ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (3 copies), putative

Species:

Leishmania major

UniProt:

Q4Q8K2_LEIMA

TriTrypDb:

LmjF.28.0680 , LMJLV39_280012400 , LMJSD75_280012400

Length:

233

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8K2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8K2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	16	20	PF00656	0.478
CLV_C14_Caspase3-7	45	49	PF00656	0.384
CLV_NRD_NRD_1	187	189	PF00675	0.637
CLV_PCSK_SKI1_1	121	125	PF00082	0.408
DEG_APCC_DBOX_1	11	19	PF00400	0.550
DEG_Nend_UBRbox_2	1	3	PF02207	0.598
DEG_SPOP_SBC_1	217	221	PF00917	0.647
DOC_PP4_FxxP_1	11	14	PF00568	0.531
DOC_USP7_MATH_1	203	207	PF00917	0.716
DOC_USP7_MATH_1	217	221	PF00917	0.610
DOC_WW_Pin1_4	187	192	PF00397	0.568
LIG_APCC_ABBA_1	1	6	PF00400	0.645
LIG_FHA_1	219	225	PF00498	0.556
LIG_FHA_2	14	20	PF00498	0.479
LIG_LIR_Apic_2	147	152	PF02991	0.637
LIG_LIR_Apic_2	2	7	PF02991	0.646
LIG_LIR_Apic_2	8	14	PF02991	0.610
LIG_LIR_Gen_1	129	140	PF02991	0.509
LIG_MYND_3	67	71	PF01753	0.365
LIG_RPA_C_Fungi	94	106	PF08784	0.384
LIG_SH2_NCK_1	27	31	PF00017	0.516
LIG_SH2_PTP2	149	152	PF00017	0.595
LIG_SH2_SRC	149	152	PF00017	0.595
LIG_SH2_STAP1	128	132	PF00017	0.523
LIG_SH2_STAT3	128	131	PF00017	0.445
LIG_SH2_STAT5	149	152	PF00017	0.542
LIG_SH2_STAT5	39	42	PF00017	0.295
LIG_SH3_1	188	194	PF00018	0.674
LIG_SH3_2	194	199	PF14604	0.619
LIG_SH3_3	188	194	PF00018	0.714
LIG_SH3_3	208	214	PF00018	0.646
LIG_SH3_3	77	83	PF00018	0.252
LIG_SUMO_SIM_anti_2	32	37	PF11976	0.400
LIG_SUMO_SIM_par_1	156	162	PF11976	0.630
MOD_CK2_1	138	144	PF00069	0.570
MOD_CK2_1	159	165	PF00069	0.558
MOD_CK2_1	201	207	PF00069	0.577
MOD_GlcNHglycan	160	164	PF01048	0.620
MOD_GlcNHglycan	203	206	PF01048	0.690
MOD_GlcNHglycan	225	228	PF01048	0.579
MOD_GlcNHglycan	23	26	PF01048	0.445
MOD_GSK3_1	134	141	PF00069	0.398
MOD_NEK2_1	119	124	PF00069	0.497
MOD_NEK2_1	21	26	PF00069	0.479
MOD_NEK2_1	223	228	PF00069	0.613
MOD_PIKK_1	150	156	PF00454	0.594
MOD_PIKK_1	218	224	PF00454	0.547
MOD_Plk_1	142	148	PF00069	0.633
MOD_Plk_2-3	13	19	PF00069	0.483
MOD_Plk_2-3	176	182	PF00069	0.603
MOD_Plk_4	134	140	PF00069	0.384
MOD_Plk_4	145	151	PF00069	0.609
MOD_Plk_4	153	159	PF00069	0.636
MOD_ProDKin_1	187	193	PF00069	0.564
MOD_SUMO_rev_2	169	179	PF00179	0.637
MOD_SUMO_rev_2	181	191	PF00179	0.532
TRG_DiLeu_BaEn_1	134	139	PF01217	0.404
TRG_ENDOCYTIC_2	132	135	PF00928	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8F3	Leptomonas seymouri	73%	100%
A0A1X0NYH9	Trypanosomatidae	39%	95%
A0A3R7KXF5	Trypanosoma rangeli	46%	100%
A0A3S7X195	Leishmania donovani	94%	100%
A4HGA8	Leishmania braziliensis	86%	100%
A4I3E2	Leishmania infantum	94%	100%
D0A806	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AZM9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	99%
Q6NSI1	Homo sapiens	24%	73%
V5BQC3	Trypanosoma cruzi	45%	98%