ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8J2_LEIMA

TriTrypDb:

LmjF.28.0770 , LMJLV39_280013400 , LMJSD75_280013400

Length:

474

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8J2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8J2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	227	229	PF00675	0.588
CLV_NRD_NRD_1	367	369	PF00675	0.795
CLV_NRD_NRD_1	89	91	PF00675	0.498
CLV_PCSK_KEX2_1	167	169	PF00082	0.711
CLV_PCSK_KEX2_1	367	369	PF00082	0.785
CLV_PCSK_KEX2_1	463	465	PF00082	0.762
CLV_PCSK_PC1ET2_1	167	169	PF00082	0.711
CLV_PCSK_PC1ET2_1	463	465	PF00082	0.762
CLV_PCSK_SKI1_1	112	116	PF00082	0.376
CLV_PCSK_SKI1_1	162	166	PF00082	0.726
CLV_PCSK_SKI1_1	185	189	PF00082	0.657
CLV_PCSK_SKI1_1	329	333	PF00082	0.768
CLV_PCSK_SKI1_1	98	102	PF00082	0.317
DEG_SCF_FBW7_1	203	209	PF00400	0.312
DOC_CKS1_1	203	208	PF01111	0.313
DOC_CYCLIN_RxL_1	109	116	PF00134	0.500
DOC_CYCLIN_yCln2_LP_2	96	102	PF00134	0.623
DOC_PP1_RVXF_1	110	116	PF00149	0.500
DOC_PP1_RVXF_1	221	228	PF00149	0.465
DOC_PP2B_LxvP_1	100	103	PF13499	0.392
DOC_PP4_FxxP_1	35	38	PF00568	0.648
DOC_USP7_MATH_1	139	143	PF00917	0.490
DOC_USP7_MATH_1	277	281	PF00917	0.495
DOC_USP7_MATH_1	55	59	PF00917	0.707
DOC_WW_Pin1_4	1	6	PF00397	0.748
DOC_WW_Pin1_4	202	207	PF00397	0.435
DOC_WW_Pin1_4	373	378	PF00397	0.518
LIG_14-3-3_CanoR_1	168	175	PF00244	0.420
LIG_14-3-3_CanoR_1	223	228	PF00244	0.419
LIG_14-3-3_CanoR_1	351	355	PF00244	0.523
LIG_14-3-3_CanoR_1	449	455	PF00244	0.543
LIG_APCC_ABBA_1	422	427	PF00400	0.615
LIG_BIR_II_1	1	5	PF00653	0.749
LIG_BRCT_BRCA1_1	123	127	PF00533	0.441
LIG_BRCT_BRCA1_1	223	227	PF00533	0.468
LIG_BRCT_BRCA1_2	223	229	PF00533	0.428
LIG_Clathr_ClatBox_1	207	211	PF01394	0.425
LIG_Clathr_ClatBox_1	56	60	PF01394	0.698
LIG_deltaCOP1_diTrp_1	128	137	PF00928	0.424
LIG_FHA_1	124	130	PF00498	0.471
LIG_FHA_1	139	145	PF00498	0.368
LIG_FHA_1	203	209	PF00498	0.459
LIG_FHA_1	437	443	PF00498	0.559
LIG_FHA_1	449	455	PF00498	0.385
LIG_FHA_1	48	54	PF00498	0.769
LIG_FHA_1	77	83	PF00498	0.673
LIG_FHA_2	123	129	PF00498	0.408
LIG_FHA_2	404	410	PF00498	0.539
LIG_GBD_Chelix_1	106	114	PF00786	0.500
LIG_HP1_1	55	59	PF01393	0.663
LIG_LIR_Apic_2	33	38	PF02991	0.645
LIG_LIR_Apic_2	372	377	PF02991	0.564
LIG_LIR_Gen_1	25	34	PF02991	0.553
LIG_LIR_Gen_1	291	299	PF02991	0.409
LIG_LIR_Gen_1	358	369	PF02991	0.579
LIG_LIR_Gen_1	386	397	PF02991	0.549
LIG_LIR_Gen_1	431	442	PF02991	0.550
LIG_LIR_Nem_3	25	29	PF02991	0.555
LIG_LIR_Nem_3	265	270	PF02991	0.409
LIG_LIR_Nem_3	291	295	PF02991	0.416
LIG_LIR_Nem_3	303	307	PF02991	0.440
LIG_LIR_Nem_3	313	319	PF02991	0.392
LIG_LIR_Nem_3	358	364	PF02991	0.583
LIG_LIR_Nem_3	386	392	PF02991	0.581
LIG_MYND_1	99	103	PF01753	0.555
LIG_NRBOX	105	111	PF00104	0.500
LIG_NRBOX	58	64	PF00104	0.574
LIG_PCNA_yPIPBox_3	151	165	PF02747	0.357
LIG_Pex14_2	263	267	PF04695	0.406
LIG_PTB_Apo_2	29	36	PF02174	0.586
LIG_REV1ctd_RIR_1	264	272	PF16727	0.449
LIG_SH2_CRK	389	393	PF00017	0.577
LIG_SH2_STAT3	20	23	PF00017	0.698
LIG_SH2_STAT5	34	37	PF00017	0.545
LIG_SH2_STAT5	348	351	PF00017	0.459
LIG_SH2_STAT5	453	456	PF00017	0.498
LIG_SH3_4	37	44	PF00018	0.689
LIG_SUMO_SIM_par_1	205	211	PF11976	0.467
LIG_SUMO_SIM_par_1	55	60	PF11976	0.663
