Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8M7_LEIMA

TriTrypDb:

LmjF.28.0440 , LMJLV39_280009800 , LMJSD75_280009800

Length:

774

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8M7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8M7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	151	155	PF00656	0.576
CLV_C14_Caspase3-7	284	288	PF00656	0.369
CLV_NRD_NRD_1	177	179	PF00675	0.523
CLV_NRD_NRD_1	275	277	PF00675	0.620
CLV_NRD_NRD_1	348	350	PF00675	0.439
CLV_NRD_NRD_1	372	374	PF00675	0.313
CLV_NRD_NRD_1	481	483	PF00675	0.583
CLV_NRD_NRD_1	493	495	PF00675	0.645
CLV_NRD_NRD_1	630	632	PF00675	0.481
CLV_PCSK_KEX2_1	177	179	PF00082	0.579
CLV_PCSK_KEX2_1	275	277	PF00082	0.593
CLV_PCSK_KEX2_1	307	309	PF00082	0.325
CLV_PCSK_KEX2_1	371	373	PF00082	0.315
CLV_PCSK_KEX2_1	570	572	PF00082	0.563
CLV_PCSK_KEX2_1	629	631	PF00082	0.458
CLV_PCSK_PC1ET2_1	307	309	PF00082	0.325
CLV_PCSK_PC1ET2_1	570	572	PF00082	0.563
CLV_PCSK_SKI1_1	158	162	PF00082	0.548
CLV_PCSK_SKI1_1	163	167	PF00082	0.484
CLV_PCSK_SKI1_1	455	459	PF00082	0.536
DEG_APCC_DBOX_1	348	356	PF00400	0.303
DOC_CKS1_1	503	508	PF01111	0.536
DOC_CKS1_1	654	659	PF01111	0.600
DOC_CYCLIN_yCln2_LP_2	443	449	PF00134	0.578
DOC_CYCLIN_yCln2_LP_2	503	509	PF00134	0.546
DOC_MAPK_gen_1	275	282	PF00069	0.570
DOC_MAPK_gen_1	583	592	PF00069	0.530
DOC_MAPK_gen_1	6	15	PF00069	0.745
DOC_MAPK_MEF2A_6	439	447	PF00069	0.576
DOC_MAPK_MEF2A_6	583	592	PF00069	0.482
DOC_MAPK_MEF2A_6	6	15	PF00069	0.624
DOC_MAPK_MEF2A_6	681	688	PF00069	0.566
DOC_PP1_RVXF_1	10	16	PF00149	0.626
DOC_PP2B_LxvP_1	443	446	PF13499	0.577
DOC_PP2B_LxvP_1	518	521	PF13499	0.458
DOC_PP2B_LxvP_1	605	608	PF13499	0.482
DOC_PP4_FxxP_1	212	215	PF00568	0.587
DOC_USP7_MATH_1	102	106	PF00917	0.656
DOC_USP7_MATH_1	144	148	PF00917	0.584
DOC_USP7_MATH_1	183	187	PF00917	0.626
DOC_USP7_MATH_1	237	241	PF00917	0.570
DOC_USP7_MATH_1	249	253	PF00917	0.758
DOC_USP7_MATH_1	29	33	PF00917	0.683
DOC_USP7_MATH_1	387	391	PF00917	0.237
DOC_USP7_MATH_1	546	550	PF00917	0.575
DOC_USP7_MATH_1	576	580	PF00917	0.643
DOC_USP7_MATH_1	706	710	PF00917	0.697
DOC_USP7_MATH_1	716	720	PF00917	0.490
DOC_USP7_MATH_1	738	742	PF00917	0.543
DOC_USP7_MATH_1	765	769	PF00917	0.455
DOC_USP7_UBL2_3	8	12	PF12436	0.604
DOC_WW_Pin1_4	106	111	PF00397	0.633
DOC_WW_Pin1_4	126	131	PF00397	0.467
DOC_WW_Pin1_4	153	158	PF00397	0.600
