Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8K4_LEIMA

TriTrypDb:

LmjF.28.0660 , LMJLV39_280012200 , LMJSD75_280012200

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005635	nuclear envelope	4	2
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	10
GO:0031967	organelle envelope	3	2
GO:0031975	envelope	2	2
GO:0110165	cellular anatomical entity	1	10
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

Q4Q8K4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8K4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.519
CLV_NRD_NRD_1	19	21	PF00675	0.374
CLV_NRD_NRD_1	322	324	PF00675	0.341
CLV_NRD_NRD_1	4	6	PF00675	0.460
CLV_PCSK_FUR_1	17	21	PF00082	0.499
CLV_PCSK_KEX2_1	17	19	PF00082	0.392
CLV_PCSK_KEX2_1	321	323	PF00082	0.341
CLV_PCSK_KEX2_1	4	6	PF00082	0.459
CLV_PCSK_PC1ET2_1	321	323	PF00082	0.428
CLV_PCSK_SKI1_1	152	156	PF00082	0.312
CLV_PCSK_SKI1_1	210	214	PF00082	0.377
CLV_PCSK_SKI1_1	28	32	PF00082	0.330
CLV_PCSK_SKI1_1	332	336	PF00082	0.466
CLV_PCSK_SKI1_1	7	11	PF00082	0.542
DEG_APCC_DBOX_1	77	85	PF00400	0.607
DEG_Nend_UBRbox_2	1	3	PF02207	0.631
DOC_MAPK_FxFP_2	58	61	PF00069	0.545
DOC_MAPK_gen_1	17	26	PF00069	0.611
DOC_MAPK_gen_1	188	196	PF00069	0.534
DOC_MAPK_gen_1	210	219	PF00069	0.595
DOC_MAPK_gen_1	227	237	PF00069	0.534
DOC_MAPK_gen_1	321	330	PF00069	0.580
DOC_MAPK_gen_1	78	86	PF00069	0.520
DOC_MAPK_MEF2A_6	321	328	PF00069	0.607
DOC_PP4_FxxP_1	10	13	PF00568	0.626
DOC_PP4_FxxP_1	58	61	PF00568	0.532
DOC_USP7_MATH_1	211	215	PF00917	0.581
DOC_USP7_MATH_1	297	301	PF00917	0.441
DOC_USP7_UBL2_3	42	46	PF12436	0.557
LIG_14-3-3_CanoR_1	17	27	PF00244	0.586
LIG_14-3-3_CanoR_1	210	219	PF00244	0.595
LIG_14-3-3_CanoR_1	274	282	PF00244	0.365
LIG_Actin_WH2_2	195	212	PF00022	0.550
LIG_BRCT_BRCA1_1	240	244	PF00533	0.367
LIG_deltaCOP1_diTrp_1	221	228	PF00928	0.505
LIG_EH_1	11	15	PF12763	0.620
LIG_eIF4E_1	261	267	PF01652	0.432
LIG_FHA_1	178	184	PF00498	0.606
LIG_FHA_1	19	25	PF00498	0.653
LIG_FHA_1	31	37	PF00498	0.575
LIG_FHA_1	331	337	PF00498	0.698
LIG_FHA_1	63	69	PF00498	0.510
LIG_FHA_2	199	205	PF00498	0.502
LIG_LIR_Apic_2	56	61	PF02991	0.533
LIG_LIR_Apic_2	70	75	PF02991	0.568
LIG_LIR_Gen_1	105	115	PF02991	0.533
LIG_LIR_Gen_1	241	252	PF02991	0.307
LIG_LIR_Gen_1	276	287	PF02991	0.290
LIG_LIR_Gen_1	308	318	PF02991	0.645
LIG_LIR_Gen_1	47	58	PF02991	0.588
LIG_LIR_Nem_3	105	110	PF02991	0.555
LIG_LIR_Nem_3	126	130	PF02991	0.519
LIG_LIR_Nem_3	21	26	PF02991	0.652
LIG_LIR_Nem_3	241	247	PF02991	0.291
LIG_LIR_Nem_3	276	282	PF02991	0.290
LIG_LIR_Nem_3	325	330	PF02991	0.645
LIG_LIR_Nem_3	47	53	PF02991	0.653
LIG_Pex14_1	6	10	PF04695	0.659
LIG_Pex14_2	10	14	PF04695	0.625
