Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8I7_LEIMA

TriTrypDb:

LmjF.28.0820 , LMJLV39_280014000 , LMJSD75_280014000

Length:

504

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q8I7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8I7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	160	164	PF00656	0.538
CLV_C14_Caspase3-7	224	228	PF00656	0.777
CLV_NRD_NRD_1	125	127	PF00675	0.510
CLV_NRD_NRD_1	164	166	PF00675	0.516
CLV_NRD_NRD_1	277	279	PF00675	0.575
CLV_NRD_NRD_1	385	387	PF00675	0.777
CLV_NRD_NRD_1	435	437	PF00675	0.600
CLV_NRD_NRD_1	77	79	PF00675	0.636
CLV_NRD_NRD_1	92	94	PF00675	0.542
CLV_PCSK_FUR_1	275	279	PF00082	0.678
CLV_PCSK_FUR_1	74	78	PF00082	0.728
CLV_PCSK_KEX2_1	275	277	PF00082	0.578
CLV_PCSK_KEX2_1	385	387	PF00082	0.778
CLV_PCSK_KEX2_1	435	437	PF00082	0.600
CLV_PCSK_KEX2_1	76	78	PF00082	0.640
CLV_PCSK_KEX2_1	92	94	PF00082	0.553
CLV_PCSK_PC7_1	272	278	PF00082	0.635
CLV_PCSK_PC7_1	88	94	PF00082	0.659
CLV_PCSK_SKI1_1	109	113	PF00082	0.604
CLV_PCSK_SKI1_1	166	170	PF00082	0.554
CLV_PCSK_SKI1_1	361	365	PF00082	0.827
CLV_PCSK_SKI1_1	96	100	PF00082	0.598
CLV_Separin_Metazoa	342	346	PF03568	0.736
DEG_APCC_DBOX_1	138	146	PF00400	0.456
DEG_Nend_UBRbox_3	1	3	PF02207	0.573
DEG_SCF_FBW7_2	217	224	PF00400	0.688
DEG_SPOP_SBC_1	62	66	PF00917	0.783
DOC_CKS1_1	82	87	PF01111	0.664
DOC_MAPK_gen_1	486	494	PF00069	0.523
DOC_PP4_FxxP_1	187	190	PF00568	0.583
DOC_PP4_FxxP_1	340	343	PF00568	0.558
DOC_PP4_FxxP_1	390	393	PF00568	0.741
DOC_USP7_MATH_1	18	22	PF00917	0.661
DOC_USP7_MATH_1	180	184	PF00917	0.546
DOC_USP7_MATH_1	208	212	PF00917	0.759
DOC_USP7_MATH_1	237	241	PF00917	0.720
DOC_USP7_MATH_1	259	263	PF00917	0.701
DOC_USP7_MATH_1	398	402	PF00917	0.686
DOC_USP7_MATH_1	62	66	PF00917	0.776
DOC_USP7_UBL2_3	162	166	PF12436	0.575
DOC_WW_Pin1_4	204	209	PF00397	0.740
DOC_WW_Pin1_4	217	222	PF00397	0.790
DOC_WW_Pin1_4	257	262	PF00397	0.571
DOC_WW_Pin1_4	298	303	PF00397	0.671
DOC_WW_Pin1_4	371	376	PF00397	0.792
DOC_WW_Pin1_4	81	86	PF00397	0.664
LIG_14-3-3_CanoR_1	179	189	PF00244	0.568
LIG_14-3-3_CanoR_1	204	208	PF00244	0.697
LIG_14-3-3_CanoR_1	4	12	PF00244	0.725
LIG_14-3-3_CanoR_1	400	405	PF00244	0.640
LIG_14-3-3_CanoR_1	409	415	PF00244	0.549
LIG_14-3-3_CanoR_1	420	426	PF00244	0.387
LIG_14-3-3_CanoR_1	451	458	PF00244	0.680
LIG_14-3-3_CanoR_1	76	82	PF00244	0.626
LIG_Actin_WH2_2	135	153	PF00022	0.531
LIG_BIR_III_2	42	46	PF00653	0.714
LIG_BIR_III_4	426	430	PF00653	0.512
LIG_BRCT_BRCA1_1	183	187	PF00533	0.635
