LeishMANIAdb
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Carbonic anhydrase-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Carbonic anhydrase-like protein
Gene product:
carbonic anhydrase-like protein
Species:
Leishmania major
UniProt:
Q4Q8M3_LEIMA
TriTrypDb:
LmjF.28.0480 , LMJLV39_280010200 , LMJSD75_280010200 *
Length:
628

Annotations

LeishMANIAdb annotations

Carbonic anhydrase protein (luminal). Based on its distant eukaryotic relatives, it probably has a signal peptide on its N-terminus and a membrane anchor at the C-terminus

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 6, no: 0
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5

Expansion

Sequence features

Q4Q8M3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8M3

Function

Biological processes
Term Name Level Count
GO:0006730 one-carbon metabolic process 3 2
GO:0008152 metabolic process 1 2
GO:0009987 cellular process 1 2
GO:0044237 cellular metabolic process 2 2
GO:0044281 small molecule metabolic process 2 2
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 7
GO:0004089 carbonate dehydratase activity 5 7
GO:0005488 binding 1 7
GO:0008270 zinc ion binding 6 7
GO:0016829 lyase activity 2 7
GO:0016835 carbon-oxygen lyase activity 3 7
GO:0016836 hydro-lyase activity 4 7
GO:0043167 ion binding 2 7
GO:0043169 cation binding 3 7
GO:0046872 metal ion binding 4 7
GO:0046914 transition metal ion binding 5 7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 282 286 PF00656 0.359
CLV_NRD_NRD_1 592 594 PF00675 0.529
CLV_NRD_NRD_1 72 74 PF00675 0.532
CLV_PCSK_KEX2_1 185 187 PF00082 0.466
CLV_PCSK_KEX2_1 220 222 PF00082 0.495
CLV_PCSK_KEX2_1 592 594 PF00082 0.529
CLV_PCSK_KEX2_1 612 614 PF00082 0.436
CLV_PCSK_KEX2_1 72 74 PF00082 0.532
CLV_PCSK_PC1ET2_1 185 187 PF00082 0.466
CLV_PCSK_PC1ET2_1 220 222 PF00082 0.532
CLV_PCSK_PC1ET2_1 612 614 PF00082 0.534
CLV_PCSK_SKI1_1 101 105 PF00082 0.504
CLV_PCSK_SKI1_1 14 18 PF00082 0.575
CLV_PCSK_SKI1_1 186 190 PF00082 0.510
CLV_PCSK_SKI1_1 543 547 PF00082 0.646
CLV_PCSK_SKI1_1 569 573 PF00082 0.353
DEG_APCC_DBOX_1 231 239 PF00400 0.261
DEG_APCC_DBOX_1 568 576 PF00400 0.379
DEG_Nend_UBRbox_1 1 4 PF02207 0.502
DEG_SPOP_SBC_1 392 396 PF00917 0.562
DOC_CYCLIN_yCln2_LP_2 271 277 PF00134 0.332
DOC_MAPK_gen_1 183 193 PF00069 0.421
DOC_MAPK_gen_1 589 597 PF00069 0.725
