Nse4_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8M5_LEIMA

TriTrypDb:

LmjF.28.0460 , LMJLV39_280010000 , LMJSD75_280010000

Length:

311

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q8M5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8M5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	304	308	PF00656	0.754
CLV_NRD_NRD_1	54	56	PF00675	0.689
CLV_PCSK_FUR_1	52	56	PF00082	0.691
CLV_PCSK_KEX2_1	29	31	PF00082	0.580
CLV_PCSK_KEX2_1	51	53	PF00082	0.707
CLV_PCSK_KEX2_1	54	56	PF00082	0.700
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.580
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.707
CLV_PCSK_SKI1_1	22	26	PF00082	0.637
DEG_COP1_1	169	180	PF00400	0.571
DEG_Nend_UBRbox_2	1	3	PF02207	0.574
DEG_SPOP_SBC_1	301	305	PF00917	0.617
DOC_CKS1_1	140	145	PF01111	0.560
DOC_CKS1_1	242	247	PF01111	0.611
DOC_MAPK_gen_1	181	189	PF00069	0.584
DOC_USP7_MATH_1	259	263	PF00917	0.665
DOC_USP7_MATH_1	268	272	PF00917	0.728
DOC_USP7_MATH_1	301	305	PF00917	0.614
DOC_USP7_MATH_1	39	43	PF00917	0.772
DOC_USP7_MATH_1	46	50	PF00917	0.669
DOC_USP7_MATH_1	53	57	PF00917	0.619
DOC_USP7_UBL2_3	284	288	PF12436	0.597
DOC_WW_Pin1_4	139	144	PF00397	0.565
DOC_WW_Pin1_4	157	162	PF00397	0.513
DOC_WW_Pin1_4	241	246	PF00397	0.635
LIG_APCC_ABBA_1	252	257	PF00400	0.527
LIG_BRCT_BRCA1_1	286	290	PF00533	0.612
LIG_CSL_BTD_1	140	143	PF09270	0.569
LIG_FHA_1	184	190	PF00498	0.637
LIG_FHA_1	208	214	PF00498	0.530
LIG_FHA_1	258	264	PF00498	0.631
LIG_FHA_2	169	175	PF00498	0.725
LIG_FHA_2	190	196	PF00498	0.597
LIG_FHA_2	241	247	PF00498	0.633
LIG_SH2_SRC	147	150	PF00017	0.571
LIG_SH2_STAT3	107	110	PF00017	0.554
LIG_SH2_STAT5	107	110	PF00017	0.496
LIG_SH2_STAT5	147	150	PF00017	0.629
LIG_SH3_2	242	247	PF14604	0.611
LIG_SH3_3	123	129	PF00018	0.598
LIG_SH3_3	239	245	PF00018	0.661
LIG_SH3_4	284	291	PF00018	0.583
LIG_SUMO_SIM_par_1	210	217	PF11976	0.558
LIG_TRAF2_1	66	69	PF00917	0.579
MOD_CDK_SPxK_1	241	247	PF00069	0.633
MOD_CK1_1	160	166	PF00069	0.640
MOD_CK1_1	266	272	PF00069	0.693
MOD_CK1_1	303	309	PF00069	0.641
MOD_CK2_1	166	172	PF00069	0.620
MOD_CK2_1	303	309	PF00069	0.665
MOD_Cter_Amidation	49	52	PF01082	0.732
MOD_GlcNHglycan	129	132	PF01048	0.606
MOD_GlcNHglycan	16	20	PF01048	0.654
MOD_GlcNHglycan	236	239	PF01048	0.611
MOD_GlcNHglycan	25	28	PF01048	0.733
MOD_GlcNHglycan	270	273	PF01048	0.721
MOD_GlcNHglycan	276	279	PF01048	0.687
MOD_GlcNHglycan	36	40	PF01048	0.662
MOD_GlcNHglycan	43	46	PF01048	0.795
MOD_GlcNHglycan	48	51	PF01048	0.633
MOD_GlcNHglycan	55	58	PF01048	0.616
MOD_GlcNHglycan	78	81	PF01048	0.586
MOD_GSK3_1	153	160	PF00069	0.593
MOD_GSK3_1	259	266	PF00069	0.710
MOD_GSK3_1	268	275	PF00069	0.681
MOD_GSK3_1	280	287	PF00069	0.735
MOD_GSK3_1	299	306	PF00069	0.734
MOD_GSK3_1	31	38	PF00069	0.640
MOD_N-GLC_1	76	81	PF02516	0.594
MOD_NEK2_1	183	188	PF00069	0.612
MOD_NEK2_1	7	12	PF00069	0.561
MOD_PIKK_1	231	237	PF00454	0.602
MOD_PKA_2	183	189	PF00069	0.585
MOD_PKA_2	272	278	PF00069	0.677
MOD_PKA_2	53	59	PF00069	0.651
MOD_PKA_2	7	13	PF00069	0.651
MOD_Plk_4	163	169	PF00069	0.594
MOD_Plk_4	248	254	PF00069	0.578
MOD_ProDKin_1	139	145	PF00069	0.560
MOD_ProDKin_1	157	163	PF00069	0.514
MOD_ProDKin_1	241	247	PF00069	0.633
TRG_ER_diArg_1	52	55	PF00400	0.691
TRG_NLS_MonoCore_2	50	55	PF00514	0.625
TRG_NLS_MonoExtC_3	50	55	PF00514	0.655

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HV17	Leptomonas seymouri	62%	99%
A0A3Q8IDN4	Leishmania donovani	95%	100%
A4HG85	Leishmania braziliensis	80%	100%
A4I3A2	Leishmania infantum	94%	100%
D0A825	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AZK6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%