WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8M4_LEIMA

TriTrypDb:

LmjF.28.0470 , LMJLV39_280010100 , LMJSD75_280010100

Length:

796

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q8M4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8M4

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	2
GO:0006356	regulation of transcription by RNA polymerase I	7	2
GO:0009889	regulation of biosynthetic process	4	2
GO:0009891	positive regulation of biosynthetic process	5	2
GO:0009893	positive regulation of metabolic process	4	2
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	2
GO:0010557	positive regulation of macromolecule biosynthetic process	6	2
GO:0010604	positive regulation of macromolecule metabolic process	5	2
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	2
GO:0019222	regulation of metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031325	positive regulation of cellular metabolic process	5	2
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0031328	positive regulation of cellular biosynthetic process	6	2
GO:0045893	positive regulation of DNA-templated transcription	7	2
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	6	2
GO:0045943	positive regulation of transcription by RNA polymerase I	8	2
GO:0048518	positive regulation of biological process	3	2
GO:0048522	positive regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051173	positive regulation of nitrogen compound metabolic process	5	2
GO:0051252	regulation of RNA metabolic process	5	2
GO:0051254	positive regulation of RNA metabolic process	6	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0080090	regulation of primary metabolic process	4	2
GO:1902680	positive regulation of RNA biosynthetic process	7	2
GO:1903506	regulation of nucleic acid-templated transcription	7	2
GO:1903508	positive regulation of nucleic acid-templated transcription	8	2
GO:2000232	regulation of rRNA processing	6	2
GO:2000234	positive regulation of rRNA processing	7	2
GO:2001141	regulation of RNA biosynthetic process	6	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	739	743	PF00656	0.627
CLV_NRD_NRD_1	105	107	PF00675	0.619
CLV_NRD_NRD_1	249	251	PF00675	0.447
CLV_NRD_NRD_1	28	30	PF00675	0.526
CLV_NRD_NRD_1	451	453	PF00675	0.501
CLV_NRD_NRD_1	479	481	PF00675	0.414
CLV_NRD_NRD_1	572	574	PF00675	0.411
CLV_NRD_NRD_1	654	656	PF00675	0.525
CLV_NRD_NRD_1	793	795	PF00675	0.627
CLV_PCSK_FUR_1	477	481	PF00082	0.415
CLV_PCSK_KEX2_1	105	107	PF00082	0.644
CLV_PCSK_KEX2_1	249	251	PF00082	0.447
