Putative dual-specificity protein phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinetoplastid-specific dual specificity phosphatase, putative

Species:

Leishmania major

UniProt:

Q4Q8J0_LEIMA

TriTrypDb:

LmjF.28.0790 , LMJLV39_280013700 , LMJSD75_280013700

Length:

629

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q8J0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8J0

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	10
GO:0006793	phosphorus metabolic process	3	10
GO:0006796	phosphate-containing compound metabolic process	4	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0007165	signal transduction	2	2
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0016311	dephosphorylation	5	10
GO:0019538	protein metabolic process	3	10
GO:0036211	protein modification process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0065007	biological regulation	1	2
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004721	phosphoprotein phosphatase activity	3	10
GO:0004725	protein tyrosine phosphatase activity	4	2
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	4	10
GO:0016787	hydrolase activity	2	10
GO:0016788	hydrolase activity, acting on ester bonds	3	10
GO:0016791	phosphatase activity	5	10
GO:0042578	phosphoric ester hydrolase activity	4	10
GO:0140096	catalytic activity, acting on a protein	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	441	445	PF00656	0.422
CLV_NRD_NRD_1	116	118	PF00675	0.510
CLV_NRD_NRD_1	151	153	PF00675	0.521
CLV_NRD_NRD_1	271	273	PF00675	0.536
CLV_NRD_NRD_1	452	454	PF00675	0.508
CLV_NRD_NRD_1	53	55	PF00675	0.444
CLV_NRD_NRD_1	90	92	PF00675	0.573
CLV_PCSK_KEX2_1	271	273	PF00082	0.536
CLV_PCSK_KEX2_1	452	454	PF00082	0.594
CLV_PCSK_KEX2_1	53	55	PF00082	0.444
CLV_PCSK_KEX2_1	90	92	PF00082	0.539
CLV_PCSK_PC1ET2_1	53	55	PF00082	0.444
CLV_PCSK_SKI1_1	117	121	PF00082	0.471
CLV_PCSK_SKI1_1	352	356	PF00082	0.550
CLV_PCSK_SKI1_1	452	456	PF00082	0.605
CLV_PCSK_SKI1_1	460	464	PF00082	0.582
CLV_PCSK_SKI1_1	544	548	PF00082	0.329
DEG_APCC_DBOX_1	603	611	PF00400	0.529
DEG_Nend_UBRbox_2	1	3	PF02207	0.353
DOC_CKS1_1	110	115	PF01111	0.323
DOC_CYCLIN_RxL_1	541	551	PF00134	0.341
DOC_CYCLIN_yCln2_LP_2	411	417	PF00134	0.300
DOC_MAPK_gen_1	114	124	PF00069	0.325
DOC_MAPK_gen_1	245	253	PF00069	0.387
DOC_MAPK_gen_1	53	61	PF00069	0.293
DOC_MAPK_MEF2A_6	218	226	PF00069	0.208
DOC_MAPK_MEF2A_6	54	63	PF00069	0.356
