Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8I5_LEIMA

TriTrypDb:

LmjF.28.0830 , LMJLV39_280014300 , LMJSD75_280014300

Length:

532

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q8I5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8I5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	4
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.620
CLV_NRD_NRD_1	135	137	PF00675	0.465
CLV_NRD_NRD_1	292	294	PF00675	0.467
CLV_NRD_NRD_1	495	497	PF00675	0.492
CLV_NRD_NRD_1	499	501	PF00675	0.483
CLV_PCSK_KEX2_1	135	137	PF00082	0.465
CLV_PCSK_KEX2_1	213	215	PF00082	0.513
CLV_PCSK_KEX2_1	392	394	PF00082	0.449
CLV_PCSK_KEX2_1	495	497	PF00082	0.494
CLV_PCSK_KEX2_1	499	501	PF00082	0.478
CLV_PCSK_KEX2_1	63	65	PF00082	0.622
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.438
CLV_PCSK_PC1ET2_1	392	394	PF00082	0.449
CLV_PCSK_PC1ET2_1	63	65	PF00082	0.622
CLV_PCSK_PC7_1	495	501	PF00082	0.480
CLV_PCSK_SKI1_1	213	217	PF00082	0.507
CLV_PCSK_SKI1_1	293	297	PF00082	0.495
DEG_APCC_DBOX_1	292	300	PF00400	0.419
DEG_SCF_FBW7_1	521	528	PF00400	0.507
DEG_SPOP_SBC_1	42	46	PF00917	0.617
DOC_CDC14_PxL_1	20	28	PF14671	0.706
DOC_CKS1_1	160	165	PF01111	0.546
DOC_CYCLIN_RxL_1	290	298	PF00134	0.480
DOC_CYCLIN_yCln2_LP_2	320	326	PF00134	0.483
DOC_MAPK_DCC_7	16	25	PF00069	0.699
DOC_MAPK_gen_1	16	25	PF00069	0.690
DOC_MAPK_gen_1	441	450	PF00069	0.604
DOC_MAPK_MEF2A_6	16	25	PF00069	0.699
DOC_MAPK_MEF2A_6	407	415	PF00069	0.497
DOC_MAPK_MEF2A_6	458	467	PF00069	0.464
DOC_PP4_FxxP_1	300	303	PF00568	0.479
DOC_USP7_MATH_1	154	158	PF00917	0.525
DOC_USP7_MATH_1	31	35	PF00917	0.711
DOC_USP7_MATH_1	329	333	PF00917	0.412
DOC_USP7_MATH_1	378	382	PF00917	0.468
DOC_USP7_MATH_1	437	441	PF00917	0.602
DOC_USP7_MATH_1	525	529	PF00917	0.537
DOC_USP7_MATH_2	31	37	PF00917	0.656
DOC_USP7_UBL2_3	483	487	PF12436	0.506
DOC_WW_Pin1_4	135	140	PF00397	0.510
DOC_WW_Pin1_4	144	149	PF00397	0.452
DOC_WW_Pin1_4	159	164	PF00397	0.505
DOC_WW_Pin1_4	319	324	PF00397	0.374
DOC_WW_Pin1_4	521	526	PF00397	0.449
DOC_WW_Pin1_4	54	59	PF00397	0.637
LIG_14-3-3_CanoR_1	204	212	PF00244	0.539
LIG_14-3-3_CanoR_1	214	222	PF00244	0.462
LIG_14-3-3_CanoR_1	257	261	PF00244	0.431
LIG_14-3-3_CanoR_1	376	385	PF00244	0.494
LIG_14-3-3_CanoR_1	407	412	PF00244	0.503
LIG_APCC_ABBA_1	189	194	PF00400	0.525
LIG_BRCT_BRCA1_1	185	189	PF00533	0.492
LIG_BRCT_BRCA1_1	446	450	PF00533	0.383
LIG_BRCT_BRCA1_1	527	531	PF00533	0.521
LIG_deltaCOP1_diTrp_1	368	377	PF00928	0.531
LIG_deltaCOP1_diTrp_1	475	478	PF00928	0.378
LIG_EH1_1	268	276	PF00400	0.463
