Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleus and spindle associated protein 1, putative

Species:

Leishmania major

UniProt:

Q4Q8N1_LEIMA

TriTrypDb:

LmjF.28.0390 , LMJLV39_280009200 , LMJSD75_280009200

Length:

929

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005819	spindle	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q8N1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8N1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	606	610	PF00656	0.553
CLV_NRD_NRD_1	14	16	PF00675	0.695
CLV_NRD_NRD_1	158	160	PF00675	0.628
CLV_NRD_NRD_1	410	412	PF00675	0.566
CLV_NRD_NRD_1	447	449	PF00675	0.569
CLV_NRD_NRD_1	484	486	PF00675	0.651
CLV_NRD_NRD_1	655	657	PF00675	0.554
CLV_NRD_NRD_1	735	737	PF00675	0.498
CLV_NRD_NRD_1	827	829	PF00675	0.613
CLV_NRD_NRD_1	871	873	PF00675	0.637
CLV_NRD_NRD_1	879	881	PF00675	0.620
CLV_NRD_NRD_1	900	902	PF00675	0.631
CLV_PCSK_FUR_1	11	15	PF00082	0.741
CLV_PCSK_FUR_1	877	881	PF00082	0.665
CLV_PCSK_KEX2_1	13	15	PF00082	0.713
CLV_PCSK_KEX2_1	158	160	PF00082	0.533
CLV_PCSK_KEX2_1	328	330	PF00082	0.568
CLV_PCSK_KEX2_1	406	408	PF00082	0.612
CLV_PCSK_KEX2_1	410	412	PF00082	0.573
CLV_PCSK_KEX2_1	447	449	PF00082	0.599
CLV_PCSK_KEX2_1	549	551	PF00082	0.566
CLV_PCSK_KEX2_1	655	657	PF00082	0.554
CLV_PCSK_KEX2_1	735	737	PF00082	0.501
CLV_PCSK_KEX2_1	826	828	PF00082	0.607
CLV_PCSK_KEX2_1	871	873	PF00082	0.572
CLV_PCSK_KEX2_1	879	881	PF00082	0.580
CLV_PCSK_KEX2_1	899	901	PF00082	0.314
CLV_PCSK_PC1ET2_1	328	330	PF00082	0.568
CLV_PCSK_PC1ET2_1	406	408	PF00082	0.537
CLV_PCSK_PC1ET2_1	549	551	PF00082	0.663
CLV_PCSK_PC1ET2_1	899	901	PF00082	0.644
CLV_PCSK_PC7_1	823	829	PF00082	0.593
CLV_PCSK_SKI1_1	163	167	PF00082	0.431
CLV_PCSK_SKI1_1	207	211	PF00082	0.679
CLV_PCSK_SKI1_1	237	241	PF00082	0.581
CLV_PCSK_SKI1_1	242	246	PF00082	0.570
CLV_PCSK_SKI1_1	307	311	PF00082	0.606
CLV_PCSK_SKI1_1	317	321	PF00082	0.566
CLV_PCSK_SKI1_1	329	333	PF00082	0.519
CLV_PCSK_SKI1_1	458	462	PF00082	0.588
CLV_PCSK_SKI1_1	481	485	PF00082	0.572
CLV_PCSK_SKI1_1	553	557	PF00082	0.637
CLV_PCSK_SKI1_1	605	609	PF00082	0.623
CLV_PCSK_SKI1_1	655	659	PF00082	0.556
CLV_PCSK_SKI1_1	673	677	PF00082	0.371
CLV_PCSK_SKI1_1	847	851	PF00082	0.649
DEG_APCC_DBOX_1	604	612	PF00400	0.647
DEG_SCF_FBW7_1	54	61	PF00400	0.629
DOC_CKS1_1	113	118	PF01111	0.548
DOC_CKS1_1	55	60	PF01111	0.743
DOC_CYCLIN_yCln2_LP_2	800	806	PF00134	0.684
DOC_MAPK_gen_1	105	113	PF00069	0.608
