Sugar transporter SWEET

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Sugar efflux transporter for intercellular exchange, putative

Species:

Leishmania major

UniProt:

Q4Q8N5_LEIMA

TriTrypDb:

LmjF.28.0350 , LMJLV39_280008900 , LMJSD75_280008800

Length:

242

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	17
GO:0110165	cellular anatomical entity	1	17

Expansion

Sequence features

Q4Q8N5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8N5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	17
GO:0008643	carbohydrate transport	5	17
GO:0051179	localization	1	17
GO:0051234	establishment of localization	2	17
GO:0071702	organic substance transport	4	17

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	3
GO:0015144	carbohydrate transmembrane transporter activity	3	3
GO:0022857	transmembrane transporter activity	2	3
GO:0051119	sugar transmembrane transporter activity	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	223	225	PF00675	0.300
CLV_NRD_NRD_1	31	33	PF00675	0.240
CLV_NRD_NRD_1	92	94	PF00675	0.301
CLV_PCSK_KEX2_1	31	33	PF00082	0.297
CLV_PCSK_KEX2_1	92	94	PF00082	0.327
CLV_PCSK_SKI1_1	108	112	PF00082	0.263
CLV_PCSK_SKI1_1	140	144	PF00082	0.530
DEG_Kelch_actinfilin_1	175	179	PF01344	0.251
DOC_CDC14_PxL_1	154	162	PF14671	0.260
DOC_CYCLIN_yClb1_LxF_4	204	210	PF00134	0.260
DOC_CYCLIN_yCln2_LP_2	155	161	PF00134	0.358
DOC_MAPK_DCC_7	169	179	PF00069	0.451
DOC_MAPK_RevD_3	18	32	PF00069	0.319
DOC_PP2B_LxvP_1	155	158	PF13499	0.335
DOC_PP2B_PxIxI_1	25	31	PF00149	0.413
DOC_WW_Pin1_4	22	27	PF00397	0.356
DOC_WW_Pin1_4	236	241	PF00397	0.717
LIG_BRCT_BRCA1_1	83	87	PF00533	0.469
LIG_FHA_2	141	147	PF00498	0.405
LIG_LIR_Gen_1	112	121	PF02991	0.341
LIG_LIR_Gen_1	198	207	PF02991	0.306
LIG_LIR_Gen_1	2	11	PF02991	0.386
LIG_LIR_Gen_1	80	90	PF02991	0.317
LIG_LIR_Nem_3	112	118	PF02991	0.341
LIG_LIR_Nem_3	186	191	PF02991	0.345
LIG_LIR_Nem_3	198	203	PF02991	0.282
LIG_LIR_Nem_3	2	7	PF02991	0.375
LIG_LIR_Nem_3	56	60	PF02991	0.286
LIG_LIR_Nem_3	64	70	PF02991	0.229
LIG_LIR_Nem_3	80	85	PF02991	0.243
LIG_LYPXL_yS_3	67	70	PF13949	0.330
LIG_Pex14_2	184	188	PF04695	0.363
LIG_PTB_Apo_2	182	189	PF02174	0.405
LIG_PTB_Apo_2	194	201	PF02174	0.330
LIG_SH2_CRK	52	56	PF00017	0.308
LIG_SH2_CRK	8	12	PF00017	0.330
LIG_SH2_CRK	82	86	PF00017	0.324
LIG_SH2_NCK_1	52	56	PF00017	0.405
LIG_SH2_STAP1	106	110	PF00017	0.533
LIG_SH2_STAP1	113	117	PF00017	0.354
LIG_SH2_STAT3	47	50	PF00017	0.332
LIG_SH2_STAT5	13	16	PF00017	0.297
LIG_SH2_STAT5	82	85	PF00017	0.324
LIG_SH3_3	170	176	PF00018	0.519
LIG_SH3_3	223	229	PF00018	0.452
LIG_SUMO_SIM_par_1	151	156	PF11976	0.328
LIG_TYR_ITIM	6	11	PF00017	0.360
LIG_TYR_ITIM	65	70	PF00017	0.333
LIG_UBA3_1	218	225	PF00899	0.308
MOD_CK1_1	109	115	PF00069	0.344
MOD_CK1_1	148	154	PF00069	0.226
MOD_CK1_1	42	48	PF00069	0.421
MOD_CK1_1	97	103	PF00069	0.578
MOD_CK2_1	140	146	PF00069	0.296
MOD_Cter_Amidation	222	225	PF01082	0.275
MOD_GlcNHglycan	119	122	PF01048	0.374
MOD_GlcNHglycan	132	135	PF01048	0.510
MOD_GlcNHglycan	155	158	PF01048	0.305
MOD_GlcNHglycan	34	38	PF01048	0.323
MOD_GlcNHglycan	94	99	PF01048	0.369
MOD_GSK3_1	102	109	PF00069	0.525
MOD_GSK3_1	124	131	PF00069	0.336
MOD_GSK3_1	35	42	PF00069	0.516
MOD_GSK3_1	77	84	PF00069	0.485
MOD_GSK3_1	93	100	PF00069	0.537
MOD_N-GLC_1	22	27	PF02516	0.405
MOD_NEK2_1	101	106	PF00069	0.549
MOD_NEK2_1	11	16	PF00069	0.376
MOD_NEK2_1	117	122	PF00069	0.270
MOD_NEK2_1	124	129	PF00069	0.315
MOD_NEK2_1	130	135	PF00069	0.335
MOD_NEK2_1	183	188	PF00069	0.363
MOD_NEK2_1	33	38	PF00069	0.560
MOD_NEK2_1	63	68	PF00069	0.251
MOD_Plk_4	106	112	PF00069	0.509
MOD_Plk_4	124	130	PF00069	0.417
MOD_Plk_4	148	154	PF00069	0.306
MOD_Plk_4	183	189	PF00069	0.314
MOD_Plk_4	42	48	PF00069	0.301
MOD_Plk_4	81	87	PF00069	0.358
MOD_ProDKin_1	22	28	PF00069	0.356
MOD_ProDKin_1	236	242	PF00069	0.720
TRG_DiLeu_BaLyEn_6	155	160	PF01217	0.260
TRG_DiLeu_BaLyEn_6	65	70	PF01217	0.330
TRG_ENDOCYTIC_2	113	116	PF00928	0.405
TRG_ENDOCYTIC_2	52	55	PF00928	0.303
TRG_ENDOCYTIC_2	60	63	PF00928	0.270
TRG_ENDOCYTIC_2	67	70	PF00928	0.222
TRG_ENDOCYTIC_2	8	11	PF00928	0.330
TRG_ENDOCYTIC_2	82	85	PF00928	0.295
TRG_ER_diArg_1	30	32	PF00400	0.497
TRG_Pf-PMV_PEXEL_1	31	35	PF00026	0.330

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVB3	Leptomonas seymouri	38%	100%
A0A0N1HZ27	Leptomonas seymouri	73%	100%
A0A0S4JK63	Bodo saltans	33%	100%
A0A0S4JP06	Bodo saltans	37%	84%
A0A1X0NHK1	Trypanosomatidae	45%	100%
A0A3Q8IJU9	Leishmania donovani	42%	100%
A0A3R7RTY4	Trypanosoma rangeli	44%	100%
A0A3S7X189	Leishmania donovani	95%	100%
A2YZ24	Oryza sativa subsp. indica	25%	91%
A3BWJ9	Oryza sativa subsp. japonica	24%	95%
A4HG76	Leishmania braziliensis	77%	100%
A4HQ04	Leishmania braziliensis	42%	100%
A4I3B9	Leishmania infantum	95%	100%
A4IDR5	Leishmania infantum	42%	100%
B9G2E6	Oryza sativa subsp. japonica	26%	88%
E9ATS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9AZJ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q0DJY3	Oryza sativa subsp. japonica	22%	98%
Q0J349	Oryza sativa subsp. japonica	25%	91%
Q19VE6	Oryza sativa subsp. indica	28%	79%
Q290X1	Drosophila pseudoobscura pseudoobscura	25%	100%
Q4Q0S5	Leishmania major	41%	100%
Q5NAZ9	Oryza sativa subsp. japonica	25%	96%
Q6NQN5	Arabidopsis thaliana	23%	92%
Q6YZF3	Oryza sativa subsp. japonica	28%	79%
Q7JVE7	Drosophila melanogaster	22%	100%
Q8LBF7	Arabidopsis thaliana	26%	94%
Q9FY94	Arabidopsis thaliana	24%	83%
Q9LUE3	Arabidopsis thaliana	27%	84%