DOC_MAPK_RevD_3	40	54	PF00069	0.225
DOC_PP1_RVXF_1	482	488	PF00149	0.361
DOC_PP2B_LxvP_1	15	18	PF13499	0.354
DOC_PP2B_LxvP_1	418	421	PF13499	0.340
DOC_SPAK_OSR1_1	107	111	PF12202	0.256
DOC_USP7_MATH_1	175	179	PF00917	0.194
DOC_USP7_MATH_1	225	229	PF00917	0.299
DOC_USP7_MATH_1	281	285	PF00917	0.308
DOC_USP7_MATH_1	387	391	PF00917	0.407
DOC_USP7_MATH_1	473	477	PF00917	0.433
DOC_USP7_MATH_1	478	482	PF00917	0.376
DOC_USP7_MATH_1	499	503	PF00917	0.338
DOC_USP7_UBL2_3	114	118	PF12436	0.319
DOC_WW_Pin1_4	109	114	PF00397	0.411
LIG_14-3-3_CanoR_1	218	223	PF00244	0.288
LIG_14-3-3_CanoR_1	340	344	PF00244	0.434
LIG_14-3-3_CanoR_1	371	377	PF00244	0.351
LIG_APCC_ABBA_1	419	424	PF00400	0.346
LIG_BRCT_BRCA1_1	411	415	PF00533	0.298
LIG_deltaCOP1_diTrp_1	431	439	PF00928	0.377
LIG_DLG_GKlike_1	218	226	PF00625	0.257
LIG_FHA_1	12	18	PF00498	0.313
LIG_FHA_1	129	135	PF00498	0.325
LIG_FHA_1	204	210	PF00498	0.325
LIG_FHA_1	234	240	PF00498	0.298
LIG_FHA_1	611	617	PF00498	0.593
LIG_FHA_2	155	161	PF00498	0.426
LIG_FHA_2	21	27	PF00498	0.373
LIG_FHA_2	439	445	PF00498	0.450
LIG_FHA_2	555	561	PF00498	0.516
LIG_LIR_Gen_1	103	113	PF02991	0.309
LIG_LIR_Gen_1	160	171	PF02991	0.348
LIG_LIR_Gen_1	221	231	PF02991	0.364
LIG_LIR_Gen_1	305	315	PF02991	0.306
LIG_LIR_Gen_1	365	373	PF02991	0.360
LIG_LIR_Gen_1	375	385	PF02991	0.319
LIG_LIR_Gen_1	412	423	PF02991	0.300
LIG_LIR_Gen_1	424	434	PF02991	0.351
LIG_LIR_Gen_1	479	488	PF02991	0.406
LIG_LIR_Gen_1	515	524	PF02991	0.327
LIG_LIR_Gen_1	586	596	PF02991	0.516
LIG_LIR_Nem_3	103	108	PF02991	0.296
LIG_LIR_Nem_3	160	166	PF02991	0.377
LIG_LIR_Nem_3	221	226	PF02991	0.299
LIG_LIR_Nem_3	305	311	PF02991	0.290
LIG_LIR_Nem_3	347	353	PF02991	0.313
LIG_LIR_Nem_3	365	370	PF02991	0.388
LIG_LIR_Nem_3	375	380	PF02991	0.314
LIG_LIR_Nem_3	412	418	PF02991	0.307
LIG_LIR_Nem_3	424	429	PF02991	0.349
LIG_LIR_Nem_3	430	435	PF02991	0.367
LIG_LIR_Nem_3	479	485	PF02991	0.443
LIG_LIR_Nem_3	496	500	PF02991	0.351
LIG_LIR_Nem_3	515	520	PF02991	0.250
LIG_LIR_Nem_3	586	592	PF02991	0.520
LIG_LIR_Nem_3	74	79	PF02991	0.359
LIG_NRBOX	606	612	PF00104	0.533
LIG_PAM2_1	404	416	PF00658	0.330
LIG_Pex14_2	373	377	PF04695	0.305
LIG_Pex14_2	413	417	PF04695	0.279
LIG_Pex14_2	462	466	PF04695	0.300
LIG_PTB_Apo_2	210	217	PF02174	0.227
LIG_PTB_Apo_2	343	350	PF02174	0.316
LIG_REV1ctd_RIR_1	600	608	PF16727	0.569
LIG_SH2_CRK	163	167	PF00017	0.339