LIG_deltaCOP1_diTrp_1	326	332	PF00928	0.525
LIG_FHA_1	26	32	PF00498	0.775
LIG_FHA_1	7	13	PF00498	0.649
LIG_FHA_2	113	119	PF00498	0.501
LIG_FHA_2	130	136	PF00498	0.481
LIG_FHA_2	217	223	PF00498	0.792
LIG_FHA_2	316	322	PF00498	0.536
LIG_FHA_2	337	343	PF00498	0.643
LIG_FHA_2	355	361	PF00498	0.766
LIG_FHA_2	411	417	PF00498	0.701
LIG_FHA_2	493	499	PF00498	0.593
LIG_FHA_2	82	88	PF00498	0.553
LIG_GBD_Chelix_1	142	150	PF00786	0.471
LIG_LIR_Apic_2	184	190	PF02991	0.615
LIG_LIR_Apic_2	338	343	PF02991	0.551
LIG_LIR_Apic_2	388	393	PF02991	0.728
LIG_LIR_Gen_1	128	138	PF02991	0.466
LIG_LIR_Nem_3	105	111	PF02991	0.690
LIG_LIR_Nem_3	128	133	PF02991	0.482
LIG_LIR_Nem_3	304	309	PF02991	0.549
LIG_LIR_Nem_3	428	434	PF02991	0.495
LIG_Pex14_1	327	331	PF04695	0.524
LIG_RPA_C_Fungi	153	165	PF08784	0.573
LIG_SH2_CRK	167	171	PF00017	0.492
LIG_SH2_STAP1	32	36	PF00017	0.773
LIG_SH2_STAT5	116	119	PF00017	0.547
LIG_SH2_STAT5	149	152	PF00017	0.467
LIG_SH2_STAT5	32	35	PF00017	0.742
LIG_SH2_STAT5	331	334	PF00017	0.542
LIG_SH3_1	101	107	PF00018	0.581
LIG_SH3_2	104	109	PF14604	0.690
LIG_SH3_3	101	107	PF00018	0.581
LIG_SH3_3	390	396	PF00018	0.771
LIG_SH3_3	462	468	PF00018	0.531
LIG_SH3_3	65	71	PF00018	0.794
LIG_SH3_3	79	85	PF00018	0.637
LIG_TRAF2_1	261	264	PF00917	0.664
LIG_WW_3	342	346	PF00397	0.736
MOD_CDK_SPK_2	81	86	PF00069	0.674
MOD_CDK_SPxxK_3	81	88	PF00069	0.668
MOD_CK1_1	206	212	PF00069	0.712
MOD_CK1_1	21	27	PF00069	0.665
MOD_CK1_1	213	219	PF00069	0.695
MOD_CK1_1	298	304	PF00069	0.703
MOD_CK1_1	481	487	PF00069	0.663
MOD_CK1_1	52	58	PF00069	0.773
MOD_CK1_1	6	12	PF00069	0.683
MOD_CK1_1	66	72	PF00069	0.655
MOD_CK2_1	134	140	PF00069	0.572
MOD_CK2_1	216	222	PF00069	0.711
MOD_CK2_1	259	265	PF00069	0.671
MOD_CK2_1	336	342	PF00069	0.633
MOD_CK2_1	356	362	PF00069	0.778
MOD_CK2_1	435	441	PF00069	0.712
MOD_CK2_1	450	456	PF00069	0.681
MOD_CK2_1	492	498	PF00069	0.532
MOD_CK2_1	81	87	PF00069	0.562
MOD_Cter_Amidation	124	127	PF01082	0.470
MOD_Cter_Amidation	383	386	PF01082	0.700
MOD_DYRK1A_RPxSP_1	204	208	PF00069	0.645
MOD_GlcNHglycan	183	186	PF01048	0.601
MOD_GlcNHglycan	255	258	PF01048	0.776
MOD_GlcNHglycan	303	306	PF01048	0.562
MOD_GlcNHglycan	387	390	PF01048	0.672
MOD_GlcNHglycan	400	403	PF01048	0.592
MOD_GlcNHglycan	65	68	PF01048	0.745
MOD_GSK3_1	18	25	PF00069	0.701
MOD_GSK3_1	2	9	PF00069	0.669
MOD_GSK3_1	203	210	PF00069	0.616
MOD_GSK3_1	211	218	PF00069	0.687
MOD_GSK3_1	237	244	PF00069	0.722
MOD_GSK3_1	253	260	PF00069	0.515
