Rab-GAP TBC domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8L9_LEIMA

TriTrypDb:

LmjF.28.0510 , LMJLV39_280010600 , LMJSD75_280010600

Length:

385

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q8L9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8L9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	206	208	PF00675	0.484
CLV_NRD_NRD_1	226	228	PF00675	0.193
CLV_NRD_NRD_1	272	274	PF00675	0.408
CLV_PCSK_FUR_1	355	359	PF00082	0.502
CLV_PCSK_KEX2_1	226	228	PF00082	0.365
CLV_PCSK_KEX2_1	272	274	PF00082	0.403
CLV_PCSK_KEX2_1	357	359	PF00082	0.481
CLV_PCSK_PC1ET2_1	357	359	PF00082	0.481
CLV_PCSK_SKI1_1	282	286	PF00082	0.383
CLV_PCSK_SKI1_1	289	293	PF00082	0.341
CLV_PCSK_SKI1_1	357	361	PF00082	0.460
CLV_PCSK_SKI1_1	60	64	PF00082	0.354
DEG_Nend_UBRbox_2	1	3	PF02207	0.510
DEG_SPOP_SBC_1	28	32	PF00917	0.530
DOC_CDC14_PxL_1	297	305	PF14671	0.501
DOC_CDC14_PxL_1	332	340	PF14671	0.534
DOC_CYCLIN_RxL_1	286	295	PF00134	0.486
DOC_CYCLIN_RxL_1	354	364	PF00134	0.524
DOC_MAPK_gen_1	176	186	PF00069	0.405
DOC_MAPK_gen_1	207	213	PF00069	0.495
DOC_MAPK_gen_1	281	288	PF00069	0.349
DOC_MAPK_gen_1	325	332	PF00069	0.513
DOC_PP1_SILK_1	203	208	PF00149	0.457
DOC_PP4_FxxP_1	315	318	PF00568	0.466
DOC_PP4_MxPP_1	316	319	PF00568	0.506
DOC_USP7_MATH_1	106	110	PF00917	0.396
DOC_USP7_MATH_1	201	205	PF00917	0.400
DOC_WW_Pin1_4	160	165	PF00397	0.565
DOC_WW_Pin1_4	6	11	PF00397	0.473
LIG_14-3-3_CanoR_1	145	152	PF00244	0.501
LIG_14-3-3_CanoR_1	18	24	PF00244	0.499
LIG_14-3-3_CanoR_1	226	232	PF00244	0.510
LIG_14-3-3_CanoR_1	327	331	PF00244	0.603
LIG_14-3-3_CanoR_1	337	345	PF00244	0.383
LIG_14-3-3_CanoR_1	358	367	PF00244	0.477
LIG_14-3-3_CanoR_1	372	380	PF00244	0.520
LIG_Actin_WH2_2	211	228	PF00022	0.334
LIG_BRCT_BRCA1_1	373	377	PF00533	0.457
LIG_Clathr_ClatBox_1	76	80	PF01394	0.312
LIG_deltaCOP1_diTrp_1	137	147	PF00928	0.362
LIG_FHA_1	189	195	PF00498	0.485
LIG_FHA_1	327	333	PF00498	0.525
LIG_FHA_2	293	299	PF00498	0.383
LIG_FHA_2	318	324	PF00498	0.598
LIG_LIR_Apic_2	312	318	PF02991	0.446
LIG_LIR_Gen_1	374	382	PF02991	0.443
LIG_LIR_Nem_3	101	107	PF02991	0.373
LIG_LIR_Nem_3	137	143	PF02991	0.374
LIG_LYPXL_SIV_4	106	114	PF13949	0.419
LIG_NRBOX	110	116	PF00104	0.440
LIG_NRBOX	261	267	PF00104	0.320
LIG_NRBOX	72	78	PF00104	0.317
LIG_Pex14_2	377	381	PF04695	0.410
LIG_Pex14_2	58	62	PF04695	0.438
LIG_PTB_Apo_2	234	241	PF02174	0.320
LIG_Rb_pABgroove_1	371	379	PF01858	0.517
LIG_SH2_SRC	121	124	PF00017	0.468
LIG_SH2_STAP1	107	111	PF00017	0.314
LIG_SH2_STAP1	121	125	PF00017	0.340
LIG_SH2_STAT3	167	170	PF00017	0.538
LIG_SH2_STAT5	104	107	PF00017	0.382
LIG_SH2_STAT5	138	141	PF00017	0.336
LIG_SH2_STAT5	167	170	PF00017	0.538
LIG_SH2_STAT5	277	280	PF00017	0.403
LIG_SH3_3	238	244	PF00018	0.467
LIG_SH3_3	248	254	PF00018	0.368
LIG_SH3_3	4	10	PF00018	0.476
LIG_SUMO_SIM_anti_2	130	137	PF11976	0.326