DOC_WW_Pin1_4	25	30	PF00397	0.652
DOC_WW_Pin1_4	339	344	PF00397	0.304
DOC_WW_Pin1_4	411	416	PF00397	0.566
DOC_WW_Pin1_4	489	494	PF00397	0.690
DOC_WW_Pin1_4	502	507	PF00397	0.620
DOC_WW_Pin1_4	616	621	PF00397	0.636
DOC_WW_Pin1_4	653	658	PF00397	0.597
DOC_WW_Pin1_4	702	707	PF00397	0.524
LIG_14-3-3_CanoR_1	148	153	PF00244	0.491
LIG_14-3-3_CanoR_1	163	168	PF00244	0.450
LIG_14-3-3_CanoR_1	197	203	PF00244	0.488
LIG_14-3-3_CanoR_1	373	383	PF00244	0.383
LIG_14-3-3_CanoR_1	501	506	PF00244	0.447
LIG_14-3-3_CanoR_1	574	584	PF00244	0.580
LIG_14-3-3_CanoR_1	646	654	PF00244	0.562
LIG_14-3-3_CanoR_1	710	718	PF00244	0.633
LIG_14-3-3_CanoR_1	735	744	PF00244	0.535
LIG_14-3-3_CanoR_1	84	92	PF00244	0.545
LIG_Actin_WH2_2	298	315	PF00022	0.304
LIG_Actin_WH2_2	359	377	PF00022	0.369
LIG_APCC_ABBA_1	528	533	PF00400	0.508
LIG_BIR_II_1	1	5	PF00653	0.566
LIG_BIR_III_2	154	158	PF00653	0.560
LIG_BIR_III_3	1	5	PF00653	0.566
LIG_BIR_III_4	16	20	PF00653	0.568
LIG_BIR_III_4	508	512	PF00653	0.438
LIG_BRCT_BRCA1_1	195	199	PF00533	0.529
LIG_BRCT_BRCA1_1	664	668	PF00533	0.604
LIG_Clathr_ClatBox_1	602	606	PF01394	0.470
LIG_Clathr_ClatBox_1	623	627	PF01394	0.581
LIG_CSL_BTD_1	518	521	PF09270	0.458
LIG_EVH1_2	620	624	PF00568	0.508
LIG_FHA_1	333	339	PF00498	0.369
LIG_FHA_1	392	398	PF00498	0.369
LIG_FHA_1	435	441	PF00498	0.531
LIG_FHA_1	465	471	PF00498	0.597
LIG_FHA_1	498	504	PF00498	0.586
LIG_FHA_1	649	655	PF00498	0.693
LIG_FHA_1	703	709	PF00498	0.686
LIG_FHA_2	220	226	PF00498	0.619
LIG_FHA_2	343	349	PF00498	0.439
LIG_FHA_2	400	406	PF00498	0.237
LIG_FHA_2	503	509	PF00498	0.503
LIG_FHA_2	552	558	PF00498	0.634
LIG_FHA_2	728	734	PF00498	0.508
LIG_GBD_Chelix_1	164	172	PF00786	0.448
LIG_Integrin_RGD_1	681	683	PF01839	0.532
LIG_LIR_Apic_2	210	215	PF02991	0.613
LIG_LIR_Apic_2	223	229	PF02991	0.663
LIG_LIR_Gen_1	166	176	PF02991	0.486
LIG_LIR_Gen_1	196	207	PF02991	0.500
LIG_LIR_Gen_1	221	230	PF02991	0.606
LIG_LIR_Gen_1	353	363	PF02991	0.283
LIG_LIR_Gen_1	687	696	PF02991	0.525
LIG_LIR_Nem_3	166	172	PF02991	0.483
LIG_LIR_Nem_3	196	202	PF02991	0.515
LIG_LIR_Nem_3	221	227	PF02991	0.675
LIG_LIR_Nem_3	353	359	PF02991	0.283
LIG_LIR_Nem_3	665	671	PF02991	0.574
LIG_LIR_Nem_3	687	691	PF02991	0.490
LIG_NRBOX	167	173	PF00104	0.509
LIG_PDZ_Class_3	769	774	PF00595	0.417
LIG_PTB_Apo_2	206	213	PF02174	0.521
LIG_SH2_CRK	169	173	PF00017	0.470
LIG_SH2_CRK	277	281	PF00017	0.629
LIG_SH2_NCK_1	41	45	PF00017	0.601
LIG_SH2_SRC	531	534	PF00017	0.523
LIG_SH2_STAP1	116	120	PF00017	0.534
LIG_SH2_STAP1	383	387	PF00017	0.369
LIG_SH2_STAP1	41	45	PF00017	0.665
LIG_SH2_STAP1	614	618	PF00017	0.399
LIG_SH2_STAT5	175	178	PF00017	0.585
LIG_SH3_1	268	274	PF00018	0.633
LIG_SH3_2	270	275	PF14604	0.664
LIG_SH3_3	23	29	PF00018	0.620
LIG_SH3_3	251	257	PF00018	0.593
LIG_SH3_3	267	273	PF00018	0.573
LIG_SH3_3	524	530	PF00018	0.548
LIG_SH3_3	589	595	PF00018	0.585
LIG_SH3_3	651	657	PF00018	0.593
LIG_SH3_3	712	718	PF00018	0.561
LIG_SH3_CIN85_PxpxPR_1	270	275	PF14604	0.656
LIG_SUMO_SIM_anti_2	278	284	PF11976	0.606
LIG_SUMO_SIM_par_1	393	402	PF11976	0.304
LIG_TYR_ITIM	167	172	PF00017	0.464
LIG_WW_3	272	276	PF00397	0.576
MOD_CDK_SPK_2	153	158	PF00069	0.600
MOD_CDK_SPK_2	489	494	PF00069	0.618
MOD_CDK_SPxK_1	489	495	PF00069	0.618
MOD_CDK_SPxK_1	653	659	PF00069	0.625
MOD_CDK_SPxxK_3	339	346	PF00069	0.304
MOD_CK1_1	153	159	PF00069	0.568
MOD_CK1_1	281	287	PF00069	0.516
MOD_CK1_1	342	348	PF00069	0.315
MOD_CK1_1	579	585	PF00069	0.513
MOD_CK1_1	647	653	PF00069	0.559
MOD_CK1_1	662	668	PF00069	0.588
MOD_CK1_1	699	705	PF00069	0.635
MOD_CK1_1	97	103	PF00069	0.590
MOD_CK2_1	183	189	PF00069	0.626
MOD_CK2_1	399	405	PF00069	0.294
MOD_CK2_1	727	733	PF00069	0.548
MOD_GlcNHglycan	2	5	PF01048	0.629
MOD_GlcNHglycan	204	207	PF01048	0.524
MOD_GlcNHglycan	239	242	PF01048	0.696
MOD_GlcNHglycan	251	254	PF01048	0.545
MOD_GlcNHglycan	31	34	PF01048	0.556
MOD_GlcNHglycan	389	392	PF01048	0.418
MOD_GlcNHglycan	407	410	PF01048	0.584
MOD_GlcNHglycan	455	458	PF01048	0.709
MOD_GlcNHglycan	660	664	PF01048	0.563
MOD_GlcNHglycan	740	743	PF01048	0.521
MOD_GlcNHglycan	8	11	PF01048	0.577
MOD_GlcNHglycan	99	102	PF01048	0.645
MOD_GSK3_1	102	109	PF00069	0.621
MOD_GSK3_1	144	151	PF00069	0.582
MOD_GSK3_1	198	205	PF00069	0.474
MOD_GSK3_1	25	32	PF00069	0.694
MOD_GSK3_1	328	335	PF00069	0.369
MOD_GSK3_1	387	394	PF00069	0.341
MOD_GSK3_1	399	406	PF00069	0.368
MOD_GSK3_1	497	504	PF00069	0.744
MOD_GSK3_1	547	554	PF00069	0.569
MOD_GSK3_1	575	582	PF00069	0.519
MOD_GSK3_1	644	651	PF00069	0.512
MOD_GSK3_1	696	703	PF00069	0.595
MOD_GSK3_1	706	713	PF00069	0.616
MOD_LATS_1	82	88	PF00433	0.620
MOD_N-GLC_1	210	215	PF02516	0.556
MOD_N-GLC_1	357	362	PF02516	0.352
MOD_N-GLC_1	644	649	PF02516	0.557
