Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q8L1_LEIMA

TriTrypDb:

LmjF.28.0590 , LMJLV39_280011500 , LMJSD75_280011500

Length:

501

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8L1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8L1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	344	348	PF00656	0.735
CLV_MEL_PAP_1	451	457	PF00089	0.717
CLV_NRD_NRD_1	151	153	PF00675	0.846
CLV_NRD_NRD_1	309	311	PF00675	0.509
CLV_NRD_NRD_1	380	382	PF00675	0.739
CLV_NRD_NRD_1	396	398	PF00675	0.608
CLV_NRD_NRD_1	446	448	PF00675	0.708
CLV_NRD_NRD_1	45	47	PF00675	0.733
CLV_NRD_NRD_1	490	492	PF00675	0.807
CLV_PCSK_KEX2_1	151	153	PF00082	0.739
CLV_PCSK_KEX2_1	395	397	PF00082	0.675
CLV_PCSK_KEX2_1	446	448	PF00082	0.708
CLV_PCSK_KEX2_1	45	47	PF00082	0.649
CLV_PCSK_KEX2_1	490	492	PF00082	0.807
CLV_PCSK_PC1ET2_1	395	397	PF00082	0.675
CLV_PCSK_PC7_1	147	153	PF00082	0.643
CLV_PCSK_SKI1_1	301	305	PF00082	0.655
CLV_PCSK_SKI1_1	397	401	PF00082	0.663
CLV_PCSK_SKI1_1	447	451	PF00082	0.732
CLV_Separin_Metazoa	75	79	PF03568	0.610
DEG_APCC_DBOX_1	160	168	PF00400	0.574
DEG_Nend_Nbox_1	1	3	PF02207	0.658
DOC_CKS1_1	440	445	PF01111	0.697
DOC_CYCLIN_RxL_1	113	123	PF00134	0.547
DOC_MAPK_gen_1	490	498	PF00069	0.567
DOC_PP2B_LxvP_1	70	73	PF13499	0.736
DOC_PP4_FxxP_1	416	419	PF00568	0.564
DOC_PP4_MxPP_1	404	407	PF00568	0.723
DOC_USP7_MATH_1	238	242	PF00917	0.686
DOC_USP7_MATH_1	44	48	PF00917	0.682
DOC_USP7_MATH_1	494	498	PF00917	0.798
DOC_USP7_MATH_1	66	70	PF00917	0.705
DOC_USP7_MATH_2	136	142	PF00917	0.690
DOC_USP7_UBL2_3	15	19	PF12436	0.479
DOC_WW_Pin1_4	142	147	PF00397	0.723
DOC_WW_Pin1_4	189	194	PF00397	0.808
DOC_WW_Pin1_4	228	233	PF00397	0.721
DOC_WW_Pin1_4	245	250	PF00397	0.683
DOC_WW_Pin1_4	252	257	PF00397	0.672
DOC_WW_Pin1_4	439	444	PF00397	0.723
DOC_WW_Pin1_4	471	476	PF00397	0.714
DOC_WW_Pin1_4	64	69	PF00397	0.777
LIG_14-3-3_CanoR_1	161	171	PF00244	0.563
LIG_14-3-3_CanoR_1	338	345	PF00244	0.629
LIG_14-3-3_CanoR_1	396	402	PF00244	0.674
LIG_14-3-3_CanoR_1	446	450	PF00244	0.708
LIG_14-3-3_CanoR_1	45	49	PF00244	0.665
LIG_14-3-3_CanoR_1	490	498	PF00244	0.698
LIG_Actin_WH2_2	197	214	PF00022	0.596
LIG_CtBP_PxDLS_1	73	77	PF00389	0.657
LIG_EVH1_2	406	410	PF00568	0.758
LIG_FHA_1	103	109	PF00498	0.713
LIG_FHA_1	257	263	PF00498	0.615
LIG_FHA_1	302	308	PF00498	0.689
LIG_FHA_1	446	452	PF00498	0.708
LIG_FHA_1	50	56	PF00498	0.739
LIG_FHA_2	15	21	PF00498	0.560
LIG_FHA_2	313	319	PF00498	0.773
LIG_GBD_Chelix_1	118	126	PF00786	0.662
LIG_LIR_Apic_2	414	419	PF02991	0.561
LIG_LIR_Gen_1	497	501	PF02991	0.783
LIG_LIR_Gen_1	79	88	PF02991	0.692
LIG_LIR_Nem_3	17	21	PF02991	0.621
LIG_LIR_Nem_3	497	501	PF02991	0.758
LIG_SH2_CRK	180	184	PF00017	0.763
LIG_SH2_CRK	34	38	PF00017	0.490
LIG_SH2_SRC	25	28	PF00017	0.497
LIG_SH2_SRC	351	354	PF00017	0.598
LIG_SH2_STAT3	353	356	PF00017	0.791
LIG_SH2_STAT5	114	117	PF00017	0.488
LIG_SH2_STAT5	25	28	PF00017	0.596
LIG_SH2_STAT5	80	83	PF00017	0.553
LIG_SH3_3	430	436	PF00018	0.741
LIG_SH3_CIN85_PxpxPR_1	146	151	PF14604	0.637
LIG_SUMO_SIM_anti_2	206	213	PF11976	0.567
LIG_TRAF2_1	104	107	PF00917	0.602
LIG_TRAF2_1	376	379	PF00917	0.651
LIG_WRC_WIRS_1	129	134	PF05994	0.583
MOD_CDK_SPK_2	142	147	PF00069	0.751