DOC_MAPK_gen_1	158	166	PF00069	0.573
DOC_MAPK_gen_1	406	417	PF00069	0.566
DOC_MAPK_gen_1	522	531	PF00069	0.525
DOC_MAPK_gen_1	549	556	PF00069	0.672
DOC_MAPK_gen_1	720	729	PF00069	0.553
DOC_MAPK_MEF2A_6	158	166	PF00069	0.564
DOC_MAPK_MEF2A_6	410	419	PF00069	0.630
DOC_PP1_RVXF_1	551	557	PF00149	0.677
DOC_USP7_MATH_1	198	202	PF00917	0.565
DOC_USP7_MATH_1	381	385	PF00917	0.471
DOC_USP7_MATH_1	475	479	PF00917	0.623
DOC_USP7_MATH_1	562	566	PF00917	0.593
DOC_USP7_MATH_1	6	10	PF00917	0.719
DOC_USP7_MATH_1	603	607	PF00917	0.622
DOC_USP7_MATH_1	757	761	PF00917	0.702
DOC_USP7_MATH_1	79	83	PF00917	0.586
DOC_USP7_MATH_1	838	842	PF00917	0.483
DOC_WW_Pin1_4	112	117	PF00397	0.559
DOC_WW_Pin1_4	46	51	PF00397	0.692
DOC_WW_Pin1_4	54	59	PF00397	0.634
DOC_WW_Pin1_4	67	72	PF00397	0.718
DOC_WW_Pin1_4	779	784	PF00397	0.555
LIG_14-3-3_CanoR_1	207	212	PF00244	0.645
LIG_14-3-3_CanoR_1	217	222	PF00244	0.626
LIG_14-3-3_CanoR_1	362	368	PF00244	0.560
LIG_14-3-3_CanoR_1	879	886	PF00244	0.582
LIG_BIR_II_1	1	5	PF00653	0.731
LIG_BRCT_BRCA1_1	759	763	PF00533	0.663
LIG_CaM_IQ_9	907	922	PF13499	0.641
LIG_Clathr_ClatBox_1	416	420	PF01394	0.585
LIG_deltaCOP1_diTrp_1	573	582	PF00928	0.510
LIG_deltaCOP1_diTrp_1	713	717	PF00928	0.600
LIG_FHA_1	124	130	PF00498	0.575
LIG_FHA_1	151	157	PF00498	0.626
LIG_FHA_1	227	233	PF00498	0.609
LIG_FHA_1	386	392	PF00498	0.641
LIG_FHA_1	546	552	PF00498	0.655
LIG_FHA_1	55	61	PF00498	0.746
LIG_FHA_1	786	792	PF00498	0.625
LIG_FHA_2	113	119	PF00498	0.652
LIG_FHA_2	238	244	PF00498	0.667
LIG_FHA_2	879	885	PF00498	0.591
LIG_LIR_Gen_1	216	226	PF02991	0.589
LIG_LIR_Gen_1	250	261	PF02991	0.605
LIG_LIR_Gen_1	383	393	PF02991	0.549
LIG_LIR_Gen_1	430	438	PF02991	0.585
LIG_LIR_Gen_1	573	583	PF02991	0.637
LIG_LIR_Gen_1	713	719	PF02991	0.570
LIG_LIR_LC3C_4	540	543	PF02991	0.498
LIG_LIR_Nem_3	216	221	PF02991	0.590
LIG_LIR_Nem_3	250	256	PF02991	0.616
LIG_LIR_Nem_3	383	389	PF02991	0.524
LIG_LIR_Nem_3	409	415	PF02991	0.591
LIG_LIR_Nem_3	430	436	PF02991	0.609
LIG_LIR_Nem_3	573	578	PF02991	0.644
LIG_LIR_Nem_3	713	718	PF02991	0.501
LIG_PCNA_yPIPBox_3	690	704	PF02747	0.509
LIG_RPA_C_Fungi	674	686	PF08784	0.535
LIG_SH2_CRK	386	390	PF00017	0.570
LIG_SH2_NCK_1	186	190	PF00017	0.432
LIG_SH2_NCK_1	755	759	PF00017	0.732
LIG_SH2_SRC	225	228	PF00017	0.665
LIG_SH2_SRC	311	314	PF00017	0.525
LIG_SH2_SRC	708	711	PF00017	0.596
LIG_SH2_SRC	755	758	PF00017	0.729
LIG_SH2_STAP1	144	148	PF00017	0.662
LIG_SH2_STAP1	186	190	PF00017	0.432