MOD_N-GLC_1	65	70	PF02516	0.616
MOD_N-GLC_2	292	294	PF02516	0.369
MOD_NEK2_1	171	176	PF00069	0.403
MOD_NEK2_1	202	207	PF00069	0.477
MOD_NEK2_1	426	431	PF00069	0.457
MOD_NEK2_1	644	649	PF00069	0.557
MOD_NEK2_2	49	54	PF00069	0.606
MOD_PKA_1	6	12	PF00069	0.543
MOD_PKA_2	374	380	PF00069	0.369
MOD_PKA_2	563	569	PF00069	0.464
MOD_PKA_2	736	742	PF00069	0.535
MOD_PKB_1	373	381	PF00069	0.369
MOD_Plk_1	220	226	PF00069	0.638
MOD_Plk_1	357	363	PF00069	0.352
MOD_Plk_1	399	405	PF00069	0.325
MOD_Plk_1	426	432	PF00069	0.440
MOD_Plk_1	434	440	PF00069	0.487
MOD_Plk_1	579	585	PF00069	0.513
MOD_Plk_1	644	650	PF00069	0.563
MOD_Plk_2-3	399	405	PF00069	0.277
MOD_Plk_4	163	169	PF00069	0.474
MOD_Plk_4	171	177	PF00069	0.469
MOD_Plk_4	198	204	PF00069	0.476
MOD_Plk_4	278	284	PF00069	0.542
MOD_Plk_4	34	40	PF00069	0.693
MOD_Plk_4	351	357	PF00069	0.424
MOD_Plk_4	391	397	PF00069	0.369
MOD_Plk_4	49	55	PF00069	0.649
MOD_Plk_4	551	557	PF00069	0.575
MOD_Plk_4	598	604	PF00069	0.487
MOD_Plk_4	717	723	PF00069	0.653
MOD_ProDKin_1	106	112	PF00069	0.632
MOD_ProDKin_1	126	132	PF00069	0.468
MOD_ProDKin_1	153	159	PF00069	0.592
MOD_ProDKin_1	25	31	PF00069	0.646
MOD_ProDKin_1	339	345	PF00069	0.304
MOD_ProDKin_1	411	417	PF00069	0.549
MOD_ProDKin_1	489	495	PF00069	0.691
MOD_ProDKin_1	502	508	PF00069	0.613
MOD_ProDKin_1	616	622	PF00069	0.648
MOD_ProDKin_1	653	659	PF00069	0.599
MOD_ProDKin_1	702	708	PF00069	0.524
MOD_SUMO_rev_2	213	222	PF00179	0.595
MOD_SUMO_rev_2	342	352	PF00179	0.369
TRG_DiLeu_BaEn_1	639	644	PF01217	0.520
TRG_DiLeu_BaLyEn_6	618	623	PF01217	0.492
TRG_DiLeu_BaLyEn_6	707	712	PF01217	0.647
TRG_ENDOCYTIC_2	169	172	PF00928	0.468
TRG_ENDOCYTIC_2	277	280	PF00928	0.572
TRG_ENDOCYTIC_2	614	617	PF00928	0.425
TRG_ER_diArg_1	176	178	PF00400	0.560
TRG_ER_diArg_1	263	266	PF00400	0.665
TRG_ER_diArg_1	274	276	PF00400	0.548
TRG_ER_diArg_1	370	373	PF00400	0.304
TRG_ER_diArg_1	629	631	PF00400	0.521
TRG_ER_diArg_1	734	737	PF00400	0.499
TRG_NES_CRM1_1	364	379	PF08389	0.325
TRG_NES_CRM1_1	386	401	PF08389	0.294
TRG_Pf-PMV_PEXEL_1	710	714	PF00026	0.618

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCI4	Leptomonas seymouri	44%	99%
A0A3S7X198	Leishmania donovani	91%	100%
A4HG83	Leishmania braziliensis	68%	98%
A4I3A4	Leishmania infantum	90%	100%
E9AZK4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%