DOC_MAPK_gen_1 72 79 PF00069 0.332
DOC_MAPK_MEF2A_6 14 21 PF00069 0.442
DOC_MAPK_MEF2A_6 165 173 PF00069 0.280
DOC_MAPK_MEF2A_6 184 193 PF00069 0.274
DOC_MAPK_MEF2A_6 62 69 PF00069 0.332
DOC_PP1_RVXF_1 12 19 PF00149 0.450
DOC_PP1_RVXF_1 93 99 PF00149 0.310
DOC_PP4_FxxP_1 46 49 PF00568 0.479
DOC_USP7_MATH_1 241 245 PF00917 0.303
DOC_USP7_MATH_1 340 344 PF00917 0.559
DOC_USP7_MATH_1 420 424 PF00917 0.535
DOC_USP7_MATH_1 441 445 PF00917 0.576
DOC_USP7_MATH_1 446 450 PF00917 0.578
DOC_USP7_MATH_1 458 462 PF00917 0.568
DOC_USP7_MATH_1 49 53 PF00917 0.517
DOC_USP7_MATH_1 536 540 PF00917 0.481
DOC_USP7_MATH_1 544 548 PF00917 0.429
DOC_USP7_MATH_1 555 559 PF00917 0.435
DOC_USP7_MATH_1 607 611 PF00917 0.698
DOC_WW_Pin1_4 265 270 PF00397 0.307
DOC_WW_Pin1_4 369 374 PF00397 0.615
DOC_WW_Pin1_4 387 392 PF00397 0.611
DOC_WW_Pin1_4 45 50 PF00397 0.478
DOC_WW_Pin1_4 482 487 PF00397 0.587
DOC_WW_Pin1_4 72 77 PF00397 0.307
DOC_WW_Pin1_4 96 101 PF00397 0.261
LIG_14-3-3_CanoR_1 221 229 PF00244 0.307
LIG_14-3-3_CanoR_1 232 236 PF00244 0.307
LIG_14-3-3_CanoR_1 383 389 PF00244 0.600
LIG_14-3-3_CanoR_1 53 57 PF00244 0.455
LIG_14-3-3_CanoR_1 543 553 PF00244 0.498
LIG_BRCT_BRCA1_1 152 156 PF00533 0.376
LIG_eIF4E_1 39 45 PF01652 0.467
LIG_FHA_1 201 207 PF00498 0.270
LIG_FHA_1 224 230 PF00498 0.330
LIG_FHA_1 256 262 PF00498 0.343
LIG_FHA_1 265 271 PF00498 0.276
LIG_FHA_1 39 45 PF00498 0.439
LIG_FHA_1 407 413 PF00498 0.543
LIG_FHA_1 620 626 PF00498 0.736
LIG_FHA_1 7 13 PF00498 0.465
LIG_FHA_2 136 142 PF00498 0.341
LIG_FHA_2 483 489 PF00498 0.570
LIG_Integrin_isoDGR_2 305 307 PF01839 0.495
LIG_LIR_Gen_1 121 131 PF02991 0.341
LIG_LIR_Gen_1 148 159 PF02991 0.277
LIG_LIR_Gen_1 291 300 PF02991 0.295
LIG_LIR_Gen_1 55 66 PF02991 0.388
LIG_LIR_Gen_1 78 87 PF02991 0.321
LIG_LIR_Nem_3 121 127 PF02991 0.341
LIG_LIR_Nem_3 148 154 PF02991 0.359
LIG_LIR_Nem_3 243 248 PF02991 0.294
LIG_LIR_Nem_3 291 295 PF02991 0.295
LIG_LIR_Nem_3 360 366 PF02991 0.462
LIG_LIR_Nem_3 55 61 PF02991 0.396
LIG_LIR_Nem_3 63 67 PF02991 0.307
LIG_PCNA_yPIPBox_3 183 194 PF02747 0.326
LIG_PCNA_yPIPBox_3 350 363 PF02747 0.463
LIG_SH2_CRK 366 370 PF00017 0.470
LIG_SH2_CRK 58 62 PF00017 0.443
LIG_SH2_GRB2like 435 438 PF00017 0.498
LIG_SH2_GRB2like 58 61 PF00017 0.382
LIG_SH2_NCK_1 562 566 PF00017 0.465
LIG_SH2_STAP1 366 370 PF00017 0.521