CLV_PCSK_KEX2_1	476	478	PF00082	0.469
CLV_PCSK_KEX2_1	479	481	PF00082	0.390
CLV_PCSK_KEX2_1	572	574	PF00082	0.411
CLV_PCSK_KEX2_1	588	590	PF00082	0.410
CLV_PCSK_KEX2_1	654	656	PF00082	0.525
CLV_PCSK_KEX2_1	793	795	PF00082	0.536
CLV_PCSK_PC1ET2_1	476	478	PF00082	0.503
CLV_PCSK_PC1ET2_1	588	590	PF00082	0.387
CLV_PCSK_SKI1_1	199	203	PF00082	0.398
CLV_PCSK_SKI1_1	306	310	PF00082	0.488
CLV_PCSK_SKI1_1	479	483	PF00082	0.341
CLV_PCSK_SKI1_1	53	57	PF00082	0.424
CLV_PCSK_SKI1_1	589	593	PF00082	0.372
CLV_PCSK_SKI1_1	735	739	PF00082	0.564
DEG_APCC_DBOX_1	660	668	PF00400	0.503
DEG_Nend_UBRbox_3	1	3	PF02207	0.571
DEG_SCF_FBW7_1	318	323	PF00400	0.347
DEG_SPOP_SBC_1	239	243	PF00917	0.354
DEG_SPOP_SBC_1	46	50	PF00917	0.375
DEG_SPOP_SBC_1	91	95	PF00917	0.665
DOC_CKS1_1	503	508	PF01111	0.543
DOC_CKS1_1	516	521	PF01111	0.354
DOC_MAPK_gen_1	249	257	PF00069	0.420
DOC_MAPK_gen_1	306	312	PF00069	0.448
DOC_MAPK_MEF2A_6	249	257	PF00069	0.469
DOC_MAPK_MEF2A_6	371	378	PF00069	0.465
DOC_MAPK_MEF2A_6	466	474	PF00069	0.449
DOC_PP1_RVXF_1	587	594	PF00149	0.323
DOC_PP2B_LxvP_1	689	692	PF13499	0.523
DOC_PP4_FxxP_1	22	25	PF00568	0.335
DOC_USP7_MATH_1	121	125	PF00917	0.573
DOC_USP7_MATH_1	152	156	PF00917	0.582
DOC_USP7_MATH_1	320	324	PF00917	0.409
DOC_USP7_MATH_1	464	468	PF00917	0.417
DOC_USP7_MATH_1	517	521	PF00917	0.451
DOC_USP7_MATH_1	530	534	PF00917	0.421
DOC_USP7_MATH_1	6	10	PF00917	0.454
DOC_USP7_MATH_1	640	644	PF00917	0.658
DOC_USP7_MATH_1	657	661	PF00917	0.517
DOC_USP7_MATH_1	699	703	PF00917	0.720
DOC_USP7_MATH_1	707	711	PF00917	0.512
DOC_USP7_MATH_1	90	94	PF00917	0.619
DOC_USP7_UBL2_3	26	30	PF12436	0.377
DOC_WW_Pin1_4	154	159	PF00397	0.717
DOC_WW_Pin1_4	235	240	PF00397	0.427
DOC_WW_Pin1_4	269	274	PF00397	0.343
DOC_WW_Pin1_4	316	321	PF00397	0.443
DOC_WW_Pin1_4	370	375	PF00397	0.490
DOC_WW_Pin1_4	407	412	PF00397	0.575
DOC_WW_Pin1_4	460	465	PF00397	0.371
DOC_WW_Pin1_4	502	507	PF00397	0.645
DOC_WW_Pin1_4	515	520	PF00397	0.345
DOC_WW_Pin1_4	574	579	PF00397	0.483
DOC_WW_Pin1_4	86	91	PF00397	0.645
LIG_14-3-3_CanoR_1	209	215	PF00244	0.494
LIG_14-3-3_CanoR_1	346	356	PF00244	0.492
LIG_14-3-3_CanoR_1	426	432	PF00244	0.347
LIG_14-3-3_CanoR_1	479	485	PF00244	0.338
LIG_Actin_WH2_2	649	667	PF00022	0.521
LIG_BRCT_BRCA1_1	532	536	PF00533	0.330
LIG_Clathr_ClatBox_1	254	258	PF01394	0.460
LIG_FHA_1	120	126	PF00498	0.566
LIG_FHA_1	186	192	PF00498	0.348
LIG_FHA_1	205	211	PF00498	0.501
LIG_FHA_1	225	231	PF00498	0.479
LIG_FHA_1	332	338	PF00498	0.355
LIG_FHA_1	361	367	PF00498	0.413
LIG_FHA_1	456	462	PF00498	0.462
