C2H2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8M9_LEIMA

TriTrypDb:

LmjF.28.0410 , LMJLV39_280009400 , LMJSD75_280009400

Length:

655

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q8M9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8M9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	340	344	PF00656	0.705
CLV_C14_Caspase3-7	590	594	PF00656	0.627
CLV_NRD_NRD_1	203	205	PF00675	0.399
CLV_NRD_NRD_1	250	252	PF00675	0.420
CLV_NRD_NRD_1	265	267	PF00675	0.449
CLV_NRD_NRD_1	412	414	PF00675	0.617
CLV_NRD_NRD_1	506	508	PF00675	0.516
CLV_NRD_NRD_1	599	601	PF00675	0.627
CLV_NRD_NRD_1	651	653	PF00675	0.470
CLV_PCSK_KEX2_1	203	205	PF00082	0.399
CLV_PCSK_KEX2_1	250	252	PF00082	0.420
CLV_PCSK_KEX2_1	265	267	PF00082	0.449
CLV_PCSK_KEX2_1	506	508	PF00082	0.516
CLV_PCSK_KEX2_1	599	601	PF00082	0.627
CLV_PCSK_KEX2_1	650	652	PF00082	0.461
CLV_PCSK_SKI1_1	183	187	PF00082	0.476
CLV_PCSK_SKI1_1	25	29	PF00082	0.566
CLV_PCSK_SKI1_1	366	370	PF00082	0.758
DEG_APCC_DBOX_1	203	211	PF00400	0.469
DEG_APCC_DBOX_1	269	277	PF00400	0.469
DEG_APCC_DBOX_1	365	373	PF00400	0.653
DEG_APCC_DBOX_1	453	461	PF00400	0.469
DEG_SPOP_SBC_1	400	404	PF00917	0.619
DEG_SPOP_SBC_1	493	497	PF00917	0.584
DEG_SPOP_SBC_1	62	66	PF00917	0.616
DOC_CKS1_1	286	291	PF01111	0.592
DOC_CYCLIN_RxL_1	363	373	PF00134	0.644
DOC_CYCLIN_yClb5_NLxxxL_5	566	575	PF00134	0.488
DOC_CYCLIN_yCln2_LP_2	368	371	PF00134	0.577
DOC_MAPK_gen_1	413	420	PF00069	0.546
DOC_MAPK_gen_1	506	514	PF00069	0.539
DOC_MAPK_gen_1	611	619	PF00069	0.484
DOC_MAPK_MEF2A_6	161	170	PF00069	0.462
DOC_MAPK_MEF2A_6	519	527	PF00069	0.531
DOC_PP2B_LxvP_1	368	371	PF13499	0.577
DOC_PP4_FxxP_1	239	242	PF00568	0.378
DOC_PP4_FxxP_1	97	100	PF00568	0.652
DOC_USP7_MATH_1	127	131	PF00917	0.597
DOC_USP7_MATH_1	133	137	PF00917	0.674
DOC_USP7_MATH_1	212	216	PF00917	0.427
DOC_USP7_MATH_1	324	328	PF00917	0.650
DOC_USP7_MATH_1	337	341	PF00917	0.822
DOC_USP7_MATH_1	395	399	PF00917	0.624
DOC_USP7_MATH_1	400	404	PF00917	0.642
DOC_USP7_MATH_1	46	50	PF00917	0.703
DOC_USP7_MATH_1	485	489	PF00917	0.549
DOC_USP7_MATH_1	57	61	PF00917	0.607
DOC_USP7_MATH_1	589	593	PF00917	0.631
DOC_USP7_MATH_1	63	67	PF00917	0.592
DOC_USP7_MATH_1	72	76	PF00917	0.530
DOC_USP7_UBL2_3	157	161	PF12436	0.487
