BTB domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

btb/poz domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q8K0_LEIMA

TriTrypDb:

LmjF.28.0700 , LMJLV39_280012600 , LMJSD75_280012600

Length:

475

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q8K0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8K0

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	6
GO:0016043	cellular component organization	3	6
GO:0022607	cellular component assembly	4	6
GO:0043933	protein-containing complex organization	4	6
GO:0051259	protein complex oligomerization	6	6
GO:0051260	protein homooligomerization	7	6
GO:0065003	protein-containing complex assembly	5	6
GO:0071840	cellular component organization or biogenesis	2	6

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	31	35	PF00656	0.682
CLV_C14_Caspase3-7	413	417	PF00656	0.551
CLV_NRD_NRD_1	205	207	PF00675	0.421
CLV_PCSK_KEX2_1	130	132	PF00082	0.446
CLV_PCSK_KEX2_1	205	207	PF00082	0.421
CLV_PCSK_KEX2_1	7	9	PF00082	0.636
CLV_PCSK_PC1ET2_1	130	132	PF00082	0.446
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.745
CLV_PCSK_SKI1_1	27	31	PF00082	0.677
CLV_Separin_Metazoa	218	222	PF03568	0.483
DEG_SPOP_SBC_1	285	289	PF00917	0.722
DEG_SPOP_SBC_1	290	294	PF00917	0.661
DOC_CKS1_1	351	356	PF01111	0.714
DOC_CYCLIN_RxL_1	297	307	PF00134	0.662
DOC_CYCLIN_yCln2_LP_2	266	272	PF00134	0.613
DOC_MAPK_DCC_7	436	446	PF00069	0.443
DOC_MAPK_gen_1	181	190	PF00069	0.385
DOC_MAPK_HePTP_8	233	245	PF00069	0.518
DOC_MAPK_MEF2A_6	184	192	PF00069	0.379
DOC_MAPK_MEF2A_6	236	245	PF00069	0.517
DOC_PP1_RVXF_1	242	248	PF00149	0.410
DOC_PP1_SILK_1	456	461	PF00149	0.448
DOC_PP2B_LxvP_1	135	138	PF13499	0.500
DOC_PP2B_LxvP_1	254	257	PF13499	0.640
DOC_PP2B_LxvP_1	266	269	PF13499	0.552
DOC_PP2B_LxvP_1	360	363	PF13499	0.628
DOC_PP4_FxxP_1	247	250	PF00568	0.484
DOC_USP7_MATH_1	290	294	PF00917	0.683
DOC_USP7_MATH_1	313	317	PF00917	0.699
DOC_USP7_MATH_1	330	334	PF00917	0.610
DOC_WW_Pin1_4	141	146	PF00397	0.523
DOC_WW_Pin1_4	276	281	PF00397	0.702
DOC_WW_Pin1_4	322	327	PF00397	0.668
DOC_WW_Pin1_4	346	351	PF00397	0.797
DOC_WW_Pin1_4	35	40	PF00397	0.664
DOC_WW_Pin1_4	378	383	PF00397	0.658
DOC_WW_Pin1_4	397	402	PF00397	0.715
DOC_WW_Pin1_4	60	65	PF00397	0.328
LIG_14-3-3_CanoR_1	206	212	PF00244	0.405
LIG_14-3-3_CanoR_1	221	229	PF00244	0.421
LIG_14-3-3_CanoR_1	57	61	PF00244	0.272
LIG_Actin_WH2_2	41	59	PF00022	0.272
LIG_BIR_III_4	467	471	PF00653	0.689
LIG_BRCT_BRCA1_1	324	328	PF00533	0.752
LIG_EVH1_2	442	446	PF00568	0.424
LIG_FHA_1	156	162	PF00498	0.465
LIG_FHA_1	165	171	PF00498	0.455
LIG_FHA_1	214	220	PF00498	0.430
LIG_FHA_1	240	246	PF00498	0.547
LIG_FHA_1	286	292	PF00498	0.708
LIG_FHA_1	459	465	PF00498	0.560
LIG_FHA_2	36	42	PF00498	0.634
LIG_LIR_Apic_2	246	250	PF02991	0.582
LIG_LIR_Gen_1	72	82	PF02991	0.437
LIG_LIR_Gen_1	93	102	PF02991	0.437
LIG_LIR_LC3C_4	112	116	PF02991	0.328
LIG_LIR_Nem_3	72	78	PF02991	0.332
LIG_LIR_Nem_3	93	98	PF02991	0.437
LIG_MYND_1	268	272	PF01753	0.615
LIG_REV1ctd_RIR_1	423	431	PF16727	0.433
LIG_SH2_CRK	105	109	PF00017	0.328
LIG_SH2_STAT3	235	238	PF00017	0.421
LIG_SH2_STAT5	101	104	PF00017	0.347
