ANAPC4_WD40 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein transport protein SEC13, putative

Species:

Leishmania major

UniProt:

Q4Q8K5_LEIMA

TriTrypDb:

LmjF.28.0650 , LMJLV39_280012100 , LMJSD75_280012100

Length:

301

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	2
GO:0030117	membrane coat	3	12
GO:0030120	vesicle coat	4	12
GO:0030127	COPII vesicle coat	5	12
GO:0031080	nuclear pore outer ring	3	2
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0098796	membrane protein complex	2	12
GO:0110165	cellular anatomical entity	1	3
GO:0140513	nuclear protein-containing complex	2	12
GO:0005643	nuclear pore	3	10
GO:0005840	ribosome	5	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

Q4Q8K5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8K5

Function

Biological processes
Term	Name	Level	Count
GO:0006606	protein import into nucleus	5	2
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	2
GO:0006900	vesicle budding from membrane	5	12
GO:0006913	nucleocytoplasmic transport	5	2
GO:0006996	organelle organization	4	12
GO:0008104	protein localization	4	12
GO:0009966	regulation of signal transduction	4	12
GO:0009967	positive regulation of signal transduction	5	12
GO:0009987	cellular process	1	12
GO:0010646	regulation of cell communication	4	12
GO:0010647	positive regulation of cell communication	5	12
GO:0015031	protein transport	4	12
GO:0015931	nucleobase-containing compound transport	5	12
GO:0016043	cellular component organization	3	12
GO:0016050	vesicle organization	5	12
GO:0023051	regulation of signaling	3	12
GO:0023056	positive regulation of signaling	4	12
GO:0032006	regulation of TOR signaling	6	12
GO:0032008	positive regulation of TOR signaling	7	12
GO:0033036	macromolecule localization	2	12
GO:0033365	protein localization to organelle	5	2
GO:0034504	protein localization to nucleus	6	2
GO:0045184	establishment of protein localization	3	12
GO:0046907	intracellular transport	3	2
GO:0048518	positive regulation of biological process	3	12
GO:0048522	positive regulation of cellular process	4	12
GO:0048583	regulation of response to stimulus	3	12
GO:0048584	positive regulation of response to stimulus	4	12
GO:0050657	nucleic acid transport	6	12
GO:0050658	RNA transport	4	12
GO:0050789	regulation of biological process	2	12
GO:0050794	regulation of cellular process	3	12
GO:0051028	mRNA transport	5	12
GO:0051169	nuclear transport	4	2
GO:0051170	import into nucleus	6	2
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051236	establishment of RNA localization	3	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	2
GO:0061024	membrane organization	4	12
GO:0065007	biological regulation	1	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0072594	establishment of protein localization to organelle	4	2
GO:0090114	COPII-coated vesicle budding	6	12
GO:1902531	regulation of intracellular signal transduction	5	12
GO:1902533	positive regulation of intracellular signal transduction	6	12
GO:1903432	regulation of TORC1 signaling	7	12
GO:1904263	positive regulation of TORC1 signaling	8	12

Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	272	276	PF00656	0.465
CLV_NRD_NRD_1	56	58	PF00675	0.472
CLV_PCSK_SKI1_1	153	157	PF00082	0.293
CLV_PCSK_SKI1_1	161	165	PF00082	0.327
DEG_Nend_Nbox_1	1	3	PF02207	0.349
DOC_CKS1_1	186	191	PF01111	0.296
DOC_CKS1_1	64	69	PF01111	0.293
DOC_CYCLIN_yCln2_LP_2	212	218	PF00134	0.386
DOC_CYCLIN_yCln2_LP_2	245	248	PF00134	0.455
DOC_PP1_RVXF_1	202	209	PF00149	0.361
DOC_PP1_RVXF_1	257	263	PF00149	0.338
DOC_PP2B_LxvP_1	129	132	PF13499	0.477
DOC_PP2B_LxvP_1	149	152	PF13499	0.391
DOC_PP2B_LxvP_1	212	215	PF13499	0.437
DOC_PP2B_LxvP_1	245	248	PF13499	0.527
DOC_PP4_FxxP_1	122	125	PF00568	0.424
DOC_USP7_MATH_1	182	186	PF00917	0.399
DOC_USP7_MATH_1	195	199	PF00917	0.328
DOC_USP7_MATH_1	220	224	PF00917	0.297
DOC_USP7_MATH_1	98	102	PF00917	0.410
DOC_USP7_MATH_2	174	180	PF00917	0.506
DOC_WW_Pin1_4	185	190	PF00397	0.486
DOC_WW_Pin1_4	197	202	PF00397	0.417
DOC_WW_Pin1_4	249	254	PF00397	0.607
DOC_WW_Pin1_4	63	68	PF00397	0.408
LIG_14-3-3_CanoR_1	153	162	PF00244	0.389
LIG_14-3-3_CanoR_1	291	299	PF00244	0.529
LIG_CSL_BTD_1	1	4	PF09270	0.468
LIG_CSL_BTD_1	186	189	PF09270	0.271
LIG_deltaCOP1_diTrp_1	99	107	PF00928	0.369
LIG_FHA_1	265	271	PF00498	0.280
LIG_FHA_1	29	35	PF00498	0.463
LIG_FHA_1	39	45	PF00498	0.282
LIG_FHA_2	186	192	PF00498	0.466
LIG_FHA_2	250	256	PF00498	0.448
LIG_FHA_2	34	40	PF00498	0.438
LIG_LIR_Gen_1	261	270	PF02991	0.346
LIG_LIR_Nem_3	118	122	PF02991	0.453
LIG_LIR_Nem_3	185	190	PF02991	0.396
LIG_LIR_Nem_3	200	206	PF02991	0.314
LIG_LIR_Nem_3	261	265	PF02991	0.359
LIG_LIR_Nem_3	267	271	PF02991	0.313
LIG_LIR_Nem_3	53	59	PF02991	0.403
LIG_LIR_Nem_3	77	81	PF02991	0.441
LIG_MAD2	291	299	PF02301	0.529
LIG_Pex14_1	166	170	PF04695	0.480
LIG_Pex14_2	119	123	PF04695	0.415
LIG_Pex14_2	162	166	PF04695	0.362
LIG_SH2_CRK	56	60	PF00017	0.425
LIG_SH2_CRK	78	82	PF00017	0.424
LIG_SH2_NCK_1	62	66	PF00017	0.450
LIG_SH2_SRC	273	276	PF00017	0.472
LIG_SH2_STAP1	30	34	PF00017	0.369
LIG_SH2_STAT5	218	221	PF00017	0.274
LIG_SH2_STAT5	30	33	PF00017	0.459
LIG_SH2_STAT5	60	63	PF00017	0.337
LIG_SH3_2	148	153	PF14604	0.393
LIG_SH3_3	118	124	PF00018	0.330
LIG_SH3_3	142	148	PF00018	0.519
LIG_SH3_3	183	189	PF00018	0.466
LIG_SH3_CIN85_PxpxPR_1	148	153	PF14604	0.374
LIG_SUMO_SIM_anti_2	3	9	PF11976	0.488
LIG_SUMO_SIM_par_1	188	193	PF11976	0.353
LIG_TRAF2_1	11	14	PF00917	0.502
LIG_TRAF2_1	132	135	PF00917	0.544
LIG_TRAF2_1	174	177	PF00917	0.647
LIG_WRC_WIRS_1	104	109	PF05994	0.485
LIG_WRC_WIRS_1	265	270	PF05994	0.302
LIG_WW_3	150	154	PF00397	0.357
MOD_CDK_SPxxK_3	197	204	PF00069	0.463
MOD_CK1_1	106	112	PF00069	0.413
MOD_CK1_1	115	121	PF00069	0.306
MOD_CK1_1	185	191	PF00069	0.473
MOD_CK2_1	185	191	PF00069	0.454
MOD_CK2_1	249	255	PF00069	0.455
MOD_CK2_1	291	297	PF00069	0.520
MOD_CK2_1	33	39	PF00069	0.342
MOD_CK2_1	8	14	PF00069	0.571
MOD_GlcNHglycan	10	13	PF01048	0.407
MOD_GlcNHglycan	114	117	PF01048	0.397
MOD_GSK3_1	260	267	PF00069	0.323
MOD_N-GLC_1	255	260	PF02516	0.422
MOD_NEK2_1	260	265	PF00069	0.337
MOD_NEK2_1	269	274	PF00069	0.328
MOD_Plk_2-3	103	109	PF00069	0.490
MOD_Plk_4	182	188	PF00069	0.496
MOD_Plk_4	264	270	PF00069	0.312
MOD_ProDKin_1	185	191	PF00069	0.489
MOD_ProDKin_1	197	203	PF00069	0.407
MOD_ProDKin_1	249	255	PF00069	0.604
MOD_ProDKin_1	63	69	PF00069	0.411
TRG_DiLeu_BaLyEn_6	241	246	PF01217	0.508
TRG_ENDOCYTIC_2	56	59	PF00928	0.487
TRG_ENDOCYTIC_2	78	81	PF00928	0.328

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEP1	Leptomonas seymouri	78%	84%
A0A0S4JEG3	Bodo saltans	39%	93%
A0A1X0NYI1	Trypanosomatidae	49%	89%
A0A3Q8IDS6	Leishmania donovani	95%	84%
A0A422P1N5	Trypanosoma rangeli	49%	93%
A1CGS0	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	29%	100%
A2QHM1	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	29%	98%
A3LNW3	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	27%	100%
A4HGA5	Leishmania braziliensis	90%	84%
A4I3D9	Leishmania infantum	94%	84%
A4REK3	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	29%	100%
A5DHD9	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	27%	100%
A5DXE2	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	29%	99%
D0A808	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	92%
E9AZM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	84%
G0SA60	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	28%	98%
O64740	Arabidopsis thaliana	34%	100%
O94319	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
P0CS50	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	30%	89%
P0CS51	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	30%	89%
P53024	Komagataella phaffii (strain GS115 / ATCC 20864)	25%	100%
P55735	Homo sapiens	30%	93%
Q04491	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
Q0CHM0	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	28%	97%
Q0UNA9	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	31%	100%
Q1DZQ0	Coccidioides immitis (strain RS)	29%	99%
Q2GSM6	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	27%	100%
Q2UG43	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	29%	100%
Q3ZCC9	Bos taurus	30%	93%
Q4PCB8	Ustilago maydis (strain 521 / FGSC 9021)	34%	83%
Q4WNK7	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	29%	98%
Q54DS8	Dictyostelium discoideum	27%	100%
Q5AEF2	Candida albicans (strain SC5314 / ATCC MYA-2876)	26%	100%
Q5B563	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	29%	97%
Q5XFW8	Rattus norvegicus	30%	93%
Q6BIR1	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	28%	100%
Q6BZX5	Yarrowia lipolytica (strain CLIB 122 / E 150)	27%	100%
Q6CSZ5	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	26%	100%
Q6FNV4	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	27%	100%
Q6FQU6	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	28%	99%
Q75BS2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	26%	100%
Q7RZF5	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	27%	99%
Q9D1M0	Mus musculus	30%	93%
Q9SRI1	Arabidopsis thaliana	33%	100%
Q9V3J4	Drosophila melanogaster	29%	85%
V5B0S9	Trypanosoma cruzi	51%	93%