LIG_SH2_CRK	351	355	PF00017	0.348
LIG_SH2_CRK	482	486	PF00017	0.416
LIG_SH2_CRK	589	593	PF00017	0.532
LIG_SH2_NCK_1	155	159	PF00017	0.397
LIG_SH2_NCK_1	163	167	PF00017	0.298
LIG_SH2_NCK_1	308	312	PF00017	0.380
LIG_SH2_SRC	422	425	PF00017	0.351
LIG_SH2_STAP1	335	339	PF00017	0.369
LIG_SH2_STAT5	105	108	PF00017	0.310
LIG_SH2_STAT5	163	166	PF00017	0.320
LIG_SH2_STAT5	187	190	PF00017	0.325
LIG_SH2_STAT5	273	276	PF00017	0.342
LIG_SH2_STAT5	308	311	PF00017	0.303
LIG_SH2_STAT5	314	317	PF00017	0.269
LIG_SH2_STAT5	381	384	PF00017	0.384
LIG_SH2_STAT5	43	46	PF00017	0.369
LIG_SH2_STAT5	482	485	PF00017	0.427
LIG_SH2_STAT5	589	592	PF00017	0.578
LIG_SH3_3	107	113	PF00018	0.308
LIG_SH3_3	119	125	PF00018	0.316
LIG_SH3_3	206	212	PF00018	0.267
LIG_SH3_3	612	618	PF00018	0.544
LIG_Sin3_3	329	336	PF02671	0.330
LIG_Sin3_3	543	550	PF02671	0.317
LIG_SUMO_SIM_anti_2	197	204	PF11976	0.384
LIG_SUMO_SIM_anti_2	491	496	PF11976	0.418
LIG_SUMO_SIM_par_1	238	243	PF11976	0.345
LIG_SUMO_SIM_par_1	248	256	PF11976	0.384
LIG_UBA3_1	257	266	PF00899	0.368
LIG_UBA3_1	376	383	PF00899	0.368
LIG_WRC_WIRS_1	494	499	PF05994	0.329
LIG_WRC_WIRS_1	514	519	PF05994	0.220
MOD_CDK_SPK_2	109	114	PF00069	0.315
MOD_CK1_1	20	26	PF00069	0.381
MOD_CK1_1	476	482	PF00069	0.401
MOD_CK1_1	513	519	PF00069	0.362
MOD_CK1_1	584	590	PF00069	0.564
MOD_CK1_1	94	100	PF00069	0.291
MOD_CK2_1	281	287	PF00069	0.373
MOD_CK2_1	357	363	PF00069	0.334
MOD_CK2_1	372	378	PF00069	0.265
MOD_CK2_1	444	450	PF00069	0.427
MOD_CK2_1	520	526	PF00069	0.255
MOD_CK2_1	554	560	PF00069	0.509
MOD_CK2_1	606	612	PF00069	0.501
MOD_GlcNHglycan	179	182	PF01048	0.484
MOD_GlcNHglycan	359	362	PF01048	0.533
MOD_GlcNHglycan	389	392	PF01048	0.704
MOD_GlcNHglycan	398	401	PF01048	0.608
MOD_GlcNHglycan	406	409	PF01048	0.449
MOD_GlcNHglycan	446	449	PF01048	0.653
MOD_GlcNHglycan	474	478	PF01048	0.706
MOD_GlcNHglycan	537	540	PF01048	0.393
MOD_GlcNHglycan	578	581	PF01048	0.327
MOD_GlcNHglycan	586	589	PF01048	0.318
MOD_GlcNHglycan	82	86	PF01048	0.637
MOD_GSK3_1	175	182	PF00069	0.308
MOD_GSK3_1	253	260	PF00069	0.430
MOD_GSK3_1	302	309	PF00069	0.406
MOD_GSK3_1	396	403	PF00069	0.521
MOD_GSK3_1	476	483	PF00069	0.419
MOD_GSK3_1	499	506	PF00069	0.392
MOD_GSK3_1	606	613	PF00069	0.591
MOD_N-GLC_1	455	460	PF02516	0.536
MOD_N-GLC_2	66	68	PF02516	0.511
MOD_NEK2_1	120	125	PF00069	0.271
MOD_NEK2_1	253	258	PF00069	0.402
MOD_NEK2_1	339	344	PF00069	0.502
