NADH-u_ox-rdase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit, putative

Species:

Leishmania major

UniProt:

Q4Q8P5_LEIMA

TriTrypDb:

LmjF.28.0250 , LMJLV39_280007800 , LMJSD75_280007700

Length:

297

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8P5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8P5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	169	171	PF00675	0.473
CLV_NRD_NRD_1	182	184	PF00675	0.349
CLV_NRD_NRD_1	200	202	PF00675	0.417
CLV_NRD_NRD_1	238	240	PF00675	0.538
CLV_NRD_NRD_1	58	60	PF00675	0.501
CLV_PCSK_KEX2_1	184	186	PF00082	0.482
CLV_PCSK_KEX2_1	195	197	PF00082	0.447
CLV_PCSK_KEX2_1	200	202	PF00082	0.438
CLV_PCSK_KEX2_1	58	60	PF00082	0.501
CLV_PCSK_PC1ET2_1	184	186	PF00082	0.496
CLV_PCSK_PC1ET2_1	195	197	PF00082	0.501
CLV_PCSK_PC7_1	180	186	PF00082	0.626
CLV_PCSK_PC7_1	196	202	PF00082	0.551
CLV_PCSK_SKI1_1	154	158	PF00082	0.426
CLV_PCSK_SKI1_1	17	21	PF00082	0.543
CLV_PCSK_SKI1_1	64	68	PF00082	0.489
DOC_AGCK_PIF_1	111	116	PF00069	0.342
DOC_CKS1_1	226	231	PF01111	0.650
DOC_CKS1_1	81	86	PF01111	0.299
DOC_PP4_FxxP_1	282	285	PF00568	0.677
DOC_SPAK_OSR1_1	136	140	PF12202	0.412
DOC_USP7_MATH_1	288	292	PF00917	0.647
DOC_USP7_MATH_1	43	47	PF00917	0.523
DOC_USP7_MATH_2	211	217	PF00917	0.481
DOC_WW_Pin1_4	225	230	PF00397	0.639
DOC_WW_Pin1_4	245	250	PF00397	0.397
DOC_WW_Pin1_4	266	271	PF00397	0.683
DOC_WW_Pin1_4	80	85	PF00397	0.486
DOC_WW_Pin1_4	88	93	PF00397	0.299
LIG_14-3-3_CanoR_1	121	127	PF00244	0.319
LIG_14-3-3_CanoR_1	136	142	PF00244	0.319
LIG_14-3-3_CanoR_1	51	55	PF00244	0.475
LIG_Actin_WH2_2	111	129	PF00022	0.412
LIG_BIR_II_1	1	5	PF00653	0.566
LIG_BIR_III_3	1	5	PF00653	0.566
LIG_BRCT_BRCA1_1	133	137	PF00533	0.412
LIG_deltaCOP1_diTrp_1	197	202	PF00928	0.474
LIG_FHA_1	212	218	PF00498	0.595
LIG_FHA_1	258	264	PF00498	0.554
LIG_FHA_1	7	13	PF00498	0.643
LIG_FHA_1	75	81	PF00498	0.578
LIG_FHA_1	89	95	PF00498	0.255
LIG_FHA_2	1	7	PF00498	0.564
LIG_FHA_2	230	236	PF00498	0.524
LIG_FHA_2	30	36	PF00498	0.573
LIG_FHA_2	65	71	PF00498	0.514
LIG_HCF-1_HBM_1	60	63	PF13415	0.540
LIG_IBAR_NPY_1	241	243	PF08397	0.523
LIG_LIR_Apic_2	281	285	PF02991	0.662
LIG_LIR_Gen_1	135	146	PF02991	0.453
LIG_LIR_Gen_1	213	223	PF02991	0.486
LIG_LIR_Gen_1	70	76	PF02991	0.530
LIG_LIR_Nem_3	135	141	PF02991	0.452
LIG_LIR_Nem_3	186	191	PF02991	0.475
LIG_LIR_Nem_3	203	207	PF02991	0.491
LIG_LIR_Nem_3	213	218	PF02991	0.481
LIG_LIR_Nem_3	227	233	PF02991	0.510
LIG_LIR_Nem_3	252	257	PF02991	0.645
LIG_LIR_Nem_3	266	271	PF02991	0.638
LIG_LIR_Nem_3	60	66	PF02991	0.482
LIG_LIR_Nem_3	70	74	PF02991	0.532
LIG_LIR_Nem_3	83	88	PF02991	0.311
LIG_PCNA_PIPBox_1	156	165	PF02747	0.319
LIG_PDZ_Class_1	292	297	PF00595	0.595
LIG_Pex14_1	198	202	PF04695	0.467
LIG_Pex14_1	226	230	PF04695	0.530
LIG_Pex14_2	137	141	PF04695	0.466
