Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8J6_LEIMA

TriTrypDb:

LmjF.28.0730 , LMJLV39_280013000 , LMJSD75_280013000

Length:

186

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8J6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8J6

PDB structure(s): 7aih_Au , 7am2_Au , 7ane_Au

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.531
CLV_NRD_NRD_1	138	140	PF00675	0.392
CLV_NRD_NRD_1	28	30	PF00675	0.552
CLV_PCSK_FUR_1	136	140	PF00082	0.515
CLV_PCSK_KEX2_1	126	128	PF00082	0.471
CLV_PCSK_KEX2_1	138	140	PF00082	0.395
CLV_PCSK_KEX2_1	28	30	PF00082	0.576
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.471
CLV_PCSK_PC7_1	24	30	PF00082	0.571
CLV_PCSK_SKI1_1	11	15	PF00082	0.704
CLV_PCSK_SKI1_1	117	121	PF00082	0.402
CLV_PCSK_SKI1_1	44	48	PF00082	0.528
DOC_CKS1_1	113	118	PF01111	0.398
DOC_MAPK_gen_1	101	111	PF00069	0.439
DOC_PP1_RVXF_1	115	121	PF00149	0.405
DOC_PP4_FxxP_1	51	54	PF00568	0.456
DOC_USP7_MATH_1	13	17	PF00917	0.443
DOC_USP7_MATH_1	52	56	PF00917	0.445
DOC_USP7_UBL2_3	64	68	PF12436	0.521
DOC_WW_Pin1_4	112	117	PF00397	0.447
DOC_WW_Pin1_4	77	82	PF00397	0.436
LIG_14-3-3_CanoR_1	28	38	PF00244	0.533
LIG_deltaCOP1_diTrp_1	148	152	PF00928	0.357
LIG_EVH1_1	17	21	PF00568	0.514
LIG_FHA_1	113	119	PF00498	0.396
LIG_FHA_1	4	10	PF00498	0.520
LIG_IBAR_NPY_1	36	38	PF08397	0.522
LIG_LIR_Apic_2	16	20	PF02991	0.432
LIG_LIR_Apic_2	49	54	PF02991	0.472
LIG_LIR_Gen_1	35	46	PF02991	0.533
LIG_LIR_Nem_3	148	153	PF02991	0.354
LIG_MAD2	94	102	PF02301	0.434
LIG_PDZ_Wminus1_1	184	186	PF00595	0.414
LIG_Pex14_1	57	61	PF04695	0.353
LIG_PTB_Apo_2	45	52	PF02174	0.470
LIG_SH2_CRK	153	157	PF00017	0.343
LIG_SH2_STAP1	130	134	PF00017	0.455
LIG_SH2_STAP1	26	30	PF00017	0.610
LIG_SH2_STAT5	65	68	PF00017	0.441
LIG_SH3_1	107	113	PF00018	0.430
LIG_SH3_3	107	113	PF00018	0.430
LIG_SH3_3	15	21	PF00018	0.518
LIG_SH3_3	171	177	PF00018	0.411
LIG_SH3_3	75	81	PF00018	0.455
LIG_WW_3	19	23	PF00397	0.632
MOD_CDK_SPK_2	112	117	PF00069	0.405
MOD_CK1_1	32	38	PF00069	0.597
MOD_GSK3_1	28	35	PF00069	0.540
MOD_GSK3_1	52	59	PF00069	0.360
MOD_NEK2_1	3	8	PF00069	0.597
MOD_NEK2_1	42	47	PF00069	0.544
MOD_PKA_1	28	34	PF00069	0.531
MOD_PKA_2	103	109	PF00069	0.450
MOD_PKA_2	28	34	PF00069	0.558
MOD_PKA_2	52	58	PF00069	0.360
MOD_Plk_4	4	10	PF00069	0.636
MOD_Plk_4	52	58	PF00069	0.360
MOD_ProDKin_1	112	118	PF00069	0.442
MOD_ProDKin_1	77	83	PF00069	0.439
TRG_ENDOCYTIC_2	153	156	PF00928	0.347
TRG_ENDOCYTIC_2	38	41	PF00928	0.465
TRG_ENDOCYTIC_2	86	89	PF00928	0.401
TRG_ER_diArg_1	138	140	PF00400	0.479
TRG_ER_diArg_1	159	162	PF00400	0.366
TRG_ER_diArg_1	21	24	PF00400	0.553
TRG_ER_diArg_1	28	30	PF00400	0.531
TRG_Pf-PMV_PEXEL_1	138	142	PF00026	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6Y9	Leptomonas seymouri	91%	100%
A0A0S4J812	Bodo saltans	72%	100%
A0A1X0NYE8	Trypanosomatidae	78%	100%
A0A3R7RRY1	Trypanosoma rangeli	78%	100%
A0A3S7X1D1	Leishmania donovani	99%	100%
A4HGB4	Leishmania braziliensis	96%	100%
A4I3E8	Leishmania infantum	99%	100%
D0A7Z9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	77%	100%
E9AZN5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%