Tox-ART-HYD1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8J5_LEIMA

TriTrypDb:

LmjF.28.0740 , LMJLV39_280013100 , LMJSD75_280013100

Length:

394

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8J5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8J5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	187	191	PF00656	0.646
CLV_C14_Caspase3-7	296	300	PF00656	0.630
CLV_NRD_NRD_1	104	106	PF00675	0.648
CLV_NRD_NRD_1	209	211	PF00675	0.581
CLV_NRD_NRD_1	229	231	PF00675	0.372
CLV_NRD_NRD_1	328	330	PF00675	0.473
CLV_NRD_NRD_1	37	39	PF00675	0.568
CLV_PCSK_KEX2_1	142	144	PF00082	0.498
CLV_PCSK_KEX2_1	208	210	PF00082	0.596
CLV_PCSK_KEX2_1	229	231	PF00082	0.629
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.498
CLV_PCSK_PC7_1	204	210	PF00082	0.695
CLV_PCSK_PC7_1	225	231	PF00082	0.439
CLV_PCSK_SKI1_1	108	112	PF00082	0.637
CLV_PCSK_SKI1_1	237	241	PF00082	0.648
CLV_PCSK_SKI1_1	274	278	PF00082	0.545
CLV_PCSK_SKI1_1	309	313	PF00082	0.685
CLV_PCSK_SKI1_1	334	338	PF00082	0.528
CLV_PCSK_SKI1_1	39	43	PF00082	0.442
DEG_Nend_UBRbox_2	1	3	PF02207	0.598
DEG_SCF_FBW7_1	148	155	PF00400	0.550
DOC_CYCLIN_RxL_1	105	115	PF00134	0.662
DOC_CYCLIN_RxL_1	35	46	PF00134	0.433
DOC_MAPK_gen_1	105	112	PF00069	0.635
DOC_MAPK_JIP1_4	106	112	PF00069	0.693
DOC_PP2B_LxvP_1	381	384	PF13499	0.675
DOC_USP7_MATH_1	152	156	PF00917	0.602
DOC_USP7_UBL2_3	330	334	PF12436	0.584
DOC_WW_Pin1_4	148	153	PF00397	0.638
DOC_WW_Pin1_4	361	366	PF00397	0.590
LIG_14-3-3_CanoR_1	108	113	PF00244	0.655
LIG_14-3-3_CanoR_1	212	218	PF00244	0.660
LIG_14-3-3_CanoR_1	219	224	PF00244	0.624
LIG_14-3-3_CanoR_1	229	233	PF00244	0.586
LIG_14-3-3_CanoR_1	281	287	PF00244	0.563
LIG_FHA_1	11	17	PF00498	0.591
LIG_FHA_1	275	281	PF00498	0.533
LIG_FHA_1	376	382	PF00498	0.723
LIG_FHA_2	163	169	PF00498	0.545
LIG_FHA_2	229	235	PF00498	0.699
LIG_FHA_2	254	260	PF00498	0.551
LIG_FHA_2	294	300	PF00498	0.635
LIG_FHA_2	302	308	PF00498	0.647
LIG_FHA_2	362	368	PF00498	0.644
LIG_LIR_Apic_2	349	353	PF02991	0.670
LIG_LIR_Apic_2	374	380	PF02991	0.718
LIG_LIR_Gen_1	166	175	PF02991	0.528
LIG_LIR_Gen_1	197	207	PF02991	0.565
LIG_LIR_Gen_1	53	64	PF02991	0.543
LIG_LIR_Nem_3	166	172	PF02991	0.623
LIG_LIR_Nem_3	197	202	PF02991	0.570
LIG_LIR_Nem_3	211	217	PF02991	0.554
LIG_LIR_Nem_3	53	59	PF02991	0.547
LIG_Pex14_1	310	314	PF04695	0.567
LIG_PTB_Apo_2	279	286	PF02174	0.647
LIG_PTB_Phospho_1	279	285	PF10480	0.643
LIG_SH2_CRK	56	60	PF00017	0.577
LIG_SH2_GRB2like	56	59	PF00017	0.627
LIG_SH2_NCK_1	199	203	PF00017	0.575
LIG_SH2_NCK_1	263	267	PF00017	0.601
LIG_SH2_NCK_1	363	367	PF00017	0.659
LIG_SH2_NCK_1	56	60	PF00017	0.533
LIG_SH2_STAP1	373	377	PF00017	0.671
LIG_SH2_STAT3	30	33	PF00017	0.665
LIG_SH2_STAT5	169	172	PF00017	0.519