LIG_TRAF2_1	212	215	PF00917	0.459
LIG_TRAF2_1	456	459	PF00917	0.570
LIG_UBA3_1	109	117	PF00899	0.438
LIG_WRC_WIRS_1	263	268	PF05994	0.401
MOD_CK1_1	123	129	PF00069	0.403
MOD_CK1_1	194	200	PF00069	0.437
MOD_CK1_1	202	208	PF00069	0.368
MOD_CK1_1	233	239	PF00069	0.446
MOD_CK1_1	353	359	PF00069	0.500
MOD_CK1_1	362	368	PF00069	0.467
MOD_CK1_1	373	379	PF00069	0.487
MOD_CK1_1	4	10	PF00069	0.778
MOD_CK1_1	417	423	PF00069	0.596
MOD_CK2_1	307	313	PF00069	0.406
MOD_CK2_1	403	409	PF00069	0.517
MOD_CK2_1	442	448	PF00069	0.535
MOD_CK2_1	453	459	PF00069	0.527
MOD_GlcNHglycan	168	171	PF01048	0.707
MOD_GlcNHglycan	193	196	PF01048	0.600
MOD_GlcNHglycan	242	245	PF01048	0.664
MOD_GlcNHglycan	286	289	PF01048	0.607
MOD_GlcNHglycan	307	310	PF01048	0.712
MOD_GlcNHglycan	443	447	PF01048	0.744
MOD_GlcNHglycan	455	458	PF01048	0.773
MOD_GlcNHglycan	6	9	PF01048	0.488
MOD_GlcNHglycan	64	67	PF01048	0.523
MOD_GSK3_1	166	173	PF00069	0.487
MOD_GSK3_1	187	194	PF00069	0.401
MOD_GSK3_1	202	209	PF00069	0.408
MOD_GSK3_1	230	237	PF00069	0.436
MOD_GSK3_1	284	291	PF00069	0.461
MOD_GSK3_1	307	314	PF00069	0.405
MOD_GSK3_1	350	357	PF00069	0.514
MOD_GSK3_1	388	395	PF00069	0.526
MOD_N-GLC_1	157	162	PF02516	0.563
MOD_N-GLC_1	284	289	PF02516	0.698
MOD_N-GLC_1	387	392	PF02516	0.737
MOD_NEK2_1	121	126	PF00069	0.458
MOD_NEK2_1	129	134	PF00069	0.403
MOD_NEK2_1	156	161	PF00069	0.425
MOD_NEK2_1	191	196	PF00069	0.388
MOD_NEK2_1	199	204	PF00069	0.345
MOD_NEK2_1	284	289	PF00069	0.504
MOD_NEK2_1	318	323	PF00069	0.392
MOD_NEK2_1	387	392	PF00069	0.567
MOD_NEK2_2	235	240	PF00069	0.418
MOD_PIKK_1	215	221	PF00454	0.447
MOD_PIKK_1	448	454	PF00454	0.544
MOD_PKA_1	370	376	PF00069	0.595
MOD_PKA_2	139	145	PF00069	0.443
MOD_PKA_2	305	311	PF00069	0.534
MOD_PKA_2	350	356	PF00069	0.521
MOD_PKA_2	448	454	PF00069	0.544
MOD_PKB_1	368	376	PF00069	0.593
MOD_Plk_1	156	162	PF00069	0.517
MOD_Plk_1	221	227	PF00069	0.390
MOD_Plk_1	387	393	PF00069	0.518
MOD_Plk_1	435	441	PF00069	0.607
MOD_Plk_1	76	82	PF00069	0.665
MOD_Plk_2-3	336	342	PF00069	0.519
MOD_Plk_4	194	200	PF00069	0.444
MOD_Plk_4	235	241	PF00069	0.443
MOD_Plk_4	262	268	PF00069	0.369
MOD_Plk_4	311	317	PF00069	0.371
MOD_Plk_4	350	356	PF00069	0.470
MOD_Plk_4	376	382	PF00069	0.509
MOD_Plk_4	436	442	PF00069	0.556
MOD_ProDKin_1	1	7	PF00069	0.745
MOD_ProDKin_1	202	208	PF00069	0.432
MOD_ProDKin_1	373	379	PF00069	0.518
MOD_SUMO_for_1	150	153	PF00179	0.462
MOD_SUMO_rev_2	226	236	PF00179	0.437
MOD_SUMO_rev_2	330	340	PF00179	0.544
TRG_DiLeu_BaEn_1	77	82	PF01217	0.620
TRG_DiLeu_BaEn_1	97	102	PF01217	0.625
TRG_DiLeu_BaLyEn_6	203	208	PF01217	0.448
TRG_DiLeu_BaLyEn_6	314	319	PF01217	0.448
TRG_DiLeu_BaLyEn_6	96	101	PF01217	0.629
TRG_ENDOCYTIC_2	316	319	PF00928	0.412
TRG_ENDOCYTIC_2	389	392	PF00928	0.579
TRG_ER_diArg_1	367	370	PF00400	0.581
TRG_Pf-PMV_PEXEL_1	112	116	PF00026	0.500
TRG_Pf-PMV_PEXEL_1	40	44	PF00026	0.464

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PES7	Leptomonas seymouri	38%	99%
A0A1X0NYH6	Trypanosomatidae	25%	84%
A0A3Q8ID12	Leishmania donovani	90%	99%
A4HGB8	Leishmania braziliensis	76%	99%
A4I3F2	Leishmania infantum	90%	99%
E9AZN9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	99%