HIT-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8P0_LEIMA

TriTrypDb:

LmjF.28.0300 , LMJLV39_280008300 , LMJSD75_280008200

Length:

631

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0070761	pre-snoRNP complex	3	2
GO:0110165	cellular anatomical entity	1	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

Q4Q8P0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8P0

Function

Biological processes
Term	Name	Level	Count
GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	2
GO:0000470	maturation of LSU-rRNA	9	2
GO:0000491	small nucleolar ribonucleoprotein complex assembly	7	2
GO:0000492	box C/D snoRNP assembly	8	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006364	rRNA processing	8	2
GO:0006396	RNA processing	6	2
GO:0006403	RNA localization	3	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0016070	RNA metabolic process	5	2
GO:0016072	rRNA metabolic process	7	2
GO:0022607	cellular component assembly	4	2
GO:0022618	ribonucleoprotein complex assembly	6	2
GO:0033036	macromolecule localization	2	2
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043933	protein-containing complex organization	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0048254	snoRNA localization	4	2
GO:0051179	localization	1	2
GO:0065003	protein-containing complex assembly	5	2
GO:0071704	organic substance metabolic process	2	2
GO:0071826	ribonucleoprotein complex subunit organization	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	30	34	PF00656	0.737
CLV_C14_Caspase3-7	328	332	PF00656	0.712
CLV_NRD_NRD_1	122	124	PF00675	0.487
CLV_NRD_NRD_1	170	172	PF00675	0.389
CLV_NRD_NRD_1	205	207	PF00675	0.446
CLV_NRD_NRD_1	217	219	PF00675	0.420
CLV_NRD_NRD_1	228	230	PF00675	0.369
CLV_NRD_NRD_1	286	288	PF00675	0.539
CLV_NRD_NRD_1	456	458	PF00675	0.550
CLV_NRD_NRD_1	507	509	PF00675	0.535
CLV_NRD_NRD_1	527	529	PF00675	0.278
CLV_NRD_NRD_1	580	582	PF00675	0.428
CLV_NRD_NRD_1	628	630	PF00675	0.621
CLV_PCSK_KEX2_1	122	124	PF00082	0.487
CLV_PCSK_KEX2_1	170	172	PF00082	0.389
CLV_PCSK_KEX2_1	204	206	PF00082	0.399
CLV_PCSK_KEX2_1	219	221	PF00082	0.349
CLV_PCSK_KEX2_1	286	288	PF00082	0.539
CLV_PCSK_KEX2_1	456	458	PF00082	0.409
CLV_PCSK_KEX2_1	509	511	PF00082	0.529
CLV_PCSK_KEX2_1	527	529	PF00082	0.516
CLV_PCSK_KEX2_1	582	584	PF00082	0.504
CLV_PCSK_KEX2_1	627	629	PF00082	0.711
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.470
CLV_PCSK_PC1ET2_1	509	511	PF00082	0.583
CLV_PCSK_PC1ET2_1	582	584	PF00082	0.504
CLV_PCSK_PC7_1	200	206	PF00082	0.475
CLV_PCSK_PC7_1	523	529	PF00082	0.447
CLV_PCSK_PC7_1	578	584	PF00082	0.553
CLV_PCSK_SKI1_1	301	305	PF00082	0.756
CLV_PCSK_SKI1_1	441	445	PF00082	0.453
CLV_PCSK_SKI1_1	456	460	PF00082	0.264
CLV_PCSK_SKI1_1	527	531	PF00082	0.397
CLV_PCSK_SKI1_1	554	558	PF00082	0.329
DEG_APCC_DBOX_1	261	269	PF00400	0.371
DOC_CYCLIN_yCln2_LP_2	192	198	PF00134	0.377
DOC_CYCLIN_yCln2_LP_2	383	389	PF00134	0.551