LIG_SH2_STAT5	193	196	PF00017	0.558
LIG_SH2_STAT5	344	347	PF00017	0.539
LIG_SH2_STAT5	363	366	PF00017	0.501
LIG_SH2_STAT5	373	376	PF00017	0.563
LIG_SH2_STAT5	377	380	PF00017	0.559
LIG_SH2_STAT5	56	59	PF00017	0.545
LIG_SH3_3	15	21	PF00018	0.616
LIG_SH3_3	38	44	PF00018	0.559
LIG_TYR_ITIM	54	59	PF00017	0.543
LIG_WW_3	16	20	PF00397	0.614
MOD_CK2_1	253	259	PF00069	0.600
MOD_CK2_1	361	367	PF00069	0.649
MOD_GlcNHglycan	154	157	PF01048	0.663
MOD_GlcNHglycan	176	180	PF01048	0.568
MOD_GlcNHglycan	247	250	PF01048	0.524
MOD_GlcNHglycan	314	317	PF01048	0.617
MOD_GlcNHglycan	320	324	PF01048	0.603
MOD_GlcNHglycan	6	9	PF01048	0.589
MOD_GSK3_1	108	115	PF00069	0.571
MOD_GSK3_1	148	155	PF00069	0.570
MOD_GSK3_1	219	226	PF00069	0.673
MOD_GSK3_1	228	235	PF00069	0.638
MOD_GSK3_1	371	378	PF00069	0.772
MOD_GSK3_1	383	390	PF00069	0.703
MOD_GSK3_1	46	53	PF00069	0.581
MOD_N-GLC_1	75	80	PF02516	0.612
MOD_NEK2_1	112	117	PF00069	0.477
MOD_NEK2_1	175	180	PF00069	0.447
MOD_NEK2_1	232	237	PF00069	0.581
MOD_NEK2_1	253	258	PF00069	0.634
MOD_NEK2_1	280	285	PF00069	0.661
MOD_NEK2_1	293	298	PF00069	0.501
MOD_NEK2_1	4	9	PF00069	0.600
MOD_NEK2_1	54	59	PF00069	0.619
MOD_NEK2_1	75	80	PF00069	0.566
MOD_NEK2_1	93	98	PF00069	0.538
MOD_PIKK_1	223	229	PF00454	0.545
MOD_PIKK_1	285	291	PF00454	0.580
MOD_PIKK_1	293	299	PF00454	0.514
MOD_PIKK_1	75	81	PF00454	0.595
MOD_PIKK_1	93	99	PF00454	0.599
MOD_PKA_2	228	234	PF00069	0.641
MOD_PKA_2	280	286	PF00069	0.635
MOD_PKB_1	208	216	PF00069	0.683
MOD_Plk_1	175	181	PF00069	0.507
MOD_Plk_1	210	216	PF00069	0.677
MOD_Plk_1	223	229	PF00069	0.588
MOD_Plk_1	274	280	PF00069	0.603
MOD_Plk_1	291	297	PF00069	0.413
MOD_Plk_1	45	51	PF00069	0.570
MOD_Plk_1	75	81	PF00069	0.616
MOD_Plk_4	372	378	PF00069	0.718
MOD_Plk_4	383	389	PF00069	0.715
MOD_ProDKin_1	148	154	PF00069	0.643
MOD_ProDKin_1	361	367	PF00069	0.588
MOD_SUMO_for_1	141	144	PF00179	0.557
TRG_AP2beta_CARGO_1	211	221	PF09066	0.635
TRG_ENDOCYTIC_2	169	172	PF00928	0.537
TRG_ENDOCYTIC_2	199	202	PF00928	0.572
TRG_ENDOCYTIC_2	373	376	PF00928	0.611
TRG_ENDOCYTIC_2	56	59	PF00928	0.540
TRG_ER_diArg_1	207	210	PF00400	0.589
TRG_ER_diArg_1	228	230	PF00400	0.630
TRG_NLS_MonoCore_2	104	109	PF00514	0.688
TRG_Pf-PMV_PEXEL_1	108	113	PF00026	0.700
TRG_Pf-PMV_PEXEL_1	230	234	PF00026	0.541

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDT5	Leptomonas seymouri	69%	92%
A0A0S4JAK0	Bodo saltans	28%	100%
A0A1X0NYG9	Trypanosomatidae	46%	93%
A0A3Q8IEQ6	Leishmania donovani	95%	100%
A0A3R7KQJ1	Trypanosoma rangeli	47%	92%
A4HGB5	Leishmania braziliensis	85%	100%
A4I3E9	Leishmania infantum	96%	100%
D0A7Z8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	94%
E9AZN6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BQC0	Trypanosoma cruzi	46%	91%