Non-specific serine/threonine protein kinase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8P4_LEIMA

TriTrypDb:

LmjF.28.0260 , LMJLV39_280007900 , LMJSD75_280007800

Length:

1062

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8P4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8P4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.771
CLV_C14_Caspase3-7	161	165	PF00656	0.535
CLV_NRD_NRD_1	471	473	PF00675	0.676
CLV_NRD_NRD_1	475	477	PF00675	0.615
CLV_NRD_NRD_1	651	653	PF00675	0.691
CLV_NRD_NRD_1	791	793	PF00675	0.552
CLV_NRD_NRD_1	797	799	PF00675	0.521
CLV_NRD_NRD_1	815	817	PF00675	0.511
CLV_NRD_NRD_1	870	872	PF00675	0.664
CLV_NRD_NRD_1	924	926	PF00675	0.603
CLV_NRD_NRD_1	988	990	PF00675	0.564
CLV_PCSK_KEX2_1	40	42	PF00082	0.720
CLV_PCSK_KEX2_1	475	477	PF00082	0.594
CLV_PCSK_KEX2_1	651	653	PF00082	0.707
CLV_PCSK_KEX2_1	791	793	PF00082	0.542
CLV_PCSK_KEX2_1	797	799	PF00082	0.531
CLV_PCSK_KEX2_1	817	819	PF00082	0.296
CLV_PCSK_KEX2_1	870	872	PF00082	0.596
CLV_PCSK_KEX2_1	924	926	PF00082	0.605
CLV_PCSK_KEX2_1	988	990	PF00082	0.564
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.609
CLV_PCSK_PC1ET2_1	817	819	PF00082	0.556
CLV_PCSK_SKI1_1	167	171	PF00082	0.571
CLV_PCSK_SKI1_1	272	276	PF00082	0.484
CLV_PCSK_SKI1_1	365	369	PF00082	0.516
CLV_PCSK_SKI1_1	410	414	PF00082	0.529
CLV_PCSK_SKI1_1	433	437	PF00082	0.395
CLV_PCSK_SKI1_1	466	470	PF00082	0.594
CLV_PCSK_SKI1_1	550	554	PF00082	0.637
CLV_PCSK_SKI1_1	607	611	PF00082	0.633
CLV_PCSK_SKI1_1	62	66	PF00082	0.610
CLV_PCSK_SKI1_1	716	720	PF00082	0.612
CLV_PCSK_SKI1_1	808	812	PF00082	0.526
CLV_PCSK_SKI1_1	902	906	PF00082	0.491
CLV_PCSK_SKI1_1	908	912	PF00082	0.551
CLV_Separin_Metazoa	59	63	PF03568	0.611
DEG_APCC_DBOX_1	364	372	PF00400	0.439
DEG_APCC_DBOX_1	715	723	PF00400	0.537
DEG_APCC_DBOX_1	815	823	PF00400	0.571
DEG_SPOP_SBC_1	586	590	PF00917	0.661
DOC_CDC14_PxL_1	336	344	PF14671	0.539
DOC_CKS1_1	12	17	PF01111	0.670
DOC_CKS1_1	351	356	PF01111	0.700
DOC_CKS1_1	735	740	PF01111	0.720
DOC_CYCLIN_RxL_1	242	253	PF00134	0.448
DOC_CYCLIN_RxL_1	463	471	PF00134	0.590
DOC_CYCLIN_RxL_1	480	492	PF00134	0.583
DOC_CYCLIN_RxL_1	713	721	PF00134	0.520
DOC_CYCLIN_RxL_1	899	909	PF00134	0.533
DOC_CYCLIN_yCln2_LP_2	1053	1059	PF00134	0.551
DOC_CYCLIN_yCln2_LP_2	653	659	PF00134	0.628
DOC_MAPK_DCC_7	79	89	PF00069	0.678
DOC_MAPK_DCC_7	797	805	PF00069	0.617
DOC_MAPK_DCC_7	814	824	PF00069	0.428
DOC_MAPK_gen_1	171	178	PF00069	0.599
DOC_MAPK_gen_1	362	370	PF00069	0.334
DOC_MAPK_gen_1	651	661	PF00069	0.557
DOC_MAPK_gen_1	797	805	PF00069	0.597
DOC_MAPK_gen_1	814	824	PF00069	0.428
DOC_MAPK_JIP1_4	1055	1061	PF00069	0.601
DOC_MAPK_MEF2A_6	171	178	PF00069	0.599
DOC_MAPK_MEF2A_6	301	308	PF00069	0.465
DOC_MAPK_MEF2A_6	362	370	PF00069	0.334
DOC_MAPK_MEF2A_6	652	661	PF00069	0.507
DOC_MAPK_MEF2A_6	816	824	PF00069	0.571
DOC_PP1_RVXF_1	649	656	PF00149	0.639
DOC_PP1_RVXF_1	987	994	PF00149	0.554
DOC_PP2B_LxvP_1	657	660	PF13499	0.472
DOC_PP2B_LxvP_1	977	980	PF13499	0.506
DOC_USP7_MATH_1	1043	1047	PF00917	0.575
DOC_USP7_MATH_1	114	118	PF00917	0.760
DOC_USP7_MATH_1	228	232	PF00917	0.506
DOC_USP7_MATH_1	239	243	PF00917	0.360
DOC_USP7_MATH_1	300	304	PF00917	0.540
DOC_USP7_MATH_1	592	596	PF00917	0.746
DOC_USP7_MATH_1	923	927	PF00917	0.609
DOC_USP7_MATH_1	95	99	PF00917	0.729
DOC_USP7_MATH_2	46	52	PF00917	0.651
DOC_WW_Pin1_4	11	16	PF00397	0.587
DOC_WW_Pin1_4	121	126	PF00397	0.660
DOC_WW_Pin1_4	325	330	PF00397	0.552
DOC_WW_Pin1_4	350	355	PF00397	0.751
DOC_WW_Pin1_4	394	399	PF00397	0.544
DOC_WW_Pin1_4	418	423	PF00397	0.525
DOC_WW_Pin1_4	443	448	PF00397	0.586
DOC_WW_Pin1_4	590	595	PF00397	0.725
DOC_WW_Pin1_4	607	612	PF00397	0.578
DOC_WW_Pin1_4	734	739	PF00397	0.686
DOC_WW_Pin1_4	87	92	PF00397	0.701
DOC_WW_Pin1_4	886	891	PF00397	0.738
DOC_WW_Pin1_4	982	987	PF00397	0.637
LIG_14-3-3_CanoR_1	234	244	PF00244	0.509
LIG_14-3-3_CanoR_1	272	280	PF00244	0.498
LIG_14-3-3_CanoR_1	433	439	PF00244	0.516
LIG_14-3-3_CanoR_1	475	483	PF00244	0.707
LIG_14-3-3_CanoR_1	528	535	PF00244	0.519
LIG_14-3-3_CanoR_1	619	625	PF00244	0.551
LIG_14-3-3_CanoR_1	635	640	PF00244	0.396
LIG_14-3-3_CanoR_1	870	880	PF00244	0.690
LIG_14-3-3_CanoR_1	924	930	PF00244	0.598
LIG_Actin_RPEL_3	469	488	PF02755	0.485
LIG_Actin_WH2_2	1008	1026	PF00022	0.515
LIG_Actin_WH2_2	897	914	PF00022	0.549
LIG_APCC_ABBA_1	1015	1020	PF00400	0.547
LIG_APCC_ABBAyCdc20_2	193	199	PF00400	0.480
LIG_BIR_III_2	82	86	PF00653	0.754
LIG_BIR_III_4	677	681	PF00653	0.556
