LeishMANIAdb
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Katanin p60 ATPase-containing subunit A1

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Katanin p60 ATPase-containing subunit A1
Gene product:
katanin, putative
Species:
Leishmania major
UniProt:
Q4Q8N0_LEIMA
TriTrypDb:
LmjF.28.0400 , LMJLV39_280009300 , LMJSD75_280009300 *
Length:
547

Annotations

LeishMANIAdb annotations

A large and likely artifical grouping of protease domain carrying proteins related to proteasomal proteases. Only a tiny subgroup (the AFG3-related mitochondrail proteins) seem to have a TM segment.. Localization: Cytoplasmic (by homology) / Mitochondrial (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
TermNameLevelCount
GO:0005737 cytoplasm 2 12
GO:0005856 cytoskeleton 5 2
GO:0005874 microtubule 6 12
GO:0015630 microtubule cytoskeleton 6 2
GO:0043226 organelle 2 2
GO:0043228 non-membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043232 intracellular non-membrane-bounded organelle 4 2
GO:0051286 cell tip 3 2
GO:0060187 cell pole 2 2
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Expansion

Sequence features

Q4Q8N0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8N0

Function

Biological processes
TermNameLevelCount
GO:0000226 microtubule cytoskeleton organization 3 12
GO:0006996 organelle organization 4 12
GO:0007010 cytoskeleton organization 5 12
GO:0007017 microtubule-based process 2 12
GO:0009987 cellular process 1 12
GO:0016043 cellular component organization 3 12
GO:0051013 microtubule severing 4 12
GO:0071840 cellular component organization or biogenesis 2 12
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Molecular functions
TermNameLevelCount
GO:0000166 nucleotide binding 3 12
GO:0003824 catalytic activity 1 12
GO:0005488 binding 1 12
GO:0005515 protein binding 2 12
GO:0005524 ATP binding 5 12
GO:0008017 microtubule binding 5 12
GO:0008092 cytoskeletal protein binding 3 12
GO:0008568 microtubule severing ATPase activity 2 12
GO:0015631 tubulin binding 4 12
GO:0016462 pyrophosphatase activity 5 12
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 362 366 PF00656 0.251
CLV_MEL_PAP_1 182 188 PF00089 0.483
CLV_NRD_NRD_1 293 295 PF00675 0.346
CLV_NRD_NRD_1 381 383 PF00675 0.225
CLV_NRD_NRD_1 420 422 PF00675 0.236
CLV_NRD_NRD_1 485 487 PF00675 0.236
CLV_NRD_NRD_1 86 88 PF00675 0.608
CLV_PCSK_KEX2_1 272 274 PF00082 0.465
CLV_PCSK_KEX2_1 293 295 PF00082 0.346
CLV_PCSK_KEX2_1 381 383 PF00082 0.225
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1HRH8 Leptomonas seymouri 68% 100%
A0A0S4IR32 Bodo saltans 41% 100%
A0A0S4IUM1 Bodo saltans 51% 92%
A0A1X0NYV7 Trypanosomatidae 57% 97%
A0A3Q8IJS0 Leishmania donovani 33% 100%
A0A3S7X163 Leishmania donovani 95% 100%
A0A3S7X2R4 Leishmania donovani 42% 100%
A0A422P1K0 Trypanosoma rangeli 57% 98%
A4HG81 Leishmania braziliensis 85% 100%
A4HPV3 Leishmania braziliensis 33% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS