Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8P1_LEIMA

TriTrypDb:

LmjF.28.0290 , LMJLV39_280008200 , LMJSD75_280008100

Length:

252

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8P1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8P1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	183	187	PF00656	0.611
CLV_C14_Caspase3-7	72	76	PF00656	0.699
CLV_NRD_NRD_1	164	166	PF00675	0.673
CLV_NRD_NRD_1	2	4	PF00675	0.697
CLV_NRD_NRD_1	212	214	PF00675	0.611
CLV_NRD_NRD_1	60	62	PF00675	0.524
CLV_PCSK_KEX2_1	138	140	PF00082	0.568
CLV_PCSK_KEX2_1	2	4	PF00082	0.697
CLV_PCSK_KEX2_1	60	62	PF00082	0.524
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.568
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.697
CLV_PCSK_SKI1_1	49	53	PF00082	0.614
CLV_PCSK_SKI1_1	61	65	PF00082	0.454
DEG_COP1_1	152	162	PF00400	0.568
DEG_Nend_UBRbox_1	1	4	PF02207	0.699
DOC_CKS1_1	198	203	PF01111	0.550
DOC_MAPK_gen_1	165	172	PF00069	0.640
DOC_USP7_MATH_1	181	185	PF00917	0.667
DOC_USP7_MATH_1	28	32	PF00917	0.541
DOC_USP7_MATH_1	42	46	PF00917	0.497
DOC_USP7_MATH_1	63	67	PF00917	0.462
DOC_WW_Pin1_4	116	121	PF00397	0.642
DOC_WW_Pin1_4	144	149	PF00397	0.649
DOC_WW_Pin1_4	174	179	PF00397	0.658
DOC_WW_Pin1_4	185	190	PF00397	0.581
DOC_WW_Pin1_4	197	202	PF00397	0.431
LIG_14-3-3_CanoR_1	165	171	PF00244	0.627
LIG_Actin_WH2_2	125	143	PF00022	0.404
LIG_APCC_ABBA_1	109	114	PF00400	0.692
LIG_BIR_III_2	117	121	PF00653	0.717
LIG_BIR_III_4	95	99	PF00653	0.689
LIG_CtBP_PxDLS_1	21	25	PF00389	0.538
LIG_eIF4E_1	198	204	PF01652	0.520
LIG_FHA_1	198	204	PF00498	0.520
LIG_FHA_1	32	38	PF00498	0.506
LIG_FHA_2	28	34	PF00498	0.647
LIG_FHA_2	70	76	PF00498	0.682
LIG_LIR_Nem_3	108	112	PF02991	0.727
LIG_LIR_Nem_3	188	194	PF02991	0.454
LIG_LIR_Nem_3	238	244	PF02991	0.623
LIG_LYPXL_S_1	190	194	PF13949	0.500
LIG_LYPXL_yS_3	191	194	PF13949	0.493
LIG_PDZ_Class_1	247	252	PF00595	0.490
LIG_SH3_3	169	175	PF00018	0.624
LIG_SH3_3	186	192	PF00018	0.506
LIG_SH3_3	225	231	PF00018	0.558
LIG_SH3_3	8	14	PF00018	0.759
LIG_SUMO_SIM_anti_2	79	85	PF11976	0.593
LIG_SUMO_SIM_par_1	230	236	PF11976	0.661
LIG_WRC_WIRS_1	106	111	PF05994	0.722
MOD_CDC14_SPxK_1	147	150	PF00782	0.687
MOD_CDK_SPxK_1	144	150	PF00069	0.657
MOD_CK1_1	233	239	PF00069	0.563
MOD_CK1_1	31	37	PF00069	0.516
MOD_CK1_1	71	77	PF00069	0.692
MOD_CK2_1	116	122	PF00069	0.642
MOD_CK2_1	221	227	PF00069	0.615
MOD_CK2_1	27	33	PF00069	0.641
MOD_CK2_1	63	69	PF00069	0.583
MOD_GlcNHglycan	183	186	PF01048	0.495
MOD_GlcNHglycan	222	226	PF01048	0.718
MOD_GlcNHglycan	235	238	PF01048	0.593
MOD_GlcNHglycan	30	33	PF01048	0.564
MOD_GlcNHglycan	44	47	PF01048	0.504
MOD_GSK3_1	181	188	PF00069	0.541
MOD_GSK3_1	27	34	PF00069	0.564
MOD_PK_1	166	172	PF00069	0.517
MOD_PKA_2	152	158	PF00069	0.665
MOD_Plk_1	68	74	PF00069	0.698
MOD_Plk_1	79	85	PF00069	0.572
MOD_Plk_2-3	69	75	PF00069	0.679
MOD_Plk_4	102	108	PF00069	0.678
MOD_Plk_4	127	133	PF00069	0.620
MOD_Plk_4	166	172	PF00069	0.741
MOD_Plk_4	244	250	PF00069	0.651
MOD_Plk_4	31	37	PF00069	0.516
MOD_ProDKin_1	116	122	PF00069	0.642
MOD_ProDKin_1	144	150	PF00069	0.657
MOD_ProDKin_1	174	180	PF00069	0.653
MOD_ProDKin_1	185	191	PF00069	0.573
MOD_ProDKin_1	197	203	PF00069	0.426
MOD_SUMO_rev_2	161	168	PF00179	0.676
TRG_DiLeu_BaEn_1	22	27	PF01217	0.521
TRG_DiLeu_BaLyEn_6	239	244	PF01217	0.642
TRG_ENDOCYTIC_2	191	194	PF00928	0.493
TRG_ER_diArg_1	59	61	PF00400	0.507
TRG_NLS_MonoExtC_3	212	218	PF00514	0.595
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.550

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7G9	Leptomonas seymouri	46%	96%
A0A3S7X157	Leishmania donovani	89%	100%
A4HG70	Leishmania braziliensis	73%	100%
A4I3B3	Leishmania infantum	90%	100%
E9AZJ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%