MOD_GSK3_1	316	323	PF00069	0.584
MOD_GSK3_1	52	59	PF00069	0.749
MOD_GSK3_1	62	69	PF00069	0.676
MOD_GSK3_1	77	84	PF00069	0.503
MOD_N-GLC_1	25	30	PF02516	0.544
MOD_NEK2_1	150	155	PF00069	0.536
MOD_NEK2_1	169	174	PF00069	0.339
MOD_NEK2_1	284	289	PF00069	0.628
MOD_NEK2_1	3	8	PF00069	0.657
MOD_NEK2_1	31	36	PF00069	0.708
MOD_NEK2_1	410	415	PF00069	0.597
MOD_NEK2_1	63	68	PF00069	0.775
MOD_PIKK_1	231	237	PF00454	0.677
MOD_PIKK_1	259	265	PF00454	0.705
MOD_PIKK_1	66	72	PF00454	0.789
MOD_PKA_1	126	132	PF00069	0.545
MOD_PKA_1	385	391	PF00069	0.784
MOD_PKA_1	435	441	PF00069	0.704
MOD_PKA_1	76	82	PF00069	0.607
MOD_PKA_2	150	156	PF00069	0.575
MOD_PKA_2	203	209	PF00069	0.693
MOD_PKA_2	3	9	PF00069	0.661
MOD_PKA_2	385	391	PF00069	0.704
MOD_PKA_2	421	427	PF00069	0.575
MOD_PKA_2	435	441	PF00069	0.406
MOD_PKA_2	450	456	PF00069	0.567
MOD_PKA_2	492	498	PF00069	0.532
MOD_PKA_2	56	62	PF00069	0.749
MOD_PKA_2	76	82	PF00069	0.538
MOD_PKB_1	74	82	PF00069	0.703
MOD_Plk_1	134	140	PF00069	0.545
MOD_Plk_1	316	322	PF00069	0.576
MOD_Plk_1	335	341	PF00069	0.525
MOD_Plk_2-3	134	140	PF00069	0.572
MOD_Plk_2-3	336	342	PF00069	0.627
MOD_Plk_2-3	354	360	PF00069	0.773
MOD_Plk_4	112	118	PF00069	0.606
MOD_Plk_4	237	243	PF00069	0.717
MOD_Plk_4	320	326	PF00069	0.527
MOD_ProDKin_1	204	210	PF00069	0.747
MOD_ProDKin_1	217	223	PF00069	0.789
MOD_ProDKin_1	257	263	PF00069	0.566
MOD_ProDKin_1	298	304	PF00069	0.662
MOD_ProDKin_1	371	377	PF00069	0.792
MOD_ProDKin_1	81	87	PF00069	0.661
MOD_SUMO_rev_2	90	98	PF00179	0.644
TRG_DiLeu_BaLyEn_6	487	492	PF01217	0.550
TRG_ENDOCYTIC_2	167	170	PF00928	0.473
TRG_ENDOCYTIC_2	431	434	PF00928	0.616
TRG_ER_diArg_1	275	278	PF00400	0.562
TRG_ER_diArg_1	309	312	PF00400	0.538
TRG_ER_diArg_1	344	347	PF00400	0.750
TRG_ER_diArg_1	385	387	PF00400	0.671
TRG_ER_diArg_1	407	410	PF00400	0.605
TRG_ER_diArg_1	434	436	PF00400	0.570
TRG_ER_diArg_1	75	78	PF00400	0.673
TRG_ER_diArg_1	91	93	PF00400	0.575
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.656
TRG_Pf-PMV_PEXEL_1	412	416	PF00026	0.703

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8G0	Leptomonas seymouri	63%	100%
A0A0S4IT28	Bodo saltans	36%	100%
A0A1X0NYF9	Trypanosomatidae	47%	100%
A0A3Q8IDQ0	Leishmania donovani	95%	100%
A0A3R7M5S0	Trypanosoma rangeli	46%	100%
A4HGC4	Leishmania braziliensis	79%	100%
A4I3F7	Leishmania infantum	95%	100%
D0A7Y3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AZP5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BKT5	Trypanosoma cruzi	45%	100%