DOC_USP7_UBL2_3	90	94	PF12436	0.770
DOC_WW_Pin1_4	135	140	PF00397	0.520
DOC_WW_Pin1_4	285	290	PF00397	0.549
DOC_WW_Pin1_4	317	322	PF00397	0.711
DOC_WW_Pin1_4	345	350	PF00397	0.637
DOC_WW_Pin1_4	462	467	PF00397	0.601
DOC_WW_Pin1_4	514	519	PF00397	0.467
DOC_WW_Pin1_4	53	58	PF00397	0.618
DOC_WW_Pin1_4	536	541	PF00397	0.544
LIG_14-3-3_CanoR_1	119	127	PF00244	0.602
LIG_14-3-3_CanoR_1	394	400	PF00244	0.731
LIG_14-3-3_CanoR_1	413	418	PF00244	0.423
LIG_14-3-3_CanoR_1	474	482	PF00244	0.676
LIG_14-3-3_CanoR_1	599	608	PF00244	0.616
LIG_14-3-3_CanoR_1	611	617	PF00244	0.353
LIG_BIR_II_1	1	5	PF00653	0.654
LIG_BIR_III_4	588	592	PF00653	0.636
LIG_BRCT_BRCA1_1	296	300	PF00533	0.634
LIG_DLG_GKlike_1	413	420	PF00625	0.551
LIG_FHA_1	107	113	PF00498	0.615
LIG_FHA_1	163	169	PF00498	0.427
LIG_FHA_1	18	24	PF00498	0.470
LIG_FHA_1	211	217	PF00498	0.446
LIG_FHA_1	286	292	PF00498	0.518
LIG_FHA_1	30	36	PF00498	0.503
LIG_FHA_1	346	352	PF00498	0.543
LIG_FHA_1	57	63	PF00498	0.658
LIG_FHA_1	596	602	PF00498	0.671
LIG_FHA_2	200	206	PF00498	0.417
LIG_FHA_2	270	276	PF00498	0.469
LIG_FHA_2	297	303	PF00498	0.804
LIG_FHA_2	371	377	PF00498	0.664
LIG_FHA_2	463	469	PF00498	0.597
LIG_FHA_2	495	501	PF00498	0.478
LIG_LIR_Apic_2	19	24	PF02991	0.472
LIG_LIR_Apic_2	238	242	PF02991	0.372
LIG_LIR_Apic_2	96	100	PF02991	0.653
LIG_LIR_Gen_1	416	421	PF02991	0.437
LIG_LIR_Gen_1	431	440	PF02991	0.411
LIG_LIR_Nem_3	220	226	PF02991	0.555
LIG_LIR_Nem_3	228	234	PF02991	0.376
LIG_LIR_Nem_3	391	396	PF02991	0.600
LIG_LIR_Nem_3	416	420	PF02991	0.445
LIG_LIR_Nem_3	563	568	PF02991	0.414
LIG_LIR_Nem_3	602	608	PF02991	0.536
LIG_LIR_Nem_3	621	626	PF02991	0.339
LIG_LIR_Nem_3	88	92	PF02991	0.597
LIG_LYPXL_yS_3	605	608	PF13949	0.524
LIG_MYND_1	367	371	PF01753	0.573
LIG_Pex14_2	196	200	PF04695	0.391
LIG_PTAP_UEV_1	42	47	PF05743	0.642
LIG_Rb_LxCxE_1	557	573	PF01857	0.493
LIG_SH2_CRK	223	227	PF00017	0.529
LIG_SH2_CRK	231	235	PF00017	0.375
LIG_SH2_CRK	552	556	PF00017	0.392
LIG_SH2_CRK	568	572	PF00017	0.409
LIG_SH2_GRB2like	219	222	PF00017	0.616
LIG_SH2_NCK_1	92	96	PF00017	0.652
LIG_SH2_PTP2	21	24	PF00017	0.463
LIG_SH2_PTP2	417	420	PF00017	0.440
LIG_SH2_STAP1	219	223	PF00017	0.720
LIG_SH2_STAP1	562	566	PF00017	0.467
LIG_SH2_STAT5	201	204	PF00017	0.436
