Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8P2_LEIMA

TriTrypDb:

LmjF.28.0280 , LMJLV39_280008100 , LMJSD75_280008000

Length:

216

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0008023	transcription elongation factor complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0070449	elongin complex	4	2
GO:0140513	nuclear protein-containing complex	2	2

Expansion

Sequence features

Q4Q8P2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8P2

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006511	ubiquitin-dependent protein catabolic process	7	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009987	cellular process	1	2
GO:0019538	protein metabolic process	3	2
GO:0019941	modification-dependent protein catabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043632	modification-dependent macromolecule catabolic process	5	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044265	obsolete cellular macromolecule catabolic process	4	2
GO:0051603	proteolysis involved in protein catabolic process	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901575	organic substance catabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0030674	protein-macromolecule adaptor activity	2	2
GO:0060090	molecular adaptor activity	1	2
GO:0003676	nucleic acid binding	3	1
GO:0003746	translation elongation factor activity	4	1
GO:0005488	binding	1	1
GO:0008135	translation factor activity, RNA binding	3	1
GO:0045182	translation regulator activity	1	1
GO:0090079	translation regulator activity, nucleic acid binding	2	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	188	190	PF00675	0.510
CLV_NRD_NRD_1	57	59	PF00675	0.435
CLV_PCSK_KEX2_1	188	190	PF00082	0.494
CLV_PCSK_KEX2_1	59	61	PF00082	0.503
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.475
CLV_PCSK_SKI1_1	162	166	PF00082	0.444
CLV_PCSK_SKI1_1	194	198	PF00082	0.651
CLV_PCSK_SKI1_1	54	58	PF00082	0.584
CLV_Separin_Metazoa	206	210	PF03568	0.438
DEG_APCC_KENBOX_2	116	120	PF00400	0.629
DEG_SPOP_SBC_1	83	87	PF00917	0.564
DOC_MAPK_MEF2A_6	156	165	PF00069	0.585
DOC_PP1_RVXF_1	160	166	PF00149	0.451
DOC_PP1_RVXF_1	52	58	PF00149	0.537
DOC_PP4_FxxP_1	197	200	PF00568	0.431
DOC_USP7_MATH_1	33	37	PF00917	0.596
DOC_USP7_MATH_1	83	87	PF00917	0.603
DOC_USP7_MATH_1	94	98	PF00917	0.767
DOC_WW_Pin1_4	47	52	PF00397	0.363
LIG_14-3-3_CanoR_1	188	197	PF00244	0.476
LIG_14-3-3_CanoR_1	58	64	PF00244	0.479
LIG_BIR_II_1	1	5	PF00653	0.583
LIG_FHA_1	200	206	PF00498	0.451
LIG_FHA_1	63	69	PF00498	0.392
LIG_FHA_2	133	139	PF00498	0.732
LIG_FHA_2	148	154	PF00498	0.586
LIG_LIR_Apic_2	20	26	PF02991	0.383
LIG_LIR_Apic_2	7	13	PF02991	0.576
LIG_LIR_Gen_1	178	186	PF02991	0.438
LIG_LIR_Gen_1	28	33	PF02991	0.439
LIG_LIR_Gen_1	66	73	PF02991	0.331
LIG_LIR_Nem_3	178	182	PF02991	0.436
LIG_LIR_Nem_3	28	32	PF02991	0.383
LIG_LIR_Nem_3	66	72	PF02991	0.322
LIG_PDZ_Class_2	211	216	PF00595	0.374
LIG_Pex14_2	6	10	PF04695	0.575
LIG_SH2_CRK	23	27	PF00017	0.472
LIG_SH2_GRB2like	23	26	PF00017	0.521
LIG_SH2_PTP2	29	32	PF00017	0.365
LIG_SH2_STAT5	179	182	PF00017	0.353
LIG_SH2_STAT5	18	21	PF00017	0.543
LIG_SH2_STAT5	29	32	PF00017	0.335
LIG_SH3_3	10	16	PF00018	0.516
LIG_SH3_3	101	107	PF00018	0.511
LIG_SH3_3	142	148	PF00018	0.750
LIG_SH3_3	160	166	PF00018	0.363
LIG_SUMO_SIM_par_1	147	154	PF11976	0.605
LIG_TRAF2_1	36	39	PF00917	0.446
LIG_WW_1	15	18	PF00397	0.495
MOD_CDK_SPxxK_3	47	54	PF00069	0.363
MOD_CK1_1	62	68	PF00069	0.349
MOD_CK1_1	84	90	PF00069	0.676
MOD_CK2_1	132	138	PF00069	0.727
MOD_CK2_1	147	153	PF00069	0.591
MOD_CK2_1	32	38	PF00069	0.588
MOD_GlcNHglycan	1	4	PF01048	0.524
MOD_GlcNHglycan	35	38	PF01048	0.529
MOD_GlcNHglycan	96	99	PF01048	0.621
MOD_GSK3_1	14	21	PF00069	0.564
MOD_GSK3_1	147	154	PF00069	0.676
MOD_GSK3_1	77	84	PF00069	0.679
MOD_NEK2_1	151	156	PF00069	0.620
MOD_NEK2_1	32	37	PF00069	0.452
MOD_NEK2_2	18	23	PF00069	0.583
MOD_PKA_1	188	194	PF00069	0.476
MOD_PKA_1	59	65	PF00069	0.335
MOD_PKA_2	188	194	PF00069	0.491
MOD_PKA_2	59	65	PF00069	0.410
MOD_Plk_1	157	163	PF00069	0.493
MOD_Plk_4	14	20	PF00069	0.574
MOD_Plk_4	175	181	PF00069	0.420
MOD_ProDKin_1	47	53	PF00069	0.360
TRG_ENDOCYTIC_2	179	182	PF00928	0.435
TRG_ENDOCYTIC_2	29	32	PF00928	0.371
TRG_ER_diArg_1	188	190	PF00400	0.469
TRG_ER_diArg_1	57	60	PF00400	0.492
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.383

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P728	Leptomonas seymouri	47%	96%
A0A1X0NVU1	Trypanosomatidae	30%	100%
A0A3Q8IDQ8	Leishmania donovani	91%	100%
A4HG69	Leishmania braziliensis	76%	100%
A4I3B2	Leishmania infantum	91%	100%
E9AZI9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%