VPS37 C-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8L4_LEIMA

TriTrypDb:

LmjF.28.0560 , LMJLV39_280011200 , LMJSD75_280011200

Length:

286

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000813	ESCRT I complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0036452	ESCRT complex	2	12
GO:0098796	membrane protein complex	2	12

Expansion

Sequence features

Q4Q8L4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8L4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0008104	protein localization	4	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0044237	cellular metabolic process	2	12
GO:0044248	cellular catabolic process	3	12
GO:0045184	establishment of protein localization	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	13	15	PF00675	0.640
CLV_NRD_NRD_1	231	233	PF00675	0.537
CLV_NRD_NRD_1	242	244	PF00675	0.468
CLV_PCSK_KEX2_1	13	15	PF00082	0.637
CLV_PCSK_KEX2_1	231	233	PF00082	0.535
CLV_PCSK_KEX2_1	242	244	PF00082	0.483
CLV_PCSK_KEX2_1	275	277	PF00082	0.485
CLV_PCSK_PC1ET2_1	275	277	PF00082	0.499
CLV_PCSK_SKI1_1	102	106	PF00082	0.590
CLV_PCSK_SKI1_1	121	125	PF00082	0.686
CLV_PCSK_SKI1_1	211	215	PF00082	0.443
CLV_PCSK_SKI1_1	242	246	PF00082	0.390
DEG_ODPH_VHL_1	39	51	PF01847	0.402
DOC_CKS1_1	216	221	PF01111	0.458
DOC_CKS1_1	74	79	PF01111	0.628
DOC_CYCLIN_RxL_1	208	218	PF00134	0.309
DOC_USP7_MATH_1	17	21	PF00917	0.619
DOC_USP7_MATH_1	3	7	PF00917	0.716
DOC_USP7_UBL2_3	263	267	PF12436	0.467
DOC_WW_Pin1_4	215	220	PF00397	0.416
DOC_WW_Pin1_4	73	78	PF00397	0.549
LIG_14-3-3_CanoR_1	121	126	PF00244	0.693
LIG_14-3-3_CanoR_1	163	172	PF00244	0.503
LIG_14-3-3_CanoR_1	211	217	PF00244	0.476
LIG_14-3-3_CanoR_1	231	240	PF00244	0.505
LIG_14-3-3_CanoR_1	276	280	PF00244	0.590
LIG_14-3-3_CanoR_1	5	12	PF00244	0.613
LIG_14-3-3_CanoR_1	63	67	PF00244	0.629
LIG_CtBP_PxDLS_1	117	121	PF00389	0.651
LIG_FHA_1	122	128	PF00498	0.658
LIG_FHA_1	129	135	PF00498	0.637
LIG_FHA_1	17	23	PF00498	0.652
LIG_FHA_1	267	273	PF00498	0.309
LIG_FHA_1	92	98	PF00498	0.575
LIG_FHA_2	163	169	PF00498	0.436
LIG_FHA_2	223	229	PF00498	0.535
LIG_FHA_2	94	100	PF00498	0.585
LIG_LIR_Gen_1	48	58	PF02991	0.499
LIG_LIR_Nem_3	110	115	PF02991	0.577
LIG_LIR_Nem_3	48	53	PF02991	0.483
LIG_PCNA_yPIPBox_3	151	163	PF02747	0.542
LIG_SH2_CRK	150	154	PF00017	0.411
LIG_SH2_PTP2	50	53	PF00017	0.507
LIG_SH2_STAP1	45	49	PF00017	0.495
LIG_SH2_STAT3	148	151	PF00017	0.411
LIG_SH2_STAT3	262	265	PF00017	0.476
LIG_SH2_STAT3	279	282	PF00017	0.583
LIG_SH2_STAT5	148	151	PF00017	0.515
LIG_SH2_STAT5	196	199	PF00017	0.309
LIG_SH2_STAT5	50	53	PF00017	0.491
LIG_SH2_STAT5	68	71	PF00017	0.612
LIG_SH3_3	111	117	PF00018	0.554
LIG_SH3_3	136	142	PF00018	0.452
LIG_SH3_3	213	219	PF00018	0.476
LIG_SH3_3	48	54	PF00018	0.481
LIG_SH3_3	71	77	PF00018	0.562
LIG_SH3_CIN85_PxpxPR_1	58	63	PF14604	0.564
LIG_SUMO_SIM_par_1	212	218	PF11976	0.550
LIG_TRAF2_1	25	28	PF00917	0.673
LIG_UBA3_1	271	275	PF00899	0.465
MOD_CK1_1	119	125	PF00069	0.605
MOD_CK1_1	128	134	PF00069	0.595
MOD_CK1_1	162	168	PF00069	0.452
MOD_CK1_1	20	26	PF00069	0.593
MOD_CK1_1	215	221	PF00069	0.452
MOD_CK1_1	266	272	PF00069	0.309
MOD_CK1_1	91	97	PF00069	0.612
MOD_CK2_1	162	168	PF00069	0.483
MOD_CK2_1	22	28	PF00069	0.539
MOD_CK2_1	93	99	PF00069	0.598
MOD_Cter_Amidation	240	243	PF01082	0.513
MOD_GlcNHglycan	127	130	PF01048	0.682
MOD_GlcNHglycan	24	27	PF01048	0.598
MOD_GSK3_1	121	128	PF00069	0.645
MOD_GSK3_1	16	23	PF00069	0.580
MOD_GSK3_1	232	239	PF00069	0.481
MOD_GSK3_1	45	52	PF00069	0.541
MOD_GSK3_1	88	95	PF00069	0.642
MOD_N-GLC_1	175	180	PF02516	0.515
MOD_NEK2_1	212	217	PF00069	0.403
MOD_NEK2_1	49	54	PF00069	0.505
MOD_NEK2_2	45	50	PF00069	0.547
MOD_PIKK_1	199	205	PF00454	0.515
MOD_PIKK_1	4	10	PF00454	0.632
MOD_PKA_1	231	237	PF00069	0.522
MOD_PKA_1	275	281	PF00069	0.616
MOD_PKA_2	162	168	PF00069	0.519
MOD_PKA_2	231	237	PF00069	0.473
MOD_PKA_2	275	281	PF00069	0.616
MOD_PKA_2	4	10	PF00069	0.649
MOD_PKA_2	62	68	PF00069	0.549
MOD_Plk_1	174	180	PF00069	0.476
MOD_Plk_2-3	182	188	PF00069	0.530
MOD_Plk_4	17	23	PF00069	0.564
MOD_Plk_4	26	32	PF00069	0.500
MOD_Plk_4	45	51	PF00069	0.510
MOD_Plk_4	93	99	PF00069	0.565
MOD_ProDKin_1	215	221	PF00069	0.416
MOD_ProDKin_1	73	79	PF00069	0.560
TRG_DiLeu_BaEn_1	130	135	PF01217	0.688
TRG_DiLeu_BaEn_1	208	213	PF01217	0.464
TRG_DiLeu_LyEn_5	130	135	PF01217	0.688
TRG_DiLeu_LyEn_5	208	213	PF01217	0.347
TRG_ENDOCYTIC_2	50	53	PF00928	0.479
TRG_ER_diArg_1	12	14	PF00400	0.618
TRG_ER_diArg_1	230	232	PF00400	0.536
TRG_Pf-PMV_PEXEL_1	133	137	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	195	199	PF00026	0.376

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1Q4	Leptomonas seymouri	77%	100%
A0A0S4JBQ7	Bodo saltans	31%	100%
A0A1X0NYI9	Trypanosomatidae	41%	100%
A0A3S7X186	Leishmania donovani	96%	100%
A0A422P1P4	Trypanosoma rangeli	40%	100%
A4HG97	Leishmania braziliensis	85%	100%
A4I3D0	Leishmania infantum	95%	100%
D0A814	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AZL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5DH66	Trypanosoma cruzi	42%	93%