LIG_BIR_III_4	96	100	PF00653	0.699
LIG_BRCT_BRCA1_1	1045	1049	PF00533	0.534
LIG_BRCT_BRCA1_1	637	641	PF00533	0.610
LIG_BRCT_BRCA1_1	770	774	PF00533	0.601
LIG_Clathr_ClatBox_1	249	253	PF01394	0.446
LIG_Clathr_ClatBox_1	658	662	PF01394	0.473
LIG_deltaCOP1_diTrp_1	583	587	PF00928	0.534
LIG_deltaCOP1_diTrp_1	720	730	PF00928	0.561
LIG_DLG_GKlike_1	635	642	PF00625	0.609
LIG_EH1_1	611	619	PF00400	0.567
LIG_eIF4E_1	691	697	PF01652	0.506
LIG_FHA_1	273	279	PF00498	0.478
LIG_FHA_1	402	408	PF00498	0.487
LIG_FHA_1	434	440	PF00498	0.445
LIG_FHA_1	528	534	PF00498	0.535
LIG_FHA_1	620	626	PF00498	0.501
LIG_FHA_1	63	69	PF00498	0.722
LIG_FHA_1	848	854	PF00498	0.654
LIG_FHA_1	953	959	PF00498	0.487
LIG_FHA_2	549	555	PF00498	0.637
LIG_FHA_2	833	839	PF00498	0.572
LIG_FHA_2	841	847	PF00498	0.568
LIG_FHA_2	856	862	PF00498	0.504
LIG_FHA_2	912	918	PF00498	0.607
LIG_GBD_Chelix_1	243	251	PF00786	0.537
LIG_GBD_Chelix_1	304	312	PF00786	0.500
LIG_LIR_Apic_2	10	15	PF02991	0.638
LIG_LIR_Apic_2	446	451	PF02991	0.453
LIG_LIR_Apic_2	728	733	PF02991	0.581
LIG_LIR_Gen_1	1046	1057	PF02991	0.516
LIG_LIR_Gen_1	181	191	PF02991	0.563
LIG_LIR_Gen_1	208	217	PF02991	0.473
LIG_LIR_Gen_1	267	278	PF02991	0.528
LIG_LIR_Gen_1	496	506	PF02991	0.489
LIG_LIR_Gen_1	560	571	PF02991	0.469
LIG_LIR_Nem_3	1046	1052	PF02991	0.541
LIG_LIR_Nem_3	181	186	PF02991	0.581
LIG_LIR_Nem_3	208	213	PF02991	0.465
LIG_LIR_Nem_3	267	273	PF02991	0.503
LIG_LIR_Nem_3	481	486	PF02991	0.671
LIG_LIR_Nem_3	496	501	PF02991	0.384
LIG_LIR_Nem_3	55	60	PF02991	0.559
LIG_LIR_Nem_3	560	566	PF02991	0.529
LIG_LIR_Nem_3	662	667	PF02991	0.508
LIG_LIR_Nem_3	720	726	PF02991	0.488
LIG_LIR_Nem_3	801	807	PF02991	0.454
LIG_LIR_Nem_3	928	933	PF02991	0.498
LIG_LIR_Nem_3	975	979	PF02991	0.470
LIG_LYPXL_yS_3	664	667	PF13949	0.644
LIG_MAD2	272	280	PF02301	0.496
LIG_MYND_1	656	660	PF01753	0.584
LIG_NRBOX	165	171	PF00104	0.567
LIG_NRBOX	246	252	PF00104	0.531
LIG_NRBOX	366	372	PF00104	0.532
LIG_NRBOX	434	440	PF00104	0.390
LIG_NRBOX	754	760	PF00104	0.430
LIG_Pex14_1	360	364	PF04695	0.464
LIG_Pex14_2	774	778	PF04695	0.611
LIG_Pex14_2	805	809	PF04695	0.529
LIG_SH2_CRK	1007	1011	PF00017	0.531
LIG_SH2_CRK	691	695	PF00017	0.515
LIG_SH2_GRB2like	933	936	PF00017	0.452
