Glycerol-3-phosphate dehydrogenase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial

Species:

Leishmania major

UniProt:

Q4Q8P6_LEIMA

TriTrypDb:

LmjF.28.0240 , LMJLV39_280007600 , LMJSD75_280007500

Length:

608

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0009331	glycerol-3-phosphate dehydrogenase complex	4	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	4
GO:1902494	catalytic complex	2	12
GO:1990204	oxidoreductase complex	3	12
GO:0016020	membrane	2	2

Expansion

Sequence features

Q4Q8P6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8P6

Function

Biological processes
Term	Name	Level	Count
GO:0006072	glycerol-3-phosphate metabolic process	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0019637	organophosphate metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0052646	alditol phosphate metabolic process	4	12
GO:0071704	organic substance metabolic process	2	12
GO:1901135	carbohydrate derivative metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003824	catalytic activity	1	12
GO:0004368	glycerol-3-phosphate dehydrogenase (quinone) activity	5	12
GO:0005488	binding	1	2
GO:0016491	oxidoreductase activity	2	12
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	12
GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor	4	12
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0050660	flavin adenine dinucleotide binding	4	2
GO:0052590	sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity	6	12
GO:0052591	sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity	7	12
GO:0097159	organic cyclic compound binding	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	210	214	PF00656	0.474
CLV_C14_Caspase3-7	82	86	PF00656	0.469
CLV_NRD_NRD_1	207	209	PF00675	0.342
CLV_NRD_NRD_1	278	280	PF00675	0.317
CLV_NRD_NRD_1	32	34	PF00675	0.361
CLV_NRD_NRD_1	324	326	PF00675	0.302
CLV_NRD_NRD_1	446	448	PF00675	0.296
CLV_NRD_NRD_1	557	559	PF00675	0.252
CLV_PCSK_KEX2_1	557	559	PF00082	0.252
CLV_PCSK_KEX2_1	590	592	PF00082	0.397
CLV_PCSK_PC1ET2_1	590	592	PF00082	0.397
CLV_PCSK_SKI1_1	122	126	PF00082	0.252
CLV_PCSK_SKI1_1	302	306	PF00082	0.313
CLV_PCSK_SKI1_1	343	347	PF00082	0.263
CLV_PCSK_SKI1_1	527	531	PF00082	0.301
CLV_PCSK_SKI1_1	560	564	PF00082	0.277
CLV_Separin_Metazoa	267	271	PF03568	0.557
DOC_CDC14_PxL_1	146	154	PF14671	0.463
DOC_CDC14_PxL_1	201	209	PF14671	0.538
DOC_CKS1_1	369	374	PF01111	0.418
DOC_MAPK_FxFP_2	194	197	PF00069	0.538
DOC_MAPK_gen_1	330	337	PF00069	0.557
DOC_MAPK_gen_1	557	563	PF00069	0.463
DOC_PP1_RVXF_1	341	347	PF00149	0.452
DOC_PP1_RVXF_1	558	564	PF00149	0.440
DOC_PP2B_LxvP_1	405	408	PF13499	0.513
DOC_PP2B_LxvP_1	493	496	PF13499	0.557
DOC_PP4_FxxP_1	194	197	PF00568	0.463
DOC_PP4_FxxP_1	346	349	PF00568	0.513
DOC_USP7_MATH_1	394	398	PF00917	0.536
DOC_USP7_MATH_1	519	523	PF00917	0.418
DOC_USP7_MATH_1	60	64	PF00917	0.551
DOC_USP7_MATH_1	601	605	PF00917	0.514
DOC_USP7_UBL2_3	202	206	PF12436	0.513
DOC_USP7_UBL2_3	459	463	PF12436	0.592
DOC_USP7_UBL2_3	465	469	PF12436	0.590
DOC_WW_Pin1_4	368	373	PF00397	0.418
DOC_WW_Pin1_4	529	534	PF00397	0.538
LIG_14-3-3_CanoR_1	232	238	PF00244	0.493
LIG_14-3-3_CanoR_1	575	583	PF00244	0.501
LIG_14-3-3_CanoR_1	89	94	PF00244	0.455
LIG_Actin_WH2_2	117	135	PF00022	0.493
LIG_BIR_II_1	1	5	PF00653	0.425
LIG_FHA_1	108	114	PF00498	0.462
LIG_FHA_1	141	147	PF00498	0.499
LIG_FHA_1	279	285	PF00498	0.482
LIG_FHA_1	317	323	PF00498	0.470
LIG_FHA_1	416	422	PF00498	0.477
LIG_FHA_1	471	477	PF00498	0.438
LIG_FHA_1	488	494	PF00498	0.562
LIG_FHA_1	86	92	PF00498	0.466
LIG_FHA_2	208	214	PF00498	0.468