LIG_SH2_STAT5	206	209	PF00017	0.425
LIG_SH2_STAT5	21	24	PF00017	0.479
LIG_SH2_STAT5	223	226	PF00017	0.445
LIG_SH2_STAT5	417	420	PF00017	0.440
LIG_SH2_STAT5	449	452	PF00017	0.428
LIG_SH2_STAT5	630	633	PF00017	0.396
LIG_SH3_2	181	186	PF14604	0.495
LIG_SH3_3	10	16	PF00018	0.581
LIG_SH3_3	178	184	PF00018	0.408
LIG_SH3_3	283	289	PF00018	0.569
LIG_SH3_3	318	324	PF00018	0.653
LIG_SH3_3	344	350	PF00018	0.579
LIG_SH3_3	364	370	PF00018	0.721
LIG_SH3_3	40	46	PF00018	0.676
LIG_SH3_3	458	464	PF00018	0.523
LIG_SH3_3	47	53	PF00018	0.602
LIG_SH3_3	512	518	PF00018	0.472
LIG_SUMO_SIM_anti_2	520	526	PF11976	0.446
LIG_SUMO_SIM_par_1	487	497	PF11976	0.566
LIG_TYR_ITIM	229	234	PF00017	0.411
LIG_TYR_ITIM	566	571	PF00017	0.486
MOD_CDK_SPK_2	514	519	PF00069	0.543
MOD_CDK_SPxK_1	135	141	PF00069	0.474
MOD_CK1_1	162	168	PF00069	0.386
MOD_CK1_1	296	302	PF00069	0.698
MOD_CK1_1	304	310	PF00069	0.645
MOD_CK1_1	317	323	PF00069	0.675
MOD_CK1_1	358	364	PF00069	0.609
MOD_CK1_1	402	408	PF00069	0.710
MOD_CK1_1	470	476	PF00069	0.626
MOD_CK1_1	492	498	PF00069	0.443
MOD_CK1_1	517	523	PF00069	0.461
MOD_CK1_1	55	61	PF00069	0.682
MOD_CK1_1	592	598	PF00069	0.645
MOD_CK1_1	64	70	PF00069	0.624
MOD_CK2_1	41	47	PF00069	0.617
MOD_CK2_1	428	434	PF00069	0.484
MOD_CK2_1	462	468	PF00069	0.618
MOD_CK2_1	626	632	PF00069	0.439
MOD_GlcNHglycan	101	104	PF01048	0.614
MOD_GlcNHglycan	121	124	PF01048	0.650
MOD_GlcNHglycan	160	164	PF01048	0.411
MOD_GlcNHglycan	296	299	PF01048	0.610
MOD_GlcNHglycan	339	342	PF01048	0.693
MOD_GlcNHglycan	357	360	PF01048	0.536
MOD_GlcNHglycan	386	389	PF01048	0.680
MOD_GlcNHglycan	390	393	PF01048	0.785
MOD_GlcNHglycan	43	46	PF01048	0.695
MOD_GlcNHglycan	468	472	PF01048	0.689
MOD_GlcNHglycan	487	490	PF01048	0.593
MOD_GlcNHglycan	59	62	PF01048	0.621
MOD_GlcNHglycan	632	635	PF01048	0.453
MOD_GlcNHglycan	66	69	PF01048	0.676
MOD_GSK3_1	217	224	PF00069	0.555
MOD_GSK3_1	294	301	PF00069	0.630
MOD_GSK3_1	304	311	PF00069	0.712
MOD_GSK3_1	380	387	PF00069	0.614
MOD_GSK3_1	395	402	PF00069	0.546
MOD_GSK3_1	440	447	PF00069	0.453
MOD_GSK3_1	470	477	PF00069	0.656
MOD_GSK3_1	485	492	PF00069	0.518
MOD_GSK3_1	513	520	PF00069	0.586
MOD_GSK3_1	52	59	PF00069	0.643
MOD_GSK3_1	532	539	PF00069	0.407
MOD_GSK3_1	575	582	PF00069	0.472
