RNA polymerase I

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

RNA polymerase I

Gene product:

kinetoplast poly(A) polymerase 1

Species:

Leishmania major

UniProt:

Q4Q8J1_LEIMA

TriTrypDb:

LmjF.28.0780 , LMJLV39_280013600 , LMJSD75_280013600

Length:

455

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	20
GO:0005737	cytoplasm	2	18
GO:0016020	membrane	2	3
GO:0031019	mitochondrial mRNA editing complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0045293	mRNA editing complex	3	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

Q4Q8J1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8J1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	21
GO:0006378	mRNA polyadenylation	7	2
GO:0006396	RNA processing	6	21
GO:0006397	mRNA processing	7	2
GO:0006725	cellular aromatic compound metabolic process	3	21
GO:0006807	nitrogen compound metabolic process	2	21
GO:0008152	metabolic process	1	21
GO:0009987	cellular process	1	21
GO:0016070	RNA metabolic process	5	21
GO:0016071	mRNA metabolic process	6	2
GO:0031123	RNA 3'-end processing	7	21
GO:0031124	mRNA 3'-end processing	8	2
GO:0034641	cellular nitrogen compound metabolic process	3	21
GO:0043170	macromolecule metabolic process	3	21
GO:0043631	RNA polyadenylation	6	2
GO:0044237	cellular metabolic process	2	21
GO:0044238	primary metabolic process	2	21
GO:0046483	heterocycle metabolic process	3	21
GO:0071076	RNA 3' uridylation	8	21
GO:0071704	organic substance metabolic process	2	21
GO:0090304	nucleic acid metabolic process	4	21
GO:1901360	organic cyclic compound metabolic process	3	21

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	21
GO:0004652	obsolete polynucleotide adenylyltransferase activity	6	5
GO:0005488	binding	1	21
GO:0016740	transferase activity	2	21
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	21
GO:0016779	nucleotidyltransferase activity	4	21
GO:0043167	ion binding	2	21
GO:0043169	cation binding	3	21
GO:0046872	metal ion binding	4	21
GO:0050265	RNA uridylyltransferase activity	4	21
GO:0070566	adenylyltransferase activity	5	5
GO:0070569	uridylyltransferase activity	5	21
GO:0140098	catalytic activity, acting on RNA	3	21
GO:0140640	catalytic activity, acting on a nucleic acid	2	21