LIG_Pex14_2	218	222	PF04695	0.596
LIG_PTB_Apo_2	238	245	PF02174	0.529
LIG_PTB_Apo_2	65	72	PF02174	0.516
LIG_PTB_Phospho_1	65	71	PF10480	0.514
LIG_SH2_CRK	230	234	PF00017	0.638
LIG_SH2_CRK	268	272	PF00017	0.639
LIG_SH2_CRK	63	67	PF00017	0.490
LIG_SH2_GRB2like	71	74	PF00017	0.533
LIG_SH2_SRC	104	107	PF00017	0.299
LIG_SH2_SRC	28	31	PF00017	0.680
LIG_SH2_STAP1	116	120	PF00017	0.363
LIG_SH2_STAP1	257	261	PF00017	0.671
LIG_SH2_STAT5	191	194	PF00017	0.547
LIG_SH2_STAT5	243	246	PF00017	0.524
LIG_SH2_STAT5	280	283	PF00017	0.570
LIG_SH2_STAT5	71	74	PF00017	0.546
LIG_TRAF2_1	37	40	PF00917	0.540
LIG_TYR_ITSM	226	233	PF00017	0.623
LIG_WRC_WIRS_1	138	143	PF05994	0.368
MOD_CDK_SPxK_1	245	251	PF00069	0.509
MOD_CDK_SPxxK_3	266	273	PF00069	0.614
MOD_CK1_1	122	128	PF00069	0.308
MOD_CK1_1	140	146	PF00069	0.388
MOD_CK1_1	216	222	PF00069	0.474
MOD_CK1_1	266	272	PF00069	0.637
MOD_CK1_1	291	297	PF00069	0.602
MOD_CK1_1	93	99	PF00069	0.255
MOD_CK2_1	29	35	PF00069	0.582
MOD_GlcNHglycan	159	162	PF01048	0.426
MOD_GlcNHglycan	218	221	PF01048	0.462
MOD_GlcNHglycan	245	248	PF01048	0.622
MOD_GlcNHglycan	294	297	PF01048	0.685
MOD_GSK3_1	122	129	PF00069	0.329
MOD_GSK3_1	225	232	PF00069	0.652
MOD_GSK3_1	288	295	PF00069	0.609
MOD_GSK3_1	90	97	PF00069	0.426
MOD_N-GLC_1	278	283	PF02516	0.589
MOD_N-GLC_1	291	296	PF02516	0.480
MOD_N-GLC_1	74	79	PF02516	0.631
MOD_NEK2_1	112	117	PF00069	0.414
MOD_NEK2_1	126	131	PF00069	0.244
MOD_NEK2_1	137	142	PF00069	0.253
MOD_NEK2_1	157	162	PF00069	0.388
MOD_NEK2_1	49	54	PF00069	0.473
MOD_NEK2_1	74	79	PF00069	0.638
MOD_NEK2_2	152	157	PF00069	0.344
MOD_PKA_2	126	132	PF00069	0.358
MOD_PKA_2	157	163	PF00069	0.299
MOD_PKA_2	50	56	PF00069	0.476
MOD_Plk_1	23	29	PF00069	0.642
MOD_Plk_1	278	284	PF00069	0.586
MOD_Plk_4	114	120	PF00069	0.434
MOD_Plk_4	140	146	PF00069	0.319
MOD_Plk_4	90	96	PF00069	0.412
MOD_ProDKin_1	225	231	PF00069	0.640
MOD_ProDKin_1	245	251	PF00069	0.400
MOD_ProDKin_1	266	272	PF00069	0.682
MOD_ProDKin_1	80	86	PF00069	0.299
MOD_ProDKin_1	88	94	PF00069	0.299
MOD_SUMO_for_1	264	267	PF00179	0.606
TRG_ENDOCYTIC_2	153	156	PF00928	0.319
TRG_ENDOCYTIC_2	230	233	PF00928	0.627
TRG_ENDOCYTIC_2	268	271	PF00928	0.663
TRG_ENDOCYTIC_2	63	66	PF00928	0.489
TRG_ENDOCYTIC_2	71	74	PF00928	0.514
TRG_ER_diArg_1	200	202	PF00400	0.467
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.543

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILT8	Leptomonas seymouri	69%	99%
A0A0S4IUG6	Bodo saltans	51%	100%
A0A1X0NVZ8	Trypanosomatidae	64%	100%
A0A3S7X178	Leishmania donovani	99%	100%
A4HG66	Leishmania braziliensis	92%	100%
A4I3A9	Leishmania infantum	98%	100%
D0A7S5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9AZI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
V5DAH1	Trypanosoma cruzi	64%	100%