LIG_Pex14_2	240	244	PF04695	0.315
LIG_Pex14_2	248	252	PF04695	0.289
LIG_PTB_Apo_2	66	73	PF02174	0.559
LIG_PTB_Phospho_1	66	72	PF10480	0.551
LIG_REV1ctd_RIR_1	28	34	PF16727	0.523
LIG_SH2_CRK	264	268	PF00017	0.391
LIG_SH2_CRK	50	54	PF00017	0.618
LIG_SH2_NCK_1	50	54	PF00017	0.566
LIG_SH2_PTP2	127	130	PF00017	0.510
LIG_SH2_PTP2	23	26	PF00017	0.602
LIG_SH2_STAP1	249	253	PF00017	0.324
LIG_SH2_STAP1	279	283	PF00017	0.417
LIG_SH2_STAT5	127	130	PF00017	0.494
LIG_SH2_STAT5	218	221	PF00017	0.498
LIG_SH2_STAT5	23	26	PF00017	0.664
LIG_SH2_STAT5	279	282	PF00017	0.308
LIG_SH2_STAT5	316	319	PF00017	0.552
LIG_SH2_STAT5	72	75	PF00017	0.620
LIG_SH3_3	253	259	PF00018	0.432
LIG_SH3_3	58	64	PF00018	0.571
LIG_TYR_ITIM	125	130	PF00017	0.316
LIG_TYR_ITIM	48	53	PF00017	0.516
LIG_UBA3_1	202	208	PF00899	0.378
LIG_WW_3	185	189	PF00397	0.446
MOD_CK1_1	288	294	PF00069	0.358
MOD_CK1_1	76	82	PF00069	0.475
MOD_CK2_1	198	204	PF00069	0.354
MOD_Cter_Amidation	337	340	PF01082	0.462
MOD_GlcNHglycan	102	105	PF01048	0.570
MOD_GlcNHglycan	287	290	PF01048	0.417
MOD_GlcNHglycan	292	295	PF01048	0.446
MOD_GlcNHglycan	307	310	PF01048	0.286
MOD_GSK3_1	273	280	PF00069	0.456
MOD_GSK3_1	281	288	PF00069	0.345
MOD_GSK3_1	297	304	PF00069	0.495
MOD_NEK2_1	290	295	PF00069	0.350
MOD_NEK2_1	30	35	PF00069	0.518
MOD_PKA_1	18	24	PF00069	0.477
MOD_PKA_2	18	24	PF00069	0.494
MOD_PKA_2	226	232	PF00069	0.540
MOD_PKA_2	273	279	PF00069	0.461
MOD_PKA_2	305	311	PF00069	0.442
MOD_Plk_1	152	158	PF00069	0.439
MOD_Plk_1	192	198	PF00069	0.377
MOD_Plk_1	223	229	PF00069	0.425
MOD_Plk_2-3	179	185	PF00069	0.391
MOD_Plk_4	198	204	PF00069	0.337
MOD_Plk_4	277	283	PF00069	0.358
MOD_Plk_4	53	59	PF00069	0.427
MOD_Plk_4	92	98	PF00069	0.374
TRG_DiLeu_BaLyEn_6	110	115	PF01217	0.502
TRG_ENDOCYTIC_2	11	14	PF00928	0.610
TRG_ENDOCYTIC_2	127	130	PF00928	0.351
TRG_ENDOCYTIC_2	23	26	PF00928	0.432
TRG_ENDOCYTIC_2	249	252	PF00928	0.293
TRG_ENDOCYTIC_2	264	267	PF00928	0.379
TRG_ENDOCYTIC_2	27	30	PF00928	0.329
TRG_ENDOCYTIC_2	279	282	PF00928	0.150
TRG_ENDOCYTIC_2	316	319	PF00928	0.413
TRG_ENDOCYTIC_2	50	53	PF00928	0.472
TRG_ER_diArg_1	17	20	PF00400	0.486
TRG_ER_diArg_1	3	5	PF00400	0.578
TRG_ER_diArg_1	322	324	PF00400	0.417
TRG_ER_diArg_1	77	80	PF00400	0.599

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM72	Leptomonas seymouri	82%	100%
A0A0S4JAZ2	Bodo saltans	48%	100%
A0A1X0NZ41	Trypanosomatidae	63%	100%
A0A3S7X196	Leishmania donovani	97%	100%
A4HGA6	Leishmania braziliensis	85%	100%
A4I3E0	Leishmania infantum	97%	100%
D0A807	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	100%
E9AZM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5BG88	Trypanosoma cruzi	62%	100%