LIG_EH1_1	308	316	PF00400	0.463
LIG_FHA_1	122	128	PF00498	0.407
LIG_FHA_1	266	272	PF00498	0.381
LIG_FHA_1	392	398	PF00498	0.541
LIG_FHA_1	406	412	PF00498	0.440
LIG_FHA_1	44	50	PF00498	0.521
LIG_FHA_1	513	519	PF00498	0.382
LIG_FHA_1	98	104	PF00498	0.689
LIG_FHA_2	204	210	PF00498	0.375
LIG_FHA_2	285	291	PF00498	0.440
LIG_FHA_2	378	384	PF00498	0.502
LIG_FHA_2	55	61	PF00498	0.733
LIG_LIR_Apic_2	298	303	PF02991	0.493
LIG_LIR_Gen_1	239	246	PF02991	0.500
LIG_LIR_Gen_1	280	289	PF02991	0.376
LIG_LIR_Gen_1	354	365	PF02991	0.358
LIG_LIR_Gen_1	379	390	PF02991	0.458
LIG_LIR_Gen_1	447	456	PF02991	0.372
LIG_LIR_Gen_1	475	486	PF02991	0.402
LIG_LIR_Nem_3	239	244	PF02991	0.549
LIG_LIR_Nem_3	280	285	PF02991	0.338
LIG_LIR_Nem_3	290	295	PF02991	0.362
LIG_LIR_Nem_3	336	340	PF02991	0.418
LIG_LIR_Nem_3	354	360	PF02991	0.208
LIG_LIR_Nem_3	379	385	PF02991	0.374
LIG_LIR_Nem_3	447	453	PF02991	0.391
LIG_LIR_Nem_3	475	481	PF02991	0.389
LIG_LIR_Nem_3	484	489	PF02991	0.363
LIG_MYND_1	159	163	PF01753	0.511
LIG_Pex14_2	48	52	PF04695	0.657
LIG_PTB_Apo_2	263	270	PF02174	0.378
LIG_PTB_Apo_2	310	317	PF02174	0.444
LIG_PTB_Phospho_1	263	269	PF10480	0.380
LIG_SH2_CRK	292	296	PF00017	0.509
LIG_SH2_CRK	486	490	PF00017	0.397
LIG_SH2_NCK_1	235	239	PF00017	0.497
LIG_SH2_SRC	352	355	PF00017	0.341
LIG_SH2_STAP1	409	413	PF00017	0.356
LIG_SH2_STAT3	131	134	PF00017	0.431
LIG_SH2_STAT3	251	254	PF00017	0.466
LIG_SH2_STAT5	126	129	PF00017	0.447
LIG_SH2_STAT5	150	153	PF00017	0.584
LIG_SH2_STAT5	251	254	PF00017	0.513
LIG_SH2_STAT5	269	272	PF00017	0.356
LIG_SH2_STAT5	352	355	PF00017	0.356
LIG_SH2_STAT5	455	458	PF00017	0.347
LIG_SH2_STAT5	466	469	PF00017	0.365
LIG_SH3_3	100	106	PF00018	0.721
LIG_SH3_3	148	154	PF00018	0.547
LIG_SH3_3	18	24	PF00018	0.718
LIG_SUMO_SIM_anti_2	429	434	PF11976	0.360
LIG_SUMO_SIM_par_1	341	348	PF11976	0.375
LIG_SUMO_SIM_par_1	417	423	PF11976	0.458
LIG_SxIP_EBH_1	16	26	PF03271	0.712
LIG_TRAF2_1	207	210	PF00917	0.467
LIG_UBA3_1	160	166	PF00899	0.575
LIG_UBA3_1	22	29	PF00899	0.649
LIG_UBA3_1	295	301	PF00899	0.496
LIG_WRC_WIRS_1	49	54	PF05994	0.531
MOD_CDK_SPxxK_3	159	166	PF00069	0.558
MOD_CK1_1	319	325	PF00069	0.371
MOD_CK1_1	34	40	PF00069	0.750
MOD_CK1_1	342	348	PF00069	0.358
MOD_CK1_1	420	426	PF00069	0.414
MOD_CK1_1	44	50	PF00069	0.762
MOD_CK1_1	51	57	PF00069	0.521
MOD_CK1_1	84	90	PF00069	0.800
MOD_CK1_1	97	103	PF00069	0.634
MOD_CK2_1	203	209	PF00069	0.496
MOD_Cter_Amidation	390	393	PF01082	0.449
MOD_Cter_Amidation	61	64	PF01082	0.649
MOD_GlcNHglycan	185	188	PF01048	0.516
MOD_GlcNHglycan	206	209	PF01048	0.487
