DUF5880 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4539), putative

Species:

Leishmania major

UniProt:

Q4Q8J9_LEIMA

TriTrypDb:

LmjF.28.0705 , LMJLV39_280012700 , LMJSD75_280012700

Length:

250

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8J9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8J9

Function

Biological processes
Term	Name	Level	Count
GO:0000725	recombinational repair	6	7
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006259	DNA metabolic process	4	7
GO:0006281	DNA repair	5	7
GO:0006310	DNA recombination	5	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0006950	response to stress	2	7
GO:0006974	DNA damage response	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0033554	cellular response to stress	3	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044260	obsolete cellular macromolecule metabolic process	3	7
GO:0046483	heterocycle metabolic process	3	7
GO:0050896	response to stimulus	1	7
GO:0051716	cellular response to stimulus	2	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	245	249	PF00656	0.553
CLV_C14_Caspase3-7	48	52	PF00656	0.304
CLV_PCSK_KEX2_1	220	222	PF00082	0.602
CLV_PCSK_PC1ET2_1	220	222	PF00082	0.643
CLV_PCSK_SKI1_1	143	147	PF00082	0.565
CLV_PCSK_SKI1_1	30	34	PF00082	0.394
CLV_PCSK_SKI1_1	43	47	PF00082	0.242
DEG_Nend_UBRbox_2	1	3	PF02207	0.437
DOC_CYCLIN_RxL_1	138	150	PF00134	0.513
DOC_PP2B_LxvP_1	113	116	PF13499	0.304
DOC_USP7_MATH_1	126	130	PF00917	0.642
DOC_USP7_MATH_1	187	191	PF00917	0.626
DOC_USP7_MATH_1	194	198	PF00917	0.646
DOC_USP7_MATH_1	49	53	PF00917	0.304
LIG_14-3-3_CanoR_1	195	199	PF00244	0.506
LIG_14-3-3_CanoR_1	20	28	PF00244	0.312
LIG_APCC_ABBA_1	84	89	PF00400	0.245
LIG_BRCT_BRCA1_1	229	233	PF00533	0.582
LIG_FHA_1	40	46	PF00498	0.319
LIG_FHA_1	51	57	PF00498	0.327
LIG_FHA_1	79	85	PF00498	0.391
LIG_FHA_1	89	95	PF00498	0.256
LIG_FHA_2	178	184	PF00498	0.633
LIG_FHA_2	3	9	PF00498	0.420
LIG_Integrin_RGD_1	173	175	PF01839	0.507
LIG_IRF3_LxIS_1	90	96	PF10401	0.325
LIG_LIR_Apic_2	189	194	PF02991	0.564
LIG_LIR_Gen_1	62	71	PF02991	0.304
LIG_LIR_Nem_3	62	67	PF02991	0.326
LIG_LIR_Nem_3	72	78	PF02991	0.378
LIG_LYPXL_yS_3	75	78	PF13949	0.304
LIG_MYND_2	100	104	PF01753	0.369
LIG_NRBOX	109	115	PF00104	0.304
LIG_SH2_CRK	64	68	PF00017	0.304
LIG_SH2_STAP1	28	32	PF00017	0.452
LIG_SH2_STAT5	64	67	PF00017	0.304
LIG_SUMO_SIM_anti_2	242	248	PF11976	0.537
LIG_SUMO_SIM_anti_2	88	94	PF11976	0.304
LIG_SUMO_SIM_par_1	51	58	PF11976	0.304
LIG_SUMO_SIM_par_1	88	97	PF11976	0.304
LIG_WRC_WIRS_1	178	183	PF05994	0.597
MOD_CK1_1	157	163	PF00069	0.660
MOD_CK1_1	26	32	PF00069	0.391
MOD_CK2_1	187	193	PF00069	0.563
MOD_CK2_1	2	8	PF00069	0.426
MOD_GlcNHglycan	120	123	PF01048	0.592
MOD_GlcNHglycan	130	133	PF01048	0.616
MOD_GlcNHglycan	155	159	PF01048	0.584
MOD_GlcNHglycan	202	205	PF01048	0.608
MOD_GlcNHglycan	229	232	PF01048	0.647
MOD_GlcNHglycan	30	33	PF01048	0.392
MOD_GlcNHglycan	47	50	PF01048	0.304
MOD_GlcNHglycan	58	62	PF01048	0.304
MOD_GSK3_1	124	131	PF00069	0.622
MOD_GSK3_1	162	169	PF00069	0.623
MOD_GSK3_1	177	184	PF00069	0.544
MOD_GSK3_1	19	26	PF00069	0.316
MOD_GSK3_1	2	9	PF00069	0.432
MOD_GSK3_1	200	207	PF00069	0.600
MOD_GSK3_1	221	228	PF00069	0.589
MOD_GSK3_1	39	46	PF00069	0.243
MOD_N-GLC_1	225	230	PF02516	0.595
MOD_NEK2_1	93	98	PF00069	0.321
MOD_NEK2_2	177	182	PF00069	0.508
MOD_NEK2_2	59	64	PF00069	0.304
MOD_PKA_2	147	153	PF00069	0.599
MOD_PKA_2	19	25	PF00069	0.315
MOD_PKA_2	194	200	PF00069	0.502
MOD_Plk_1	50	56	PF00069	0.294
MOD_Plk_1	88	94	PF00069	0.304
MOD_Plk_2-3	2	8	PF00069	0.426
MOD_Plk_4	187	193	PF00069	0.738
MOD_Plk_4	2	8	PF00069	0.426
MOD_Plk_4	50	56	PF00069	0.304
TRG_DiLeu_BaEn_1	242	247	PF01217	0.538
TRG_ENDOCYTIC_2	64	67	PF00928	0.304
TRG_ENDOCYTIC_2	75	78	PF00928	0.316
TRG_Pf-PMV_PEXEL_1	206	211	PF00026	0.583

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1R0	Leptomonas seymouri	49%	97%
A0A3S7X1B4	Leishmania donovani	94%	100%
A4HGB1	Leishmania braziliensis	72%	100%
A4I3E5	Leishmania infantum	94%	100%
E9AZN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%