MOD_CDK_SPxxK_3	439	446	PF00069	0.719
MOD_CK1_1	101	107	PF00069	0.624
MOD_CK1_1	131	137	PF00069	0.766
MOD_CK1_1	155	161	PF00069	0.815
MOD_CK1_1	189	195	PF00069	0.755
MOD_CK1_1	412	418	PF00069	0.793
MOD_CK1_1	456	462	PF00069	0.683
MOD_CK1_1	474	480	PF00069	0.766
MOD_CK1_1	483	489	PF00069	0.749
MOD_CK1_1	5	11	PF00069	0.704
MOD_CK2_1	101	107	PF00069	0.602
MOD_CK2_1	14	20	PF00069	0.560
MOD_CK2_1	184	190	PF00069	0.736
MOD_CK2_1	21	27	PF00069	0.590
MOD_CK2_1	220	226	PF00069	0.532
MOD_CK2_1	312	318	PF00069	0.769
MOD_GlcNHglycan	164	167	PF01048	0.805
MOD_GlcNHglycan	186	189	PF01048	0.749
MOD_GlcNHglycan	222	225	PF01048	0.534
MOD_GlcNHglycan	39	42	PF01048	0.504
MOD_GlcNHglycan	437	440	PF01048	0.738
MOD_GlcNHglycan	456	459	PF01048	0.703
MOD_GlcNHglycan	492	495	PF01048	0.723
MOD_GlcNHglycan	99	103	PF01048	0.688
MOD_GSK3_1	10	17	PF00069	0.611
MOD_GSK3_1	138	145	PF00069	0.719
MOD_GSK3_1	2	9	PF00069	0.768
MOD_GSK3_1	21	28	PF00069	0.398
MOD_GSK3_1	216	223	PF00069	0.620
MOD_GSK3_1	252	259	PF00069	0.667
MOD_GSK3_1	328	335	PF00069	0.707
MOD_GSK3_1	337	344	PF00069	0.715
MOD_GSK3_1	435	442	PF00069	0.728
MOD_GSK3_1	456	463	PF00069	0.695
MOD_GSK3_1	485	492	PF00069	0.691
MOD_GSK3_1	64	71	PF00069	0.682
MOD_GSK3_1	98	105	PF00069	0.672
MOD_LATS_1	452	458	PF00433	0.703
MOD_N-GLC_1	412	417	PF02516	0.714
MOD_NEK2_1	162	167	PF00069	0.586
MOD_NEK2_1	184	189	PF00069	0.794
MOD_NEK2_1	2	7	PF00069	0.735
MOD_NEK2_1	21	26	PF00069	0.434
MOD_NEK2_1	323	328	PF00069	0.683
MOD_NEK2_1	98	103	PF00069	0.590
MOD_OFUCOSY	253	258	PF10250	0.668
MOD_PIKK_1	216	222	PF00454	0.614
MOD_PIKK_1	474	480	PF00454	0.806
MOD_PKA_1	490	496	PF00069	0.802
MOD_PKA_2	102	108	PF00069	0.726
MOD_PKA_2	160	166	PF00069	0.576
MOD_PKA_2	220	226	PF00069	0.765
MOD_PKA_2	329	335	PF00069	0.689
MOD_PKA_2	337	343	PF00069	0.683
MOD_PKA_2	420	426	PF00069	0.592
MOD_PKA_2	44	50	PF00069	0.637
MOD_PKA_2	445	451	PF00069	0.708
MOD_PKA_2	453	459	PF00069	0.702
MOD_PKA_2	489	495	PF00069	0.750
MOD_Plk_1	26	32	PF00069	0.521
MOD_Plk_1	412	418	PF00069	0.715
MOD_Plk_1	460	466	PF00069	0.694
MOD_Plk_2-3	312	318	PF00069	0.691
MOD_Plk_2-3	341	347	PF00069	0.575
MOD_Plk_4	179	185	PF00069	0.800
MOD_Plk_4	21	27	PF00069	0.678
MOD_Plk_4	461	467	PF00069	0.743
MOD_ProDKin_1	142	148	PF00069	0.723
MOD_ProDKin_1	189	195	PF00069	0.805
MOD_ProDKin_1	228	234	PF00069	0.721
MOD_ProDKin_1	245	251	PF00069	0.681
MOD_ProDKin_1	252	258	PF00069	0.669
MOD_ProDKin_1	439	445	PF00069	0.721
MOD_ProDKin_1	471	477	PF00069	0.714
MOD_ProDKin_1	64	70	PF00069	0.772
MOD_SUMO_for_1	83	86	PF00179	0.693
TRG_DiLeu_BaEn_1	206	211	PF01217	0.565
TRG_ENDOCYTIC_2	180	183	PF00928	0.803
TRG_ENDOCYTIC_2	34	37	PF00928	0.488
TRG_ENDOCYTIC_2	80	83	PF00928	0.678
TRG_ER_diArg_1	150	152	PF00400	0.647
TRG_ER_diArg_1	242	245	PF00400	0.638
TRG_ER_diArg_1	445	447	PF00400	0.810
TRG_Pf-PMV_PEXEL_1	216	220	PF00026	0.579
TRG_Pf-PMV_PEXEL_1	263	267	PF00026	0.635
TRG_Pf-PMV_PEXEL_1	277	281	PF00026	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7S4	Leptomonas seymouri	42%	95%
A0A3Q8IHY9	Leishmania donovani	90%	100%
A4HG99	Leishmania braziliensis	69%	96%
A4I3D3	Leishmania infantum	91%	100%
E9AZM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	96%