MOD_NEK2_1	42	47	PF00069	0.365
MOD_NEK2_1	466	471	PF00069	0.408
MOD_NEK2_1	533	538	PF00069	0.340
MOD_NEK2_1	554	559	PF00069	0.522
MOD_NEK2_1	562	567	PF00069	0.544
MOD_NEK2_1	610	615	PF00069	0.587
MOD_NEK2_2	372	377	PF00069	0.304
MOD_NEK2_2	620	625	PF00069	0.552
MOD_PIKK_1	192	198	PF00454	0.319
MOD_PIKK_1	518	524	PF00454	0.319
MOD_PIKK_1	552	558	PF00454	0.525
MOD_PIKK_1	91	97	PF00454	0.359
MOD_PK_1	179	185	PF00069	0.317
MOD_PKA_2	203	209	PF00069	0.304
MOD_PKA_2	339	345	PF00069	0.362
MOD_PKA_2	387	393	PF00069	0.341
MOD_Plk_1	100	106	PF00069	0.347
MOD_Plk_1	161	167	PF00069	0.367
MOD_Plk_1	455	461	PF00069	0.296
MOD_Plk_1	605	611	PF00069	0.567
MOD_Plk_2-3	156	162	PF00069	0.508
MOD_Plk_2-3	363	369	PF00069	0.385
MOD_Plk_2-3	564	570	PF00069	0.568
MOD_Plk_2-3	606	612	PF00069	0.555
MOD_Plk_4	179	185	PF00069	0.308
MOD_Plk_4	218	224	PF00069	0.325
MOD_Plk_4	253	259	PF00069	0.302
MOD_Plk_4	273	279	PF00069	0.190
MOD_Plk_4	339	345	PF00069	0.421
MOD_Plk_4	372	378	PF00069	0.305
MOD_Plk_4	513	519	PF00069	0.375
MOD_Plk_4	606	612	PF00069	0.555
MOD_Plk_4	620	626	PF00069	0.487
MOD_Plk_4	94	100	PF00069	0.354
MOD_ProDKin_1	109	115	PF00069	0.414
MOD_SUMO_for_1	454	457	PF00179	0.300
MOD_SUMO_rev_2	501	506	PF00179	0.431
TRG_DiLeu_BaEn_1	140	145	PF01217	0.249
TRG_DiLeu_BaEn_1	606	611	PF01217	0.525
TRG_DiLeu_BaEn_2	525	531	PF01217	0.194
TRG_DiLeu_BaLyEn_6	541	546	PF01217	0.341
TRG_ENDOCYTIC_2	105	108	PF00928	0.341
TRG_ENDOCYTIC_2	155	158	PF00928	0.410
TRG_ENDOCYTIC_2	163	166	PF00928	0.292
TRG_ENDOCYTIC_2	292	295	PF00928	0.319
TRG_ENDOCYTIC_2	308	311	PF00928	0.237
TRG_ENDOCYTIC_2	350	353	PF00928	0.275
TRG_ENDOCYTIC_2	482	485	PF00928	0.427
TRG_ENDOCYTIC_2	589	592	PF00928	0.534
TRG_ENDOCYTIC_2	76	79	PF00928	0.334
TRG_ER_diArg_1	149	152	PF00400	0.304
TRG_ER_diArg_1	271	273	PF00400	0.336
TRG_ER_diArg_1	451	453	PF00400	0.317
TRG_ER_diArg_1	89	91	PF00400	0.352
TRG_Pf-PMV_PEXEL_1	452	457	PF00026	0.499
TRG_Pf-PMV_PEXEL_1	544	548	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	90	95	PF00026	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM74	Leptomonas seymouri	55%	100%
A0A1X0NYU6	Trypanosomatidae	30%	100%
A0A3S7X1C5	Leishmania donovani	95%	100%
A4HGC1	Leishmania braziliensis	78%	100%
A4I3F4	Leishmania infantum	95%	100%
D0A7Y6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AZP2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BQB3	Trypanosoma cruzi	28%	100%