LIG_SH2_STAP1	227	231	PF00017	0.663
LIG_SH2_STAP1	401	405	PF00017	0.650
LIG_SH2_STAP1	680	684	PF00017	0.608
LIG_SH2_STAP1	715	719	PF00017	0.580
LIG_SH2_STAT3	171	174	PF00017	0.614
LIG_SH2_STAT3	227	230	PF00017	0.668
LIG_SH2_STAT3	642	645	PF00017	0.600
LIG_SH2_STAT5	352	355	PF00017	0.624
LIG_SH2_STAT5	412	415	PF00017	0.402
LIG_SH2_STAT5	624	627	PF00017	0.522
LIG_SH2_STAT5	710	713	PF00017	0.463
LIG_SH2_STAT5	747	750	PF00017	0.589
LIG_SH3_1	13	19	PF00018	0.740
LIG_SH3_3	13	19	PF00018	0.733
LIG_SH3_3	49	55	PF00018	0.732
LIG_SUMO_SIM_anti_2	153	158	PF11976	0.644
LIG_SUMO_SIM_par_1	195	203	PF11976	0.629
LIG_SUMO_SIM_par_1	415	421	PF11976	0.555
LIG_SUMO_SIM_par_1	815	822	PF11976	0.571
LIG_TRAF2_1	284	287	PF00917	0.555
LIG_TRAF2_1	521	524	PF00917	0.596
LIG_TRAF2_1	588	591	PF00917	0.606
LIG_TRAF2_1	593	596	PF00917	0.659
LIG_TRAF2_1	615	618	PF00917	0.602
LIG_TRAF2_1	743	746	PF00917	0.653
LIG_TRAF2_1	830	833	PF00917	0.598
LIG_TRAF2_1	881	884	PF00917	0.462
MOD_CDK_SPK_2	779	784	PF00069	0.555
MOD_CDK_SPxxK_3	112	119	PF00069	0.555
MOD_CK1_1	131	137	PF00069	0.662
MOD_CK1_1	699	705	PF00069	0.583
MOD_CK2_1	112	118	PF00069	0.637
MOD_CK2_1	122	128	PF00069	0.533
MOD_CK2_1	143	149	PF00069	0.614
MOD_CK2_1	237	243	PF00069	0.645
MOD_CK2_1	277	283	PF00069	0.601
MOD_CK2_1	512	518	PF00069	0.572
MOD_CK2_1	740	746	PF00069	0.669
MOD_CK2_1	838	844	PF00069	0.599
MOD_CK2_1	867	873	PF00069	0.658
MOD_CK2_1	878	884	PF00069	0.588
MOD_CMANNOS	714	717	PF00535	0.623
MOD_Cter_Amidation	326	329	PF01082	0.595
MOD_Cter_Amidation	445	448	PF01082	0.646
MOD_Cter_Amidation	824	827	PF01082	0.548
MOD_GlcNHglycan	322	325	PF01048	0.627
MOD_GlcNHglycan	383	386	PF01048	0.472
MOD_GlcNHglycan	564	567	PF01048	0.667
MOD_GlcNHglycan	605	608	PF01048	0.593
MOD_GlcNHglycan	700	704	PF01048	0.565
MOD_GlcNHglycan	809	812	PF01048	0.565
MOD_GlcNHglycan	839	843	PF01048	0.647
MOD_GSK3_1	18	25	PF00069	0.750
MOD_GSK3_1	26	33	PF00069	0.773
MOD_GSK3_1	277	284	PF00069	0.650
MOD_GSK3_1	381	388	PF00069	0.533
MOD_GSK3_1	46	53	PF00069	0.659
MOD_GSK3_1	512	519	PF00069	0.639
MOD_GSK3_1	54	61	PF00069	0.667
MOD_GSK3_1	684	691	PF00069	0.564
MOD_GSK3_1	867	874	PF00069	0.664
MOD_GSK3_1	878	885	PF00069	0.657
MOD_LATS_1	235	241	PF00433	0.613
MOD_N-GLC_1	247	252	PF02516	0.673
MOD_N-GLC_1	888	893	PF02516	0.642
MOD_NEK2_1	277	282	PF00069	0.622
MOD_NEK2_1	582	587	PF00069	0.600
MOD_NEK2_1	919	924	PF00069	0.550
MOD_NEK2_2	385	390	PF00069	0.534
