Sugar transporter SWEET

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Sugar efflux transporter for intercellular exchange, putative

Species:

Leishmania major

UniProt:

Q4Q8N5_LEIMA

TriTrypDb:

LmjF.28.0350 , LMJLV39_280008900 , LMJSD75_280008800

Length:

242

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	17
GO:0110165	cellular anatomical entity	1	17

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Expansion

Sequence features

Q4Q8N5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8N5

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	17
GO:0008643	carbohydrate transport	5	17
GO:0051179	localization	1	17
GO:0051234	establishment of localization	2	17
GO:0071702	organic substance transport	4	17

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Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	3
GO:0015144	carbohydrate transmembrane transporter activity	3	3
GO:0022857	transmembrane transporter activity	2	3
GO:0051119	sugar transmembrane transporter activity	4	3

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	223	225	PF00675	0.300
CLV_NRD_NRD_1	31	33	PF00675	0.240
CLV_NRD_NRD_1	92	94	PF00675	0.301
CLV_PCSK_KEX2_1	31	33	PF00082	0.297
CLV_PCSK_KEX2_1	92	94	PF00082	0.327
CLV_PCSK_SKI1_1	108	112	PF00082	0.263
CLV_PCSK_SKI1_1	140	144	PF00082	0.530
DEG_Kelch_actinfilin_1	175	179	PF01344	0.251
DOC_CDC14_PxL_1	154	162	PF14671	0.260
DOC_CYCLIN_yClb1_LxF_4	204	210	PF00134	0.260

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVB3	Leptomonas seymouri	38%	100%
A0A0N1HZ27	Leptomonas seymouri	73%	100%
A0A0S4JK63	Bodo saltans	33%	100%
A0A0S4JP06	Bodo saltans	37%	84%
A0A1X0NHK1	Trypanosomatidae	45%	100%
A0A3Q8IJU9	Leishmania donovani	42%	100%
A0A3R7RTY4	Trypanosoma rangeli	44%	100%
A0A3S7X189	Leishmania donovani	95%	100%
A2YZ24	Oryza sativa subsp. indica	25%	91%
A3BWJ9	Oryza sativa subsp. japonica	24%	95%

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