LIG_SUMO_SIM_anti_2	217	222	PF11976	0.379
LIG_SUMO_SIM_anti_2	75	80	PF11976	0.318
LIG_SUMO_SIM_par_1	130	137	PF11976	0.344
LIG_SUMO_SIM_par_1	328	333	PF11976	0.521
LIG_TRAF2_1	24	27	PF00917	0.485
LIG_TRAF2_1	309	312	PF00917	0.403
LIG_WRC_WIRS_1	20	25	PF05994	0.509
LIG_WRC_WIRS_1	59	64	PF05994	0.468
MOD_CK1_1	361	367	PF00069	0.543
MOD_CK1_1	49	55	PF00069	0.312
MOD_CK2_1	21	27	PF00069	0.480
MOD_CK2_1	311	317	PF00069	0.463
MOD_GlcNHglycan	199	202	PF01048	0.480
MOD_GlcNHglycan	227	230	PF01048	0.512
MOD_GlcNHglycan	339	342	PF01048	0.482
MOD_GlcNHglycan	345	348	PF01048	0.430
MOD_GSK3_1	150	157	PF00069	0.499
MOD_GSK3_1	197	204	PF00069	0.390
MOD_GSK3_1	361	368	PF00069	0.510
MOD_GSK3_1	92	99	PF00069	0.447
MOD_N-GLC_1	150	155	PF02516	0.459
MOD_N-GLC_1	245	250	PF02516	0.550
MOD_N-GLC_1	292	297	PF02516	0.370
MOD_N-GLC_1	49	54	PF02516	0.311
MOD_N-GLC_2	44	46	PF02516	0.366
MOD_NEK2_1	225	230	PF00069	0.534
MOD_NEK2_1	292	297	PF00069	0.370
MOD_NEK2_1	326	331	PF00069	0.507
MOD_NEK2_1	371	376	PF00069	0.457
MOD_NEK2_1	58	63	PF00069	0.468
MOD_NEK2_2	13	18	PF00069	0.485
MOD_PIKK_1	245	251	PF00454	0.533
MOD_PIKK_1	275	281	PF00454	0.405
MOD_PIKK_1	371	377	PF00454	0.459
MOD_PIKK_1	49	55	PF00454	0.312
MOD_PKA_2	225	231	PF00069	0.472
MOD_PKA_2	326	332	PF00069	0.627
MOD_PKA_2	371	377	PF00069	0.417
MOD_Plk_1	13	19	PF00069	0.457
MOD_Plk_1	292	298	PF00069	0.377
MOD_Plk_1	311	317	PF00069	0.430
MOD_Plk_2-3	311	317	PF00069	0.515
MOD_Plk_4	106	112	PF00069	0.391
MOD_Plk_4	201	207	PF00069	0.438
MOD_Plk_4	292	298	PF00069	0.366
MOD_Plk_4	311	317	PF00069	0.430
MOD_Plk_4	326	332	PF00069	0.509
MOD_Plk_4	58	64	PF00069	0.490
MOD_Plk_4	98	104	PF00069	0.440
MOD_ProDKin_1	160	166	PF00069	0.553
MOD_ProDKin_1	6	12	PF00069	0.471
MOD_SUMO_rev_2	317	326	PF00179	0.499
TRG_DiLeu_BaEn_2	310	316	PF01217	0.427
TRG_DiLeu_BaLyEn_6	355	360	PF01217	0.497
TRG_ENDOCYTIC_2	107	110	PF00928	0.330
TRG_ENDOCYTIC_2	121	124	PF00928	0.401
TRG_ER_diArg_1	225	227	PF00400	0.341
TRG_ER_diArg_1	82	85	PF00400	0.345
TRG_NES_CRM1_1	210	222	PF08389	0.359
TRG_NES_CRM1_1	67	80	PF08389	0.325
TRG_Pf-PMV_PEXEL_1	289	294	PF00026	0.402
TRG_Pf-PMV_PEXEL_1	308	312	PF00026	0.275
TRG_Pf-PMV_PEXEL_1	358	362	PF00026	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB59	Leptomonas seymouri	79%	97%
A0A0S4JB68	Bodo saltans	50%	93%
A0A1X0NYX9	Trypanosomatidae	56%	94%
A0A3Q8IEP5	Leishmania donovani	95%	100%
A0A422P1Q9	Trypanosoma rangeli	55%	99%
A4HG91	Leishmania braziliensis	87%	100%
A4I3C5	Leishmania infantum	95%	100%
D0A821	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	97%
E9AZL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
F1QN74	Danio rerio	27%	86%
O75800	Homo sapiens	31%	88%
Q5FWU8	Xenopus laevis	33%	88%
Q6AXZ5	Rattus norvegicus	31%	88%
Q99ML0	Mus musculus	32%	88%
Q9VU41	Drosophila melanogaster	30%	85%
V5B0T6	Trypanosoma cruzi	54%	98%