LIG_FHA_1	523	529	PF00498	0.409
LIG_FHA_1	566	572	PF00498	0.459
LIG_FHA_1	620	626	PF00498	0.381
LIG_FHA_1	629	635	PF00498	0.362
LIG_FHA_1	723	729	PF00498	0.589
LIG_FHA_1	78	84	PF00498	0.528
LIG_FHA_2	170	176	PF00498	0.435
LIG_FHA_2	347	353	PF00498	0.440
LIG_FHA_2	496	502	PF00498	0.584
LIG_FHA_2	62	68	PF00498	0.409
LIG_FHA_2	707	713	PF00498	0.708
LIG_GBD_Chelix_1	77	85	PF00786	0.320
LIG_LIR_Apic_2	447	451	PF02991	0.410
LIG_LIR_Apic_2	501	506	PF02991	0.541
LIG_LIR_Apic_2	775	781	PF02991	0.539
LIG_LIR_Gen_1	200	210	PF02991	0.478
LIG_LIR_Gen_1	430	439	PF02991	0.403
LIG_LIR_Gen_1	614	624	PF02991	0.264
LIG_LIR_LC3C_4	188	192	PF02991	0.444
LIG_LIR_LC3C_4	363	367	PF02991	0.322
LIG_LIR_Nem_3	200	206	PF02991	0.379
LIG_LIR_Nem_3	430	434	PF02991	0.342
LIG_LIR_Nem_3	614	619	PF02991	0.257
LIG_LIR_Nem_3	684	689	PF02991	0.378
LIG_MYND_1	221	225	PF01753	0.498
LIG_PCNA_yPIPBox_3	135	145	PF02747	0.424
LIG_Pex14_2	202	206	PF04695	0.412
LIG_Pex14_2	265	269	PF04695	0.362
LIG_Rb_LxCxE_1	252	272	PF01857	0.282
LIG_REV1ctd_RIR_1	731	739	PF16727	0.656
LIG_SH2_CRK	448	452	PF00017	0.422
LIG_SH2_CRK	503	507	PF00017	0.599
LIG_SH2_CRK	778	782	PF00017	0.528
LIG_SH2_NCK_1	778	782	PF00017	0.506
LIG_SH2_STAP1	149	153	PF00017	0.363
LIG_SH2_STAP1	397	401	PF00017	0.369
LIG_SH2_STAT3	391	394	PF00017	0.490
LIG_SH2_STAT3	545	548	PF00017	0.483
LIG_SH2_STAT5	181	184	PF00017	0.512
LIG_SH2_STAT5	287	290	PF00017	0.366
LIG_SH2_STAT5	391	394	PF00017	0.490
LIG_SH2_STAT5	45	48	PF00017	0.433
LIG_SH2_STAT5	565	568	PF00017	0.531
LIG_SH2_STAT5	778	781	PF00017	0.530
LIG_SH2_STAT5	790	793	PF00017	0.517
LIG_SH3_1	84	90	PF00018	0.419
LIG_SH3_3	190	196	PF00018	0.420
LIG_SH3_3	212	218	PF00018	0.558
LIG_SH3_3	219	225	PF00018	0.496
LIG_SH3_3	384	390	PF00018	0.356
LIG_SH3_3	406	412	PF00018	0.521
LIG_SH3_3	435	441	PF00018	0.484
LIG_SH3_3	458	464	PF00018	0.500
LIG_SH3_3	551	557	PF00018	0.324
LIG_SH3_3	572	578	PF00018	0.500
LIG_SH3_3	695	701	PF00018	0.582
LIG_SH3_3	84	90	PF00018	0.463
LIG_SUMO_SIM_anti_2	188	194	PF11976	0.356
LIG_SUMO_SIM_anti_2	292	299	PF11976	0.367
LIG_SUMO_SIM_par_1	292	299	PF11976	0.356
LIG_SUMO_SIM_par_1	334	341	PF11976	0.409
LIG_TRAF2_1	710	713	PF00917	0.519
LIG_TRAF2_1	750	753	PF00917	0.573
LIG_UBA3_1	138	145	PF00899	0.402
LIG_WRC_WIRS_1	170	175	PF05994	0.453
LIG_WRC_WIRS_1	431	436	PF05994	0.507
LIG_WRC_WIRS_1	730	735	PF05994	0.654
LIG_WW_3	410	414	PF00397	0.494
MOD_CDC14_SPxK_1	410	413	PF00782	0.561
MOD_CDC14_SPxK_1	463	466	PF00782	0.421
MOD_CDK_SPxK_1	407	413	PF00069	0.577