DOC_MAPK_gen_1	122	130	PF00069	0.383
DOC_MAPK_MEF2A_6	123	132	PF00069	0.451
DOC_MAPK_MEF2A_6	393	401	PF00069	0.490
DOC_PP1_RVXF_1	454	461	PF00149	0.323
DOC_PP2B_LxvP_1	192	195	PF13499	0.387
DOC_PP2B_LxvP_1	383	386	PF13499	0.565
DOC_PP2B_LxvP_1	399	402	PF13499	0.391
DOC_PP4_FxxP_1	623	626	PF00568	0.677
DOC_USP7_MATH_1	15	19	PF00917	0.612
DOC_USP7_MATH_1	181	185	PF00917	0.539
DOC_USP7_MATH_1	369	373	PF00917	0.723
DOC_USP7_MATH_1	374	378	PF00917	0.667
DOC_USP7_MATH_1	406	410	PF00917	0.444
DOC_USP7_MATH_1	488	492	PF00917	0.480
DOC_USP7_UBL2_3	134	138	PF12436	0.412
DOC_WW_Pin1_4	543	548	PF00397	0.504
DOC_WW_Pin1_4	87	92	PF00397	0.650
LIG_14-3-3_CanoR_1	122	128	PF00244	0.384
LIG_14-3-3_CanoR_1	182	186	PF00244	0.522
LIG_14-3-3_CanoR_1	477	481	PF00244	0.439
LIG_14-3-3_CanoR_1	490	494	PF00244	0.616
LIG_14-3-3_CanoR_1	508	515	PF00244	0.370
LIG_14-3-3_CanoR_1	567	571	PF00244	0.335
LIG_14-3-3_CanoR_1	73	81	PF00244	0.536
LIG_14-3-3_CterR_2	627	631	PF00244	0.647
LIG_APCC_ABBA_1	130	135	PF00400	0.422
LIG_EVH1_1	399	403	PF00568	0.485
LIG_FHA_1	222	228	PF00498	0.412
LIG_FHA_1	229	235	PF00498	0.348
LIG_FHA_1	345	351	PF00498	0.642
LIG_FHA_2	315	321	PF00498	0.808
LIG_FHA_2	326	332	PF00498	0.456
LIG_FHA_2	338	344	PF00498	0.548
LIG_FHA_2	406	412	PF00498	0.557
LIG_FHA_2	448	454	PF00498	0.322
LIG_FHA_2	480	486	PF00498	0.385
LIG_FHA_2	544	550	PF00498	0.502
LIG_IBAR_NPY_1	446	448	PF08397	0.295
LIG_LIR_Gen_1	162	167	PF02991	0.390
LIG_LIR_Gen_1	425	433	PF02991	0.491
LIG_LIR_Gen_1	555	563	PF02991	0.448
LIG_LIR_Nem_3	162	166	PF02991	0.393
LIG_LIR_Nem_3	425	430	PF02991	0.489
LIG_LIR_Nem_3	462	467	PF02991	0.285
LIG_LIR_Nem_3	555	559	PF02991	0.407
LIG_Pex14_1	185	189	PF04695	0.481
LIG_Pex14_1	236	240	PF04695	0.318
LIG_Pex14_2	417	421	PF04695	0.428
LIG_Pex14_2	460	464	PF04695	0.301
LIG_SH2_CRK	115	119	PF00017	0.360
LIG_SH2_CRK	189	193	PF00017	0.543
LIG_SH2_CRK	288	292	PF00017	0.440
LIG_SH2_CRK	448	452	PF00017	0.390
LIG_SH2_NCK_1	115	119	PF00017	0.360
LIG_SH2_NCK_1	288	292	PF00017	0.465
LIG_SH2_PTP2	427	430	PF00017	0.419
LIG_SH2_STAP1	395	399	PF00017	0.550
LIG_SH2_STAT5	11	14	PF00017	0.712
LIG_SH2_STAT5	115	118	PF00017	0.358
LIG_SH2_STAT5	271	274	PF00017	0.338
LIG_SH2_STAT5	294	297	PF00017	0.638
LIG_SH2_STAT5	427	430	PF00017	0.468
LIG_SH2_STAT5	442	445	PF00017	0.284
LIG_SH2_STAT5	61	64	PF00017	0.618
LIG_SH3_3	359	365	PF00018	0.599
LIG_SH3_3	394	400	PF00018	0.484
LIG_TRAF2_1	95	98	PF00917	0.704
LIG_TRFH_1	443	447	PF08558	0.415
LIG_WW_3	624	628	PF00397	0.559
MOD_CK1_1	101	107	PF00069	0.582
MOD_CK1_1	152	158	PF00069	0.408
MOD_CK1_1	27	33	PF00069	0.773
MOD_CK1_1	35	41	PF00069	0.546
MOD_CK1_1	479	485	PF00069	0.321
MOD_CK1_1	492	498	PF00069	0.597
MOD_CK1_1	72	78	PF00069	0.594
MOD_CK1_1	87	93	PF00069	0.597
MOD_CK2_1	405	411	PF00069	0.422
MOD_CK2_1	428	434	PF00069	0.365
MOD_CK2_1	447	453	PF00069	0.329
MOD_CK2_1	543	549	PF00069	0.484
MOD_CK2_1	79	85	PF00069	0.740
MOD_GlcNHglycan	243	246	PF01048	0.471
MOD_GlcNHglycan	28	32	PF01048	0.703
MOD_GlcNHglycan	297	300	PF01048	0.614
MOD_GlcNHglycan	333	336	PF01048	0.686
MOD_GlcNHglycan	64	67	PF01048	0.592
MOD_GlcNHglycan	76	79	PF01048	0.530
MOD_GSK3_1	249	256	PF00069	0.461
MOD_GSK3_1	295	302	PF00069	0.754
MOD_GSK3_1	344	351	PF00069	0.693
MOD_GSK3_1	488	495	PF00069	0.488
MOD_GSK3_1	6	13	PF00069	0.742
MOD_GSK3_1	79	86	PF00069	0.599
MOD_GSK3_1	96	103	PF00069	0.559
MOD_N-GLC_1	222	227	PF02516	0.389
MOD_N-GLC_1	35	40	PF02516	0.638
MOD_NEK2_1	137	142	PF00069	0.508
MOD_NEK2_1	240	245	PF00069	0.338
MOD_NEK2_1	84	89	PF00069	0.623
MOD_OFUCOSY	120	125	PF10250	0.349
MOD_PIKK_1	314	320	PF00454	0.604
MOD_PIKK_1	470	476	PF00454	0.340
MOD_PIKK_1	96	102	PF00454	0.637
MOD_PKA_1	508	514	PF00069	0.573
MOD_PKA_2	121	127	PF00069	0.469
MOD_PKA_2	15	21	PF00069	0.619
MOD_PKA_2	181	187	PF00069	0.501
MOD_PKA_2	228	234	PF00069	0.382
MOD_PKA_2	289	295	PF00069	0.500
MOD_PKA_2	476	482	PF00069	0.447
MOD_PKA_2	489	495	PF00069	0.435
MOD_PKA_2	519	525	PF00069	0.471
MOD_PKA_2	566	572	PF00069	0.305
MOD_PKA_2	62	68	PF00069	0.659
MOD_PKA_2	72	78	PF00069	0.461
MOD_Plk_1	222	228	PF00069	0.387
MOD_Plk_1	249	255	PF00069	0.462
MOD_Plk_1	348	354	PF00069	0.586
MOD_Plk_1	69	75	PF00069	0.601
MOD_Plk_4	123	129	PF00069	0.523
MOD_Plk_4	230	236	PF00069	0.381
MOD_Plk_4	6	12	PF00069	0.498
MOD_ProDKin_1	543	549	PF00069	0.505
MOD_ProDKin_1	87	93	PF00069	0.647
MOD_SUMO_for_1	513	516	PF00179	0.487
MOD_SUMO_rev_2	135	140	PF00179	0.457
MOD_SUMO_rev_2	222	231	PF00179	0.526
MOD_SUMO_rev_2	479	488	PF00179	0.328
MOD_SUMO_rev_2	511	515	PF00179	0.394
TRG_DiLeu_BaEn_2	462	468	PF01217	0.415
TRG_DiLeu_BaEn_4	516	522	PF01217	0.512
TRG_DiLeu_BaLyEn_6	275	280	PF01217	0.485
TRG_ENDOCYTIC_2	163	166	PF00928	0.510
TRG_ENDOCYTIC_2	189	192	PF00928	0.556
TRG_ENDOCYTIC_2	288	291	PF00928	0.440
TRG_ENDOCYTIC_2	395	398	PF00928	0.572
TRG_ENDOCYTIC_2	427	430	PF00928	0.426
TRG_ENDOCYTIC_2	442	445	PF00928	0.263
TRG_ENDOCYTIC_2	448	451	PF00928	0.358
TRG_ER_diArg_1	204	206	PF00400	0.497
TRG_ER_diArg_1	217	220	PF00400	0.512
TRG_ER_diArg_1	262	265	PF00400	0.399
TRG_ER_diArg_1	286	288	PF00400	0.539
TRG_ER_diArg_1	455	457	PF00400	0.404
TRG_ER_diArg_1	507	510	PF00400	0.530
TRG_ER_diArg_1	527	529	PF00400	0.394
TRG_ER_diArg_1	595	598	PF00400	0.639
TRG_ER_diArg_1	626	629	PF00400	0.709
TRG_NES_CRM1_1	449	463	PF08389	0.377
TRG_NLS_MonoExtC_3	580	585	PF00514	0.447
TRG_NLS_MonoExtN_4	578	585	PF00514	0.562
TRG_Pf-PMV_PEXEL_1	157	162	PF00026	0.408

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0N9	Leptomonas seymouri	58%	100%
A0A3Q8IQB2	Leishmania donovani	91%	100%
A0A422N6T6	Trypanosoma rangeli	41%	100%
A4HG71	Leishmania braziliensis	77%	95%
A4I3B4	Leishmania infantum	91%	100%
D0A7T3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AZJ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BJ07	Trypanosoma cruzi	46%	100%