MOD_GSK3_1	595	602	PF00069	0.434
MOD_GSK3_1	626	633	PF00069	0.437
MOD_GSK3_1	72	79	PF00069	0.558
MOD_N-GLC_1	217	222	PF02516	0.611
MOD_N-GLC_1	293	298	PF02516	0.633
MOD_N-GLC_2	147	149	PF02516	0.393
MOD_NEK2_1	148	153	PF00069	0.466
MOD_NEK2_1	159	164	PF00069	0.366
MOD_NEK2_1	17	22	PF00069	0.540
MOD_NEK2_1	27	32	PF00069	0.437
MOD_NEK2_1	300	305	PF00069	0.660
MOD_NEK2_1	308	313	PF00069	0.622
MOD_NEK2_1	380	385	PF00069	0.665
MOD_NEK2_1	428	433	PF00069	0.400
MOD_NEK2_1	575	580	PF00069	0.453
MOD_NEK2_2	212	217	PF00069	0.435
MOD_PIKK_1	395	401	PF00454	0.616
MOD_PIKK_1	474	480	PF00454	0.583
MOD_PKA_1	413	419	PF00069	0.566
MOD_PKA_1	599	605	PF00069	0.621
MOD_PKA_2	118	124	PF00069	0.600
MOD_PKA_2	269	275	PF00069	0.474
MOD_PKA_2	473	479	PF00069	0.681
MOD_PKA_2	599	605	PF00069	0.576
MOD_PKB_1	39	47	PF00069	0.604
MOD_Plk_1	104	110	PF00069	0.605
MOD_Plk_1	301	307	PF00069	0.588
MOD_Plk_1	380	386	PF00069	0.664
MOD_Plk_1	46	52	PF00069	0.631
MOD_Plk_1	592	598	PF00069	0.612
MOD_Plk_2-3	88	94	PF00069	0.600
MOD_Plk_4	17	23	PF00069	0.507
MOD_Plk_4	358	364	PF00069	0.578
MOD_Plk_4	413	419	PF00069	0.490
MOD_ProDKin_1	135	141	PF00069	0.513
MOD_ProDKin_1	285	291	PF00069	0.557
MOD_ProDKin_1	317	323	PF00069	0.713
MOD_ProDKin_1	345	351	PF00069	0.626
MOD_ProDKin_1	462	468	PF00069	0.609
MOD_ProDKin_1	514	520	PF00069	0.465
MOD_ProDKin_1	53	59	PF00069	0.620
MOD_ProDKin_1	536	542	PF00069	0.548
MOD_SUMO_for_1	185	188	PF00179	0.472
TRG_DiLeu_BaLyEn_6	364	369	PF01217	0.573
TRG_ENDOCYTIC_2	197	200	PF00928	0.402
TRG_ENDOCYTIC_2	223	226	PF00928	0.535
TRG_ENDOCYTIC_2	231	234	PF00928	0.371
TRG_ENDOCYTIC_2	417	420	PF00928	0.440
TRG_ENDOCYTIC_2	562	565	PF00928	0.391
TRG_ENDOCYTIC_2	568	571	PF00928	0.410
TRG_ENDOCYTIC_2	605	608	PF00928	0.529
TRG_ER_diArg_1	174	177	PF00400	0.454
TRG_ER_diArg_1	249	251	PF00400	0.398
TRG_ER_diArg_1	505	507	PF00400	0.528
TRG_ER_diArg_1	599	601	PF00400	0.627
TRG_ER_diArg_1	649	652	PF00400	0.461
TRG_Pf-PMV_PEXEL_1	394	399	PF00026	0.622

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3E5	Leptomonas seymouri	50%	96%
A0A3S7X161	Leishmania donovani	96%	100%
A4HG82	Leishmania braziliensis	82%	100%
A4I3A7	Leishmania infantum	96%	100%
E9AZK2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%