TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR repeat, putative

Species:

Leishmania major

UniProt:

Q4Q8M0_LEIMA

TriTrypDb:

LmjF.28.0500 , LMJLV39_280010500 , LMJSD75_280010500

Length:

712

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8M0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8M0

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	12
GO:0009987	cellular process	1	12

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0030544	Hsp70 protein binding	4	12
GO:0031072	heat shock protein binding	3	12
GO:0051879	Hsp90 protein binding	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	602	608	PF00089	0.630
CLV_NRD_NRD_1	208	210	PF00675	0.471
CLV_NRD_NRD_1	549	551	PF00675	0.599
CLV_NRD_NRD_1	86	88	PF00675	0.565
CLV_PCSK_FUR_1	332	336	PF00082	0.622
CLV_PCSK_KEX2_1	207	209	PF00082	0.505
CLV_PCSK_KEX2_1	224	226	PF00082	0.453
CLV_PCSK_KEX2_1	334	336	PF00082	0.598
CLV_PCSK_KEX2_1	348	350	PF00082	0.508
CLV_PCSK_KEX2_1	549	551	PF00082	0.592
CLV_PCSK_KEX2_1	85	87	PF00082	0.566
CLV_PCSK_PC1ET2_1	224	226	PF00082	0.610
CLV_PCSK_PC1ET2_1	334	336	PF00082	0.668
CLV_PCSK_PC1ET2_1	348	350	PF00082	0.586
CLV_PCSK_SKI1_1	291	295	PF00082	0.460
CLV_PCSK_SKI1_1	317	321	PF00082	0.548
CLV_PCSK_SKI1_1	414	418	PF00082	0.603
CLV_PCSK_SKI1_1	550	554	PF00082	0.525
CLV_Separin_Metazoa	670	674	PF03568	0.701
DEG_APCC_DBOX_1	134	142	PF00400	0.733
DEG_COP1_1	22	30	PF00400	0.721
DEG_Nend_UBRbox_3	1	3	PF02207	0.664
DOC_ANK_TNKS_1	640	647	PF00023	0.665
DOC_CYCLIN_RxL_1	314	324	PF00134	0.558
DOC_CYCLIN_RxL_1	411	419	PF00134	0.672
DOC_CYCLIN_yCln2_LP_2	151	157	PF00134	0.722
DOC_MAPK_gen_1	332	341	PF00069	0.565
DOC_MAPK_gen_1	458	467	PF00069	0.564
DOC_MAPK_gen_1	586	594	PF00069	0.517
DOC_PP1_RVXF_1	57	64	PF00149	0.664
DOC_PP4_FxxP_1	81	84	PF00568	0.684
DOC_USP7_MATH_1	159	163	PF00917	0.771
DOC_USP7_MATH_1	178	182	PF00917	0.694
DOC_USP7_MATH_1	277	281	PF00917	0.524
DOC_USP7_MATH_1	374	378	PF00917	0.561
DOC_USP7_MATH_1	428	432	PF00917	0.586
DOC_USP7_MATH_1	67	71	PF00917	0.676
DOC_USP7_UBL2_3	334	338	PF12436	0.662
DOC_WW_Pin1_4	490	495	PF00397	0.686
DOC_WW_Pin1_4	615	620	PF00397	0.713
LIG_14-3-3_CanoR_1	110	116	PF00244	0.586
LIG_14-3-3_CanoR_1	117	123	PF00244	0.578
LIG_14-3-3_CanoR_1	129	138	PF00244	0.497
LIG_14-3-3_CanoR_1	186	191	PF00244	0.615
LIG_14-3-3_CanoR_1	194	200	PF00244	0.535
LIG_14-3-3_CanoR_1	207	212	PF00244	0.488
LIG_14-3-3_CanoR_1	247	256	PF00244	0.510
LIG_14-3-3_CanoR_1	479	485	PF00244	0.586
LIG_14-3-3_CanoR_1	521	527	PF00244	0.486
LIG_14-3-3_CanoR_1	565	575	PF00244	0.513
LIG_14-3-3_CanoR_1	605	613	PF00244	0.630
LIG_14-3-3_CanoR_1	689	694	PF00244	0.682
LIG_APCC_ABBA_1	1	6	PF00400	0.551
LIG_APCC_ABBA_1	577	582	PF00400	0.522
LIG_BRCT_BRCA1_1	369	373	PF00533	0.636
LIG_BRCT_BRCA1_1	563	567	PF00533	0.558
LIG_FHA_1	217	223	PF00498	0.515