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	416	418	PF00675	0.473
CLV_NRD_NRD_1	45	47	PF00675	0.408
CLV_NRD_NRD_1	52	54	PF00675	0.356
CLV_PCSK_KEX2_1	418	420	PF00082	0.480
CLV_PCSK_KEX2_1	45	47	PF00082	0.428
CLV_PCSK_KEX2_1	52	54	PF00082	0.417
CLV_PCSK_PC1ET2_1	418	420	PF00082	0.564
CLV_PCSK_SKI1_1	198	202	PF00082	0.320
CLV_PCSK_SKI1_1	406	410	PF00082	0.550
CLV_PCSK_SKI1_1	427	431	PF00082	0.592
CLV_PCSK_SKI1_1	443	447	PF00082	0.461
CLV_Separin_Metazoa	42	46	PF03568	0.504
DEG_APCC_DBOX_1	197	205	PF00400	0.304
DEG_APCC_DBOX_1	405	413	PF00400	0.544
DEG_SPOP_SBC_1	133	137	PF00917	0.470
DOC_CYCLIN_RxL_1	336	346	PF00134	0.468
DOC_CYCLIN_yClb1_LxF_4	409	414	PF00134	0.581
DOC_CYCLIN_yCln2_LP_2	155	161	PF00134	0.392
DOC_MAPK_MEF2A_6	146	155	PF00069	0.358
DOC_MAPK_MEF2A_6	351	359	PF00069	0.526
DOC_PP1_RVXF_1	409	415	PF00149	0.543
DOC_PP2B_LxvP_1	155	158	PF13499	0.364
DOC_PP2B_LxvP_1	379	382	PF13499	0.510
DOC_PP4_FxxP_1	364	367	PF00568	0.388
DOC_USP7_MATH_1	133	137	PF00917	0.403
DOC_USP7_MATH_1	82	86	PF00917	0.572
DOC_USP7_UBL2_3	238	242	PF12436	0.299
DOC_USP7_UBL2_3	376	380	PF12436	0.539
DOC_WW_Pin1_4	78	83	PF00397	0.418
LIG_14-3-3_CanoR_1	383	389	PF00244	0.465
LIG_14-3-3_CanoR_1	391	399	PF00244	0.467
LIG_14-3-3_CanoR_1	417	422	PF00244	0.516
LIG_14-3-3_CanoR_1	45	54	PF00244	0.515
LIG_14-3-3_CanoR_1	73	79	PF00244	0.490
LIG_BRCT_BRCA1_1	123	127	PF00533	0.470
LIG_deltaCOP1_diTrp_1	120	127	PF00928	0.378
LIG_eIF4E_1	8	14	PF01652	0.423
LIG_FHA_1	13	19	PF00498	0.458
LIG_FHA_1	133	139	PF00498	0.367
LIG_FHA_1	225	231	PF00498	0.327
LIG_FHA_1	344	350	PF00498	0.336
LIG_FHA_1	366	372	PF00498	0.518
LIG_FHA_1	440	446	PF00498	0.554
LIG_FHA_1	69	75	PF00498	0.419
LIG_FHA_2	115	121	PF00498	0.442
LIG_FHA_2	279	285	PF00498	0.266
LIG_FHA_2	435	441	PF00498	0.459
LIG_LIR_Apic_2	166	171	PF02991	0.356
LIG_LIR_Apic_2	362	367	PF02991	0.394
LIG_LIR_Gen_1	124	133	PF02991	0.428
LIG_LIR_Gen_1	81	91	PF02991	0.503
LIG_LIR_Nem_3	124	130	PF02991	0.416
LIG_LIR_Nem_3	24	30	PF02991	0.320
LIG_LIR_Nem_3	281	285	PF02991	0.294
LIG_LIR_Nem_3	81	86	PF02991	0.486
LIG_Pex14_1	121	125	PF04695	0.508
LIG_Pex14_2	170	174	PF04695	0.341
LIG_Pex14_2	282	286	PF04695	0.445
LIG_PTB_Apo_2	255	262	PF02174	0.554
LIG_PTB_Phospho_1	255	261	PF10480	0.557
LIG_SH2_CRK	168	172	PF00017	0.333
LIG_SH2_STAP1	224	228	PF00017	0.305
LIG_SH2_STAP1	3	7	PF00017	0.371
LIG_SH2_STAT5	277	280	PF00017	0.373
LIG_SH2_STAT5	285	288	PF00017	0.373
LIG_SH2_STAT5	348	351	PF00017	0.378
LIG_SH2_STAT5	8	11	PF00017	0.348
LIG_SH3_1	76	82	PF00018	0.418
LIG_SH3_2	378	383	PF14604	0.408
LIG_SH3_3	148	154	PF00018	0.339
LIG_SH3_3	375	381	PF00018	0.378
LIG_SH3_3	76	82	PF00018	0.418
LIG_SUMO_SIM_anti_2	227	232	PF11976	0.356
LIG_SUMO_SIM_par_1	29	34	PF11976	0.453
LIG_UBA3_1	138	146	PF00899	0.368
LIG_UBA3_1	200	206	PF00899	0.326