LIG_SH2_NCK_1	12	16	PF00017	0.582
LIG_SH2_STAP1	1007	1011	PF00017	0.531
LIG_SH2_STAT5	168	171	PF00017	0.526
LIG_SH2_STAT5	337	340	PF00017	0.427
LIG_SH2_STAT5	548	551	PF00017	0.566
LIG_SH2_STAT5	8	11	PF00017	0.473
LIG_SH2_STAT5	804	807	PF00017	0.467
LIG_SH3_3	1031	1037	PF00018	0.599
LIG_SH3_3	1039	1045	PF00018	0.526
LIG_SH3_3	274	280	PF00018	0.506
LIG_SH3_3	345	351	PF00018	0.686
LIG_SH3_3	416	422	PF00018	0.529
LIG_SH3_3	454	460	PF00018	0.494
LIG_SH3_3	504	510	PF00018	0.553
LIG_SH3_3	553	559	PF00018	0.577
LIG_SUMO_SIM_anti_2	116	124	PF11976	0.728
LIG_SUMO_SIM_anti_2	613	618	PF11976	0.459
LIG_SUMO_SIM_anti_2	752	760	PF11976	0.448
LIG_SUMO_SIM_par_1	486	492	PF11976	0.603
LIG_SUMO_SIM_par_1	752	760	PF11976	0.582
LIG_TRAF2_1	857	860	PF00917	0.672
LIG_TRAF2_1	926	929	PF00917	0.626
LIG_TRAF2_2	152	157	PF00917	0.619
LIG_TRAF2_2	91	96	PF00917	0.559
LIG_UBA3_1	162	171	PF00899	0.434
LIG_ULM_U2AF65_1	651	656	PF00076	0.684
LIG_WRC_WIRS_1	839	844	PF05994	0.595
LIG_WW_3	213	217	PF00397	0.479
MOD_CDK_SPxK_1	982	988	PF00069	0.632
MOD_CDK_SPxxK_3	394	401	PF00069	0.532
MOD_CDK_SPxxK_3	590	597	PF00069	0.676
MOD_CDK_SPxxK_3	87	94	PF00069	0.784
MOD_CDK_SPxxK_3	982	989	PF00069	0.630
MOD_CK1_1	200	206	PF00069	0.495
MOD_CK1_1	343	349	PF00069	0.643
MOD_CK1_1	443	449	PF00069	0.502
MOD_CK1_1	478	484	PF00069	0.696
MOD_CK1_1	588	594	PF00069	0.673
MOD_CK1_1	600	606	PF00069	0.599
MOD_CK1_1	670	676	PF00069	0.645
MOD_CK1_1	712	718	PF00069	0.616
MOD_CK1_1	754	760	PF00069	0.570
MOD_CK1_1	874	880	PF00069	0.708
MOD_CK1_1	952	958	PF00069	0.527
MOD_CK2_1	400	406	PF00069	0.561
MOD_CK2_1	548	554	PF00069	0.624
MOD_CK2_1	670	676	PF00069	0.613
MOD_CK2_1	838	844	PF00069	0.575
MOD_CK2_1	855	861	PF00069	0.584
MOD_CK2_1	923	929	PF00069	0.507
MOD_Cter_Amidation	38	41	PF01082	0.593
MOD_Cter_Amidation	473	476	PF01082	0.511
MOD_Cter_Amidation	814	817	PF01082	0.585
MOD_DYRK1A_RPxSP_1	607	611	PF00069	0.633
MOD_GlcNHglycan	1025	1028	PF01048	0.635
MOD_GlcNHglycan	1045	1048	PF01048	0.594
MOD_GlcNHglycan	131	134	PF01048	0.502
MOD_GlcNHglycan	198	202	PF01048	0.575
MOD_GlcNHglycan	226	229	PF01048	0.522
MOD_GlcNHglycan	237	240	PF01048	0.467
MOD_GlcNHglycan	477	480	PF01048	0.715
MOD_GlcNHglycan	50	53	PF01048	0.715