LIG_FHA_1	284	290	PF00498	0.467
LIG_FHA_1	367	373	PF00498	0.557
LIG_FHA_1	404	410	PF00498	0.653
LIG_FHA_1	411	417	PF00498	0.617
LIG_FHA_1	501	507	PF00498	0.556
LIG_FHA_1	574	580	PF00498	0.465
LIG_FHA_1	645	651	PF00498	0.677
LIG_FHA_1	96	102	PF00498	0.540
LIG_FHA_2	168	174	PF00498	0.743
LIG_FHA_2	612	618	PF00498	0.708
LIG_FHA_2	665	671	PF00498	0.702
LIG_FHA_2	678	684	PF00498	0.680
LIG_Integrin_isoDGR_2	384	386	PF01839	0.615
LIG_LIR_Apic_2	78	84	PF02991	0.674
LIG_LIR_Gen_1	106	116	PF02991	0.521
LIG_LIR_Gen_1	128	138	PF02991	0.727
LIG_LIR_Gen_1	558	567	PF02991	0.430
LIG_LIR_Gen_1	60	67	PF02991	0.679
LIG_LIR_Gen_1	94	105	PF02991	0.536
LIG_LIR_Nem_3	106	111	PF02991	0.533
LIG_LIR_Nem_3	128	134	PF02991	0.727
LIG_LIR_Nem_3	210	214	PF02991	0.545
LIG_LIR_Nem_3	377	383	PF02991	0.615
LIG_LIR_Nem_3	558	563	PF02991	0.415
LIG_LIR_Nem_3	576	580	PF02991	0.359
LIG_LIR_Nem_3	597	602	PF02991	0.542
LIG_LIR_Nem_3	60	66	PF02991	0.620
LIG_LIR_Nem_3	70	76	PF02991	0.509
LIG_LIR_Nem_3	94	100	PF02991	0.545
LIG_RPA_C_Fungi	247	259	PF08784	0.541
LIG_SH2_CRK	131	135	PF00017	0.725
LIG_SH2_CRK	380	384	PF00017	0.603
LIG_SH2_CRK	560	564	PF00017	0.444
LIG_SH2_CRK	97	101	PF00017	0.509
LIG_SH2_GRB2like	233	236	PF00017	0.541
LIG_SH2_SRC	343	346	PF00017	0.635
LIG_SH2_STAP1	303	307	PF00017	0.419
LIG_SH2_STAP1	343	347	PF00017	0.641
LIG_SH2_STAP1	97	101	PF00017	0.509
LIG_SH2_STAT5	256	259	PF00017	0.499
LIG_SH2_STAT5	283	286	PF00017	0.400
LIG_SH2_STAT5	437	440	PF00017	0.456
LIG_SH2_STAT5	97	100	PF00017	0.511
LIG_SH3_3	25	31	PF00018	0.650
LIG_SH3_3	39	45	PF00018	0.477
LIG_SH3_3	668	674	PF00018	0.713
LIG_SUMO_SIM_anti_2	607	614	PF11976	0.617
LIG_TRAF2_1	10	13	PF00917	0.742
LIG_TRAF2_1	237	240	PF00917	0.545
LIG_TRAF2_1	242	245	PF00917	0.579
LIG_TRAF2_1	528	531	PF00917	0.607
LIG_TRAF2_1	697	700	PF00917	0.683
LIG_WRC_WIRS_1	678	683	PF05994	0.701
MOD_CK1_1	133	139	PF00069	0.701
MOD_CK1_1	189	195	PF00069	0.659
MOD_CK1_1	198	204	PF00069	0.542
MOD_CK1_1	250	256	PF00069	0.420
MOD_CK1_1	431	437	PF00069	0.504
MOD_CK1_1	480	486	PF00069	0.669
MOD_CK1_1	561	567	PF00069	0.552
MOD_CK1_1	569	575	PF00069	0.447
MOD_CK1_1	659	665	PF00069	0.691
MOD_CK2_1	136	142	PF00069	0.760
MOD_CK2_1	480	486	PF00069	0.625
MOD_CK2_1	650	656	PF00069	0.601
MOD_CK2_1	664	670	PF00069	0.651
MOD_CK2_1	677	683	PF00069	0.697
MOD_CK2_1	68	74	PF00069	0.695
MOD_Cter_Amidation	222	225	PF01082	0.606
MOD_GlcNHglycan	135	138	PF01048	0.735
MOD_GlcNHglycan	161	164	PF01048	0.700
MOD_GlcNHglycan	180	183	PF01048	0.722
MOD_GlcNHglycan	194	197	PF01048	0.697
MOD_GlcNHglycan	201	204	PF01048	0.617
MOD_GlcNHglycan	312	315	PF01048	0.615
MOD_GlcNHglycan	376	379	PF01048	0.555
MOD_GlcNHglycan	433	436	PF01048	0.495
MOD_GlcNHglycan	479	482	PF01048	0.569
MOD_GlcNHglycan	683	686	PF01048	0.601
MOD_GSK3_1	125	132	PF00069	0.727
MOD_GSK3_1	167	174	PF00069	0.662