LIG_FHA_2	269	275	PF00498	0.470
LIG_FHA_2	303	309	PF00498	0.390
LIG_LIR_Apic_2	192	197	PF02991	0.477
LIG_LIR_Apic_2	24	28	PF02991	0.444
LIG_LIR_Gen_1	248	259	PF02991	0.477
LIG_LIR_Nem_3	188	194	PF02991	0.453
LIG_LIR_Nem_3	248	254	PF02991	0.477
LIG_LIR_Nem_3	397	402	PF02991	0.452
LIG_LIR_Nem_3	509	514	PF02991	0.452
LIG_LYPXL_yS_3	204	207	PF13949	0.538
LIG_MYND_1	157	161	PF01753	0.538
LIG_NRP_CendR_1	606	608	PF00754	0.278
LIG_Pex14_1	503	507	PF04695	0.452
LIG_Pex14_2	346	350	PF04695	0.452
LIG_SH2_CRK	25	29	PF00017	0.554
LIG_SH2_CRK	251	255	PF00017	0.538
LIG_SH2_CRK	599	603	PF00017	0.600
LIG_SH2_GRB2like	25	28	PF00017	0.554
LIG_SH2_NCK_1	25	29	PF00017	0.586
LIG_SH2_NCK_1	45	49	PF00017	0.381
LIG_SH2_SRC	8	11	PF00017	0.374
LIG_SH2_STAP1	178	182	PF00017	0.448
LIG_SH2_STAP1	235	239	PF00017	0.557
LIG_SH2_STAP1	285	289	PF00017	0.463
LIG_SH2_STAP1	599	603	PF00017	0.619
LIG_SH2_STAT3	224	227	PF00017	0.435
LIG_SH2_STAT3	541	544	PF00017	0.493
LIG_SH2_STAT5	119	122	PF00017	0.452
LIG_SH2_STAT5	25	28	PF00017	0.503
LIG_SH2_STAT5	327	330	PF00017	0.452
LIG_SH3_3	366	372	PF00018	0.509
LIG_SH3_3	61	67	PF00018	0.509
LIG_SUMO_SIM_anti_2	473	480	PF11976	0.418
LIG_SUMO_SIM_anti_2	69	74	PF11976	0.452
LIG_SUMO_SIM_par_1	280	286	PF11976	0.474
LIG_SUMO_SIM_par_1	424	430	PF11976	0.457
LIG_TYR_ITIM	249	254	PF00017	0.493
LIG_TYR_ITIM	43	48	PF00017	0.626
LIG_UBA3_1	435	442	PF00899	0.515
LIG_UBA3_1	524	530	PF00899	0.523
LIG_WRC_WIRS_1	602	607	PF05994	0.514
MOD_CK1_1	106	112	PF00069	0.460
MOD_CK1_1	155	161	PF00069	0.513
MOD_CK1_1	397	403	PF00069	0.531
MOD_CK1_1	47	53	PF00069	0.524
MOD_CK2_1	268	274	PF00069	0.523
MOD_CK2_1	302	308	PF00069	0.390
MOD_GlcNHglycan	190	194	PF01048	0.291
MOD_GlcNHglycan	296	299	PF01048	0.356
MOD_GlcNHglycan	305	308	PF01048	0.273
MOD_GlcNHglycan	396	399	PF01048	0.277
MOD_GlcNHglycan	599	602	PF01048	0.415
MOD_GlcNHglycan	81	84	PF01048	0.274
MOD_GSK3_1	102	109	PF00069	0.410
MOD_GSK3_1	185	192	PF00069	0.462
MOD_GSK3_1	233	240	PF00069	0.444
MOD_GSK3_1	364	371	PF00069	0.501
MOD_GSK3_1	597	604	PF00069	0.600
MOD_GSK3_1	85	92	PF00069	0.449
MOD_N-GLC_1	436	441	PF02516	0.329
MOD_NEK2_1	1	6	PF00069	0.463
MOD_NEK2_1	152	157	PF00069	0.513
MOD_NEK2_1	189	194	PF00069	0.477
MOD_NEK2_1	23	28	PF00069	0.453
MOD_NEK2_1	233	238	PF00069	0.483
MOD_NEK2_1	268	273	PF00069	0.474
MOD_NEK2_1	35	40	PF00069	0.514
MOD_NEK2_1	386	391	PF00069	0.538
MOD_NEK2_1	436	441	PF00069	0.512
MOD_NEK2_1	457	462	PF00069	0.536
MOD_NEK2_2	601	606	PF00069	0.519
MOD_PIKK_1	28	34	PF00454	0.535
MOD_PIKK_1	415	421	PF00454	0.477
MOD_PK_1	44	50	PF00069	0.455
MOD_PK_1	89	95	PF00069	0.477
MOD_PKA_2	107	113	PF00069	0.448
MOD_PKA_2	207	213	PF00069	0.474
MOD_PKA_2	278	284	PF00069	0.555
MOD_PKA_2	556	562	PF00069	0.452
MOD_PKA_2	574	580	PF00069	0.550
MOD_Plk_1	140	146	PF00069	0.493
MOD_Plk_1	273	279	PF00069	0.548
MOD_Plk_4	155	161	PF00069	0.452
MOD_Plk_4	457	463	PF00069	0.503
MOD_ProDKin_1	368	374	PF00069	0.418
MOD_ProDKin_1	529	535	PF00069	0.538
MOD_SUMO_for_1	43	46	PF00179	0.611
MOD_SUMO_rev_2	424	433	PF00179	0.529
TRG_DiLeu_BaEn_2	189	195	PF01217	0.557
TRG_ENDOCYTIC_2	163	166	PF00928	0.452
TRG_ENDOCYTIC_2	178	181	PF00928	0.439
TRG_ENDOCYTIC_2	191	194	PF00928	0.434
TRG_ENDOCYTIC_2	198	201	PF00928	0.321
TRG_ENDOCYTIC_2	204	207	PF00928	0.442
TRG_ENDOCYTIC_2	251	254	PF00928	0.477
TRG_ENDOCYTIC_2	446	449	PF00928	0.494
TRG_ENDOCYTIC_2	45	48	PF00928	0.626
TRG_ENDOCYTIC_2	511	514	PF00928	0.452
TRG_ENDOCYTIC_2	599	602	PF00928	0.596
TRG_ER_diArg_1	557	560	PF00400	0.452
TRG_Pf-PMV_PEXEL_1	270	274	PF00026	0.301