MOD_GlcNHglycan	524	527	PF01048	0.540
MOD_GlcNHglycan	558	562	PF01048	0.570
MOD_GlcNHglycan	590	593	PF01048	0.727
MOD_GlcNHglycan	602	605	PF01048	0.635
MOD_GlcNHglycan	739	742	PF01048	0.730
MOD_GlcNHglycan	759	762	PF01048	0.544
MOD_GlcNHglycan	770	773	PF01048	0.535
MOD_GlcNHglycan	811	814	PF01048	0.561
MOD_GlcNHglycan	876	879	PF01048	0.686
MOD_GlcNHglycan	925	928	PF01048	0.635
MOD_GlcNHglycan	951	954	PF01048	0.573
MOD_GlcNHglycan	958	961	PF01048	0.555
MOD_GlcNHglycan	96	100	PF01048	0.730
MOD_GSK3_1	224	231	PF00069	0.507
MOD_GSK3_1	235	242	PF00069	0.545
MOD_GSK3_1	300	307	PF00069	0.547
MOD_GSK3_1	349	356	PF00069	0.728
MOD_GSK3_1	443	450	PF00069	0.436
MOD_GSK3_1	474	481	PF00069	0.627
MOD_GSK3_1	586	593	PF00069	0.725
MOD_GSK3_1	68	75	PF00069	0.702
MOD_GSK3_1	870	877	PF00069	0.601
MOD_GSK3_1	929	936	PF00069	0.553
MOD_GSK3_1	952	959	PF00069	0.568
MOD_GSK3_1	978	985	PF00069	0.600
MOD_N-GLC_1	181	186	PF02516	0.472
MOD_N-GLC_1	906	911	PF02516	0.616
MOD_NEK2_1	1023	1028	PF00069	0.600
MOD_NEK2_1	162	167	PF00069	0.488
MOD_NEK2_1	219	224	PF00069	0.425
MOD_NEK2_1	434	439	PF00069	0.442
MOD_NEK2_1	462	467	PF00069	0.534
MOD_NEK2_1	587	592	PF00069	0.554
MOD_NEK2_1	618	623	PF00069	0.482
MOD_NEK2_1	697	702	PF00069	0.493
MOD_NEK2_1	809	814	PF00069	0.474
MOD_NEK2_1	872	877	PF00069	0.666
MOD_NEK2_1	911	916	PF00069	0.614
MOD_NEK2_1	967	972	PF00069	0.488
MOD_NEK2_1	991	996	PF00069	0.530
MOD_NEK2_2	205	210	PF00069	0.554
MOD_NEK2_2	548	553	PF00069	0.614
MOD_NEK2_2	690	695	PF00069	0.514
MOD_PIKK_1	150	156	PF00454	0.612
MOD_PIKK_1	353	359	PF00454	0.670
MOD_PKA_1	40	46	PF00069	0.614
MOD_PKA_1	475	481	PF00069	0.628
MOD_PKA_1	597	603	PF00069	0.765
MOD_PKA_1	870	876	PF00069	0.581
MOD_PKA_2	1023	1029	PF00069	0.595
MOD_PKA_2	19	25	PF00069	0.676
MOD_PKA_2	300	306	PF00069	0.453
MOD_PKA_2	40	46	PF00069	0.614
MOD_PKA_2	474	480	PF00069	0.664
MOD_PKA_2	527	533	PF00069	0.543
MOD_PKA_2	600	606	PF00069	0.650
MOD_PKA_2	618	624	PF00069	0.507
MOD_PKA_2	768	774	PF00069	0.545
MOD_PKA_2	870	876	PF00069	0.674
MOD_PKA_2	911	917	PF00069	0.645
MOD_PKA_2	923	929	PF00069	0.566
MOD_Plk_1	401	407	PF00069	0.575
MOD_Plk_1	670	676	PF00069	0.653
MOD_Plk_1	751	757	PF00069	0.470
MOD_Plk_1	829	835	PF00069	0.554
MOD_Plk_1	906	912	PF00069	0.624