MOD_GSK3_1	195	202	PF00069	0.674
MOD_GSK3_1	517	524	PF00069	0.446
MOD_GSK3_1	555	562	PF00069	0.495
MOD_GSK3_1	565	572	PF00069	0.494
MOD_GSK3_1	611	618	PF00069	0.638
MOD_GSK3_1	656	663	PF00069	0.619
MOD_GSK3_1	677	684	PF00069	0.664
MOD_GSK3_1	91	98	PF00069	0.606
MOD_N-GLC_1	167	172	PF02516	0.748
MOD_N-GLC_1	431	436	PF02516	0.560
MOD_N-GLC_1	664	669	PF02516	0.704
MOD_N-GLC_2	664	666	PF02516	0.700
MOD_NEK2_1	302	307	PF00069	0.516
MOD_NEK2_1	33	38	PF00069	0.703
MOD_NEK2_1	416	421	PF00069	0.627
MOD_NEK2_1	475	480	PF00069	0.498
MOD_NEK2_1	522	527	PF00069	0.602
MOD_NEK2_1	555	560	PF00069	0.468
MOD_NEK2_1	660	665	PF00069	0.599
MOD_NEK2_1	677	682	PF00069	0.718
MOD_NEK2_2	130	135	PF00069	0.728
MOD_NEK2_2	343	348	PF00069	0.587
MOD_PIKK_1	453	459	PF00454	0.491
MOD_PK_1	588	594	PF00069	0.573
MOD_PKA_1	207	213	PF00069	0.563
MOD_PKA_1	216	222	PF00069	0.555
MOD_PKA_2	207	213	PF00069	0.563
MOD_PKA_2	248	254	PF00069	0.526
MOD_PKA_2	277	283	PF00069	0.511
MOD_PKA_2	604	610	PF00069	0.593
MOD_PKA_2	91	97	PF00069	0.574
MOD_Plk_1	167	173	PF00069	0.683
MOD_Plk_1	343	349	PF00069	0.629
MOD_Plk_1	431	437	PF00069	0.494
MOD_Plk_1	625	631	PF00069	0.602
MOD_Plk_1	68	74	PF00069	0.704
MOD_Plk_1	95	101	PF00069	0.517
MOD_Plk_4	111	117	PF00069	0.531
MOD_Plk_4	167	173	PF00069	0.701
MOD_Plk_4	522	528	PF00069	0.564
MOD_Plk_4	588	594	PF00069	0.550
MOD_Plk_4	656	662	PF00069	0.624
MOD_Plk_4	95	101	PF00069	0.517
MOD_ProDKin_1	490	496	PF00069	0.684
MOD_ProDKin_1	615	621	PF00069	0.711
MOD_SUMO_for_1	697	700	PF00179	0.656
MOD_SUMO_rev_2	121	125	PF00179	0.616
TRG_DiLeu_BaEn_1	12	17	PF01217	0.672
TRG_DiLeu_BaEn_1	551	556	PF01217	0.521
TRG_DiLeu_BaEn_1	656	661	PF01217	0.610
TRG_DiLeu_BaLyEn_6	467	472	PF01217	0.539
TRG_ENDOCYTIC_2	131	134	PF00928	0.723
TRG_ENDOCYTIC_2	336	339	PF00928	0.618
TRG_ENDOCYTIC_2	380	383	PF00928	0.597
TRG_ENDOCYTIC_2	536	539	PF00928	0.523
TRG_ENDOCYTIC_2	560	563	PF00928	0.383
TRG_ENDOCYTIC_2	97	100	PF00928	0.511
TRG_ER_diArg_1	207	209	PF00400	0.514
TRG_ER_diArg_1	458	461	PF00400	0.505
TRG_ER_diArg_1	688	691	PF00400	0.660
TRG_ER_diArg_1	84	87	PF00400	0.689
TRG_NLS_MonoExtC_3	333	338	PF00514	0.693
TRG_NLS_MonoExtN_4	332	338	PF00514	0.692
TRG_Pf-PMV_PEXEL_1	236	240	PF00026	0.551
TRG_Pf-PMV_PEXEL_1	264	268	PF00026	0.556
TRG_Pf-PMV_PEXEL_1	317	321	PF00026	0.583
TRG_Pf-PMV_PEXEL_1	470	474	PF00026	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I228	Leptomonas seymouri	71%	100%
A0A0S4JB35	Bodo saltans	28%	96%
A0A1X0NZW8	Trypanosomatidae	31%	92%
A0A3Q8IAV8	Leishmania donovani	96%	100%
A0A3R7KXE4	Trypanosoma rangeli	32%	100%
A4HG90	Leishmania braziliensis	86%	100%
A4I3C4	Leishmania infantum	96%	100%
D0A822	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	97%
E9AZL1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5DH70	Trypanosoma cruzi	30%	95%