MOD_CDK_SPxK_1	460	466	PF00069	0.426
MOD_CDK_SPxxK_3	574	581	PF00069	0.454
MOD_CK1_1	204	210	PF00069	0.488
MOD_CK1_1	238	244	PF00069	0.476
MOD_CK1_1	331	337	PF00069	0.376
MOD_CK1_1	395	401	PF00069	0.448
MOD_CK1_1	427	433	PF00069	0.424
MOD_CK1_1	48	54	PF00069	0.312
MOD_CK1_1	611	617	PF00069	0.400
MOD_CK2_1	169	175	PF00069	0.428
MOD_CK2_1	346	352	PF00069	0.472
MOD_CK2_1	400	406	PF00069	0.456
MOD_CK2_1	604	610	PF00069	0.386
MOD_CK2_1	61	67	PF00069	0.438
MOD_CK2_1	629	635	PF00069	0.393
MOD_CK2_1	699	705	PF00069	0.717
MOD_CK2_1	706	712	PF00069	0.748
MOD_CK2_1	92	98	PF00069	0.707
MOD_Cter_Amidation	247	250	PF01082	0.430
MOD_Cter_Amidation	477	480	PF01082	0.431
MOD_Cter_Amidation	586	589	PF01082	0.366
MOD_GlcNHglycan	154	157	PF01048	0.612
MOD_GlcNHglycan	165	168	PF01048	0.447
MOD_GlcNHglycan	210	213	PF01048	0.518
MOD_GlcNHglycan	282	286	PF01048	0.377
MOD_GlcNHglycan	322	325	PF01048	0.410
MOD_GlcNHglycan	349	352	PF01048	0.398
MOD_GlcNHglycan	466	469	PF01048	0.514
MOD_GlcNHglycan	50	53	PF01048	0.428
MOD_GlcNHglycan	513	516	PF01048	0.461
MOD_GlcNHglycan	528	531	PF01048	0.495
MOD_GlcNHglycan	616	619	PF01048	0.376
MOD_GlcNHglycan	711	717	PF01048	0.748
MOD_GlcNHglycan	783	786	PF01048	0.526
MOD_GlcNHglycan	94	97	PF01048	0.652
MOD_GSK3_1	107	114	PF00069	0.699
MOD_GSK3_1	159	166	PF00069	0.540
MOD_GSK3_1	204	211	PF00069	0.494
MOD_GSK3_1	231	238	PF00069	0.451
MOD_GSK3_1	281	288	PF00069	0.450
MOD_GSK3_1	316	323	PF00069	0.441
MOD_GSK3_1	328	335	PF00069	0.290
MOD_GSK3_1	395	402	PF00069	0.390
MOD_GSK3_1	430	437	PF00069	0.486
MOD_GSK3_1	460	467	PF00069	0.429
MOD_GSK3_1	495	502	PF00069	0.535
MOD_GSK3_1	511	518	PF00069	0.391
MOD_GSK3_1	522	529	PF00069	0.319
MOD_GSK3_1	604	611	PF00069	0.481
MOD_GSK3_1	707	714	PF00069	0.792
MOD_GSK3_1	73	80	PF00069	0.442
MOD_GSK3_1	736	743	PF00069	0.672
MOD_GSK3_1	755	762	PF00069	0.663
MOD_GSK3_1	781	788	PF00069	0.510
MOD_GSK3_1	86	93	PF00069	0.481
MOD_N-GLC_1	36	41	PF02516	0.454
MOD_N-GLC_1	422	427	PF02516	0.381
MOD_N-GLC_1	511	516	PF02516	0.451
MOD_N-GLC_1	657	662	PF02516	0.487
MOD_NEK2_1	201	206	PF00069	0.401
MOD_NEK2_1	281	286	PF00069	0.531
MOD_NEK2_1	328	333	PF00069	0.452
MOD_NEK2_1	345	350	PF00069	0.493
MOD_NEK2_1	36	41	PF00069	0.527
MOD_NEK2_1	399	404	PF00069	0.445
MOD_NEK2_1	422	427	PF00069	0.443
MOD_NEK2_1	434	439	PF00069	0.401
MOD_NEK2_1	592	597	PF00069	0.518
MOD_NEK2_1	619	624	PF00069	0.473
MOD_NEK2_1	628	633	PF00069	0.478
MOD_NEK2_1	746	751	PF00069	0.511
MOD_NEK2_1	77	82	PF00069	0.438
MOD_NEK2_2	61	66	PF00069	0.529
MOD_PIKK_1	389	395	PF00454	0.351