LIG_SH2_STAT5	213	216	PF00017	0.398
LIG_SH3_3	247	253	PF00018	0.514
LIG_SH3_3	266	272	PF00018	0.613
LIG_SH3_3	295	301	PF00018	0.590
LIG_SH3_3	351	357	PF00018	0.741
LIG_SH3_3	395	401	PF00018	0.612
LIG_SH3_3	406	412	PF00018	0.591
LIG_SH3_3	437	443	PF00018	0.455
LIG_SUMO_SIM_anti_2	112	120	PF11976	0.328
LIG_SUMO_SIM_anti_2	41	47	PF11976	0.328
LIG_SUMO_SIM_anti_2	454	463	PF11976	0.446
LIG_SUMO_SIM_par_1	112	120	PF11976	0.328
LIG_SUMO_SIM_par_1	302	307	PF11976	0.705
LIG_SUMO_SIM_par_1	406	411	PF11976	0.603
LIG_WRC_WIRS_1	422	427	PF05994	0.406
MOD_CDK_SPxxK_3	35	42	PF00069	0.639
MOD_CK1_1	284	290	PF00069	0.643
MOD_CK1_1	292	298	PF00069	0.612
MOD_CK1_1	346	352	PF00069	0.727
MOD_CK1_1	384	390	PF00069	0.651
MOD_CK1_1	454	460	PF00069	0.441
MOD_CK1_1	62	68	PF00069	0.328
MOD_CK2_1	234	240	PF00069	0.420
MOD_CK2_1	314	320	PF00069	0.638
MOD_Cter_Amidation	5	8	PF01082	0.760
MOD_GlcNHglycan	11	15	PF01048	0.752
MOD_GlcNHglycan	223	226	PF01048	0.567
MOD_GlcNHglycan	257	260	PF01048	0.624
MOD_GlcNHglycan	316	319	PF01048	0.693
MOD_GlcNHglycan	332	335	PF01048	0.604
MOD_GlcNHglycan	368	371	PF01048	0.807
MOD_GlcNHglycan	383	386	PF01048	0.767
MOD_GlcNHglycan	391	394	PF01048	0.706
MOD_GlcNHglycan	453	456	PF01048	0.432
MOD_GlcNHglycan	464	467	PF01048	0.518
MOD_GSK3_1	164	171	PF00069	0.440
MOD_GSK3_1	255	262	PF00069	0.688
MOD_GSK3_1	272	279	PF00069	0.674
MOD_GSK3_1	281	288	PF00069	0.616
MOD_GSK3_1	292	299	PF00069	0.602
MOD_GSK3_1	345	352	PF00069	0.673
MOD_GSK3_1	362	369	PF00069	0.742
MOD_GSK3_1	373	380	PF00069	0.742
MOD_GSK3_1	454	461	PF00069	0.534
MOD_GSK3_1	48	55	PF00069	0.328
MOD_GSK3_1	56	63	PF00069	0.328
MOD_N-GLC_1	313	318	PF02516	0.761
MOD_NEK2_1	174	179	PF00069	0.385
MOD_NEK2_1	274	279	PF00069	0.716
MOD_NEK2_1	291	296	PF00069	0.505
MOD_NEK2_1	343	348	PF00069	0.719
MOD_NEK2_1	366	371	PF00069	0.759
MOD_NEK2_1	446	451	PF00069	0.409
MOD_NEK2_1	459	464	PF00069	0.465
MOD_NEK2_1	56	61	PF00069	0.328
MOD_NEK2_2	421	426	PF00069	0.406
MOD_PIKK_1	234	240	PF00454	0.420
MOD_PK_1	460	466	PF00069	0.480
MOD_PKA_2	22	28	PF00069	0.676
MOD_PKA_2	56	62	PF00069	0.272
MOD_PKB_1	8	16	PF00069	0.749
MOD_Plk_1	239	245	PF00069	0.414
MOD_Plk_1	306	312	PF00069	0.678
MOD_Plk_1	415	421	PF00069	0.605
MOD_Plk_4	136	142	PF00069	0.507
MOD_Plk_4	174	180	PF00069	0.381
MOD_Plk_4	292	298	PF00069	0.705
MOD_Plk_4	421	427	PF00069	0.407
MOD_Plk_4	454	460	PF00069	0.441
MOD_Plk_4	62	68	PF00069	0.328
MOD_ProDKin_1	141	147	PF00069	0.513
MOD_ProDKin_1	276	282	PF00069	0.698
MOD_ProDKin_1	322	328	PF00069	0.673
MOD_ProDKin_1	346	352	PF00069	0.799
MOD_ProDKin_1	35	41	PF00069	0.649
MOD_ProDKin_1	378	384	PF00069	0.658
MOD_ProDKin_1	397	403	PF00069	0.716
MOD_ProDKin_1	60	66	PF00069	0.328
MOD_SUMO_for_1	129	132	PF00179	0.431
TRG_DiLeu_BaLyEn_6	398	403	PF01217	0.716
TRG_ER_diArg_1	204	206	PF00400	0.416
TRG_ER_diArg_1	434	437	PF00400	0.439
TRG_Pf-PMV_PEXEL_1	341	345	PF00026	0.735

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P854	Leptomonas seymouri	59%	96%
A0A3S7X191	Leishmania donovani	98%	100%
A4I3E4	Leishmania infantum	98%	100%
E9AZN1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%