LIG_SH2_STAT5 245 248 PF00017 0.336
LIG_SH2_STAT5 421 424 PF00017 0.508
LIG_SH2_STAT5 435 438 PF00017 0.469
LIG_SH2_STAT5 562 565 PF00017 0.367
LIG_SH2_STAT5 58 61 PF00017 0.371
LIG_SH2_STAT5 596 599 PF00017 0.690
LIG_SH3_3 136 142 PF00018 0.359
LIG_SH3_3 367 373 PF00018 0.552
LIG_SUMO_SIM_anti_2 230 237 PF11976 0.277
LIG_SUMO_SIM_par_1 267 273 PF11976 0.332
LIG_SUMO_SIM_par_1 377 382 PF11976 0.500
LIG_SxIP_EBH_1 232 242 PF03271 0.332
LIG_TRAF2_1 105 108 PF00917 0.332
MOD_CDK_SPK_2 96 101 PF00069 0.278
MOD_CK1_1 120 126 PF00069 0.388
MOD_CK1_1 135 141 PF00069 0.294
MOD_CK1_1 176 182 PF00069 0.385
MOD_CK1_1 234 240 PF00069 0.339
MOD_CK1_1 372 378 PF00069 0.647
MOD_CK1_1 394 400 PF00069 0.616
MOD_CK1_1 444 450 PF00069 0.749
MOD_CK1_1 451 457 PF00069 0.678
MOD_CK1_1 460 466 PF00069 0.686
MOD_CK1_1 479 485 PF00069 0.774
MOD_CK1_1 48 54 PF00069 0.573
MOD_CK1_1 487 493 PF00069 0.767
MOD_CK1_1 494 500 PF00069 0.687
MOD_CK1_1 523 529 PF00069 0.771
MOD_CK1_1 539 545 PF00069 0.549
MOD_CK1_1 75 81 PF00069 0.354
MOD_CK2_1 30 36 PF00069 0.647
MOD_CK2_1 352 358 PF00069 0.713
MOD_CK2_1 463 469 PF00069 0.687
MOD_CK2_1 524 530 PF00069 0.562
MOD_Cter_Amidation 70 73 PF01082 0.379
MOD_GlcNHglycan 197 200 PF01048 0.449
MOD_GlcNHglycan 366 369 PF01048 0.672
MOD_GlcNHglycan 41 44 PF01048 0.464
MOD_GlcNHglycan 438 442 PF01048 0.708
MOD_GlcNHglycan 448 451 PF01048 0.701
MOD_GlcNHglycan 456 459 PF01048 0.703
MOD_GlcNHglycan 460 463 PF01048 0.675
MOD_GlcNHglycan 465 468 PF01048 0.654
MOD_GlcNHglycan 472 475 PF01048 0.669
MOD_GlcNHglycan 480 484 PF01048 0.671
MOD_GlcNHglycan 488 492 PF01048 0.756
MOD_GlcNHglycan 509 512 PF01048 0.825
MOD_GlcNHglycan 546 549 PF01048 0.494
MOD_GlcNHglycan 609 612 PF01048 0.680
MOD_GSK3_1 145 152 PF00069 0.391
MOD_GSK3_1 223 230 PF00069 0.327
MOD_GSK3_1 379 386 PF00069 0.789
MOD_GSK3_1 387 394 PF00069 0.697
MOD_GSK3_1 397 404 PF00069 0.563
MOD_GSK3_1 420 427 PF00069 0.848
MOD_GSK3_1 437 444 PF00069 0.669
MOD_GSK3_1 449 456 PF00069 0.693
MOD_GSK3_1 45 52 PF00069 0.569
MOD_GSK3_1 458 465 PF00069 0.821
MOD_GSK3_1 478 485 PF00069 0.587
MOD_GSK3_1 487 494 PF00069 0.824
MOD_GSK3_1 495 502 PF00069 0.752
MOD_GSK3_1 503 510 PF00069 0.711
MOD_GSK3_1 520 527 PF00069 0.669
MOD_GSK3_1 539 546 PF00069 0.672
MOD_GSK3_1 556 563 PF00069 0.470
MOD_GSK3_1 617 624 PF00069 0.685