MOD_GlcNHglycan	347	350	PF01048	0.393
MOD_GlcNHglycan	53	56	PF01048	0.727
MOD_GlcNHglycan	66	69	PF01048	0.563
MOD_GlcNHglycan	96	99	PF01048	0.742
MOD_GSK3_1	11	18	PF00069	0.709
MOD_GSK3_1	121	128	PF00069	0.431
MOD_GSK3_1	31	38	PF00069	0.737
MOD_GSK3_1	407	414	PF00069	0.382
MOD_GSK3_1	44	51	PF00069	0.751
MOD_GSK3_1	521	528	PF00069	0.507
MOD_GSK3_1	80	87	PF00069	0.653
MOD_N-GLC_1	265	270	PF02516	0.437
MOD_N-GLC_1	42	47	PF02516	0.718
MOD_N-GLC_1	512	517	PF02516	0.417
MOD_N-GLC_1	84	89	PF02516	0.712
MOD_NEK2_1	125	130	PF00069	0.444
MOD_NEK2_1	316	321	PF00069	0.363
MOD_NEK2_1	405	410	PF00069	0.524
MOD_NEK2_1	481	486	PF00069	0.399
MOD_NEK2_2	121	126	PF00069	0.413
MOD_PIKK_1	213	219	PF00454	0.547
MOD_PIKK_1	35	41	PF00454	0.661
MOD_PK_1	407	413	PF00069	0.490
MOD_PKA_1	213	219	PF00069	0.522
MOD_PKA_2	203	209	PF00069	0.421
MOD_PKA_2	213	219	PF00069	0.438
MOD_PKA_2	256	262	PF00069	0.430
MOD_PKA_2	79	85	PF00069	0.703
MOD_PKB_1	374	382	PF00069	0.480
MOD_PKB_1	441	449	PF00069	0.569
MOD_Plk_1	265	271	PF00069	0.436
MOD_Plk_1	31	37	PF00069	0.592
MOD_Plk_1	443	449	PF00069	0.416
MOD_Plk_1	512	518	PF00069	0.409
MOD_Plk_4	121	127	PF00069	0.441
MOD_Plk_4	256	262	PF00069	0.398
MOD_Plk_4	329	335	PF00069	0.432
MOD_Plk_4	339	345	PF00069	0.476
MOD_Plk_4	426	432	PF00069	0.395
MOD_Plk_4	44	50	PF00069	0.521
MOD_Plk_4	459	465	PF00069	0.472
MOD_ProDKin_1	135	141	PF00069	0.504
MOD_ProDKin_1	144	150	PF00069	0.448
MOD_ProDKin_1	159	165	PF00069	0.504
MOD_ProDKin_1	319	325	PF00069	0.371
MOD_ProDKin_1	521	527	PF00069	0.457
MOD_ProDKin_1	54	60	PF00069	0.639
MOD_SUMO_for_1	285	288	PF00179	0.468
MOD_SUMO_rev_2	207	215	PF00179	0.512
TRG_DiLeu_BaEn_4	210	216	PF01217	0.511
TRG_DiLeu_BaLyEn_6	156	161	PF01217	0.516
TRG_ENDOCYTIC_2	176	179	PF00928	0.459
TRG_ENDOCYTIC_2	235	238	PF00928	0.409
TRG_ENDOCYTIC_2	282	285	PF00928	0.350
TRG_ENDOCYTIC_2	292	295	PF00928	0.387
TRG_ENDOCYTIC_2	486	489	PF00928	0.376
TRG_ER_diArg_1	494	496	PF00400	0.467
TRG_ER_diArg_1	498	500	PF00400	0.479
TRG_ER_diArg_1	519	522	PF00400	0.434
TRG_NES_CRM1_1	354	369	PF08389	0.482
TRG_Pf-PMV_PEXEL_1	293	298	PF00026	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6Z5	Leptomonas seymouri	68%	100%
A0A0S4IP32	Bodo saltans	39%	100%
A0A1X0NYG7	Trypanosomatidae	53%	100%
A0A3Q8IDT7	Leishmania donovani	96%	100%
A0A3R7LMJ5	Trypanosoma rangeli	55%	100%
A4HGC7	Leishmania braziliensis	85%	100%
A4I3F9	Leishmania infantum	96%	100%
D0A7X9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9AZP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5DH50	Trypanosoma cruzi	55%	100%