MOD_PIKK_1	400	406	PF00454	0.456
MOD_PIKK_1	455	461	PF00454	0.418
MOD_PIKK_1	517	523	PF00454	0.536
MOD_PIKK_1	565	571	PF00454	0.427
MOD_PIKK_1	6	12	PF00454	0.398
MOD_PIKK_1	740	746	PF00454	0.644
MOD_PK_1	79	85	PF00069	0.475
MOD_PKA_2	208	214	PF00069	0.496
MOD_PKA_2	216	222	PF00069	0.586
MOD_PKA_2	290	296	PF00069	0.419
MOD_PKA_2	345	351	PF00069	0.482
MOD_Plk_1	15	21	PF00069	0.395
MOD_Plk_1	511	517	PF00069	0.517
MOD_Plk_1	61	67	PF00069	0.411
MOD_Plk_1	620	626	PF00069	0.464
MOD_Plk_1	628	634	PF00069	0.464
MOD_Plk_1	657	663	PF00069	0.484
MOD_Plk_1	735	741	PF00069	0.653
MOD_Plk_2-3	629	635	PF00069	0.447
MOD_Plk_2-3	736	742	PF00069	0.668
MOD_Plk_4	121	127	PF00069	0.502
MOD_Plk_4	201	207	PF00069	0.378
MOD_Plk_4	290	296	PF00069	0.429
MOD_Plk_4	392	398	PF00069	0.436
MOD_Plk_4	434	440	PF00069	0.477
MOD_Plk_4	457	463	PF00069	0.476
MOD_Plk_4	61	67	PF00069	0.430
MOD_Plk_4	620	626	PF00069	0.345
MOD_Plk_4	629	635	PF00069	0.350
MOD_Plk_4	699	705	PF00069	0.661
MOD_Plk_4	729	735	PF00069	0.656
MOD_Plk_4	73	79	PF00069	0.500
MOD_Plk_4	786	792	PF00069	0.513
MOD_ProDKin_1	154	160	PF00069	0.717
MOD_ProDKin_1	235	241	PF00069	0.431
MOD_ProDKin_1	269	275	PF00069	0.341
MOD_ProDKin_1	316	322	PF00069	0.446
MOD_ProDKin_1	370	376	PF00069	0.483
MOD_ProDKin_1	407	413	PF00069	0.577
MOD_ProDKin_1	460	466	PF00069	0.382
MOD_ProDKin_1	502	508	PF00069	0.633
MOD_ProDKin_1	515	521	PF00069	0.352
MOD_ProDKin_1	574	580	PF00069	0.482
MOD_ProDKin_1	86	92	PF00069	0.656
TRG_AP2beta_CARGO_1	200	209	PF09066	0.427
TRG_DiLeu_BaEn_1	292	297	PF01217	0.340
TRG_DiLeu_BaEn_1	629	634	PF01217	0.371
TRG_DiLeu_BaLyEn_6	219	224	PF01217	0.462
TRG_DiLeu_BaLyEn_6	438	443	PF01217	0.409
TRG_DiLeu_BaLyEn_6	554	559	PF01217	0.397
TRG_ENDOCYTIC_2	181	184	PF00928	0.409
TRG_ENDOCYTIC_2	203	206	PF00928	0.404
TRG_ENDOCYTIC_2	431	434	PF00928	0.382
TRG_ER_diArg_1	477	480	PF00400	0.454
TRG_ER_diArg_1	571	573	PF00400	0.406
TRG_ER_diArg_1	653	655	PF00400	0.531
TRG_ER_diArg_1	793	795	PF00400	0.548
TRG_NLS_MonoExtC_3	28	34	PF00514	0.377
TRG_NLS_MonoExtN_4	26	33	PF00514	0.388
TRG_Pf-PMV_PEXEL_1	767	771	PF00026	0.595

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4K6	Leptomonas seymouri	69%	97%
A0A0S4J855	Bodo saltans	35%	100%
A0A1X0NYJ9	Trypanosomatidae	41%	100%
A0A3Q8IGL7	Leishmania donovani	94%	100%
A0A422P1N8	Trypanosoma rangeli	42%	100%
A4HG86	Leishmania braziliensis	84%	100%
A4I3A1	Leishmania infantum	94%	100%
D0A824	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	95%
E9AZK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%