MOD_NEK2_2	6	11	PF00069	0.647
MOD_OFUCOSY	579	586	PF10250	0.635
MOD_PIKK_1	226	232	PF00454	0.628
MOD_PIKK_1	248	254	PF00454	0.670
MOD_PIKK_1	530	536	PF00454	0.589
MOD_PIKK_1	650	656	PF00454	0.543
MOD_PIKK_1	688	694	PF00454	0.634
MOD_PIKK_1	888	894	PF00454	0.578
MOD_PKA_1	871	877	PF00069	0.494
MOD_PKA_2	123	129	PF00069	0.651
MOD_PKA_2	30	36	PF00069	0.714
MOD_PKA_2	363	369	PF00069	0.538
MOD_PKA_2	65	71	PF00069	0.728
MOD_PKA_2	871	877	PF00069	0.617
MOD_PKA_2	878	884	PF00069	0.599
MOD_PKB_1	15	23	PF00069	0.705
MOD_PKB_1	215	223	PF00069	0.430
MOD_Plk_1	248	254	PF00069	0.670
MOD_Plk_1	475	481	PF00069	0.641
MOD_Plk_2-3	128	134	PF00069	0.668
MOD_Plk_2-3	150	156	PF00069	0.665
MOD_Plk_4	143	149	PF00069	0.666
MOD_Plk_4	385	391	PF00069	0.573
MOD_Plk_4	468	474	PF00069	0.555
MOD_Plk_4	757	763	PF00069	0.658
MOD_ProDKin_1	112	118	PF00069	0.555
MOD_ProDKin_1	46	52	PF00069	0.695
MOD_ProDKin_1	54	60	PF00069	0.638
MOD_ProDKin_1	67	73	PF00069	0.719
MOD_ProDKin_1	779	785	PF00069	0.550
MOD_SUMO_rev_2	398	408	PF00179	0.416
MOD_SUMO_rev_2	908	916	PF00179	0.636
TRG_DiLeu_BaEn_1	262	267	PF01217	0.679
TRG_DiLeu_BaEn_1	725	730	PF01217	0.594
TRG_DiLeu_BaEn_4	863	869	PF01217	0.659
TRG_DiLeu_LyEn_5	725	730	PF01217	0.637
TRG_ENDOCYTIC_2	386	389	PF00928	0.560
TRG_ENDOCYTIC_2	412	415	PF00928	0.580
TRG_ENDOCYTIC_2	624	627	PF00928	0.405
TRG_ENDOCYTIC_2	708	711	PF00928	0.564
TRG_ENDOCYTIC_2	715	718	PF00928	0.508
TRG_ER_diArg_1	11	14	PF00400	0.737
TRG_ER_diArg_1	137	140	PF00400	0.545
TRG_ER_diArg_1	15	18	PF00400	0.667
TRG_ER_diArg_1	157	159	PF00400	0.342
TRG_ER_diArg_1	290	293	PF00400	0.635
TRG_ER_diArg_1	339	342	PF00400	0.517
TRG_ER_diArg_1	356	359	PF00400	0.571
TRG_ER_diArg_1	410	412	PF00400	0.566
TRG_ER_diArg_1	447	449	PF00400	0.626
TRG_ER_diArg_1	735	737	PF00400	0.521
TRG_ER_diArg_1	741	744	PF00400	0.542
TRG_ER_diArg_1	826	828	PF00400	0.564
TRG_ER_diArg_1	900	902	PF00400	0.572
TRG_NES_CRM1_1	89	100	PF08389	0.494
TRG_Pf-PMV_PEXEL_1	735	739	PF00026	0.484
TRG_Pf-PMV_PEXEL_1	900	904	PF00026	0.635

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB25	Leptomonas seymouri	56%	100%
A0A1X0NYM1	Trypanosomatidae	25%	100%
A0A3Q8ICZ1	Leishmania donovani	92%	100%
A0A3R7NTV6	Trypanosoma rangeli	29%	100%
A4HG80	Leishmania braziliensis	80%	100%
A4I3C1	Leishmania infantum	92%	100%
D0A834	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AZK0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BKX1	Trypanosoma cruzi	26%	100%