MOD_Plk_2-3	838	844	PF00069	0.629
MOD_Plk_4	205	211	PF00069	0.451
MOD_Plk_4	239	245	PF00069	0.468
MOD_Plk_4	257	263	PF00069	0.483
MOD_Plk_4	434	440	PF00069	0.523
MOD_Plk_4	478	484	PF00069	0.704
MOD_Plk_4	751	757	PF00069	0.461
MOD_ProDKin_1	11	17	PF00069	0.582
MOD_ProDKin_1	121	127	PF00069	0.660
MOD_ProDKin_1	325	331	PF00069	0.546
MOD_ProDKin_1	350	356	PF00069	0.750
MOD_ProDKin_1	394	400	PF00069	0.537
MOD_ProDKin_1	418	424	PF00069	0.516
MOD_ProDKin_1	443	449	PF00069	0.576
MOD_ProDKin_1	590	596	PF00069	0.725
MOD_ProDKin_1	607	613	PF00069	0.566
MOD_ProDKin_1	734	740	PF00069	0.691
MOD_ProDKin_1	87	93	PF00069	0.701
MOD_ProDKin_1	886	892	PF00069	0.735
MOD_ProDKin_1	982	988	PF00069	0.632
TRG_DiLeu_BaEn_1	158	163	PF01217	0.532
TRG_DiLeu_BaEn_4	158	164	PF01217	0.626
TRG_DiLeu_BaEn_4	860	866	PF01217	0.635
TRG_DiLeu_BaLyEn_6	430	435	PF01217	0.426
TRG_DiLeu_BaLyEn_6	497	502	PF01217	0.534
TRG_DiLeu_BaLyEn_6	653	658	PF01217	0.661
TRG_ENDOCYTIC_2	1007	1010	PF00928	0.519
TRG_ENDOCYTIC_2	664	667	PF00928	0.644
TRG_ENDOCYTIC_2	691	694	PF00928	0.515
TRG_ENDOCYTIC_2	804	807	PF00928	0.529
TRG_ER_diArg_1	651	654	PF00400	0.697
TRG_ER_diArg_1	790	792	PF00400	0.613
TRG_ER_diArg_1	816	819	PF00400	0.579
TRG_ER_diArg_1	869	871	PF00400	0.556
TRG_NES_CRM1_1	241	253	PF08389	0.406
TRG_NES_CRM1_1	720	735	PF08389	0.523
TRG_NLS_MonoExtC_3	471	476	PF00514	0.587
TRG_NLS_MonoExtC_3	596	601	PF00514	0.632
TRG_NLS_MonoExtC_3	815	820	PF00514	0.572
TRG_NLS_MonoExtN_4	470	476	PF00514	0.486
TRG_NLS_MonoExtN_4	594	601	PF00514	0.678
TRG_NLS_MonoExtN_4	814	820	PF00514	0.573
TRG_Pf-PMV_PEXEL_1	1021	1025	PF00026	0.551
TRG_Pf-PMV_PEXEL_1	272	276	PF00026	0.499
TRG_Pf-PMV_PEXEL_1	365	369	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	484	489	PF00026	0.664
TRG_Pf-PMV_PEXEL_1	500	505	PF00026	0.293
TRG_Pf-PMV_PEXEL_1	716	720	PF00026	0.612
TRG_Pf-PMV_PEXEL_1	791	795	PF00026	0.563

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I917	Leptomonas seymouri	38%	86%
A0A1X0NVC0	Trypanosomatidae	22%	96%
A0A3Q8IGK9	Leishmania donovani	92%	99%
A0A422N0G7	Trypanosoma rangeli	24%	100%
A4HG67	Leishmania braziliensis	78%	100%
E9AZI7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BEI0	Trypanosoma cruzi	24%	100%