Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8M2_LEIMA

TriTrypDb:

LmjF.28.0485 , LMJLV39_280010300 , LMJSD75_280010300

Length:

227

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4Q8M2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8M2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	207	209	PF00675	0.444
DEG_Nend_UBRbox_1	1	4	PF02207	0.466
DEG_ODPH_VHL_1	62	73	PF01847	0.410
DEG_SCF_FBW7_1	182	189	PF00400	0.671
DEG_SPOP_SBC_1	186	190	PF00917	0.629
DEG_SPOP_SBC_1	219	223	PF00917	0.623
DEG_SPOP_SBC_1	90	94	PF00917	0.442
DOC_MAPK_MEF2A_6	111	118	PF00069	0.367
DOC_USP7_MATH_1	186	190	PF00917	0.629
DOC_USP7_MATH_1	219	223	PF00917	0.674
DOC_USP7_MATH_1	64	68	PF00917	0.450
DOC_USP7_MATH_1	74	78	PF00917	0.551
DOC_WW_Pin1_4	182	187	PF00397	0.697
DOC_WW_Pin1_4	221	226	PF00397	0.655
DOC_WW_Pin1_4	9	14	PF00397	0.476
LIG_14-3-3_CanoR_1	91	98	PF00244	0.476
LIG_FHA_1	104	110	PF00498	0.418
LIG_FHA_1	128	134	PF00498	0.312
LIG_FHA_1	177	183	PF00498	0.658
LIG_FHA_1	57	63	PF00498	0.391
LIG_FHA_1	92	98	PF00498	0.478
LIG_GBD_Chelix_1	118	126	PF00786	0.484
LIG_LIR_Nem_3	135	141	PF02991	0.303
LIG_Pex14_1	124	128	PF04695	0.304
LIG_SH2_GRB2like	25	28	PF00017	0.410
LIG_SH2_STAT5	141	144	PF00017	0.569
LIG_SH3_3	7	13	PF00018	0.428
LIG_SUMO_SIM_par_1	129	135	PF11976	0.325
MOD_CK1_1	103	109	PF00069	0.465
MOD_CK1_1	149	155	PF00069	0.657
MOD_CK1_1	171	177	PF00069	0.698
MOD_CK1_1	187	193	PF00069	0.647
MOD_CK1_1	207	213	PF00069	0.577
MOD_CK1_1	26	32	PF00069	0.420
MOD_GlcNHglycan	148	151	PF01048	0.428
MOD_GlcNHglycan	182	185	PF01048	0.490
MOD_GlcNHglycan	209	212	PF01048	0.405
MOD_GlcNHglycan	66	69	PF01048	0.672
MOD_GlcNHglycan	7	10	PF01048	0.605
MOD_GlcNHglycan	76	79	PF01048	0.632
MOD_GSK3_1	127	134	PF00069	0.293
MOD_GSK3_1	142	149	PF00069	0.638
MOD_GSK3_1	176	183	PF00069	0.696
MOD_GSK3_1	217	224	PF00069	0.664
MOD_GSK3_1	23	30	PF00069	0.393
MOD_GSK3_1	5	12	PF00069	0.459
MOD_GSK3_1	85	92	PF00069	0.540
MOD_GSK3_1	98	105	PF00069	0.462
MOD_N-GLC_1	26	31	PF02516	0.609
MOD_N-GLC_1	37	42	PF02516	0.620
MOD_N-GLC_1	49	54	PF02516	0.597
MOD_N-GLC_1	64	69	PF02516	0.591
MOD_N-GLC_1	85	90	PF02516	0.670
MOD_N-GLC_1	98	103	PF02516	0.655
MOD_N-GLC_2	140	142	PF02516	0.399
MOD_NEK2_1	127	132	PF00069	0.287
MOD_NEK2_1	170	175	PF00069	0.676
MOD_NEK2_1	192	197	PF00069	0.626
MOD_NEK2_1	204	209	PF00069	0.617
MOD_NEK2_1	98	103	PF00069	0.445
MOD_PIKK_1	171	177	PF00454	0.646
MOD_PIKK_1	50	56	PF00454	0.435
MOD_PKA_2	103	109	PF00069	0.425
MOD_PKA_2	207	213	PF00069	0.722
MOD_PKA_2	34	40	PF00069	0.418
MOD_PKA_2	90	96	PF00069	0.464
MOD_Plk_1	37	43	PF00069	0.416
MOD_Plk_1	98	104	PF00069	0.437
MOD_Plk_4	114	120	PF00069	0.378
MOD_Plk_4	134	140	PF00069	0.281
MOD_ProDKin_1	182	188	PF00069	0.694
MOD_ProDKin_1	221	227	PF00069	0.660
MOD_ProDKin_1	9	15	PF00069	0.476
TRG_DiLeu_BaLyEn_6	188	193	PF01217	0.639
TRG_ER_FFAT_2	84	93	PF00635	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4Z6	Leptomonas seymouri	40%	100%
A0A3Q8IQC4	Leishmania donovani	82%	100%
A4HG88	Leishmania braziliensis	52%	100%
E9AHH3	Leishmania infantum	81%	81%
E9AZK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%