TRAF2_1	133	136	PF00917	0.713
LIG_TRAF2_1	143	146	PF00917	0.590
LIG_TRAF2_1	267	270	PF00917	0.611
MOD_CDK_SPxxK_3	14	21	PF00069	0.664
MOD_CDK_SPxxK_3	28	35	PF00069	0.549
MOD_CK1_1	100	106	PF00069	0.643
MOD_CK1_1	192	198	PF00069	0.675
MOD_CK1_1	224	230	PF00069	0.673
MOD_CK1_1	288	294	PF00069	0.522
MOD_CK1_1	71	77	PF00069	0.698
MOD_CK2_1	152	158	PF00069	0.573
MOD_CK2_1	173	179	PF00069	0.724
MOD_CK2_1	224	230	PF00069	0.673
MOD_CK2_1	288	294	PF00069	0.437
MOD_CK2_1	5	11	PF00069	0.670
MOD_CK2_1	70	76	PF00069	0.631
MOD_CK2_1	87	93	PF00069	0.539
MOD_GlcNHglycan	158	162	PF01048	0.668
MOD_GlcNHglycan	287	290	PF01048	0.646
MOD_GlcNHglycan	73	76	PF01048	0.706
MOD_GlcNHglycan	98	102	PF01048	0.683
MOD_GSK3_1	10	17	PF00069	0.592
MOD_GSK3_1	169	176	PF00069	0.573
MOD_GSK3_1	188	195	PF00069	0.601
MOD_GSK3_1	224	231	PF00069	0.664
MOD_GSK3_1	256	263	PF00069	0.642
MOD_GSK3_1	40	47	PF00069	0.668
MOD_GSK3_1	70	77	PF00069	0.707
MOD_N-GLC_1	55	60	PF02516	0.676
MOD_NEK2_1	212	217	PF00069	0.565
MOD_NEK2_1	306	311	PF00069	0.609
MOD_NEK2_1	55	60	PF00069	0.618
MOD_NEK2_1	70	75	PF00069	0.664
MOD_PIKK_1	147	153	PF00454	0.613
MOD_PIKK_1	212	218	PF00454	0.654
MOD_PIKK_1	68	74	PF00454	0.663
MOD_PKA_2	152	158	PF00069	0.613
MOD_PKA_2	173	179	PF00069	0.618
MOD_PKA_2	68	74	PF00069	0.663
MOD_PKB_1	35	43	PF00069	0.668
MOD_Plk_1	10	16	PF00069	0.604
MOD_Plk_1	124	130	PF00069	0.686
MOD_Plk_1	157	163	PF00069	0.650
MOD_Plk_1	37	43	PF00069	0.714
MOD_Plk_4	10	16	PF00069	0.607
MOD_Plk_4	189	195	PF00069	0.635
MOD_Plk_4	203	209	PF00069	0.503
MOD_Plk_4	221	227	PF00069	0.489
MOD_Plk_4	37	43	PF00069	0.670
MOD_Plk_4	74	80	PF00069	0.704
MOD_ProDKin_1	100	106	PF00069	0.627
MOD_ProDKin_1	137	143	PF00069	0.649
MOD_ProDKin_1	14	20	PF00069	0.678
MOD_ProDKin_1	260	266	PF00069	0.491
MOD_ProDKin_1	28	34	PF00069	0.595
TRG_DiLeu_BaEn_1	158	163	PF01217	0.624
TRG_DiLeu_BaEn_3	269	275	PF01217	0.445
TRG_DiLeu_BaLyEn_6	161	166	PF01217	0.648
TRG_ENDOCYTIC_2	209	212	PF00928	0.685
TRG_ER_diArg_1	247	250	PF00400	0.629
TRG_ER_diArg_1	34	37	PF00400	0.639
TRG_Pf-PMV_PEXEL_1	250	254	PF00026	0.613

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IHW6	Leishmania donovani	88%	100%
A4HG64	Leishmania braziliensis	52%	97%
A4I396	Leishmania infantum	88%	100%
E9AZI4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%