Sacchrp_dh_NADP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

saccharopine dehydrogenase, putative

Species:

Leishmania major

UniProt:

Q4Q8N2_LEIMA

TriTrypDb:

LmjF.28.0380 , LMJLV39_280009100 , LMJSD75_280009100

Length:

392

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005811	lipid droplet	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4Q8N2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8N2

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	2
GO:0006643	membrane lipid metabolic process	4	2
GO:0006664	glycolipid metabolic process	5	2
GO:0008152	metabolic process	1	2
GO:0008610	lipid biosynthetic process	4	2
GO:0009058	biosynthetic process	2	2
GO:0009247	glycolipid biosynthetic process	5	2
GO:0009987	cellular process	1	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044255	cellular lipid metabolic process	3	2
GO:0046467	membrane lipid biosynthetic process	4	2
GO:0071704	organic substance metabolic process	2	2
GO:1901135	carbohydrate derivative metabolic process	3	2
GO:1901137	carbohydrate derivative biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2
GO:1903509	liposaccharide metabolic process	4	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016491	oxidoreductase activity	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	114	116	PF00675	0.412
CLV_NRD_NRD_1	125	127	PF00675	0.433
CLV_NRD_NRD_1	235	237	PF00675	0.329
CLV_NRD_NRD_1	278	280	PF00675	0.399
CLV_NRD_NRD_1	346	348	PF00675	0.470
CLV_PCSK_KEX2_1	114	116	PF00082	0.377
CLV_PCSK_KEX2_1	235	237	PF00082	0.370
CLV_PCSK_KEX2_1	278	280	PF00082	0.399
CLV_PCSK_KEX2_1	315	317	PF00082	0.392
CLV_PCSK_PC1ET2_1	315	317	PF00082	0.414
CLV_PCSK_SKI1_1	279	283	PF00082	0.473
CLV_PCSK_SKI1_1	284	288	PF00082	0.496
DEG_COP1_1	50	58	PF00400	0.258
DOC_CKS1_1	355	360	PF01111	0.291
DOC_MAPK_gen_1	369	377	PF00069	0.338
DOC_MAPK_MEF2A_6	48	55	PF00069	0.392
DOC_PP1_RVXF_1	258	264	PF00149	0.248
DOC_USP7_MATH_1	169	173	PF00917	0.451
DOC_USP7_MATH_1	195	199	PF00917	0.473
DOC_USP7_MATH_1	299	303	PF00917	0.407
DOC_USP7_MATH_1	37	41	PF00917	0.399
DOC_USP7_UBL2_3	344	348	PF12436	0.471
DOC_WW_Pin1_4	107	112	PF00397	0.258
DOC_WW_Pin1_4	164	169	PF00397	0.501
DOC_WW_Pin1_4	189	194	PF00397	0.440
DOC_WW_Pin1_4	204	209	PF00397	0.460
DOC_WW_Pin1_4	354	359	PF00397	0.285
LIG_14-3-3_CanoR_1	18	24	PF00244	0.392
LIG_14-3-3_CanoR_1	235	241	PF00244	0.437
LIG_14-3-3_CanoR_1	260	270	PF00244	0.547
LIG_14-3-3_CanoR_1	347	352	PF00244	0.472
LIG_Actin_WH2_2	336	354	PF00022	0.386
LIG_BIR_II_1	1	5	PF00653	0.445
LIG_DLG_GKlike_1	347	355	PF00625	0.345
LIG_eIF4E_1	328	334	PF01652	0.330
LIG_FHA_1	108	114	PF00498	0.250
LIG_FHA_1	14	20	PF00498	0.309
LIG_FHA_1	235	241	PF00498	0.287
LIG_FHA_1	25	31	PF00498	0.309
LIG_FHA_1	263	269	PF00498	0.413
LIG_FHA_1	377	383	PF00498	0.528
LIG_FHA_1	55	61	PF00498	0.407
LIG_FHA_1	73	79	PF00498	0.146
LIG_FHA_1	99	105	PF00498	0.250
LIG_FHA_2	185	191	PF00498	0.511
LIG_Integrin_isoDGR_2	217	219	PF01839	0.391
LIG_LIR_Gen_1	254	263	PF02991	0.364
LIG_LIR_Gen_1	264	274	PF02991	0.331
LIG_LIR_Nem_3	254	258	PF02991	0.360
LIG_LIR_Nem_3	262	266	PF02991	0.433
LIG_NRP_CendR_1	389	392	PF00754	0.485
LIG_Pex14_2	220	224	PF04695	0.425
LIG_Pex14_2	303	307	PF04695	0.390
LIG_PTB_Apo_2	214	221	PF02174	0.382
LIG_SH2_GRB2like	215	218	PF00017	0.490
LIG_SH2_PTP2	266	269	PF00017	0.551
LIG_SH2_SRC	215	218	PF00017	0.493
LIG_SH2_SRC	247	250	PF00017	0.306
LIG_SH2_STAP1	328	332	PF00017	0.427
LIG_SH2_STAT5	103	106	PF00017	0.260
LIG_SH2_STAT5	147	150	PF00017	0.292
LIG_SH2_STAT5	163	166	PF00017	0.244
LIG_SH2_STAT5	23	26	PF00017	0.336