LIG_WRC_WIRS_1	279	284	PF05994	0.273
LIG_WW_3	380	384	PF00397	0.463
MOD_CK1_1	372	378	PF00069	0.458
MOD_CK1_1	436	442	PF00069	0.521
MOD_CK2_1	114	120	PF00069	0.475
MOD_CK2_1	278	284	PF00069	0.266
MOD_CK2_1	44	50	PF00069	0.566
MOD_GlcNHglycan	210	213	PF01048	0.328
MOD_GlcNHglycan	371	374	PF01048	0.337
MOD_GSK3_1	176	183	PF00069	0.436
MOD_GSK3_1	220	227	PF00069	0.317
MOD_GSK3_1	292	299	PF00069	0.389
MOD_GSK3_1	365	372	PF00069	0.538
MOD_GSK3_1	68	75	PF00069	0.403
MOD_GSK3_1	78	85	PF00069	0.456
MOD_N-GLC_1	121	126	PF02516	0.396
MOD_N-GLC_1	433	438	PF02516	0.616
MOD_NEK2_1	13	18	PF00069	0.419
MOD_NEK2_1	132	137	PF00069	0.366
MOD_NEK2_1	174	179	PF00069	0.314
MOD_NEK2_1	181	186	PF00069	0.314
MOD_NEK2_1	220	225	PF00069	0.323
MOD_NEK2_1	278	283	PF00069	0.273
MOD_NEK2_1	302	307	PF00069	0.310
MOD_NEK2_1	343	348	PF00069	0.484
MOD_NEK2_1	369	374	PF00069	0.488
MOD_NEK2_1	44	49	PF00069	0.543
MOD_NEK2_1	92	97	PF00069	0.326
MOD_NEK2_2	3	8	PF00069	0.419
MOD_PKA_1	417	423	PF00069	0.511
MOD_PKA_1	45	51	PF00069	0.505
MOD_PKA_2	181	187	PF00069	0.322
MOD_PKA_2	208	214	PF00069	0.292
MOD_PKA_2	44	50	PF00069	0.362
MOD_PKA_2	72	78	PF00069	0.424
MOD_PKB_1	107	115	PF00069	0.364
MOD_Plk_1	121	127	PF00069	0.420
MOD_Plk_1	3	9	PF00069	0.410
MOD_Plk_1	343	349	PF00069	0.424
MOD_Plk_4	134	140	PF00069	0.477
MOD_Plk_4	224	230	PF00069	0.311
MOD_Plk_4	232	238	PF00069	0.335
MOD_Plk_4	278	284	PF00069	0.445
MOD_Plk_4	292	298	PF00069	0.358
MOD_Plk_4	3	9	PF00069	0.411
MOD_Plk_4	343	349	PF00069	0.361
MOD_Plk_4	365	371	PF00069	0.440
MOD_ProDKin_1	78	84	PF00069	0.413
TRG_DiLeu_BaEn_1	274	279	PF01217	0.381
TRG_ENDOCYTIC_2	261	264	PF00928	0.393
TRG_ER_diArg_1	106	109	PF00400	0.467
TRG_ER_diArg_1	44	46	PF00400	0.398
TRG_ER_diArg_1	51	53	PF00400	0.356
TRG_ER_diArg_1	56	59	PF00400	0.291
TRG_NLS_MonoExtC_3	416	422	PF00514	0.619
TRG_Pf-PMV_PEXEL_1	262	266	PF00026	0.421
TRG_Pf-PMV_PEXEL_1	339	344	PF00026	0.384
TRG_Pf-PMV_PEXEL_1	386	390	PF00026	0.598

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P857	Leptomonas seymouri	74%	87%
A0A0N1IJQ4	Leptomonas seymouri	25%	90%
A0A0S4JJT6	Bodo saltans	43%	78%
A0A1X0NSS0	Trypanosomatidae	23%	93%
A0A1X0NZU6	Trypanosomatidae	58%	87%
A0A3Q8IC11	Leishmania donovani	26%	89%
A0A3Q8IHZ8	Leishmania donovani	95%	100%
A0A3R7K3P5	Trypanosoma rangeli	56%	86%
A0A422NVH7	Trypanosoma rangeli	24%	93%
A4HEP5	Leishmania braziliensis	26%	89%
A4HGC0	Leishmania braziliensis	89%	100%
A4I1X5	Leishmania infantum	26%	89%
A4I3F3	Leishmania infantum	95%	100%
D0A7Y7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	86%
E9AY21	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	89%
E9AZP1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4Q9F2	Leishmania major	25%	89%
V5BG78	Trypanosoma cruzi	54%	86%
V5BQ07	Trypanosoma cruzi	24%	94%