V-type proton ATPase subunit e

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP synthase subunit H, putative

Species:

Leishmania major

UniProt:

Q4Q8K6_LEIMA

TriTrypDb:

LmjF.28.0640 , LMJLV39_280012000 , LMJSD75_280012000

Length:

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0032991	protein-containing complex	1	8
GO:0033177	proton-transporting two-sector ATPase complex, proton-transporting domain	3	8
GO:0033179	proton-transporting V-type ATPase, V0 domain	4	8
GO:0098796	membrane protein complex	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

Q4Q8K6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8K6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0009987	cellular process	1	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0055085	transmembrane transport	2	2

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	8
GO:0008324	monoatomic cation transmembrane transporter activity	4	8
GO:0009678	pyrophosphate hydrolysis-driven proton transmembrane transporter activity	5	8
GO:0015075	monoatomic ion transmembrane transporter activity	3	8
GO:0015078	proton transmembrane transporter activity	5	8
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	8
GO:0015399	primary active transmembrane transporter activity	4	8
GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	3	8
GO:0022804	active transmembrane transporter activity	3	8
GO:0022853	active monoatomic ion transmembrane transporter activity	4	8
GO:0022857	transmembrane transporter activity	2	8
GO:0022890	inorganic cation transmembrane transporter activity	4	8
GO:0042625	ATPase-coupled ion transmembrane transporter activity	3	8
GO:0042626	ATPase-coupled transmembrane transporter activity	2	8
GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	4	8
GO:0046961	proton-transporting ATPase activity, rotational mechanism	4	8
GO:0140657	ATP-dependent activity	1	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	63	67	PF00082	0.507
DOC_CYCLIN_yCln2_LP_2	19	25	PF00134	0.272
DOC_PP2B_LxvP_1	19	22	PF13499	0.273
DOC_PP2B_LxvP_1	58	61	PF13499	0.257
DOC_USP7_MATH_1	61	65	PF00917	0.262
LIG_CORNRBOX	8	16	PF00104	0.292
LIG_FHA_1	60	66	PF00498	0.234
LIG_LIR_Gen_1	46	55	PF02991	0.253
LIG_LIR_Gen_1	7	18	PF02991	0.291
LIG_LIR_Nem_3	46	50	PF02991	0.253
LIG_LIR_Nem_3	7	13	PF02991	0.282
LIG_MYND_1	57	61	PF01753	0.220
LIG_PCNA_yPIPBox_3	26	35	PF02747	0.462
LIG_Pex14_1	47	51	PF04695	0.312
LIG_SH2_STAT3	51	54	PF00017	0.253
LIG_SUMO_SIM_anti_2	27	33	PF11976	0.462
LIG_SUMO_SIM_par_1	56	62	PF11976	0.220
LIG_WRC_WIRS_1	38	43	PF05994	0.277
MOD_CMANNOS	44	47	PF00535	0.312
MOD_GlcNHglycan	19	22	PF01048	0.277
MOD_NEK2_1	4	9	PF00069	0.312
MOD_NEK2_2	61	66	PF00069	0.237
MOD_NMyristoyl	1	7	PF02799	0.262
MOD_PIKK_1	24	30	PF00454	0.462
MOD_Plk_4	4	10	PF00069	0.305
MOD_Plk_4	43	49	PF00069	0.312
MOD_SUMO_for_1	65	68	PF00179	0.360
TRG_DiLeu_BaLyEn_6	54	59	PF01217	0.257

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM00	Leptomonas seymouri	82%	100%
A0A0S4JAV9	Bodo saltans	68%	100%
A0A3S7X1B6	Leishmania donovani	99%	100%
A4HGA4	Leishmania braziliensis	88%	100%
A4I3D8	Leishmania infantum	99%	100%
E9AZM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
Q9FLN5	Arabidopsis thaliana	39%	97%
Q9SZ13	Arabidopsis thaliana	34%	97%