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDC6	Leptomonas seymouri	68%	100%
A0A0S4IY53	Bodo saltans	42%	95%
A0A1X0NVE3	Trypanosomatidae	54%	99%
A0A3Q8IDM8	Leishmania donovani	95%	100%
A0A422N0G9	Trypanosoma rangeli	56%	100%
A4HG65	Leishmania braziliensis	86%	100%
A4I397	Leishmania infantum	95%	100%
A6QLU1	Bos taurus	36%	84%
A7DZP8	Mesocricetus auratus	38%	84%
D0A7S4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
D4GQU6	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	24%	100%
E9AZI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O14400	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	94%
O83004	Pseudomonas tolaasii	25%	100%
O86963	Enterococcus casseliflavus	28%	100%
P0A9C0	Escherichia coli (strain K12)	24%	100%
P0A9C1	Escherichia coli O157:H7	24%	100%
P0A9C2	Shigella flexneri	24%	100%
P0DB20	Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315)	27%	99%
P0DB21	Streptococcus pyogenes serotype M3 (strain SSI-1)	27%	99%
P13035	Escherichia coli (strain K12)	26%	100%
P18158	Bacillus subtilis (strain 168)	31%	100%
P32191	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	94%
P35571	Rattus norvegicus	36%	84%
P35596	Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)	27%	100%
P43304	Homo sapiens	36%	84%
P43799	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	24%	100%
P52111	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	27%	100%
P53435	Mycobacterium leprae (strain TN)	29%	100%
P64183	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	30%	100%
P64185	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	29%	100%
P74257	Synechocystis sp. (strain PCC 6803 / Kazusa)	30%	100%
P90795	Caenorhabditis elegans	36%	84%
P9WN78	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	29%	100%
P9WN79	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	29%	100%
P9WN80	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	30%	100%
P9WN81	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	30%	100%
Q2FHD8	Staphylococcus aureus (strain USA300)	31%	100%
Q2FYZ4	Staphylococcus aureus (strain NCTC 8325 / PS 47)	31%	100%
Q2YIQ2	Brucella abortus (strain 2308)	28%	100%
Q2YXR5	Staphylococcus aureus (strain bovine RF122 / ET3-1)	31%	100%
Q49X94	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	31%	100%
Q4L608	Staphylococcus haemolyticus (strain JCSC1435)	32%	100%
Q4R755	Macaca fascicularis	37%	84%
Q54QC1	Dictyostelium discoideum	34%	95%
Q5HGD1	Staphylococcus aureus (strain COL)	31%	100%
Q5HPP0	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	32%	100%
Q5XAK0	Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)	27%	99%
Q64521	Mus musculus	37%	84%
Q6G9R2	Staphylococcus aureus (strain MSSA476)	31%	100%
Q6GHD4	Staphylococcus aureus (strain MRSA252)	31%	100%
Q7A105	Staphylococcus aureus (strain MW2)	31%	100%
Q7A5V7	Staphylococcus aureus (strain N315)	31%	100%
Q8CPE6	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	32%	100%
Q8NZX0	Streptococcus pyogenes serotype M18 (strain MGAS8232)	27%	99%
Q8SR40	Encephalitozoon cuniculi (strain GB-M1)	33%	99%
Q99UH2	Staphylococcus aureus (strain Mu50 / ATCC 700699)	31%	100%
Q99YI8	Streptococcus pyogenes serotype M1	27%	99%
Q9CG65	Lactococcus lactis subsp. lactis (strain IL1403)	26%	100%
Q9SS48	Arabidopsis thaliana	39%	97%
V5AUH1	Trypanosoma cruzi	56%	88%
V5BVH7	Trypanosoma cruzi	24%	99%