Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q8K3_LEIMA

TriTrypDb:

LmjF.28.0670 , LMJLV39_280012300 , LMJSD75_280012300

Length:

360

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8K3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8K3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.664
CLV_C14_Caspase3-7	283	287	PF00656	0.450
CLV_NRD_NRD_1	207	209	PF00675	0.668
CLV_NRD_NRD_1	212	214	PF00675	0.654
CLV_PCSK_KEX2_1	142	144	PF00082	0.411
CLV_PCSK_KEX2_1	212	214	PF00082	0.578
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.411
CLV_PCSK_PC7_1	208	214	PF00082	0.546
CLV_PCSK_SKI1_1	200	204	PF00082	0.631
CLV_PCSK_SKI1_1	256	260	PF00082	0.335
DEG_SCF_FBW7_1	290	296	PF00400	0.514
DOC_CKS1_1	242	247	PF01111	0.352
DOC_CKS1_1	290	295	PF01111	0.523
DOC_CYCLIN_yCln2_LP_2	331	337	PF00134	0.364
DOC_MAPK_gen_1	208	218	PF00069	0.515
DOC_MAPK_MEF2A_6	327	335	PF00069	0.371
DOC_PP1_RVXF_1	336	343	PF00149	0.424
DOC_PP2B_LxvP_1	235	238	PF13499	0.368
DOC_PP2B_LxvP_1	331	334	PF13499	0.378
DOC_PP4_FxxP_1	295	298	PF00568	0.397
DOC_USP7_MATH_1	103	107	PF00917	0.486
DOC_USP7_MATH_1	115	119	PF00917	0.512
DOC_USP7_MATH_1	285	289	PF00917	0.526
DOC_USP7_MATH_1	44	48	PF00917	0.330
DOC_WW_Pin1_4	24	29	PF00397	0.418
DOC_WW_Pin1_4	241	246	PF00397	0.436
DOC_WW_Pin1_4	286	291	PF00397	0.563
LIG_14-3-3_CanoR_1	143	149	PF00244	0.387
LIG_14-3-3_CanoR_1	212	218	PF00244	0.509
LIG_14-3-3_CanoR_1	280	285	PF00244	0.503
LIG_Actin_WH2_2	247	262	PF00022	0.368
LIG_CaM_IQ_9	268	283	PF13499	0.389
LIG_FHA_1	181	187	PF00498	0.435
LIG_FHA_2	242	248	PF00498	0.447
LIG_FHA_2	272	278	PF00498	0.439
LIG_LIR_Apic_2	241	245	PF02991	0.367
LIG_LIR_Apic_2	292	298	PF02991	0.434
LIG_LIR_Gen_1	14	21	PF02991	0.411
LIG_LIR_Nem_3	129	134	PF02991	0.354
LIG_LIR_Nem_3	14	19	PF02991	0.403
LIG_LIR_Nem_3	247	251	PF02991	0.403
LIG_LIR_Nem_3	346	352	PF02991	0.373
LIG_LIR_Nem_3	355	359	PF02991	0.399
LIG_LIR_Nem_3	53	58	PF02991	0.360
LIG_PTB_Apo_2	133	140	PF02174	0.414
LIG_SH2_CRK	242	246	PF00017	0.361
LIG_SH2_STAP1	263	267	PF00017	0.331
LIG_SH2_STAT3	138	141	PF00017	0.313
LIG_SH2_STAT3	38	41	PF00017	0.473
LIG_SH2_STAT5	138	141	PF00017	0.349
LIG_SH2_STAT5	242	245	PF00017	0.360
LIG_SH2_STAT5	352	355	PF00017	0.388
LIG_SH2_STAT5	58	61	PF00017	0.376
LIG_SH2_STAT5	99	102	PF00017	0.405
LIG_SH3_1	351	357	PF00018	0.420
LIG_SH3_3	287	293	PF00018	0.539
LIG_SH3_3	351	357	PF00018	0.454
LIG_SH3_5	238	242	PF00018	0.380
LIG_SUMO_SIM_anti_2	183	188	PF11976	0.405
LIG_SUMO_SIM_par_1	177	183	PF11976	0.356
LIG_SUMO_SIM_par_1	184	190	PF11976	0.422
LIG_TRFH_1	295	299	PF08558	0.388
LIG_TRFH_1	58	62	PF08558	0.372
MOD_CK1_1	233	239	PF00069	0.547
MOD_CK1_1	24	30	PF00069	0.446
MOD_CK1_1	289	295	PF00069	0.519
MOD_CK2_1	19	25	PF00069	0.461
MOD_CK2_1	241	247	PF00069	0.476
MOD_GlcNHglycan	105	108	PF01048	0.575
MOD_GlcNHglycan	110	113	PF01048	0.571
MOD_GlcNHglycan	121	124	PF01048	0.319
MOD_GlcNHglycan	232	235	PF01048	0.399
MOD_GlcNHglycan	247	251	PF01048	0.426
MOD_GlcNHglycan	318	321	PF01048	0.356
MOD_GlcNHglycan	322	325	PF01048	0.332
MOD_GlcNHglycan	46	49	PF01048	0.322
MOD_GSK3_1	103	110	PF00069	0.517
MOD_GSK3_1	115	122	PF00069	0.434
MOD_GSK3_1	20	27	PF00069	0.399
MOD_GSK3_1	246	253	PF00069	0.397
MOD_GSK3_1	259	266	PF00069	0.304
MOD_GSK3_1	285	292	PF00069	0.508
MOD_GSK3_1	316	323	PF00069	0.402
MOD_N-GLC_1	116	121	PF02516	0.480
MOD_N-GLC_1	2	7	PF02516	0.356
MOD_NEK2_1	19	24	PF00069	0.452
MOD_NEK2_1	246	251	PF00069	0.444
MOD_NEK2_1	50	55	PF00069	0.378
MOD_NEK2_1	65	70	PF00069	0.548
MOD_PIKK_1	11	17	PF00454	0.342
MOD_PIKK_1	225	231	PF00454	0.375
MOD_PIKK_1	37	43	PF00454	0.429
MOD_PKA_2	103	109	PF00069	0.532
MOD_PKA_2	211	217	PF00069	0.513
MOD_PKA_2	259	265	PF00069	0.330
MOD_Plk_1	167	173	PF00069	0.417
MOD_Plk_1	263	269	PF00069	0.340
MOD_Plk_2-3	159	165	PF00069	0.460
MOD_Plk_4	182	188	PF00069	0.487
MOD_Plk_4	263	269	PF00069	0.340
MOD_Plk_4	50	56	PF00069	0.376
MOD_ProDKin_1	24	30	PF00069	0.423
MOD_ProDKin_1	241	247	PF00069	0.427
MOD_ProDKin_1	286	292	PF00069	0.559
MOD_SUMO_rev_2	204	211	PF00179	0.720
TRG_ER_diArg_1	211	213	PF00400	0.580
TRG_Pf-PMV_PEXEL_1	200	204	PF00026	0.631
TRG_Pf-PMV_PEXEL_1	276	281	PF00026	0.401

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IA55	Leptomonas seymouri	48%	75%
A0A3Q8IQE0	Leishmania donovani	89%	71%
A4HGA7	Leishmania braziliensis	74%	100%
A4I3E1	Leishmania infantum	89%	100%
E9AZM8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%