Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8M8_LEIMA

TriTrypDb:

LmjF.28.0430 , LMJLV39_280009700 , LMJSD75_280009700

Length:

426

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8M8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8M8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	88	92	PF00656	0.486
CLV_PCSK_KEX2_1	115	117	PF00082	0.494
CLV_PCSK_KEX2_1	70	72	PF00082	0.471
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.494
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.471
CLV_PCSK_SKI1_1	122	126	PF00082	0.465
CLV_PCSK_SKI1_1	281	285	PF00082	0.415
CLV_PCSK_SKI1_1	327	331	PF00082	0.380
CLV_PCSK_SKI1_1	372	376	PF00082	0.427
CLV_PCSK_SKI1_1	389	393	PF00082	0.321
CLV_PCSK_SKI1_1	39	43	PF00082	0.432
CLV_PCSK_SKI1_1	8	12	PF00082	0.473
DEG_APCC_DBOX_1	106	114	PF00400	0.303
DEG_SCF_FBW7_1	254	259	PF00400	0.643
DOC_CKS1_1	185	190	PF01111	0.491
DOC_MAPK_gen_1	276	285	PF00069	0.557
DOC_MAPK_gen_1	380	388	PF00069	0.552
DOC_MAPK_gen_1	8	18	PF00069	0.463
DOC_MAPK_MEF2A_6	313	320	PF00069	0.511
DOC_USP7_MATH_1	249	253	PF00917	0.588
DOC_USP7_MATH_1	264	268	PF00917	0.665
DOC_USP7_MATH_1	297	301	PF00917	0.475
DOC_USP7_MATH_1	34	38	PF00917	0.484
DOC_USP7_MATH_1	358	362	PF00917	0.475
DOC_USP7_UBL2_3	406	410	PF12436	0.562
DOC_USP7_UBL2_3	66	70	PF12436	0.466
DOC_WW_Pin1_4	184	189	PF00397	0.488
DOC_WW_Pin1_4	252	257	PF00397	0.744
LIG_14-3-3_CanoR_1	231	239	PF00244	0.629
LIG_14-3-3_CanoR_1	240	248	PF00244	0.553
LIG_14-3-3_CanoR_1	281	286	PF00244	0.563
LIG_14-3-3_CanoR_1	350	354	PF00244	0.495
LIG_14-3-3_CanoR_1	382	387	PF00244	0.334
LIG_14-3-3_CanoR_1	82	87	PF00244	0.492
LIG_APCC_ABBA_1	22	27	PF00400	0.338
LIG_BIR_II_1	1	5	PF00653	0.558
LIG_BRCT_BRCA1_1	384	388	PF00533	0.472
LIG_BRCT_BRCA1_1	54	58	PF00533	0.523
LIG_FHA_1	101	107	PF00498	0.437
LIG_FHA_1	205	211	PF00498	0.469
LIG_FHA_1	219	225	PF00498	0.310
LIG_FHA_1	253	259	PF00498	0.744
LIG_FHA_1	307	313	PF00498	0.341
LIG_FHA_1	366	372	PF00498	0.510
LIG_FHA_1	63	69	PF00498	0.404
LIG_FHA_2	185	191	PF00498	0.542
LIG_FHA_2	240	246	PF00498	0.760
LIG_FHA_2	410	416	PF00498	0.309
LIG_LIR_Apic_2	184	188	PF02991	0.484
LIG_LIR_Gen_1	325	332	PF02991	0.433
LIG_LIR_Gen_1	334	343	PF02991	0.307
LIG_LIR_Gen_1	83	91	PF02991	0.458
LIG_LIR_Nem_3	325	331	PF02991	0.438
LIG_LIR_Nem_3	334	340	PF02991	0.308
LIG_LIR_Nem_3	385	391	PF02991	0.429
LIG_LIR_Nem_3	55	61	PF02991	0.408
LIG_LIR_Nem_3	83	89	PF02991	0.449
LIG_SH2_CRK	185	189	PF00017	0.490
LIG_SH2_NCK_1	185	189	PF00017	0.565
LIG_SH2_STAP1	195	199	PF00017	0.496
LIG_SH2_STAP1	308	312	PF00017	0.448
LIG_SH2_STAT5	185	188	PF00017	0.487
LIG_SH2_STAT5	195	198	PF00017	0.409
LIG_SH2_STAT5	25	28	PF00017	0.420
LIG_SH2_STAT5	308	311	PF00017	0.487
LIG_SH3_3	221	227	PF00018	0.450
LIG_SH3_4	410	417	PF00018	0.461
LIG_SH3_4	50	57	PF00018	0.493
LIG_SUMO_SIM_anti_2	20	25	PF11976	0.257
LIG_TYR_ITIM	23	28	PF00017	0.253
LIG_UBA3_1	398	406	PF00899	0.378
MOD_CK1_1	120	126	PF00069	0.441
MOD_CK1_1	184	190	PF00069	0.571
MOD_CK1_1	252	258	PF00069	0.673
MOD_CK1_1	300	306	PF00069	0.671
MOD_CK1_1	37	43	PF00069	0.438
MOD_CK1_1	384	390	PF00069	0.400
MOD_CK1_1	402	408	PF00069	0.357
MOD_CK1_1	44	50	PF00069	0.430
MOD_CK2_1	184	190	PF00069	0.496
MOD_CK2_1	358	364	PF00069	0.469
MOD_CK2_1	384	390	PF00069	0.481
MOD_CK2_1	409	415	PF00069	0.312
MOD_GlcNHglycan	119	122	PF01048	0.514
MOD_GlcNHglycan	251	254	PF01048	0.753
MOD_GlcNHglycan	261	264	PF01048	0.673
MOD_GlcNHglycan	266	269	PF01048	0.653
MOD_GlcNHglycan	299	302	PF01048	0.672
MOD_GlcNHglycan	324	327	PF01048	0.451
MOD_GlcNHglycan	36	39	PF01048	0.462
MOD_GlcNHglycan	46	49	PF01048	0.429
MOD_GlcNHglycan	54	57	PF01048	0.491
MOD_GSK3_1	248	255	PF00069	0.744
MOD_GSK3_1	264	271	PF00069	0.442
MOD_GSK3_1	281	288	PF00069	0.504
MOD_GSK3_1	302	309	PF00069	0.541
MOD_GSK3_1	316	323	PF00069	0.360
MOD_GSK3_1	327	334	PF00069	0.350
MOD_GSK3_1	33	40	PF00069	0.454
MOD_GSK3_1	390	397	PF00069	0.493
MOD_GSK3_1	80	87	PF00069	0.428
MOD_N-GLC_1	264	269	PF02516	0.696
MOD_N-GLC_1	281	286	PF02516	0.491
MOD_NEK2_1	117	122	PF00069	0.532
MOD_NEK2_1	125	130	PF00069	0.359
MOD_NEK2_1	154	159	PF00069	0.584
MOD_NEK2_1	181	186	PF00069	0.550
MOD_NEK2_1	191	196	PF00069	0.515
MOD_NEK2_1	218	223	PF00069	0.398
MOD_NEK2_1	320	325	PF00069	0.469
MOD_NEK2_1	42	47	PF00069	0.422
MOD_NEK2_1	52	57	PF00069	0.394
MOD_NEK2_1	81	86	PF00069	0.471
MOD_NEK2_2	349	354	PF00069	0.443
MOD_PIKK_1	171	177	PF00454	0.537
MOD_PIKK_1	256	262	PF00454	0.701
MOD_PIKK_1	300	306	PF00454	0.563
MOD_PKA_2	239	245	PF00069	0.696
MOD_PKA_2	349	355	PF00069	0.534
MOD_PKA_2	381	387	PF00069	0.339
MOD_PKA_2	81	87	PF00069	0.485
MOD_Plk_1	234	240	PF00069	0.751
MOD_Plk_1	281	287	PF00069	0.453
MOD_Plk_4	120	126	PF00069	0.406
MOD_Plk_4	17	23	PF00069	0.469
MOD_Plk_4	218	224	PF00069	0.394
MOD_Plk_4	37	43	PF00069	0.425
MOD_Plk_4	394	400	PF00069	0.550
MOD_ProDKin_1	184	190	PF00069	0.484
MOD_ProDKin_1	252	258	PF00069	0.742
MOD_SUMO_rev_2	2	10	PF00179	0.592
MOD_SUMO_rev_2	243	249	PF00179	0.767
MOD_SUMO_rev_2	271	280	PF00179	0.637
TRG_ENDOCYTIC_2	147	150	PF00928	0.413
TRG_ENDOCYTIC_2	25	28	PF00928	0.364
TRG_NES_CRM1_1	390	403	PF08389	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJS3	Leptomonas seymouri	54%	100%
A0A0S4KFQ7	Bodo saltans	28%	100%
A0A1X0NYM7	Trypanosomatidae	30%	87%
A0A3R7KQG6	Trypanosoma rangeli	39%	95%
A0A3S7X164	Leishmania donovani	91%	100%
A4I3A5	Leishmania infantum	91%	100%
D0A828	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AZK3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5B0U4	Trypanosoma cruzi	34%	90%