LIG_SH2_STAT5	247	250	PF00017	0.288
LIG_SH2_STAT5	266	269	PF00017	0.461
LIG_SH2_STAT5	285	288	PF00017	0.334
LIG_SH2_STAT5	328	331	PF00017	0.306
LIG_SH3_3	352	358	PF00018	0.317
LIG_SH3_3	85	91	PF00018	0.284
LIG_SUMO_SIM_anti_2	155	161	PF11976	0.332
LIG_SUMO_SIM_anti_2	192	198	PF11976	0.475
LIG_SUMO_SIM_anti_2	264	271	PF11976	0.359
LIG_SUMO_SIM_anti_2	3	9	PF11976	0.363
LIG_SUMO_SIM_par_1	192	198	PF11976	0.385
LIG_SUMO_SIM_par_1	378	383	PF11976	0.495
LIG_WRC_WIRS_1	55	60	PF05994	0.392
MOD_CDK_SPxK_1	204	210	PF00069	0.375
MOD_CDK_SPxxK_3	107	114	PF00069	0.258
MOD_CK1_1	172	178	PF00069	0.334
MOD_CK1_1	376	382	PF00069	0.444
MOD_CK2_1	225	231	PF00069	0.503
MOD_CK2_1	319	325	PF00069	0.352
MOD_Cter_Amidation	313	316	PF01082	0.500
MOD_GlcNHglycan	243	246	PF01048	0.426
MOD_GlcNHglycan	312	315	PF01048	0.382
MOD_GlcNHglycan	321	324	PF01048	0.414
MOD_GSK3_1	13	20	PF00069	0.365
MOD_GSK3_1	236	243	PF00069	0.434
MOD_GSK3_1	287	294	PF00069	0.532
MOD_GSK3_1	64	71	PF00069	0.291
MOD_GSK3_1	73	80	PF00069	0.320
MOD_N-GLC_1	172	177	PF02516	0.476
MOD_N-GLC_1	98	103	PF02516	0.343
MOD_NEK2_1	10	15	PF00069	0.284
MOD_NEK2_1	223	228	PF00069	0.433
MOD_NEK2_1	240	245	PF00069	0.287
MOD_NEK2_1	251	256	PF00069	0.470
MOD_NEK2_1	259	264	PF00069	0.529
MOD_NEK2_1	286	291	PF00069	0.554
MOD_NEK2_1	298	303	PF00069	0.393
MOD_NEK2_2	17	22	PF00069	0.392
MOD_NEK2_2	299	304	PF00069	0.349
MOD_OFUCOSY	72	77	PF10250	0.400
MOD_PIKK_1	37	43	PF00454	0.369
MOD_PKA_1	347	353	PF00069	0.362
MOD_PKA_2	17	23	PF00069	0.396
MOD_PKA_2	218	224	PF00069	0.328
MOD_PKA_2	234	240	PF00069	0.211
MOD_PKA_2	259	265	PF00069	0.540
MOD_Plk_1	317	323	PF00069	0.431
MOD_Plk_4	155	161	PF00069	0.463
MOD_Plk_4	236	242	PF00069	0.321
MOD_Plk_4	262	268	PF00069	0.532
MOD_Plk_4	338	344	PF00069	0.356
MOD_Plk_4	376	382	PF00069	0.471
MOD_Plk_4	54	60	PF00069	0.383
MOD_ProDKin_1	107	113	PF00069	0.258
MOD_ProDKin_1	164	170	PF00069	0.500
MOD_ProDKin_1	189	195	PF00069	0.437
MOD_ProDKin_1	204	210	PF00069	0.460
MOD_ProDKin_1	354	360	PF00069	0.290
MOD_SUMO_for_1	47	50	PF00179	0.343
MOD_SUMO_rev_2	228	234	PF00179	0.310
MOD_SUMO_rev_2	383	391	PF00179	0.479
TRG_ENDOCYTIC_2	266	269	PF00928	0.335
TRG_ER_diArg_1	113	115	PF00400	0.436
TRG_ER_diArg_1	234	236	PF00400	0.346
TRG_ER_diArg_1	277	279	PF00400	0.393
TRG_ER_diLys_1	389	392	PF00400	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYN7	Leptomonas seymouri	61%	100%
A0A0S4IJU8	Bodo saltans	42%	99%
A0A1X0NQA2	Trypanosomatidae	43%	99%
A0A3R7KXD1	Trypanosoma rangeli	46%	100%
A0A3S7X166	Leishmania donovani	96%	100%
A0A422NEM4	Trypanosoma rangeli	42%	100%
A0PQ21	Mycobacterium ulcerans (strain Agy99)	30%	94%
A1KMU7	Mycobacterium bovis (strain BCG / Pasteur 1173P2)	30%	94%
A4HG79	Leishmania braziliensis	83%	100%
A4I3C3	Leishmania infantum	96%	100%
A5U6W1	Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)	30%	94%
E9AZJ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O53176	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	34%	94%
P9WGV4	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	30%	94%
P9WGV5	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	30%	94%
Q3T067	Bos taurus	29%	91%
Q5R5C9	Pongo abelii	29%	91%
Q6AY30	Rattus norvegicus	29%	91%
Q7D745	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	34%	94%
Q7TXK2	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	30%	94%
Q8LGI2	Arabidopsis thaliana	28%	86%
Q8NBX0	Homo sapiens	29%	91%
Q8R127	Mus musculus	28%	91%
Q9CD87	Mycobacterium leprae (strain TN)	31%	94%
Q9GZE9	Caenorhabditis elegans	25%	92%
V5AMR3	Trypanosoma cruzi	41%	100%
V5CHW2	Trypanosoma cruzi	40%	100%