MOD_N-GLC_1 143 148 PF02516 0.343
MOD_N-GLC_1 201 206 PF02516 0.353
MOD_N-GLC_1 321 326 PF02516 0.608
MOD_N-GLC_1 340 345 PF02516 0.677
MOD_N-GLC_1 383 388 PF02516 0.699
MOD_N-GLC_1 401 406 PF02516 0.573
MOD_N-GLC_1 425 430 PF02516 0.586
MOD_N-GLC_1 436 441 PF02516 0.666
MOD_N-GLC_1 444 449 PF02516 0.687
MOD_N-GLC_1 524 529 PF02516 0.608
MOD_N-GLC_1 56 61 PF02516 0.389
MOD_NEK2_1 143 148 PF00069 0.376
MOD_NEK2_1 17 22 PF00069 0.624
MOD_NEK2_1 173 178 PF00069 0.381
MOD_NEK2_1 195 200 PF00069 0.343
MOD_NEK2_1 352 357 PF00069 0.644
MOD_NEK2_1 556 561 PF00069 0.537
MOD_NEK2_1 582 587 PF00069 0.454
MOD_NEK2_1 6 11 PF00069 0.485
MOD_NEK2_1 67 72 PF00069 0.343
MOD_NEK2_2 223 228 PF00069 0.343
MOD_PIKK_1 106 112 PF00454 0.374
MOD_PIKK_1 248 254 PF00454 0.391
MOD_PIKK_1 321 327 PF00454 0.585
MOD_PIKK_1 352 358 PF00454 0.563
MOD_PIKK_1 520 526 PF00454 0.608
MOD_PKA_2 231 237 PF00069 0.366
MOD_PKA_2 241 247 PF00069 0.330
MOD_PKA_2 406 412 PF00069 0.599
MOD_PKA_2 454 460 PF00069 0.649
MOD_PKA_2 52 58 PF00069 0.542
MOD_Plk_1 106 112 PF00069 0.504
MOD_Plk_1 135 141 PF00069 0.419
MOD_Plk_1 201 207 PF00069 0.320
MOD_Plk_1 313 319 PF00069 0.507
MOD_Plk_1 340 346 PF00069 0.612
MOD_Plk_2-3 30 36 PF00069 0.610
MOD_Plk_4 135 141 PF00069 0.527
MOD_Plk_4 231 237 PF00069 0.353
MOD_Plk_4 241 247 PF00069 0.328
MOD_Plk_4 30 36 PF00069 0.610
MOD_Plk_4 431 437 PF00069 0.593
MOD_Plk_4 536 542 PF00069 0.604
MOD_ProDKin_1 265 271 PF00069 0.343
MOD_ProDKin_1 369 375 PF00069 0.775
MOD_ProDKin_1 387 393 PF00069 0.768
MOD_ProDKin_1 45 51 PF00069 0.584
MOD_ProDKin_1 482 488 PF00069 0.738
MOD_ProDKin_1 72 78 PF00069 0.343
MOD_ProDKin_1 96 102 PF00069 0.278
MOD_SUMO_rev_2 463 472 PF00179 0.598
TRG_DiLeu_BaEn_1 231 236 PF01217 0.304
TRG_DiLeu_BaLyEn_6 304 309 PF01217 0.379
TRG_ENDOCYTIC_2 366 369 PF00928 0.572
TRG_ENDOCYTIC_2 58 61 PF00928 0.451
TRG_ER_diArg_1 591 593 PF00400 0.651
TRG_NLS_MonoCore_2 182 187 PF00514 0.278
TRG_NLS_MonoExtN_4 183 188 PF00514 0.302
TRG_Pf-PMV_PEXEL_1 165 170 PF00026 0.372

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PBI8 Leptomonas seymouri 47% 100%
A0A3Q8IDR5 Leishmania donovani 86% 100%
A4HG87 Leishmania braziliensis 59% 100%
A4I3A0 Leishmania infantum 85% 100%
E9AZK8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 77% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS