LeishMANIAdb
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Katanin p60 ATPase-containing subunit A1

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Katanin p60 ATPase-containing subunit A1
Gene product:
katanin, putative
Species:
Leishmania major
UniProt:
Q4Q8N0_LEIMA
TriTrypDb:
LmjF.28.0400 , LMJLV39_280009300 , LMJSD75_280009300 *
Length:
547

Annotations

LeishMANIAdb annotations

A large and likely artifical grouping of protease domain carrying proteins related to proteasomal proteases. Only a tiny subgroup (the AFG3-related mitochondrail proteins) seem to have a TM segment.. Localization: Cytoplasmic (by homology) / Mitochondrial (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 12
GO:0005856 cytoskeleton 5 2
GO:0005874 microtubule 6 12
GO:0015630 microtubule cytoskeleton 6 2
GO:0043226 organelle 2 2
GO:0043228 non-membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043232 intracellular non-membrane-bounded organelle 4 2
GO:0051286 cell tip 3 2
GO:0060187 cell pole 2 2
GO:0099080 supramolecular complex 2 12
GO:0099081 supramolecular polymer 3 12
GO:0099512 supramolecular fiber 4 12
GO:0099513 polymeric cytoskeletal fiber 5 12
GO:0110165 cellular anatomical entity 1 12

Expansion

Sequence features

Q4Q8N0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8N0

Function

Biological processes
Term Name Level Count
GO:0000226 microtubule cytoskeleton organization 3 12
GO:0006996 organelle organization 4 12
GO:0007010 cytoskeleton organization 5 12
GO:0007017 microtubule-based process 2 12
GO:0009987 cellular process 1 12
GO:0016043 cellular component organization 3 12
GO:0051013 microtubule severing 4 12
GO:0071840 cellular component organization or biogenesis 2 12
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0003824 catalytic activity 1 12
GO:0005488 binding 1 12
GO:0005515 protein binding 2 12
GO:0005524 ATP binding 5 12
GO:0008017 microtubule binding 5 12
GO:0008092 cytoskeletal protein binding 3 12
GO:0008568 microtubule severing ATPase activity 2 12
GO:0015631 tubulin binding 4 12
GO:0016462 pyrophosphatase activity 5 12
GO:0016787 hydrolase activity 2 12
GO:0016817 hydrolase activity, acting on acid anhydrides 3 12
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 12
GO:0016853 isomerase activity 2 12
GO:0016887 ATP hydrolysis activity 7 12
GO:0017076 purine nucleotide binding 4 12
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 12
GO:0030554 adenyl nucleotide binding 5 12
GO:0032553 ribonucleotide binding 3 12
GO:0032555 purine ribonucleotide binding 4 12
GO:0032559 adenyl ribonucleotide binding 5 12
GO:0035639 purine ribonucleoside triphosphate binding 4 12
GO:0036094 small molecule binding 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0097159 organic cyclic compound binding 2 12
GO:0097367 carbohydrate derivative binding 2 12
GO:0140096 catalytic activity, acting on a protein 2 12
GO:0140657 ATP-dependent activity 1 12
GO:0140776 protein-containing complex destabilizing activity 1 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 362 366 PF00656 0.251
CLV_MEL_PAP_1 182 188 PF00089 0.483
CLV_NRD_NRD_1 293 295 PF00675 0.346
CLV_NRD_NRD_1 381 383 PF00675 0.225
CLV_NRD_NRD_1 420 422 PF00675 0.236
CLV_NRD_NRD_1 485 487 PF00675 0.236
CLV_NRD_NRD_1 86 88 PF00675 0.608
CLV_PCSK_KEX2_1 272 274 PF00082 0.465
CLV_PCSK_KEX2_1 293 295 PF00082 0.346
CLV_PCSK_KEX2_1 381 383 PF00082 0.225
CLV_PCSK_KEX2_1 419 421 PF00082 0.236
CLV_PCSK_KEX2_1 424 426 PF00082 0.236
CLV_PCSK_KEX2_1 485 487 PF00082 0.256
CLV_PCSK_KEX2_1 85 87 PF00082 0.592
CLV_PCSK_PC1ET2_1 272 274 PF00082 0.465
CLV_PCSK_PC1ET2_1 424 426 PF00082 0.236
CLV_PCSK_PC1ET2_1 85 87 PF00082 0.561
CLV_PCSK_PC7_1 420 426 PF00082 0.236
CLV_PCSK_SKI1_1 26 30 PF00082 0.495
CLV_PCSK_SKI1_1 272 276 PF00082 0.307
CLV_PCSK_SKI1_1 297 301 PF00082 0.236
CLV_PCSK_SKI1_1 309 313 PF00082 0.236
CLV_PCSK_SKI1_1 345 349 PF00082 0.236
CLV_PCSK_SKI1_1 381 385 PF00082 0.236
CLV_PCSK_SKI1_1 445 449 PF00082 0.395
CLV_PCSK_SKI1_1 486 490 PF00082 0.332
DEG_APCC_DBOX_1 435 443 PF00400 0.307
DEG_APCC_KENBOX_2 496 500 PF00400 0.381
DEG_Nend_UBRbox_3 1 3 PF02207 0.425
DOC_CYCLIN_RxL_1 342 349 PF00134 0.236
DOC_MAPK_gen_1 419 430 PF00069 0.251
DOC_MAPK_gen_1 445 455 PF00069 0.359
DOC_MAPK_gen_1 540 547 PF00069 0.454
DOC_MAPK_MEF2A_6 421 430 PF00069 0.236
DOC_PP1_RVXF_1 343 349 PF00149 0.236
DOC_PP4_FxxP_1 78 81 PF00568 0.523
DOC_USP7_MATH_1 162 166 PF00917 0.571
DOC_USP7_MATH_1 172 176 PF00917 0.430
DOC_USP7_MATH_1 184 188 PF00917 0.721
DOC_USP7_MATH_1 213 217 PF00917 0.646
DOC_USP7_MATH_1 315 319 PF00917 0.251
DOC_USP7_UBL2_3 11 15 PF12436 0.346
DOC_USP7_UBL2_3 441 445 PF12436 0.377
DOC_USP7_UBL2_3 489 493 PF12436 0.255
DOC_WW_Pin1_4 167 172 PF00397 0.540
DOC_WW_Pin1_4 325 330 PF00397 0.236
LIG_14-3-3_CanoR_1 116 122 PF00244 0.728
LIG_14-3-3_CanoR_1 160 169 PF00244 0.636
LIG_14-3-3_CanoR_1 185 195 PF00244 0.607
LIG_14-3-3_CanoR_1 96 106 PF00244 0.723
LIG_APCC_ABBA_1 75 80 PF00400 0.468
LIG_BRCT_BRCA1_1 169 173 PF00533 0.550
LIG_BRCT_BRCA1_1 356 360 PF00533 0.236
LIG_CtBP_PxDLS_1 511 515 PF00389 0.257
LIG_deltaCOP1_diTrp_1 537 543 PF00928 0.236
LIG_FHA_1 187 193 PF00498 0.586
LIG_FHA_1 232 238 PF00498 0.363
LIG_FHA_1 356 362 PF00498 0.236
LIG_FHA_1 396 402 PF00498 0.336
LIG_FHA_1 41 47 PF00498 0.399
LIG_FHA_1 442 448 PF00498 0.318
LIG_FHA_1 471 477 PF00498 0.251
LIG_FHA_2 259 265 PF00498 0.485
LIG_FHA_2 493 499 PF00498 0.343
LIG_FHA_2 69 75 PF00498 0.434
LIG_GBD_Chelix_1 245 253 PF00786 0.325
LIG_Integrin_RGD_1 337 339 PF01839 0.251
LIG_LIR_Gen_1 164 173 PF02991 0.539
LIG_LIR_Gen_1 261 268 PF02991 0.325
LIG_LIR_Gen_1 452 462 PF02991 0.273
LIG_LIR_Gen_1 52 61 PF02991 0.502
LIG_LIR_Nem_3 164 169 PF02991 0.553
LIG_LIR_Nem_3 261 265 PF02991 0.336
LIG_LIR_Nem_3 287 292 PF02991 0.355
LIG_LIR_Nem_3 322 327 PF02991 0.237
LIG_LIR_Nem_3 452 458 PF02991 0.257
LIG_LIR_Nem_3 52 57 PF02991 0.512
LIG_LYPXL_S_1 280 284 PF13949 0.316
LIG_LYPXL_yS_3 281 284 PF13949 0.321
LIG_MYND_1 282 286 PF01753 0.330
LIG_NRBOX 457 463 PF00104 0.301
LIG_PDZ_Class_2 542 547 PF00595 0.514
LIG_Pex14_1 539 543 PF04695 0.284
LIG_SH2_CRK 166 170 PF00017 0.681
LIG_SH2_CRK 289 293 PF00017 0.387
LIG_SH2_CRK 302 306 PF00017 0.190
LIG_SH2_CRK 32 36 PF00017 0.467
LIG_SH2_NCK_1 166 170 PF00017 0.552
LIG_SH2_PTP2 427 430 PF00017 0.236
LIG_SH2_SRC 354 357 PF00017 0.251
LIG_SH2_STAT5 22 25 PF00017 0.474
LIG_SH2_STAT5 427 430 PF00017 0.236
LIG_SH3_3 166 172 PF00018 0.620
LIG_SH3_3 194 200 PF00018 0.612
LIG_SH3_3 276 282 PF00018 0.301
LIG_TRAF2_1 240 243 PF00917 0.379
LIG_TYR_ITIM 279 284 PF00017 0.311
LIG_UBA3_1 439 445 PF00899 0.343
LIG_UBA3_1 481 489 PF00899 0.314
LIG_WW_3 182 186 PF00397 0.638
MOD_CK1_1 124 130 PF00069 0.569
MOD_CK1_1 174 180 PF00069 0.551
MOD_CK1_1 187 193 PF00069 0.446
MOD_CK1_1 216 222 PF00069 0.658
MOD_CK1_1 231 237 PF00069 0.526
MOD_CK1_1 328 334 PF00069 0.251
MOD_CK1_1 97 103 PF00069 0.685
MOD_CK2_1 492 498 PF00069 0.391
MOD_CK2_1 68 74 PF00069 0.498
MOD_CK2_1 96 102 PF00069 0.720
MOD_GlcNHglycan 123 126 PF01048 0.691
MOD_GlcNHglycan 174 177 PF01048 0.543
MOD_GlcNHglycan 179 182 PF01048 0.613
MOD_GlcNHglycan 192 195 PF01048 0.623
MOD_GlcNHglycan 216 219 PF01048 0.643
MOD_GlcNHglycan 230 233 PF01048 0.591
MOD_GlcNHglycan 467 470 PF01048 0.330
MOD_GlcNHglycan 99 102 PF01048 0.683
MOD_GSK3_1 117 124 PF00069 0.582
MOD_GSK3_1 167 174 PF00069 0.531
MOD_GSK3_1 184 191 PF00069 0.453
MOD_GSK3_1 315 322 PF00069 0.251
MOD_GSK3_1 49 56 PF00069 0.508
MOD_GSK3_1 519 526 PF00069 0.169
MOD_N-GLC_1 127 132 PF02516 0.531
MOD_N-GLC_1 320 325 PF02516 0.247
MOD_N-GLC_1 512 517 PF02516 0.257
MOD_N-GLC_1 94 99 PF02516 0.608
MOD_NEK2_1 1 6 PF00069 0.505
MOD_NEK2_1 121 126 PF00069 0.678
MOD_NEK2_1 405 410 PF00069 0.249
MOD_NEK2_2 31 36 PF00069 0.406
MOD_NEK2_2 320 325 PF00069 0.236
MOD_NEK2_2 480 485 PF00069 0.236
MOD_PIKK_1 456 462 PF00454 0.363
MOD_PIKK_1 49 55 PF00454 0.503
MOD_PIKK_1 68 74 PF00454 0.412
MOD_PK_1 188 194 PF00069 0.464
MOD_PKA_2 184 190 PF00069 0.636
MOD_PKA_2 68 74 PF00069 0.412
MOD_PKA_2 95 101 PF00069 0.696
MOD_Plk_1 127 133 PF00069 0.540
MOD_Plk_1 320 326 PF00069 0.295
MOD_Plk_1 491 497 PF00069 0.372
MOD_Plk_2-3 492 498 PF00069 0.454
MOD_Plk_4 307 313 PF00069 0.236
MOD_Plk_4 320 326 PF00069 0.236
MOD_Plk_4 355 361 PF00069 0.236
MOD_Plk_4 383 389 PF00069 0.251
MOD_Plk_4 53 59 PF00069 0.405
MOD_ProDKin_1 167 173 PF00069 0.524
MOD_ProDKin_1 325 331 PF00069 0.236
MOD_SUMO_rev_2 264 274 PF00179 0.335
TRG_DiLeu_BaEn_1 244 249 PF01217 0.342
TRG_DiLeu_BaEn_1 270 275 PF01217 0.344
TRG_DiLeu_BaEn_2 73 79 PF01217 0.534
TRG_DiLeu_LyEn_5 270 275 PF01217 0.455
TRG_ENDOCYTIC_2 166 169 PF00928 0.556
TRG_ENDOCYTIC_2 281 284 PF00928 0.321
TRG_ENDOCYTIC_2 289 292 PF00928 0.355
TRG_ENDOCYTIC_2 32 35 PF00928 0.340
TRG_ENDOCYTIC_2 427 430 PF00928 0.236
TRG_ER_diArg_1 224 227 PF00400 0.654
TRG_ER_diArg_1 292 294 PF00400 0.368
TRG_ER_diArg_1 418 421 PF00400 0.236
TRG_ER_diArg_1 484 486 PF00400 0.236
TRG_NLS_MonoCore_2 112 117 PF00514 0.675
TRG_NLS_MonoExtC_3 111 116 PF00514 0.612
TRG_NLS_MonoExtN_4 112 117 PF00514 0.613
TRG_Pf-PMV_PEXEL_1 272 276 PF00026 0.355
TRG_Pf-PMV_PEXEL_1 345 349 PF00026 0.236
TRG_Pf-PMV_PEXEL_1 44 48 PF00026 0.421
TRG_Pf-PMV_PEXEL_1 59 64 PF00026 0.353

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HRH8 Leptomonas seymouri 68% 100%
A0A0S4IR32 Bodo saltans 41% 100%
A0A0S4IUM1 Bodo saltans 51% 92%
A0A1X0NYV7 Trypanosomatidae 57% 97%
A0A3Q8IJS0 Leishmania donovani 33% 100%
A0A3S7X163 Leishmania donovani 95% 100%
A0A3S7X2R4 Leishmania donovani 42% 100%
A0A422P1K0 Trypanosoma rangeli 57% 98%
A4HG81 Leishmania braziliensis 85% 100%
A4HPV3 Leishmania braziliensis 33% 100%
A4I3C0 Leishmania infantum 95% 91%
A4I4W4 Leishmania infantum 42% 100%
A4IE38 Leishmania infantum 33% 100%
A9RA82 Papio anubis 50% 100%
B2RYN7 Rattus norvegicus 37% 94%
B3EX35 Sorex araneus 49% 100%
B3M301 Drosophila ananassae 41% 71%
B3P8A3 Drosophila erecta 40% 72%
B4G437 Drosophila persimilis 41% 69%
B4HGG6 Drosophila sechellia 40% 72%
B4NBP4 Drosophila willistoni 42% 70%
B4PL32 Drosophila yakuba 40% 72%
B4QSF0 Drosophila simulans 40% 72%
B4USW8 Otolemur garnettii 49% 100%
B7NZ88 Oryctolagus cuniculus 50% 100%
D0A833 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 56% 99%
E9AEB2 Leishmania major 42% 100%
E9ATM0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
E9AZK1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
O75449 Homo sapiens 49% 100%
Q05AS3 Xenopus tropicalis 38% 91%
Q0IIR9 Xenopus tropicalis 41% 100%
Q1HGK7 Gallus gallus 42% 100%
Q4Q0X8 Leishmania major 33% 100%
Q5ZK92 Gallus gallus 38% 89%
Q6AZT2 Xenopus laevis 38% 91%
Q8I0P1 Drosophila melanogaster 40% 72%
Q9BW62 Homo sapiens 50% 100%
Q9ERZ6 Mus musculus 30% 72%
Q9QYY8 Mus musculus 37% 89%
Q9SEX2 Arabidopsis thaliana 41% 100%
V5B0U7 Trypanosoma cruzi 54% 98%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS