Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8N9_LEIMA

TriTrypDb:

LmjF.28.0310 , LMJLV39_280008400 , LMJSD75_280008300

Length:

317

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4Q8N9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8N9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	133	135	PF00675	0.600
CLV_NRD_NRD_1	59	61	PF00675	0.511
CLV_PCSK_FUR_1	301	305	PF00082	0.323
CLV_PCSK_FUR_1	57	61	PF00082	0.550
CLV_PCSK_KEX2_1	133	135	PF00082	0.599
CLV_PCSK_KEX2_1	303	305	PF00082	0.395
CLV_PCSK_KEX2_1	59	61	PF00082	0.509
CLV_PCSK_PC1ET2_1	303	305	PF00082	0.427
CLV_PCSK_SKI1_1	108	112	PF00082	0.595
CLV_PCSK_SKI1_1	253	257	PF00082	0.282
CLV_PCSK_SKI1_1	28	32	PF00082	0.501
CLV_PCSK_SKI1_1	41	45	PF00082	0.423
DOC_CKS1_1	122	127	PF01111	0.450
DOC_CYCLIN_yCln2_LP_2	290	296	PF00134	0.402
DOC_MAPK_gen_1	251	258	PF00069	0.520
DOC_MAPK_MEF2A_6	145	152	PF00069	0.362
DOC_MAPK_MEF2A_6	227	235	PF00069	0.355
DOC_PP2B_LxvP_1	150	153	PF13499	0.447
DOC_PP2B_LxvP_1	256	259	PF13499	0.355
DOC_USP7_MATH_1	113	117	PF00917	0.320
DOC_USP7_MATH_1	284	288	PF00917	0.450
DOC_WW_Pin1_4	121	126	PF00397	0.459
DOC_WW_Pin1_4	202	207	PF00397	0.391
DOC_WW_Pin1_4	236	241	PF00397	0.489
DOC_WW_Pin1_4	69	74	PF00397	0.735
LIG_14-3-3_CanoR_1	59	64	PF00244	0.718
LIG_deltaCOP1_diTrp_1	243	252	PF00928	0.614
LIG_deltaCOP1_diTrp_1	84	92	PF00928	0.670
LIG_FHA_1	159	165	PF00498	0.405
LIG_FHA_1	24	30	PF00498	0.650
LIG_FHA_1	309	315	PF00498	0.757
LIG_FHA_1	51	57	PF00498	0.615
LIG_FHA_2	70	76	PF00498	0.744
LIG_LIR_Gen_1	193	204	PF02991	0.430
LIG_LIR_Gen_1	269	280	PF02991	0.572
LIG_LIR_Nem_3	193	199	PF02991	0.425
LIG_LIR_Nem_3	269	275	PF02991	0.589
LIG_LIR_Nem_3	88	93	PF02991	0.515
LIG_LYPXL_S_1	92	96	PF13949	0.480
LIG_LYPXL_yS_3	93	96	PF13949	0.480
LIG_Pex14_1	246	250	PF04695	0.602
LIG_SH2_NCK_1	272	276	PF00017	0.476
LIG_SH2_SRC	166	169	PF00017	0.568
LIG_SH2_SRC	272	275	PF00017	0.481
LIG_SH2_STAP1	160	164	PF00017	0.480
LIG_SH2_STAP1	25	29	PF00017	0.639
LIG_SH2_STAT5	101	104	PF00017	0.379
LIG_SH2_STAT5	160	163	PF00017	0.447
LIG_SH2_STAT5	166	169	PF00017	0.593
LIG_SH2_STAT5	25	28	PF00017	0.628
LIG_SH3_3	119	125	PF00018	0.450
LIG_SH3_3	143	149	PF00018	0.344
LIG_SH3_3	225	231	PF00018	0.426
LIG_SH3_3	273	279	PF00018	0.300
LIG_SUMO_SIM_anti_2	11	22	PF11976	0.679
LIG_SUMO_SIM_par_1	160	165	PF11976	0.431
LIG_TYR_ITIM	91	96	PF00017	0.440
LIG_TYR_ITIM	99	104	PF00017	0.456
MOD_CK1_1	184	190	PF00069	0.355
MOD_CK1_1	205	211	PF00069	0.362
MOD_Cter_Amidation	131	134	PF01082	0.612
MOD_Cter_Amidation	57	60	PF01082	0.404
MOD_GlcNHglycan	35	38	PF01048	0.503
MOD_GSK3_1	14	21	PF00069	0.719
MOD_GSK3_1	158	165	PF00069	0.361
MOD_GSK3_1	29	36	PF00069	0.661
MOD_NEK2_1	162	167	PF00069	0.404
MOD_NEK2_1	192	197	PF00069	0.476
MOD_NEK2_1	267	272	PF00069	0.419
MOD_NEK2_1	77	82	PF00069	0.717
MOD_PIKK_1	190	196	PF00454	0.495
MOD_PIKK_1	23	29	PF00454	0.713
MOD_PKA_1	59	65	PF00069	0.670
MOD_PKA_2	59	65	PF00069	0.649
MOD_PKA_2	6	12	PF00069	0.755
MOD_PKB_1	57	65	PF00069	0.598
MOD_Plk_1	12	18	PF00069	0.748
MOD_Plk_1	50	56	PF00069	0.731
MOD_Plk_4	138	144	PF00069	0.386
MOD_Plk_4	14	20	PF00069	0.706
MOD_Plk_4	162	168	PF00069	0.463
MOD_Plk_4	181	187	PF00069	0.353
MOD_Plk_4	192	198	PF00069	0.358
MOD_Plk_4	221	227	PF00069	0.484
MOD_Plk_4	267	273	PF00069	0.395
MOD_Plk_4	284	290	PF00069	0.361
MOD_ProDKin_1	121	127	PF00069	0.456
MOD_ProDKin_1	202	208	PF00069	0.390
MOD_ProDKin_1	236	242	PF00069	0.488
MOD_ProDKin_1	69	75	PF00069	0.735
TRG_DiLeu_BaLyEn_6	228	233	PF01217	0.378
TRG_ENDOCYTIC_2	101	104	PF00928	0.408
TRG_ENDOCYTIC_2	272	275	PF00928	0.486
TRG_ENDOCYTIC_2	93	96	PF00928	0.408
TRG_ER_diArg_1	133	135	PF00400	0.402
TRG_ER_diArg_1	5	8	PF00400	0.730
TRG_ER_diArg_1	56	59	PF00400	0.712
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.550

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P732	Leptomonas seymouri	58%	92%
A0A1X0NVF3	Trypanosomatidae	34%	100%
A0A3Q8IAV0	Leishmania donovani	94%	100%
A0A3R7KTP8	Trypanosoma rangeli	35%	100%
A4HG72	Leishmania braziliensis	82%	92%
A4I3B5	Leishmania infantum	94%	100%
D0A7T4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AZJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5DAH6	Trypanosoma cruzi	37%	100%